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- PDB-1f0f: Cecropin A(1-8)-magainin 2(1-12) gig deletion modification in dod... -
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Open data
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Basic information
Entry | Database: PDB / ID: 1f0f | ||||||
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Title | Cecropin A(1-8)-magainin 2(1-12) gig deletion modification in dodecylphosphocholine micelles | ||||||
![]() | CECROPIN A-MAGAININ 2 HYBRID PEPTIDE | ||||||
![]() | ANTITUMOR PROTEIN / Helix | ||||||
Function / homology | ![]() regulation of defense response to virus / defense response to fungus / antibacterial humoral response / defense response to Gram-negative bacterium / killing of cells of another organism / defense response to Gram-positive bacterium / defense response to bacterium / innate immune response / extracellular space / extracellular region Similarity search - Function | ||||||
Method | SOLUTION NMR / Distance Geometry-Dynamical Simulated Annealing Hybrid Method | ||||||
![]() | Oh, D. / Shin, S.Y. / Lee, S. / Kim, Y. | ||||||
![]() | ![]() Title: Role of the hinge region and the tryptophan residue in the synthetic antimicrobial peptides, cecropin A(1-8)-magainin 2(1-12) and its analogues, on their antibiotic activities and structures. Authors: Oh, D. / Shin, S.Y. / Lee, S. / Kang, J.H. / Kim, S.D. / Ryu, P.D. / Hahm, K.S. / Kim, Y. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 121.8 KB | Display | ![]() |
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PDB format | ![]() | 95.6 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 344.5 KB | Display | ![]() |
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Full document | ![]() | 440.2 KB | Display | |
Data in XML | ![]() | 7.4 KB | Display | |
Data in CIF | ![]() | 11.2 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
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Links
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Assembly
Deposited unit | ![]()
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NMR ensembles |
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Components
#1: Protein/peptide | Mass: 2183.789 Da / Num. of mol.: 1 / Mutation: GIG DELETION IN MAGAININ SEGMENT / Source method: obtained synthetically Details: THIS PEPTIDE WAS CHEMICALLY SYNTHESIZED. THE SEQUENCE FOR THIS PEPTIDE IS A HYBRID OF SEQUENCES WHICH OCCUR NATURALLY IN HYALOPHORA CECROPIA (CECROPIA MOTH) AND XENOPUS LAEVIS (AFRICAN CLAWED FROG) References: UniProt: P01507, UniProt: P11006 |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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NMR experiment | Type: 2D NOESY |
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Sample preparation
Details | Contents: DODECYLPHOSPHOCHOLINE-d38 MICELLES / Solvent system: 90% H2O/10% D2O |
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Sample conditions | pH: 4.29 / Temperature: 298 K |
Crystal grow | *PLUS Method: other / Details: NMR |
-NMR measurement
NMR spectrometer | Type: Bruker AVANCE / Manufacturer: Bruker / Model: AVANCE / Field strength: 400 MHz |
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Processing
NMR software | Name: ![]() |
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Refinement | Method: Distance Geometry-Dynamical Simulated Annealing Hybrid Method Software ordinal: 1 |
NMR ensemble | Conformer selection criteria: structures with the lowest energy Conformers calculated total number: 50 / Conformers submitted total number: 20 |