+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 1edp | ||||||
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タイトル | CONFORMATIONAL ISOMERISM OF ENDOTHELIN IN ACIDIC AQUEOUS MEDIA: A QUANTITATIVE NOESY ANALYSIS | ||||||
要素 | ENDOTHELIN-1 PRECURSOR | ||||||
キーワード | VASOCONSTRICTOR | ||||||
機能・相同性 | 機能・相同性情報 positive regulation of prostaglandin-endoperoxide synthase activity / endothelin A receptor binding / protein kinase C deactivation / phospholipase D-activating G protein-coupled receptor signaling pathway / rhythmic excitation / peptide hormone secretion / endothelin B receptor binding / cellular response to human chorionic gonadotropin stimulus / meiotic cell cycle process involved in oocyte maturation / positive regulation of artery morphogenesis ...positive regulation of prostaglandin-endoperoxide synthase activity / endothelin A receptor binding / protein kinase C deactivation / phospholipase D-activating G protein-coupled receptor signaling pathway / rhythmic excitation / peptide hormone secretion / endothelin B receptor binding / cellular response to human chorionic gonadotropin stimulus / meiotic cell cycle process involved in oocyte maturation / positive regulation of artery morphogenesis / semaphorin-plexin signaling pathway involved in axon guidance / body fluid secretion / neural crest cell fate commitment / vein smooth muscle contraction / glomerular endothelium development / response to prostaglandin F / sympathetic neuron axon guidance / positive regulation of sarcomere organization / noradrenergic neuron differentiation / positive regulation of renal sodium excretion / histamine secretion / leukocyte activation / maternal process involved in parturition / positive regulation of chemokine-mediated signaling pathway / rough endoplasmic reticulum lumen / pharyngeal arch artery morphogenesis / regulation of D-glucose transmembrane transport / positive regulation of odontogenesis / epithelial fluid transport / endothelin receptor signaling pathway involved in heart process / negative regulation of hormone secretion / cardiac neural crest cell migration involved in outflow tract morphogenesis / Weibel-Palade body / response to leptin / endothelin receptor signaling pathway / response to ozone / podocyte differentiation / positive regulation of cell growth involved in cardiac muscle cell development / renal sodium ion absorption / artery smooth muscle contraction / glomerular filtration / axonogenesis involved in innervation / positive regulation of cation channel activity / cellular response to follicle-stimulating hormone stimulus / cellular response to luteinizing hormone stimulus / negative regulation of nitric-oxide synthase biosynthetic process / regulation of pH / positive regulation of prostaglandin secretion / respiratory gaseous exchange by respiratory system / basal part of cell / cellular response to mineralocorticoid stimulus / positive regulation of smooth muscle contraction / response to salt / positive regulation of urine volume / positive regulation of hormone secretion / regulation of systemic arterial blood pressure by endothelin / vasoconstriction / negative regulation of blood coagulation / : / embryonic heart tube development / dorsal/ventral pattern formation / axon extension / superoxide anion generation / positive regulation of neutrophil chemotaxis / positive regulation of signaling receptor activity / cartilage development / middle ear morphogenesis / cellular response to glucocorticoid stimulus / negative regulation of protein metabolic process / prostaglandin biosynthetic process / cellular response to fatty acid / nitric oxide transport / positive regulation of heart rate / branching involved in blood vessel morphogenesis / positive regulation of cardiac muscle hypertrophy / response to dexamethasone / response to testosterone / negative regulation of smooth muscle cell apoptotic process / thyroid gland development / membrane depolarization / positive regulation of cell size / cellular response to interleukin-1 / regulation of vasoconstriction / response to amino acid / canonical Wnt signaling pathway / Transcriptional and post-translational regulation of MITF-M expression and activity / positive regulation of JUN kinase activity / cellular response to transforming growth factor beta stimulus / positive regulation of vascular associated smooth muscle cell proliferation / transport vesicle / protein kinase A signaling / response to muscle stretch / response to amphetamine / ERK1 and ERK2 cascade / positive regulation of calcium-mediated signaling / phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of endothelial cell migration / adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway / positive regulation of mitotic nuclear division / cellular response to calcium ion 類似検索 - 分子機能 | ||||||
生物種 | Homo sapiens (ヒト) | ||||||
手法 | 溶液NMR | ||||||
データ登録者 | Andersen, N.H. / Chen, C. | ||||||
引用 | ジャーナル: Biochemistry / 年: 1992 タイトル: Conformational isomerism of endothelin in acidic aqueous media: a quantitative NOESY analysis. 著者: Andersen, N.H. / Chen, C.P. / Marschner, T.M. / Krystek Jr., S.R. / Bassolino, D.A. #1: ジャーナル: FEBS Lett. / 年: 1991 タイトル: Conformation of Endothelin in Aqueous Ethylene Glycol Determined by 1H-NMR and Molecular Dynamics Simulations 著者: Krystekjunior, S.R. / Bassolino, D.A. / Novotny, J. / Chen, C. / Marschner, T.M. / Andersen, N.H. | ||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 1edp.cif.gz | 12.5 KB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb1edp.ent.gz | 6.6 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 1edp.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
文書・要旨 | 1edp_validation.pdf.gz | 324.2 KB | 表示 | wwPDB検証レポート |
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文書・詳細版 | 1edp_full_validation.pdf.gz | 323.9 KB | 表示 | |
XML形式データ | 1edp_validation.xml.gz | 1.7 KB | 表示 | |
CIF形式データ | 1edp_validation.cif.gz | 1.8 KB | 表示 | |
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/ed/1edp ftp://data.pdbj.org/pub/pdb/validation_reports/ed/1edp | HTTPS FTP |
-関連構造データ
-リンク
-集合体
登録構造単位 |
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1 |
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NMR アンサンブル |
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-要素
#1: タンパク質・ペプチド | 分子量: 1970.338 Da / 分子数: 1 / 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) / 参照: UniProt: P05305 |
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Has protein modification | Y |
-実験情報
-実験
実験 | 手法: 溶液NMR |
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-試料調製
結晶化 | *PLUS 手法: other / 詳細: NMR |
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-解析
ソフトウェア |
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NMR software | 名称: X-PLOR / 開発者: BRUNGER / 分類: 精密化 | ||||||||
NMRアンサンブル | 登録したコンフォーマーの数: 1 |