giant virus / nucleocytoplasmic large DNA viruses (NCLDVs) / viral assembly / Paramecium bursaria chlorella virus 1 (PBCV-1) / chlorovirus / major capsid protein / minor capsid protein / VIRUS / VIRAL PROTEIN
Chlorovirus glycoprotein repeat / Domain of unknown function DUF5901 / Chlorovirus glycoprotein repeat / Family of unknown function (DUF5901) / Protein of unknown function DUF5762 / Protein of unknown function DUF5761 / Domain of unknown function DUF5899 / : / Minor capsid protein P8 central region / Minor capsid protein P9 transmembrane helices ...Chlorovirus glycoprotein repeat / Domain of unknown function DUF5901 / Chlorovirus glycoprotein repeat / Family of unknown function (DUF5901) / Protein of unknown function DUF5762 / Protein of unknown function DUF5761 / Domain of unknown function DUF5899 / : / Minor capsid protein P8 central region / Minor capsid protein P9 transmembrane helices / Minor capsid protein P2, DUF5899 / Minor capsid protein P11, C-terminal conserved region / Peptidase G2, IMC autoproteolytic cleavage domain / Peptidase_G2, IMC autoproteolytic cleavage domain / Major capsid protein, N-terminal / Major capsid protein N-terminus / Major capsid protein, C-terminal / Major capsid protein, C-terminal domain superfamily / Large eukaryotic DNA virus major capsid protein / Group II dsDNA virus coat/capsid protein / Parallel beta-helix repeat / Parallel beta-helix repeats 類似検索 - ドメイン・相同性
Major capsid protein VP54 / DUF5901 domain-containing protein / Capsid protein / Minor capsid protein P4 / Capsid protein / Minor capsid protein P8 / Major capsid protein / Peptidase G2 IMC autoproteolytic cleavage domain-containing protein / Minor capsid protein P12 / Minor capsid protein P6 ...Major capsid protein VP54 / DUF5901 domain-containing protein / Capsid protein / Minor capsid protein P4 / Capsid protein / Minor capsid protein P8 / Major capsid protein / Peptidase G2 IMC autoproteolytic cleavage domain-containing protein / Minor capsid protein P12 / Minor capsid protein P6 / Uncharacterized protein / Capsid protein / Uncharacterized protein / Minor capsid protein P2 / Minor capsid protein P11 / Capsid protein / Capsid protein / Chlorovirus glycoprotein repeat domain-containing protein / Chlorovirus glycoprotein repeat domain-containing protein / Chlorovirus glycoprotein repeat domain-containing protein / Minor capsid protein P9 / Minor capsid protein P13 / Uncharacterized protein / Uncharacterized protein / Minor capsid protein 3 / Minor capsid protein P5 類似検索 - 構成要素
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)
AI011219
米国
引用
ジャーナル: Nat Commun / 年: 2022 タイトル: Near-atomic, non-icosahedrally averaged structure of giant virus Paramecium bursaria chlorella virus 1. 著者: Qianqian Shao / Irina V Agarkova / Eric A Noel / David D Dunigan / Yunshu Liu / Aohan Wang / Mingcheng Guo / Linlin Xie / Xinyue Zhao / Michael G Rossmann / James L Van Etten / Thomas Klose / Qianglin Fang / 要旨: Giant viruses are a large group of viruses that infect many eukaryotes. Although components that do not obey the overall icosahedral symmetry of their capsids have been observed and found to play ...Giant viruses are a large group of viruses that infect many eukaryotes. Although components that do not obey the overall icosahedral symmetry of their capsids have been observed and found to play critical roles in the viral life cycles, identities and high-resolution structures of these components remain unknown. Here, by determining a near-atomic-resolution, five-fold averaged structure of Paramecium bursaria chlorella virus 1, we unexpectedly found the viral capsid possesses up to five major capsid protein variants and a penton protein variant. These variants create varied capsid microenvironments for the associations of fibers, a vesicle, and previously unresolved minor capsid proteins. Our structure reveals the identities and atomic models of the capsid components that do not obey the overall icosahedral symmetry and leads to a model for how these components are assembled and initiate capsid assembly, and this model might be applicable to many other giant viruses.
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機能・相同性情報
Paramecium bursaria Chlorella virus 1 (ウイルス)
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米国, 2件 
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emd_34438.png
http://ftp.pdbj.org/pub/emdb/structures/EMD-34438
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