登録情報 | データベース: EMDB / ID: EMD-52325 |
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タイトル | The TMD and the LBD region of the AMPAR complex GluA3- TARP gamma2 in the apo state. |
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マップデータ | |
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試料 | - 複合体: homomeric AMPAR complex GluA3 in tandem with the auxiliary subunit TARP gamma2
- タンパク質・ペプチド: Isoform Flip of Glutamate receptor 3,Voltage-dependent calcium channel gamma-2 subunit
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キーワード | AMPAR / ion channels / neurotransmission / MEMBRANE PROTEIN |
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機能・相同性 | 機能・相同性情報
Presynaptic depolarization and calcium channel opening / eye blink reflex / positive regulation of protein localization to basolateral plasma membrane / cerebellar mossy fiber / LGI-ADAM interactions / postsynaptic neurotransmitter receptor diffusion trapping / Trafficking of AMPA receptors / channel regulator activity / regulation of AMPA receptor activity / membrane hyperpolarization ...Presynaptic depolarization and calcium channel opening / eye blink reflex / positive regulation of protein localization to basolateral plasma membrane / cerebellar mossy fiber / LGI-ADAM interactions / postsynaptic neurotransmitter receptor diffusion trapping / Trafficking of AMPA receptors / channel regulator activity / regulation of AMPA receptor activity / membrane hyperpolarization / nervous system process / Synaptic adhesion-like molecules / protein targeting to membrane / voltage-gated calcium channel complex / neurotransmitter receptor localization to postsynaptic specialization membrane / protein heterotetramerization / neuromuscular junction development / parallel fiber to Purkinje cell synapse / Activation of AMPA receptors / AMPA glutamate receptor activity / transmission of nerve impulse / Trafficking of GluR2-containing AMPA receptors / response to lithium ion / AMPA glutamate receptor complex / ionotropic glutamate receptor complex / membrane depolarization / asymmetric synapse / regulation of receptor recycling / Unblocking of NMDA receptors, glutamate binding and activation / synaptic cleft / regulation of postsynaptic membrane neurotransmitter receptor levels / voltage-gated calcium channel activity / response to fungicide / glutamate-gated receptor activity / ionotropic glutamate receptor binding / presynaptic active zone membrane / somatodendritic compartment / glutamate-gated calcium ion channel activity / ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential / calcium channel regulator activity / positive regulation of synaptic transmission, glutamatergic / hippocampal mossy fiber to CA3 synapse / dendritic shaft / regulation of membrane potential / transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential / synaptic transmission, glutamatergic / modulation of chemical synaptic transmission / postsynaptic density membrane / terminal bouton / Schaffer collateral - CA1 synapse / long-term synaptic potentiation / response to calcium ion / amyloid-beta binding / presynaptic membrane / protein homotetramerization / perikaryon / dendritic spine / postsynaptic membrane / postsynaptic density / neuronal cell body / dendrite / glutamatergic synapse / cell surface / protein-containing complex / membrane / plasma membrane類似検索 - 分子機能 Voltage-dependent calcium channel, gamma-2 subunit / : / PMP-22/EMP/MP20/Claudin family / Voltage-dependent calcium channel, gamma subunit / PMP-22/EMP/MP20/Claudin superfamily / Ionotropic glutamate receptor, metazoa / Ligated ion channel L-glutamate- and glycine-binding site / Ionotropic glutamate receptor, L-glutamate and glycine-binding domain / Ligated ion channel L-glutamate- and glycine-binding site / Ligand-gated ion channel ...Voltage-dependent calcium channel, gamma-2 subunit / : / PMP-22/EMP/MP20/Claudin family / Voltage-dependent calcium channel, gamma subunit / PMP-22/EMP/MP20/Claudin superfamily / Ionotropic glutamate receptor, metazoa / Ligated ion channel L-glutamate- and glycine-binding site / Ionotropic glutamate receptor, L-glutamate and glycine-binding domain / Ligated ion channel L-glutamate- and glycine-binding site / Ligand-gated ion channel / : / Ionotropic glutamate receptor / Eukaryotic homologues of bacterial periplasmic substrate binding proteins. / Receptor, ligand binding region / Receptor family ligand binding region / Periplasmic binding protein-like I類似検索 - ドメイン・相同性 Glutamate receptor 3 / Voltage-dependent calcium channel gamma-2 subunit類似検索 - 構成要素 |
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生物種 |  Rattus (ネズミ) /  Rattus norvegicus (ドブネズミ) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 2.59 Å |
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データ登録者 | Pokharna A / Krieger J / Greger I / Ho H / Yamashita K / Cais O |
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資金援助 | 英国, 2件 Organization | Grant number | 国 |
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Wellcome Trust | 223194/Z/21/Z | 英国 | Medical Research Council (MRC, United Kingdom) | MC_U105174197 | 英国 |
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引用 | ジャーナル: To Be Published タイトル: The NTD dimer and the interfacing LBD region of the AMPAR complex GluA3- TARP gamma2 in the apo state. 著者: Pokharna A / Krieger J / Greger I |
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履歴 | 登録 | 2024年12月12日 | - |
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ヘッダ(付随情報) 公開 | 2025年7月9日 | - |
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マップ公開 | 2025年7月9日 | - |
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更新 | 2025年7月9日 | - |
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現状 | 2025年7月9日 | 処理サイト: PDBe / 状態: 公開 |
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