登録情報 | データベース: EMDB / ID: EMD-44425 |
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タイトル | HCN1 M305L with propofol |
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マップデータ | |
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試料 | - 複合体: HCN1
- タンパク質・ペプチド: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
- リガンド: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
- リガンド: 2,6-BIS(1-METHYLETHYL)PHENOL
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キーワード | Inhibitor / complex / membrane protein / nanodisc / transport protein |
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機能・相同性 | 機能・相同性情報
intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential / HCN channels / general adaptation syndrome, behavioral process / HCN channel complex / retinal cone cell development / regulation of membrane depolarization / intracellularly cAMP-activated cation channel activity / apical protein localization / voltage-gated monoatomic cation channel activity / voltage-gated sodium channel activity ...intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential / HCN channels / general adaptation syndrome, behavioral process / HCN channel complex / retinal cone cell development / regulation of membrane depolarization / intracellularly cAMP-activated cation channel activity / apical protein localization / voltage-gated monoatomic cation channel activity / voltage-gated sodium channel activity / voltage-gated potassium channel activity / potassium channel activity / sodium ion transmembrane transport / neuronal action potential / cAMP binding / cellular response to cAMP / presynaptic active zone membrane / potassium ion transmembrane transport / regulation of membrane potential / postsynaptic membrane / protein homotetramerization / axon / glutamatergic synapse / dendrite / identical protein binding / plasma membrane類似検索 - 分子機能 Ion transport N-terminal / Ion transport protein N-terminal / Potassium channel, voltage-dependent, EAG/ELK/ERG / Cyclic nucleotide-binding domain signature 1. / Cyclic nucleotide-binding, conserved site / Cyclic nucleotide-monophosphate binding domain / Cyclic nucleotide-binding domain / cAMP/cGMP binding motif profile. / Cyclic nucleotide-binding domain / Cyclic nucleotide-binding domain superfamily ...Ion transport N-terminal / Ion transport protein N-terminal / Potassium channel, voltage-dependent, EAG/ELK/ERG / Cyclic nucleotide-binding domain signature 1. / Cyclic nucleotide-binding, conserved site / Cyclic nucleotide-monophosphate binding domain / Cyclic nucleotide-binding domain / cAMP/cGMP binding motif profile. / Cyclic nucleotide-binding domain / Cyclic nucleotide-binding domain superfamily / RmlC-like jelly roll fold / Ion transport domain / Ion transport protein類似検索 - ドメイン・相同性 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 2.5 Å |
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データ登録者 | Kim ED / Nimigean CM |
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資金援助 | 米国, 2件 Organization | Grant number | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM124451 | 米国 | National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) | NS137561 | 米国 |
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引用 | ジャーナル: Nature / 年: 2024 タイトル: Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants 著者: Kim ED / Wu X / Lee S / Tibbs GR / Cunningham KP / Di Zanni E / Perez ME / Goldstein PA / Accardi A / Larsson HP / Nimigean CM |
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履歴 | 登録 | 2024年4月7日 | - |
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ヘッダ(付随情報) 公開 | 2024年7月31日 | - |
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マップ公開 | 2024年7月31日 | - |
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更新 | 2024年7月31日 | - |
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現状 | 2024年7月31日 | 処理サイト: RCSB / 状態: 公開 |
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