+Open data
-Basic information
Entry | Database: EMDB / ID: EMD-39050 | |||||||||
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Title | The structure of hAE3 | |||||||||
Map data | ||||||||||
Sample |
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Keywords | TRANSPORT PROTEIN | |||||||||
Function / homology | Function and homology information pH reduction / cardiac muscle cell action potential / Bicarbonate transporters / cardiac conduction / chloride:bicarbonate antiporter activity / solute:inorganic anion antiporter activity / bicarbonate transport / bicarbonate transmembrane transporter activity / regulation of cardiac muscle cell action potential / transmembrane transporter activity ...pH reduction / cardiac muscle cell action potential / Bicarbonate transporters / cardiac conduction / chloride:bicarbonate antiporter activity / solute:inorganic anion antiporter activity / bicarbonate transport / bicarbonate transmembrane transporter activity / regulation of cardiac muscle cell action potential / transmembrane transporter activity / transport across blood-brain barrier / regulation of intracellular pH / transmembrane transport / external side of plasma membrane / membrane / plasma membrane Similarity search - Function | |||||||||
Biological species | Homo sapiens (human) | |||||||||
Method | single particle reconstruction / cryo EM / Resolution: 2.89 Å | |||||||||
Authors | Jian L / Zhang Q / Yao D / Wang Q / Xia Y / Qin A / Cao Y | |||||||||
Funding support | China, 2 items
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Citation | Journal: Nat Commun / Year: 2024 Title: The structural insight into the functional modulation of human anion exchanger 3 Authors: Jian L / Zhang Q / Yao D / Wang Q / Chen M / Xia Y / Li S / Shen Y / Cao M / Qin A / Li L / Cao Y | |||||||||
History |
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-Structure visualization
Supplemental images |
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-Downloads & links
-EMDB archive
Map data | emd_39050.map.gz | 59.8 MB | EMDB map data format | |
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Header (meta data) | emd-39050-v30.xml emd-39050.xml | 14.4 KB 14.4 KB | Display Display | EMDB header |
FSC (resolution estimation) | emd_39050_fsc.xml | 8.4 KB | Display | FSC data file |
Images | emd_39050.png | 60.9 KB | ||
Filedesc metadata | emd-39050.cif.gz | 5.9 KB | ||
Others | emd_39050_half_map_1.map.gz emd_39050_half_map_2.map.gz | 59.1 MB 59.1 MB | ||
Archive directory | http://ftp.pdbj.org/pub/emdb/structures/EMD-39050 ftp://ftp.pdbj.org/pub/emdb/structures/EMD-39050 | HTTPS FTP |
-Validation report
Summary document | emd_39050_validation.pdf.gz | 771.4 KB | Display | EMDB validaton report |
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Full document | emd_39050_full_validation.pdf.gz | 771 KB | Display | |
Data in XML | emd_39050_validation.xml.gz | 16.4 KB | Display | |
Data in CIF | emd_39050_validation.cif.gz | 21.2 KB | Display | |
Arichive directory | https://ftp.pdbj.org/pub/emdb/validation_reports/EMD-39050 ftp://ftp.pdbj.org/pub/emdb/validation_reports/EMD-39050 | HTTPS FTP |
-Related structure data
Related structure data | 8y8kMC 8y85C 8y86C 8zleC M: atomic model generated by this map C: citing same article (ref.) |
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Similar structure data | Similarity search - Function & homologyF&H Search |
-Links
EMDB pages | EMDB (EBI/PDBe) / EMDataResource |
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-Map
File | Download / File: emd_39050.map.gz / Format: CCP4 / Size: 64 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) | ||||||||||||||||||||||||||||||||||||
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Projections & slices | Image control
Images are generated by Spider. | ||||||||||||||||||||||||||||||||||||
Voxel size | X=Y=Z: 1.1 Å | ||||||||||||||||||||||||||||||||||||
Density |
