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Open data
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Basic information
Entry | Database: PDB / ID: 1bd8 | ||||||
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Title | STRUCTURE OF CDK INHIBITOR P19INK4D | ||||||
![]() | P19INK4D CDK4/6 INHIBITOR | ||||||
![]() | TUMOR SUPPRESSOR / CDK4/6 INHIBITOR / ANKYRIN MOTIF | ||||||
Function / homology | ![]() cyclin D2-CDK4 complex / autophagic cell death / negative regulation of cell cycle G1/S phase transition / negative regulation of phosphorylation / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage / cyclin-dependent protein serine/threonine kinase inhibitor activity / response to vitamin D / regulation of cyclin-dependent protein serine/threonine kinase activity / DNA synthesis involved in DNA repair / regulation of G1/S transition of mitotic cell cycle ...cyclin D2-CDK4 complex / autophagic cell death / negative regulation of cell cycle G1/S phase transition / negative regulation of phosphorylation / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage / cyclin-dependent protein serine/threonine kinase inhibitor activity / response to vitamin D / regulation of cyclin-dependent protein serine/threonine kinase activity / DNA synthesis involved in DNA repair / regulation of G1/S transition of mitotic cell cycle / response to UV / response to retinoic acid / sensory perception of sound / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / Oncogene Induced Senescence / negative regulation of cell growth / Cyclin D associated events in G1 / Senescence-Associated Secretory Phenotype (SASP) / Oxidative Stress Induced Senescence / cell cycle / negative regulation of cell population proliferation / protein kinase binding / nucleoplasm / nucleus / cytoplasm / cytosol Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() | ||||||
![]() | Baumgartner, R. / Fernandez-Catalan, C. / Winoto, A. / Huber, R. / Engh, R. / Holak, T.A. | ||||||
![]() | ![]() Title: Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a. Authors: Baumgartner, R. / Fernandez-Catalan, C. / Winoto, A. / Huber, R. / Engh, R.A. / Holak, T.A. #1: ![]() Title: Crystal Structure of the Cdk4/6 Inhibitory Protein P18Ink4C Provides Insights Into Ankyrin-Like Repeat Structure/Function and Tumor-Derived P16Ink4 Mutations Authors: Venkataramani, R. / Swaminathan, K. / Marmorstein, R. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 45.1 KB | Display | ![]() |
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PDB format | ![]() | 32.4 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 361.2 KB | Display | ![]() |
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Full document | ![]() | 368.3 KB | Display | |
Data in XML | ![]() | 5.8 KB | Display | |
Data in CIF | ![]() | 9 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Components
#1: Protein | Mass: 16627.812 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() |
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#2: Water | ChemComp-HOH / |
-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 1.86 Å3/Da / Density % sol: 34 % / Description: DATA COLLECTED IN THE OSCILLATION MODE. | ||||||||||||||||||||||||||||||
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Crystal grow | Temperature: 277 K / Method: vapor diffusion, sitting drop / pH: 8.5 Details: PROTEIN WAS CRYSTALLIZED FROM 35% PEG 4000, 200 MM MGSO4 AND 200 MM TRIS/HCL PH 8.5, SITTING DROP METHOD, AT 4 DEG. C., vapor diffusion - sitting drop, temperature 277K | ||||||||||||||||||||||||||||||
Crystal | *PLUS Density % sol: 35 % | ||||||||||||||||||||||||||||||
Crystal grow | *PLUS Temperature: 4 ℃ / Method: vapor diffusion, sitting drop | ||||||||||||||||||||||||||||||
Components of the solutions | *PLUS
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-Data collection
Diffraction | Mean temperature: 280 K |
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Diffraction source | Source: ![]() |
Detector | Type: MARRESEARCH / Detector: IMAGE PLATE / Date: Oct 1, 1997 / Details: MIRRORS |
Radiation | Monochromator: GRAPHITE(002) / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 1.5418 Å / Relative weight: 1 |
Reflection | Resolution: 1.8→25 Å / Num. obs: 13017 / % possible obs: 99.9 % / Observed criterion σ(I): 2 / Rmerge(I) obs: 0.073 / Net I/σ(I): 11.7 |
Reflection | *PLUS % possible obs: 99.4 % |
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Processing
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Refinement | Method to determine structure: ![]()
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Refinement step | Cycle: LAST / Highest resolution: 1.8 Å
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Software | *PLUS Name: REFMAC / Classification: refinement | ||||||||||||||||||
Refinement | *PLUS Rfactor obs: 0.19 | ||||||||||||||||||
Solvent computation | *PLUS | ||||||||||||||||||
Displacement parameters | *PLUS | ||||||||||||||||||
Refine LS restraints | *PLUS
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