- EMDB-30232: Structure of Dot1L-H2BK34ub Nucleosome Complex -
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Basic information
Entry
Database: EMDB / ID: EMD-30232
Title
Structure of Dot1L-H2BK34ub Nucleosome Complex
Map data
Sample
Complex: Structure of Dot1L-H2BK34ub Nucleosome Complex
Protein or peptide: Histone-lysine N-methyltransferase, H3 lysine-79 specific
Protein or peptide: Histone H4
Protein or peptide: Histone H2A type 1-B/E
Protein or peptide: Histone H2B type 1-K
Protein or peptide: Histone H3.1
DNA: DNA (146-MER)
DNA: DNA (146-MER)
Protein or peptide: Ubiquitin
Ligand: S-ADENOSYL-L-HOMOCYSTEINE
Keywords
Nucleosome / TRANSLATION
Function / homology
Function and homology information
[histone H3]-lysine79 N-trimethyltransferase / histone H3K79 methyltransferase activity / histone H3K79 trimethyltransferase activity / regulation of transcription regulatory region DNA binding / regulation of receptor signaling pathway via JAK-STAT / histone H3 methyltransferase activity / Formation of the ternary complex, and subsequently, the 43S complex / histone methyltransferase activity / Ribosomal scanning and start codon recognition / Translation initiation complex formation ...[histone H3]-lysine79 N-trimethyltransferase / histone H3K79 methyltransferase activity / histone H3K79 trimethyltransferase activity / regulation of transcription regulatory region DNA binding / regulation of receptor signaling pathway via JAK-STAT / histone H3 methyltransferase activity / Formation of the ternary complex, and subsequently, the 43S complex / histone methyltransferase activity / Ribosomal scanning and start codon recognition / Translation initiation complex formation / SARS-CoV-1 modulates host translation machinery / Peptide chain elongation / Selenocysteine synthesis / Formation of a pool of free 40S subunits / Eukaryotic Translation Termination / Response of EIF2AK4 (GCN2) to amino acid deficiency / SRP-dependent cotranslational protein targeting to membrane / Viral mRNA Translation / Maturation of protein E / Maturation of protein E / Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) / GTP hydrolysis and joining of the 60S ribosomal subunit / ER Quality Control Compartment (ERQC) / Myoclonic epilepsy of Lafora / FLT3 signaling by CBL mutants / Prevention of phagosomal-lysosomal fusion / L13a-mediated translational silencing of Ceruloplasmin expression / IRAK2 mediated activation of TAK1 complex / Alpha-protein kinase 1 signaling pathway / Glycogen synthesis / IRAK1 recruits IKK complex / IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation / Membrane binding and targetting of GAG proteins / Endosomal Sorting Complex Required For Transport (ESCRT) / Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 / Negative regulation of FLT3 / PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 / Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation / Constitutive Signaling by NOTCH1 HD Domain Mutants / IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation / NOTCH2 Activation and Transmission of Signal to the Nucleus / Major pathway of rRNA processing in the nucleolus and cytosol / TICAM1,TRAF6-dependent induction of TAK1 complex / negative regulation of megakaryocyte differentiation / subtelomeric heterochromatin formation / TICAM1-dependent activation of IRF3/IRF7 / APC/C:Cdc20 mediated degradation of Cyclin B / Regulation of FZD by ubiquitination / protein localization to CENP-A containing chromatin / Downregulation of ERBB4 signaling / p75NTR recruits signalling complexes / APC-Cdc20 mediated degradation of Nek2A / Chromatin modifying enzymes / InlA-mediated entry of Listeria monocytogenes into host cells / Regulation of pyruvate metabolism / TRAF6-mediated induction of TAK1 complex within TLR4 complex / TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling / Regulation of innate immune responses to cytosolic DNA / NF-kB is activated and signals survival / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / Replacement of protamines by nucleosomes in the male pronucleus / Downregulation of ERBB2:ERBB3 signaling / NRIF signals cell death from the nucleus / Pexophagy / CENP-A containing nucleosome / VLDLR internalisation and degradation / Regulation of PTEN localization / Packaging Of Telomere Ends / Activated NOTCH1 Transmits Signal to the Nucleus / Regulation of BACH1 activity / MAP3K8 (TPL2)-dependent MAPK1/3 activation / Translesion synthesis by REV1 / Synthesis of active ubiquitin: roles of E1 and E2 enzymes / InlB-mediated entry of Listeria monocytogenes into host cell / Translesion synthesis by POLK / Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) / Recognition and association of DNA glycosylase with site containing an affected purine / Cleavage of the damaged purine / Downregulation of TGF-beta receptor signaling / Josephin domain DUBs / TICAM1, RIP1-mediated IKK complex recruitment / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / Translesion synthesis by POLI / Gap-filling DNA repair synthesis and ligation in GG-NER / IKK complex recruitment mediated by RIP1 / TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) / Regulation of activated PAK-2p34 by proteasome mediated degradation / Deposition of new CENPA-containing nucleosomes at the centromere / Recognition and association of DNA glycosylase with site containing an affected pyrimidine / Cleavage of the damaged pyrimidine / TNFR1-induced NF-kappa-B signaling pathway / PINK1-PRKN Mediated Mitophagy / telomere organization / cytosolic ribosome / TCF dependent signaling in response to WNT / Interleukin-7 signaling / Inhibition of DNA recombination at telomere / RNA Polymerase I Promoter Opening / Meiotic synapsis / Autodegradation of Cdh1 by Cdh1:APC/C Similarity search - Function
National Natural Science Foundation of China (NSFC)
21532004
China
National Natural Science Foundation of China (NSFC)
91753205
China
National Natural Science Foundation of China (NSFC)
81621002
China
Citation
Journal: To Be Published Title: Structure of the Dot1L-H2BK34ub Nucleosome Complex Reveals an Unprecedented Crosstalk Activation Mechanism through Nucleosome Shape Distortion Authors: Liu L / Lou ZY / Ai HS / Cao L
History
Deposition
Apr 14, 2020
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Header (metadata) release
Apr 14, 2021
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Map release
Apr 14, 2021
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Update
Jun 18, 2025
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Current status
Jun 18, 2025
Processing site: PDBj / Status: Released
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Structure visualization
Movie
Surface view with section colored by density value
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