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Symmetry | Space group: 1 | ||||||||||||||||||||||||||||||||||||
Details | EMDB XML:
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-Supplemental data
-Half map: #1
File | emd_39050_half_map_1.map | ||||||||||||
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Projections & Slices |
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Density Histograms |
-Half map: #2
File | emd_39050_half_map_2.map | ||||||||||||
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Projections & Slices |
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Density Histograms |
-Sample components
-Entire : Anion exchange protein 3
Entire | Name: Anion exchange protein 3 |
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Components |
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-Supramolecule #1: Anion exchange protein 3
Supramolecule | Name: Anion exchange protein 3 / type: complex / ID: 1 / Parent: 0 / Macromolecule list: all |
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Source (natural) | Organism: Homo sapiens (human) |
Molecular weight | Theoretical: 135 KDa |
-Macromolecule #1: Anion exchange protein 3
Macromolecule | Name: Anion exchange protein 3 / type: protein_or_peptide / ID: 1 / Number of copies: 2 / Enantiomer: LEVO |
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Source (natural) | Organism: Homo sapiens (human) |
Molecular weight | Theoretical: 135.961516 KDa |
Recombinant expression | Organism: Homo sapiens (human) |
Sequence | String: MANGVIPPPG GASPLPQVRV PLEEPPLSPD VEEEDDDLGK TLAVSRFGDL ISKPPAWDPE KPSRSYSERD FEFHRHTSHH THHPLSARL PPPHKLRRLP PTSARHTRRK RKKEKTSAPP SEGTPPIQEE GGAGVDEEEE EEEEEEGESE AEPVEPPHSG T PQKAKFSI ...String: MANGVIPPPG GASPLPQVRV PLEEPPLSPD VEEEDDDLGK TLAVSRFGDL ISKPPAWDPE KPSRSYSERD FEFHRHTSHH THHPLSARL PPPHKLRRLP PTSARHTRRK RKKEKTSAPP SEGTPPIQEE GGAGVDEEEE EEEEEEGESE AEPVEPPHSG T PQKAKFSI GSDEDDSPGL PGRAAVTKPL PSVGPHTDKS PQHSSSSPSP RARASRLAGE KSRPWSPSAS YDLRERLCPG SA LGNPGGP EQQVPTDEAE AQMLGSADLD DMKSHRLEDN PGVRRHLVKK PSRTQGGRGS PSGLAPILRR KKKKKKLDRR PHE VFVELN ELMLDRSQEP HWRETARWIK FEEDVEEETE RWGKPHVASL SFRSLLELRR TIAHGAALLD LEQTTLPGIA HLVV ETMIV SDQIRPEDRA SVLRTLLLKH SHPNDDKDSG FFPRNPSSSS MNSVLGNHHP TPSHGPDGAV PTMADDLGEP APLWP HDPD AKEKPLHMPG GDGHRGKSLK LLEKIPEDAE ATVVLVGCVP FLEQPAAAFV RLNEAVLLES VLEVPVPVRF LFVMLG PSH TSTDYHELGR SIATLMSDKL FHEAAYQADD RQDLLSAISE FLDGSIVIPP SEVEGRDLLR SVAAFQRELL RKRRERE QT KVEMTTRGGY TAPGKELSLE LGGSEATPED DPLLRTGSVF GGLVRDVRRR YPHYPSDLRD ALHSQCVAAV LFIYFAAL S PAITFGGLLG EKTEGLMGVS ELIVSTAVLG VLFSLLGAQP LLVVGFSGPL LVFEEAFFKF CRAQDLEYLT GRVWVGLWL VVFVLALVAA EGSFLVRYIS PFTQEIFAFL ISLIFIYETF YKLYKVFTEH PLLPFYPPEG ALEGSLDAGL EPNGSALPPT EGPPSPRNQ PNTALLSLIL MLGTFFIAFF LRKFRNSRFL GGKARRIIGD FGIPISILVM VLVDYSITDT YTQKLTVPTG L SVTSPDKR SWFIPPLGSA RPFPPWMMVA AAVPALLVLI LIFMETQITA LIVSQKARRL LKGSGFHLDL LLIGSLGGLC GL FGLPWLT AATVRSVTHV NALTVMRTAI APGDKPQIQE VREQRVTGVL IASLVGLSIV MGAVLRRIPL AVLFGIFLYM GVT SLSGIQ LSQRLLLILM PAKHHPEQPY VTKVKTWRMH LFTCIQLGCI ALLWVVKSTA ASLAFPFLLL LTVPLRHCLL PRLF QDREL QALDSEDAEP NFDEDGQDEY NELHMPV UniProtKB: Anion exchange protein 3 |
-Experimental details
-Structure determination
Method | cryo EM |
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Processing | single particle reconstruction |
Aggregation state | particle |
-Sample preparation
Buffer | pH: 7.4 |
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Vitrification | Cryogen name: ETHANE |
-Electron microscopy
Microscope | FEI TITAN KRIOS |
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Image recording | Film or detector model: GATAN K3 BIOQUANTUM (6k x 4k) / Average electron dose: 50.0 e/Å2 |
Electron beam | Acceleration voltage: 300 kV / Electron source: FIELD EMISSION GUN |
Electron optics | Illumination mode: SPOT SCAN / Imaging mode: BRIGHT FIELD / Nominal defocus max: 2.6 µm / Nominal defocus min: 1.0 µm |
Experimental equipment | Model: Titan Krios / Image courtesy: FEI Company |