Entry Database : PDB / ID : 11gn Structure visualization Downloads & linksTitle Crystal structure of mSTING in complex with 3'3'-di-AMP ComponentsStimulator of interferon genes protein Details Keywords IMMUNE SYSTEM / Innate immunity / cGAS-STING / complexFunction / homology Function and homology informationFunction Domain/homology Component
STING mediated induction of host immune responses / STING complex / STAT6-mediated induction of chemokines / IRF3-mediated induction of type I IFN / protein exit from endoplasmic reticulum / Regulation of innate immune responses to cytosolic DNA / protein localization to endoplasmic reticulum / 2',3'-cyclic GMP-AMP binding / cyclic-di-GMP binding / positive regulation of cGAS/STING signaling pathway ... STING mediated induction of host immune responses / STING complex / STAT6-mediated induction of chemokines / IRF3-mediated induction of type I IFN / protein exit from endoplasmic reticulum / Regulation of innate immune responses to cytosolic DNA / protein localization to endoplasmic reticulum / 2',3'-cyclic GMP-AMP binding / cyclic-di-GMP binding / positive regulation of cGAS/STING signaling pathway / positive regulation of type I interferon-mediated signaling pathway / proton channel activity / reticulophagy / pattern recognition receptor signaling pathway / cGAS/STING signaling pathway / cellular response to exogenous dsRNA / cytoplasmic pattern recognition receptor signaling pathway / protein complex oligomerization / positive regulation of macroautophagy / autophagosome membrane / cellular response to interferon-beta / autophagosome assembly / positive regulation of defense response to virus by host / positive regulation of type I interferon production / Neutrophil degranulation / endoplasmic reticulum-Golgi intermediate compartment membrane / activation of innate immune response / signaling adaptor activity / positive regulation of interferon-beta production / autophagosome / antiviral innate immune response / protein serine/threonine kinase binding / peroxisome / regulation of gene expression / regulation of inflammatory response / cilium / defense response to virus / ciliary basal body / RNA polymerase II-specific DNA-binding transcription factor binding / mitochondrial outer membrane / transcription coactivator activity / endosome / Golgi membrane / innate immune response / lysosomal membrane / ubiquitin protein ligase binding / protein kinase binding / endoplasmic reticulum membrane / perinuclear region of cytoplasm / Golgi apparatus / endoplasmic reticulum / positive regulation of transcription by RNA polymerase II / protein homodimerization activity / nucleoplasm / identical protein binding / plasma membrane / cytosol / cytoplasm Similarity search - Function : / STING transmembrane domain / : / : / Stimulator of interferon genes protein / Stimulator of interferon genes protein, C-terminal domain superfamily / STING ligand-binding domain Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.29 Å DetailsAuthors Kranzusch, P.J. / Li, Y. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) 1DP2GM146250-01 United States
CitationJournal : To Be Published Title : Crystal structure of mSTING in complex with 3'3'-di-AMPAuthors : Kranzusch, P.J. / Li, Y. History Deposition Feb 23, 2026 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jul 29, 2026 Provider : repository / Type : Initial release