登録情報 | データベース: EMDB / ID: EMD-40207 |
---|
タイトル | Complex of human cystic fibrosis transmembrane conductance regulator (CFTR) and Z1834339853 |
---|
マップデータ | Complex of human cystic fibrosis transmembrane conductance regulator (CFTR) and Z1834339853 |
---|
試料 | - 細胞器官・細胞要素: CFTR
- タンパク質・ペプチド: Cystic fibrosis transmembrane conductance regulator
- タンパク質・ペプチド: human cystic fibrosis transmembrane conductance regulator
- リガンド: MAGNESIUM ION
- リガンド: ADENOSINE-5'-TRIPHOSPHATE
- リガンド: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate
- リガンド: (2S)-1-(3-amino-6-fluoro-1H-indazol-1-yl)-2-methyl-3-phenoxypropan-1-one
|
---|
キーワード | transporter / ion channel / TRANSPORT PROTEIN |
---|
機能・相同性 | 機能・相同性情報
positive regulation of voltage-gated chloride channel activity / positive regulation of cyclic nucleotide-gated ion channel activity / Sec61 translocon complex binding / channel-conductance-controlling ATPase / intracellularly ATP-gated chloride channel activity / positive regulation of enamel mineralization / transepithelial water transport / RHO GTPases regulate CFTR trafficking / intracellular pH elevation / amelogenesis ...positive regulation of voltage-gated chloride channel activity / positive regulation of cyclic nucleotide-gated ion channel activity / Sec61 translocon complex binding / channel-conductance-controlling ATPase / intracellularly ATP-gated chloride channel activity / positive regulation of enamel mineralization / transepithelial water transport / RHO GTPases regulate CFTR trafficking / intracellular pH elevation / amelogenesis / chloride channel inhibitor activity / ATPase-coupled inorganic anion transmembrane transporter activity / Golgi-associated vesicle membrane / multicellular organismal-level water homeostasis / cholesterol transport / membrane hyperpolarization / bicarbonate transport / bicarbonate transmembrane transporter activity / vesicle docking involved in exocytosis / chloride channel regulator activity / chloride transmembrane transporter activity / sperm capacitation / chloride channel activity / RHOQ GTPase cycle / cholesterol biosynthetic process / positive regulation of exocytosis / positive regulation of insulin secretion involved in cellular response to glucose stimulus / chloride channel complex / ATPase-coupled transmembrane transporter activity / ABC-type transporter activity / cellular response to cAMP / cellular response to forskolin / chloride transmembrane transport / response to endoplasmic reticulum stress / isomerase activity / establishment of localization in cell / PDZ domain binding / Defective CFTR causes cystic fibrosis / Late endosomal microautophagy / clathrin-coated endocytic vesicle membrane / ABC-family proteins mediated transport / recycling endosome / transmembrane transport / Aggrephagy / Chaperone Mediated Autophagy / recycling endosome membrane / Cargo recognition for clathrin-mediated endocytosis / Clathrin-mediated endocytosis / early endosome membrane / protein-folding chaperone binding / early endosome / endosome membrane / Ub-specific processing proteases / apical plasma membrane / lysosomal membrane / endoplasmic reticulum membrane / enzyme binding / cell surface / ATP hydrolysis activity / protein-containing complex / ATP binding / membrane / nucleus / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 : / CFTR regulator domain / Cystic fibrosis TM conductance regulator (CFTR), regulator domain / Cystic fibrosis transmembrane conductance regulator / ABC transporter transmembrane region / ABC transporter type 1, transmembrane domain / ABC transporter integral membrane type-1 fused domain profile. / ABC transporter type 1, transmembrane domain superfamily / ABC transporter-like, conserved site / ABC transporters family signature. ...: / CFTR regulator domain / Cystic fibrosis TM conductance regulator (CFTR), regulator domain / Cystic fibrosis transmembrane conductance regulator / ABC transporter transmembrane region / ABC transporter type 1, transmembrane domain / ABC transporter integral membrane type-1 fused domain profile. / ABC transporter type 1, transmembrane domain superfamily / ABC transporter-like, conserved site / ABC transporters family signature. / ABC transporter / ABC transporter-like, ATP-binding domain / ATP-binding cassette, ABC transporter-type domain profile. / ATPases associated with a variety of cellular activities / AAA+ ATPase domain / P-loop containing nucleoside triphosphate hydrolase類似検索 - ドメイン・相同性 Cystic fibrosis transmembrane conductance regulator類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.8 Å |
---|
データ登録者 | Liu F / Chen J |
---|
資金援助 | 1件 Organization | Grant number | 国 |
---|
Howard Hughes Medical Institute (HHMI) | | |
|
---|
引用 | ジャーナル: To Be Published タイトル: Structure-based discovery of positive and negative CFTR modulators 著者: Liu F / Kaplan AL / Levring J / Einsiedel J / Tiedt S / Distler K / Omattage NS / Kondratov IS / Moroz YS / Irwin JJ / Gmeiner P / Shoichet BK / Chen J |
---|
履歴 | 登録 | 2023年3月23日 | - |
---|
ヘッダ(付随情報) 公開 | 2024年6月26日 | - |
---|
マップ公開 | 2024年6月26日 | - |
---|
更新 | 2024年6月26日 | - |
---|
現状 | 2024年6月26日 | 処理サイト: RCSB / 状態: 公開 |
---|
|
---|