Entry Database : EMDB / ID : EMD-37849 Downloads & linksTitle Cryo-EM structure of CB1-beta-arrestin1 complex Map data Details SampleComplex : Cryo-EM structure of human cannabinoid receptor 1 with effector proteinProtein or peptide : Beta-arrestin-1Protein or peptide : Fab30 heavy chainProtein or peptide : Fab30 light chainProtein or peptide : Cannabinoid receptor 1,Vasopressin V2 receptorLigand : methyl N-{1-[(4-fluorophenyl)methyl]-1H-indazole-3-carbonyl}-3-methyl-L-valinate Details Keywords cannabinoid receptor / arrestin / biased signal / class A GPCR / MEMBRANE PROTEINFunction / homology Function and homology informationFunction Domain/homology Component
renal water retention / Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) / MAP2K and MAPK activation / Vasopressin-like receptors / cannabinoid signaling pathway / regulation of penile erection / retrograde trans-synaptic signaling by endocannabinoid / regulation of systemic arterial blood pressure by vasopressin / vasopressin receptor activity / Activation of SMO ... renal water retention / Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) / MAP2K and MAPK activation / Vasopressin-like receptors / cannabinoid signaling pathway / regulation of penile erection / retrograde trans-synaptic signaling by endocannabinoid / regulation of systemic arterial blood pressure by vasopressin / vasopressin receptor activity / Activation of SMO / Golgi Associated Vesicle Biogenesis / cannabinoid receptor activity / Lysosome Vesicle Biogenesis / negative regulation of mast cell activation / trans-synaptic signaling by endocannabinoid, modulating synaptic transmission / AP-2 adaptor complex binding / negative regulation of fatty acid beta-oxidation / clathrin heavy chain binding / negative regulation of dopamine secretion / Ub-specific processing proteases / positive regulation of acute inflammatory response to antigenic stimulus / regulation of feeding behavior / clathrin coat of coated pit / negative regulation of serotonin secretion / regulation of presynaptic cytosolic calcium ion concentration / hemostasis / desensitization of G protein-coupled receptor signaling pathway / telencephalon development / Cargo recognition for clathrin-mediated endocytosis / negative regulation of action potential / positive regulation of systemic arterial blood pressure / inositol hexakisphosphate binding / Class A/1 (Rhodopsin-like receptors) / Clathrin-mediated endocytosis / clathrin-dependent endocytosis / positive regulation of blood pressure / positive regulation of fever generation / regulation of metabolic process / G protein-coupled receptor internalization / acetylcholine receptor binding / axonal fasciculation / Thrombin signalling through proteinase activated receptors (PARs) / G alpha (s) signalling events / positive regulation of intracellular signal transduction / regulation of synaptic transmission, GABAergic / clathrin binding / negative regulation of Notch signaling pathway / pseudopodium / phosphatidylinositol-3,4,5-trisphosphate binding / regulation of insulin secretion / positive regulation of receptor internalization / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / endocytic vesicle / GABA-ergic synapse / small molecule binding / maternal process involved in female pregnancy / positive regulation of vasoconstriction / regulation of synaptic transmission, glutamatergic / cellular response to hormone stimulus / activation of adenylate cyclase activity / visual perception / negative regulation of blood pressure / response to nutrient / response to cocaine / response to cytokine / G protein-coupled receptor binding / G protein-coupled receptor activity / peptide binding / response to nicotine / clathrin-coated endocytic vesicle membrane / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / adenylate cyclase-activating G protein-coupled receptor signaling pathway / receptor internalization / memory / positive regulation of neuron projection development / Vasopressin regulates renal water homeostasis via Aquaporins / protein transport / actin cytoskeleton / Cargo recognition for clathrin-mediated endocytosis / glucose homeostasis / Clathrin-mediated endocytosis / presynaptic membrane / G alpha (i) signalling events / growth cone / cytoplasmic vesicle / ubiquitin-dependent protein catabolic process / G alpha (s) signalling events / spermatogenesis / response to ethanol / mitochondrial outer membrane / response to lipopolysaccharide / molecular adaptor activity / positive regulation of ERK1 and ERK2 cascade / endosome / positive regulation of protein phosphorylation / positive regulation of apoptotic process / membrane raft / G protein-coupled receptor signaling pathway / negative regulation of cell population proliferation / glutamatergic synapse Similarity search - Function Vasopressin V2 receptor / Vasopressin receptor / Cannabinoid receptor type 1 / Cannabinoid receptor family / Arrestin, conserved site / Arrestins signature. / Arrestin / Arrestin, N-terminal / Arrestin-like, N-terminal / Arrestin C-terminal-like domain ... Vasopressin V2 receptor / Vasopressin receptor / Cannabinoid receptor type 1 / Cannabinoid receptor family / Arrestin, conserved site / Arrestins signature. / Arrestin / Arrestin, N-terminal / Arrestin-like, N-terminal / Arrestin C-terminal-like domain / Arrestin (or S-antigen), N-terminal domain / Arrestin (or S-antigen), C-terminal domain / Arrestin (or S-antigen), C-terminal domain / Arrestin-like, C-terminal / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Immunoglobulin E-set Similarity search - Domain/homologyBiological species Bos taurus (cattle) / Homo sapiens (human)Method single particle reconstruction / cryo EM / Resolution : 3.2 Å Details AuthorsLiao Y / Zhang H / Shen Q / Cai C Funding support China, 1 items Details Hide detailsOrganization Grant number Country National Natural Science Foundation of China (NSFC) China
CitationJournal : to be published Title : Cryo-EM structure of CB1-beta-arrestin1 complexAuthors : Liao Y / Zhang H / Shen Q / Cai C History Deposition Oct 19, 2023 - Header (metadata) release Mar 20, 2024 - Map release Mar 20, 2024 - Update Mar 20, 2024 - Current status Mar 20, 2024 Processing site : PDBj / Status : Released
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