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- PDB-1b4g: CONTROL OF K+ CHANNEL GATING BY PROTEIN PHOSPHORYLATION: STRUCTUR... -

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Basic information

Entry
Database: PDB / ID: 1b4g
TitleCONTROL OF K+ CHANNEL GATING BY PROTEIN PHOSPHORYLATION: STRUCTURAL SWITCHES OF THE INACTIVATION GATE, NMR, 22 STRUCTURES
ComponentsPOTASSIUM CHANNEL
KeywordsPOTASSIUM CHANNEL / INACTIVATION GATE / PHOSPHORYLATION
Function / homology
Function and homology information


delayed rectifier potassium channel activity / Voltage gated Potassium channels / neuronal cell body membrane / voltage-gated potassium channel activity / potassium channel activity / axon terminus / voltage-gated potassium channel complex / potassium ion transmembrane transport / dendrite membrane / protein homooligomerization ...delayed rectifier potassium channel activity / Voltage gated Potassium channels / neuronal cell body membrane / voltage-gated potassium channel activity / potassium channel activity / axon terminus / voltage-gated potassium channel complex / potassium ion transmembrane transport / dendrite membrane / protein homooligomerization / potassium ion transport / presynaptic membrane / chemical synaptic transmission / postsynaptic membrane / plasma membrane
Similarity search - Function
Potassium channel, voltage dependent, Kv3.4 / Potassium channel, voltage dependent, Kv3, inactivation domain / Potassium voltage-gated channel / Potassium channel, voltage dependent, Kv3 / Potassium channel, voltage dependent, Kv / Potassium channel tetramerisation-type BTB domain / BTB/POZ domain / Broad-Complex, Tramtrack and Bric a brac / BTB/POZ domain / Voltage-dependent channel domain superfamily ...Potassium channel, voltage dependent, Kv3.4 / Potassium channel, voltage dependent, Kv3, inactivation domain / Potassium voltage-gated channel / Potassium channel, voltage dependent, Kv3 / Potassium channel, voltage dependent, Kv / Potassium channel tetramerisation-type BTB domain / BTB/POZ domain / Broad-Complex, Tramtrack and Bric a brac / BTB/POZ domain / Voltage-dependent channel domain superfamily / SKP1/BTB/POZ domain superfamily / Ion transport domain / Ion transport protein
Similarity search - Domain/homology
Potassium voltage-gated channel subfamily C member 4
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodSOLUTION NMR
AuthorsAntz, C. / Bauer, T. / Kalbacher, H. / Frank, R. / Covarrubias, M. / Kalbitzer, H.R. / Ruppersberg, J.P. / Baukrowitz, T. / Fakler, B.
CitationJournal: Nat.Struct.Biol. / Year: 1999
Title: Control of K+ channel gating by protein phosphorylation: structural switches of the inactivation gate.
Authors: Antz, C. / Bauer, T. / Kalbacher, H. / Frank, R. / Covarrubias, M. / Kalbitzer, H.R. / Ruppersberg, J.P. / Baukrowitz, T. / Fakler, B.
History
DepositionDec 22, 1998Processing site: BNL
Revision 1.0Apr 27, 1999Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Feb 16, 2022Group: Database references / Derived calculations / Other
Category: database_2 / pdbx_database_status ...database_2 / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_oper_list / struct_conn
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.process_site / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: POTASSIUM CHANNEL


Theoretical massNumber of molelcules
Total (without water)3,3611
Polymers3,3611
Non-polymers00
Water0
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)22 / -
Representative

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Components

#1: Protein/peptide POTASSIUM CHANNEL /


Mass: 3360.841 Da / Num. of mol.: 1 / Fragment: INACTIVATION DOMAIN / Source method: obtained synthetically / Details: SER 8 IS PHOSPHORLYATED / Source: (synth.) Homo sapiens (human) / References: UniProt: Q03721

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Sample conditionspH: 3.5 / Temperature: 283 K
Crystal grow
*PLUS
Method: other / Details: NMR

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Processing

Software
NameVersionClassification
X-PLOR3.8model building
X-PLOR3.8refinement
X-PLOR3.8phasing
NMR softwareName: X-PLOR / Version: 3.8 / Developer: BRUNGER / Classification: refinement
NMR ensembleConformers submitted total number: 22

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