cyclin D2-CDK4 complex / autophagic cell death / negative regulation of cell cycle G1/S phase transition / negative regulation of phosphorylation / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage / response to vitamin D / cyclin-dependent protein serine/threonine kinase inhibitor activity / DNA synthesis involved in DNA repair / regulation of G1/S transition of mitotic cell cycle / response to retinoic acid ...cyclin D2-CDK4 complex / autophagic cell death / negative regulation of cell cycle G1/S phase transition / negative regulation of phosphorylation / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage / response to vitamin D / cyclin-dependent protein serine/threonine kinase inhibitor activity / DNA synthesis involved in DNA repair / regulation of G1/S transition of mitotic cell cycle / response to retinoic acid / response to UV / sensory perception of sound / negative regulation of cell growth / negative regulation of cell population proliferation / protein kinase binding / nucleoplasm / cytosol Similarity search - Function
Mass: 17976.506 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Mus musculus (house mouse) / Cell line: BL21 / Plasmid: BL21 / Species (production host): Escherichia coli / Production host: Escherichia coli BL21(DE3) (bacteria) / Strain (production host): BL21 (DE3) / References: UniProt: Q60773
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Experimental details
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Experiment
Experiment
Method: SOLUTION NMR
NMR experiment
Conditions-ID
Experiment-ID
Solution-ID
Type
1
1
1
3D N13 NOESY
1
2
1
4D N15 NOESY
1
3
1
3D C13 NOESY
1
4
1
4D C13 NOESY
1
5
1
3D HNHA
NMR details
Text: THE STRUCTURE WAS DETERMINED USING TRIPLE-RESONANCE NMR SPECTROSCOPY ON 13C, 15N-LABELED P19INK4D. ADDITIONAL RESTRAINTS WERE DETERMINED FROM NMR ON 2H, 15N-LABELED P19INK4D AND SELECTIVELY LABELED P19INK4D.
Type: Bruker AMX600 / Manufacturer: Bruker / Model: AMX600 / Field strength: 600 MHz
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Processing
Software
Name
Version
Classification
X-PLOR
3.1
modelbuilding
X-PLOR
3.1
refinement
X-PLOR
3.1
phasing
NMR software
Name
Version
Developer
Classification
X-PLOR
3.1
BRUNGER
refinement
Azara
structuresolution
ANSIG
structuresolution
XPLOR
structuresolution
PIPP
structuresolution
NMRPipe
structuresolution
Refinement
Method: XPLOR SA WITH AMBIGUOUS RESTRAINTS / Software ordinal: 1 Details: REFINEMENT DETAILS CAN BE FOUND IN THE JRNL CITATION ABOVE.
NMR ensemble
Conformer selection criteria: LOWEST ENERGY STRUCTURES WITH NO VIOLATIONS Conformers calculated total number: 30 / Conformers submitted total number: 20
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