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データを開く
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基本情報
登録情報 | データベース: PDB / ID: 1eta | |||||||||
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タイトル | THE X-RAY CRYSTAL STRUCTURE REFINEMENTS OF NORMAL HUMAN TRANSTHYRETIN AND THE AMYLOIDOGENIC VAL 30-->MET VARIANT TO 1.7 ANGSTROMS RESOLUTION | |||||||||
![]() | TRANSTHYRETIN | |||||||||
![]() | TRANSPORT(THYROXINE) | |||||||||
機能・相同性 | ![]() Retinoid cycle disease events / The canonical retinoid cycle in rods (twilight vision) / thyroid hormone binding / purine nucleobase metabolic process / Non-integrin membrane-ECM interactions / Retinoid metabolism and transport / hormone activity / azurophil granule lumen / Amyloid fiber formation / Neutrophil degranulation ...Retinoid cycle disease events / The canonical retinoid cycle in rods (twilight vision) / thyroid hormone binding / purine nucleobase metabolic process / Non-integrin membrane-ECM interactions / Retinoid metabolism and transport / hormone activity / azurophil granule lumen / Amyloid fiber formation / Neutrophil degranulation / extracellular space / extracellular exosome / extracellular region / identical protein binding 類似検索 - 分子機能 | |||||||||
生物種 | ![]() | |||||||||
手法 | ![]() | |||||||||
![]() | Braden, B.C. / Steinrauf, L.K. / Hamilton, J.A. | |||||||||
![]() | ![]() タイトル: The x-ray crystal structure refinements of normal human transthyretin and the amyloidogenic Val-30-->Met variant to 1.7-A resolution. 著者: Hamilton, J.A. / Steinrauf, L.K. / Braden, B.C. / Liepnieks, J. / Benson, M.D. / Holmgren, G. / Sandgren, O. / Steen, L. #1: ![]() タイトル: X-Ray Crystal Structure of the Ala 109-->Thr Variant of Human Transthyretin which Produces Euthyroid Hyperthyroxinemia 著者: Steinrauf, L.K. / Hamilton, J.A. / Braden, B.C. / Murrell, J.R. / Benson, M.D. #2: ![]() タイトル: Alteration in Molecular Structure which Results in Disease: The met 30 Variant of Human Plasma Transthyretin 著者: Hamilton, J.A. / Steinrauf, L.K. / Liepnieks, J.J. / Benson, M.D. / Holmgren, G. / Sandgren, O. / Steen, L. | |||||||||
履歴 |
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Remark 700 | SHEET SHEET IDENTIFIERS ARE BASED ON ENTRY 2PAB (PREALBUMIN, BLAKE ET AL.). A SHIFT OF THE CHAIN 1 ...SHEET SHEET IDENTIFIERS ARE BASED ON ENTRY 2PAB (PREALBUMIN, BLAKE ET AL.). A SHIFT OF THE CHAIN 1 AND 2 BETA SHEETS AT RESIDUE 30 WAS NECESSARY TO MODEL THE MET SIDE CHAIN. BETA SHEET MAIN CHAIN CONNECTIVITIES IN THE COORDINATE SET ARE TO THE VAL 30 PEPTIDE ATOMS. |
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構造の表示
構造ビューア | 分子: ![]() ![]() |
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PDBx/mmCIF形式 | ![]() | 69.7 KB | 表示 | ![]() |
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PDB形式 | ![]() | 51.8 KB | 表示 | ![]() |
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その他 | ![]() |
-検証レポート
文書・要旨 | ![]() | 965 KB | 表示 | ![]() |
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文書・詳細版 | ![]() | 984.7 KB | 表示 | |
XML形式データ | ![]() | 19.1 KB | 表示 | |
CIF形式データ | ![]() | 25.6 KB | 表示 | |
アーカイブディレクトリ | ![]() ![]() | HTTPS FTP |
