登録情報 データベース : EMDB / ID : EMD-43746 ダウンロードとリンクタイトル Plasmodium falciparum 20S proteasome bound to an inhibitor マップデータPlasmodium falciparum 20S proteasome bound with inhibitor 詳細 試料複合体 : Plasmodium falciparum 20S proteasome bound with an inhibitorリガンド : x 1種 詳細 キーワード Malaria / Plasmodium falciparum / proteasome / drug discovery / CYTOSOLIC PROTEIN / CYTOSOLIC PROTEIN-INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
Cross-presentation of soluble exogenous antigens (endosomes) / Orc1 removal from chromatin / CDK-mediated phosphorylation and removal of Cdc6 / FBXL7 down-regulates AURKA during mitotic entry and in early mitosis / KEAP1-NFE2L2 pathway / UCH proteinases / Ub-specific processing proteases / Neddylation / MAPK6/MAPK4 signaling / Antigen processing: Ubiquitination & Proteasome degradation ... Cross-presentation of soluble exogenous antigens (endosomes) / Orc1 removal from chromatin / CDK-mediated phosphorylation and removal of Cdc6 / FBXL7 down-regulates AURKA during mitotic entry and in early mitosis / KEAP1-NFE2L2 pathway / UCH proteinases / Ub-specific processing proteases / Neddylation / MAPK6/MAPK4 signaling / Antigen processing: Ubiquitination & Proteasome degradation / ABC-family proteins mediated transport / AUF1 (hnRNP D0) binds and destabilizes mRNA / Neutrophil degranulation / proteasome core complex / proteasome endopeptidase complex / proteasome core complex, beta-subunit complex / proteasome core complex, alpha-subunit complex / proteasomal protein catabolic process / threonine-type endopeptidase activity / ubiquitin-dependent protein catabolic process / proteasome-mediated ubiquitin-dependent protein catabolic process / endopeptidase activity / hydrolase activity / nucleus / cytoplasm / cytosol 類似検索 - 分子機能 Proteasome subunit beta 1 / Proteasome subunit alpha 1 / : / Proteasome subunit beta 4 / Proteasome subunit beta 2 / Proteasome beta 3 subunit / Proteasome subunit alpha6 / Proteasome subunit alpha5 / Proteasome beta-type subunits signature. / Peptidase T1A, proteasome beta-subunit ... Proteasome subunit beta 1 / Proteasome subunit alpha 1 / : / Proteasome subunit beta 4 / Proteasome subunit beta 2 / Proteasome beta 3 subunit / Proteasome subunit alpha6 / Proteasome subunit alpha5 / Proteasome beta-type subunits signature. / Peptidase T1A, proteasome beta-subunit / Proteasome beta-type subunit, conserved site / Proteasome subunit A N-terminal signature / Proteasome alpha-type subunits signature. / Proteasome alpha-subunit, N-terminal domain / Proteasome subunit A N-terminal signature Add an annotation / Proteasome alpha-type subunit / Proteasome alpha-type subunit profile. / Proteasome B-type subunit / Proteasome beta-type subunit profile. / Proteasome subunit / Proteasome, subunit alpha/beta / Nucleophile aminohydrolases, N-terminal 類似検索 - ドメイン・相同性 Proteasome subunit beta / Proteasome subunit alpha type-2, putative / Proteasome subunit alpha type-3, putative / Proteasome subunit beta / Proteasome subunit beta type-6, putative / Proteasome subunit beta / Proteasome subunit beta / Proteasome subunit alpha type-6, putative / Proteasome subunit alpha type / Proteasome subunit alpha type ... Proteasome subunit beta / Proteasome subunit alpha type-2, putative / Proteasome subunit alpha type-3, putative / Proteasome subunit beta / Proteasome subunit beta type-6, putative / Proteasome subunit beta / Proteasome subunit beta / Proteasome subunit alpha type-6, putative / Proteasome subunit alpha type / Proteasome subunit alpha type / Proteasome subunit alpha type / Proteasome subunit beta / Proteasome subunit alpha type-1, putative / Proteasome subunit beta 類似検索 - 構成要素生物種 Plasmodium falciparum 3D7 (マラリア病原虫)手法 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度 : 3.1 Å 詳細 データ登録者Han Y / Deng X / Ray S / Chen Z / Phillips M 資金援助 米国, 4件 詳細 詳細を隠すOrganization Grant number 国 National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) R01AI103947 米国 National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) R01AI155784 米国 National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) GM007062 米国 Cancer Prevention and Research Institute of Texas (CPRIT) RP220582 米国
引用ジャーナル : Cell Chem Biol / 年 : 2024タイトル : Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria著者 : Lawong A / Gahalawat S 履歴 登録 2024年2月20日 - ヘッダ(付随情報) 公開 2024年7月31日 - マップ公開 2024年7月31日 - 更新 2024年7月31日 - 現状 2024年7月31日 処理サイト : RCSB / 状態 : 公開
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