CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR: SOLUTION STRUCTURES OF PEPTIDES BASED ON THE PHE508 REGION, THE MOST COMMON SITE OF DISEASE-CAUSING DELTA-F508 MUTATION
要素
PROTEIN (CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR))
キーワード
METAL TRANSPORT / P25_TFE / CYSTIC FIBROSIS / PEPTIDES
機能・相同性
機能・相同性情報
Sec61 translocon complex binding / channel-conductance-controlling ATPase / intracellularly ATP-gated chloride channel activity / positive regulation of enamel mineralization / transepithelial water transport / intracellular pH elevation / amelogenesis / chloride channel inhibitor activity / multicellular organismal-level water homeostasis / membrane hyperpolarization ...Sec61 translocon complex binding / channel-conductance-controlling ATPase / intracellularly ATP-gated chloride channel activity / positive regulation of enamel mineralization / transepithelial water transport / intracellular pH elevation / amelogenesis / chloride channel inhibitor activity / multicellular organismal-level water homeostasis / membrane hyperpolarization / cholesterol transport / bicarbonate transport / bicarbonate transmembrane transporter activity / vesicle docking involved in exocytosis / chloride transmembrane transporter activity / sperm capacitation / chloride channel activity / cholesterol biosynthetic process / positive regulation of exocytosis / positive regulation of insulin secretion involved in cellular response to glucose stimulus / chloride channel complex / ABC-type transporter activity / cellular response to cAMP / cellular response to forskolin / chloride transmembrane transport / isomerase activity / response to endoplasmic reticulum stress / establishment of localization in cell / PDZ domain binding / recycling endosome membrane / early endosome membrane / protein-folding chaperone binding / early endosome / apical plasma membrane / endoplasmic reticulum membrane / enzyme binding / cell surface / ATP hydrolysis activity / ATP binding / membrane / nucleus / plasma membrane / cytosol 類似検索 - 分子機能
PROTEIN (CYSTICFIBROSISTRANSMEMBRANECONDUCTANCEREGULATOR (CFTR)) / P25
分子量: 2907.346 Da / 分子数: 1 / 断片: F508 MUTATION REGION / 由来タイプ: 合成 詳細: THE PEPTIDE WAS CHEMICALLY SYNTHESIZED. THE SEQUENCE IS BASED ON THE PHE508 REGION OF CF TRANSMEMBRANE REGULATOR NUCLEOTIDE BINDING DOMAIN 1. 参照: UniProt: Q00555
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実験情報
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実験
実験
手法: 溶液NMR
NMR実験
Conditions-ID
Experiment-ID
Solution-ID
タイプ
1
1
1
NOESY
1
2
1
COSY
1
3
1
TOCSY
NMR実験の詳細
Text: THE SOLUTION STRUCTURES THE P25 (25 AMINO ACID FRAGMENT FROM THE CFTR NBD-1) PEPTIDE WERE DETERMINED IN 43% TRIFLUROETHANOL AND H2O BY HOMONUCLEAR 1H NMR SPECTROSCOPY PREFORMED ON A 600 MHZ ...Text: THE SOLUTION STRUCTURES THE P25 (25 AMINO ACID FRAGMENT FROM THE CFTR NBD-1) PEPTIDE WERE DETERMINED IN 43% TRIFLUROETHANOL AND H2O BY HOMONUCLEAR 1H NMR SPECTROSCOPY PREFORMED ON A 600 MHZ SPECTROMETER.. NOESY SPECTRA AT 100,200 AND 300 MS MIXING TIMES, TOCSY SPECTRUM AT 65 MS, AND COSY SPECTRUM WERE COLLECTED AND USED TO ASSIGN THE 1H RESONANCES AND NOES TO DETERMINE THE SOLUTION STRUCTURE