登録情報 | データベース: EMDB / ID: EMD-41710 |
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タイトル | Cryo-EM structure of coagulation factor VIII bound to NB2E9 |
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マップデータ | |
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試料 | - 複合体: Coagulation factor VIII bound to NB2E9
- タンパク質・ペプチド: Coagulation factor VIII
- タンパク質・ペプチド: NB2E9 light chain
- タンパク質・ペプチド: NB2E9 heavy chain
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キーワード | Coagulation / Inhibitor antibody / factor VIII / BLOOD CLOTTING-INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
Defective F8 accelerates dissociation of the A2 domain / Defective F8 binding to the cell membrane / Defective F8 secretion / Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation / Defective F8 sulfation at Y1699 / Defective F8 binding to von Willebrand factor / blood coagulation, intrinsic pathway / Cargo concentration in the ER / Defective factor IX causes thrombophilia / Defective cofactor function of FVIIIa variant ...Defective F8 accelerates dissociation of the A2 domain / Defective F8 binding to the cell membrane / Defective F8 secretion / Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation / Defective F8 sulfation at Y1699 / Defective F8 binding to von Willebrand factor / blood coagulation, intrinsic pathway / Cargo concentration in the ER / Defective factor IX causes thrombophilia / Defective cofactor function of FVIIIa variant / Defective F9 variant does not activate FX / COPII-mediated vesicle transport / COPII-coated ER to Golgi transport vesicle / Defective F8 cleavage by thrombin / Common Pathway of Fibrin Clot Formation / Intrinsic Pathway of Fibrin Clot Formation / endoplasmic reticulum-Golgi intermediate compartment membrane / platelet alpha granule lumen / acute-phase response / Golgi lumen / blood coagulation / Platelet degranulation / signaling receptor activity / oxidoreductase activity / copper ion binding / endoplasmic reticulum lumen / extracellular space / extracellular region / plasma membrane類似検索 - 分子機能 Coagulation factor 5/8-like / Coagulation factors 5/8 type C domain (FA58C) signature 2. / Multicopper oxidases, conserved site / Multicopper oxidases signature 1. / Coagulation factors 5/8 type C domain (FA58C) signature 1. / Coagulation factor 5/8 C-terminal domain, discoidin domain / Coagulation factors 5/8 type C domain (FA58C) profile. / Multicopper oxidase, C-terminal / Multicopper oxidase / F5/8 type C domain ...Coagulation factor 5/8-like / Coagulation factors 5/8 type C domain (FA58C) signature 2. / Multicopper oxidases, conserved site / Multicopper oxidases signature 1. / Coagulation factors 5/8 type C domain (FA58C) signature 1. / Coagulation factor 5/8 C-terminal domain, discoidin domain / Coagulation factors 5/8 type C domain (FA58C) profile. / Multicopper oxidase, C-terminal / Multicopper oxidase / F5/8 type C domain / Coagulation factor 5/8 C-terminal domain / Multicopper oxidase, type 1 / Multicopper oxidase / Multicopper oxidase, N-terminal / Multicopper oxidase / Cupredoxin / Galactose-binding-like domain superfamily類似検索 - ドメイン・相同性 Coagulation factor VIII / Coagulation factor VIII類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.46 Å |
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データ登録者 | Childers KC / Spiegel PC |
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資金援助 | 米国, 2件 Organization | Grant number | 国 |
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National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) | HL141981 | 米国 | National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) | HL135658 | 米国 |
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引用 | ジャーナル: To Be Published タイトル: Structural basis for inhibition of coagulation factor VIII reveals a shared immunogenic hot-spot on the C1 domain 著者: Childers KC / Vaughan J / McGill J / Davulcu O / Lollar P / Doering CB / Coxon CH / Spiegel PC |
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履歴 | 登録 | 2023年8月24日 | - |
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ヘッダ(付随情報) 公開 | 2023年9月13日 | - |
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マップ公開 | 2023年9月13日 | - |
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更新 | 2023年9月13日 | - |
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現状 | 2023年9月13日 | 処理サイト: RCSB / 状態: 公開 |
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