-関連構造データ
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リンク
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集合体
登録構造単位 | ![]()
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2 | ![]()
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単位格子 |
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Atom site foot note | 1: THIS IS A NATURALLY OCCURRING VARIANT WITH MICROHETEROGENEITY AT POSITION 30. BOTH VAL AND MET OCCUR AT THIS POSITION. THE RATIO OF MET VAL AT POSITION 30 IS 1:1 AND BOTH VAL AND MET ARE MODELLED WITH 0.50 OCCUPANCY. | ||||||||
Components on special symmetry positions |
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非結晶学的対称性 (NCS) | NCS oper: (Code: given Matrix: (-0.9886, 0.1508, -0.0004), ベクター: 詳細 | THERE ARE TWO T4 BINDING SITES PER TETRAMER (AA, BB). SITE AA CONTAINS RESIDUES FROM CHAIN 1 AND CHAIN 1* WHERE CHAINS 1 AND 1* ARE RELATED BY CRYSTALLOGRAPHIC TWO-FOLD SYMMETRY. LIKEWISE, SITE BB CONTAINS RESIDUES FROM CHAIN 2 AND CHAIN 2* WHERE CHAINS 2 AND 2* ARE RELATED BY CRYSTALLOGRAPHIC SYMMETRY. BECAUSE OF PDB FORMAT SPECIFICATIONS, ONLY THE RESIDUES FROM CHAIN 1 ARE LISTED FOR SITE AA ON SITE RECORDS BELOW AND ONLY THE RESIDUES FROM CHAIN 2 ARE LISTED FOR SITE BB ON SITE RECORDS BELOW. THE TRANSFORMATION PRESENTED ON *MTRIX* RECORDS BELOW WILL YIELD APPROXIMATE COORDINATES FOR CHAIN 2 WHEN APPLIED TO CHAIN 1. | |
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要素
#1: タンパク質 | 分子量: 13809.426 Da / 分子数: 2 / 由来タイプ: 組換発現 / 由来: (組換発現) ![]() #2: 化合物 | #3: 水 | ChemComp-HOH / | |
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-実験情報
-実験
実験 | 手法: ![]() |
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試料調製
結晶 | マシュー密度: 2.24 Å3/Da / 溶媒含有率: 45.02 % |
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結晶化 | *PLUS 手法: unknown |
-データ収集
放射 | 散乱光タイプ: x-ray |
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放射波長 | 相対比: 1 |
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解析
ソフトウェア | 名称: PROLSQ / 分類: 精密化 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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精密化 | 解像度: 1.7→5 Å / Rfactor obs: 0.184 / σ(F): 2 詳細: OCCUPANCIES OF DISORDERED SIDE CHAINS OR OF ATOMS WITH LESS THAN UNIT OCCUPANCY WERE SELECTED TO FLATTEN THE FINAL DIFFERENCE FOURIER. OCCUPANCIES OF SOLVENT WATER MOLECULES WERE REFINED WITH ...詳細: OCCUPANCIES OF DISORDERED SIDE CHAINS OR OF ATOMS WITH LESS THAN UNIT OCCUPANCY WERE SELECTED TO FLATTEN THE FINAL DIFFERENCE FOURIER. OCCUPANCIES OF SOLVENT WATER MOLECULES WERE REFINED WITH PROLSQ. OCCUPANCIES OF DISORDERED SIDE CHAINS OR OF ATOMS WITH LESS THAN UNIT OCCUPANCY WERE SELECTED TO FLATTEN THE FINAL DIFFERENCE FOURIER. ATOMS WITH OCCUPANCIES OF .001 HAVE NO OBSERVABLE ELECTRON DENSITY. SOME WATER MOLECULES WERE PLACED IN POSITIONS THAT PROBABLY REPRESENT ALTERNATE CONFORMATIONS. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
精密化ステップ | サイクル: LAST / 解像度: 1.7→5 Å
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拘束条件 |
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拘束条件 | *PLUS タイプ: p_angle_d / Dev ideal: 0.027 |