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- EMDB-19942: Structure of a B-state intermediate committed to discard (Bd-II state) -

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基本情報

登録情報
データベース: EMDB / ID: EMD-19942
タイトルStructure of a B-state intermediate committed to discard (Bd-II state)
マップデータ
試料
  • 複合体: Bd-II complex
    • タンパク質・ペプチド: x 36種
    • RNA: x 4種
  • リガンド: x 5種
キーワードHelicase / G-patch protein / discard pathway / SPLICING
機能・相同性
機能・相同性情報


nucleolar peripheral inclusion body / mRNA Splicing - Major Pathway / Formation of TC-NER Pre-Incision Complex / Dual incision in TC-NER / Gap-filling DNA repair synthesis and ligation in TC-NER / spliceosomal complex disassembly / spliceosomal conformational changes to generate catalytic conformation / U2-type post-mRNA release spliceosomal complex / siRNA-mediated pericentric heterochromatin formation / post-mRNA release spliceosomal complex ...nucleolar peripheral inclusion body / mRNA Splicing - Major Pathway / Formation of TC-NER Pre-Incision Complex / Dual incision in TC-NER / Gap-filling DNA repair synthesis and ligation in TC-NER / spliceosomal complex disassembly / spliceosomal conformational changes to generate catalytic conformation / U2-type post-mRNA release spliceosomal complex / siRNA-mediated pericentric heterochromatin formation / post-mRNA release spliceosomal complex / generation of catalytic spliceosome for first transesterification step / pICln-Sm protein complex / U2-type catalytic step 1 spliceosome / pre-mRNA binding / snRNP binding / spindle pole body / SMN-Sm protein complex / regulatory ncRNA-mediated gene silencing / spliceosomal tri-snRNP complex / U2-type spliceosomal complex / commitment complex / mRNA cis splicing, via spliceosome / U2-type catalytic step 2 spliceosome / U4 snRNP / U2 snRNP / U1 snRNP / U2-type prespliceosome / precatalytic spliceosome / spliceosomal complex assembly / mRNA 5'-splice site recognition / pericentric heterochromatin / spliceosomal tri-snRNP complex assembly / Prp19 complex / protein K63-linked ubiquitination / U5 snRNA binding / U5 snRNP / U2 snRNA binding / U6 snRNA binding / pre-mRNA intronic binding / spliceosomal snRNP assembly / U1 snRNA binding / U4/U6 x U5 tri-snRNP complex / catalytic step 2 spliceosome / RNA splicing / peptidylprolyl isomerase / peptidyl-prolyl cis-trans isomerase activity / spliceosomal complex / mRNA splicing, via spliceosome / RING-type E3 ubiquitin transferase / spindle / metallopeptidase activity / ubiquitin-protein transferase activity / ubiquitin protein ligase activity / nuclear envelope / protein folding / protein-macromolecule adaptor activity / molecular adaptor activity / microtubule / cysteine-type deubiquitinase activity / RNA helicase activity / RNA helicase / DNA repair / mRNA binding / GTPase activity / GTP binding / ATP hydrolysis activity / DNA binding / RNA binding / zinc ion binding / ATP binding / nucleus / cytosol / cytoplasm
類似検索 - 分子機能
G patch domain-containing protein, N-terminal / Protein of unknown function (DUF1604) / Nuclear protein DGCR14/ESS-2 / Nuclear protein Es2 / GCF, C-terminal / GC-rich sequence DNA-binding factor-like protein / : / TFP11/STIP/Ntr1 / Nineteen complex-related protein 2 / Saf4/Yju2 protein ...G patch domain-containing protein, N-terminal / Protein of unknown function (DUF1604) / Nuclear protein DGCR14/ESS-2 / Nuclear protein Es2 / GCF, C-terminal / GC-rich sequence DNA-binding factor-like protein / : / TFP11/STIP/Ntr1 / Nineteen complex-related protein 2 / Saf4/Yju2 protein / Saf4/Yju2 protein / cwf21 / Slt11, RNA recognition motif / Pre-mRNA-splicing factor Cwc2, RNA recognition motif / Pre-mRNA-splicing factor SPF27 / Torus domain / Breast carcinoma amplified sequence 2 (BCAS2) / Torus domain / CWF11 family / Intron-binding protein aquarius, N-terminal / Intron-binding protein aquarius N-terminal / mRNA splicing factor SYF2 / SYF2 splicing factor / G-patch domain / : / : / mRNA splicing factor Cwf21 domain / cwf21 domain / G-patch domain profile. / G-patch domain / glycine rich nucleic binding domain / Pre-mRNA-processing factor 17 / Pre-mRNA-splicing factor 19 / Pre-mRNA-processing factor 19 / : / Prp19/Pso4-like / : / Pre-mRNA-splicing factor SYF1 middle HAT repeat / Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like / : / : / STL11, N-terminal / : / Pre-mRNA-splicing factor Syf1/CRNKL1 C-terminal HAT repeat / SKI-interacting protein SKIP, SNW domain / SKI-interacting protein, SKIP / SKIP/SNW domain / : / Pre-mRNA-splicing factor Syf1/CNRKL1 N-terminal HAT repeat / Pre-mRNA-splicing factor Cwf15/Cwc15 / Cwf15/Cwc15 cell cycle control protein / WD repeat Prp46/PLRG1-like / Pre-mRNA-splicing factor Cwc2/Slt11 / Anaphase-promoting complex subunit 4, WD40 domain / : / G10 protein / Pre-mRNA-splicing factor BUD31 / Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal / : / : / pre-mRNA splicing factor component / DNA2/NAM7-like helicase / : / Initiation factor eIF-4 gamma, MA3 / MA3 domain / MI domain profile. / Domain in DAP-5, eIF4G, MA-3 and other proteins. / MIF4G domain / Myb-like DNA-binding domain / Anaphase-promoting complex subunit 4 WD40 domain / Middle domain of eukaryotic initiation factor 4G (eIF4G) / MIF4G-like, type 3 / Small nuclear ribonucleoprotein D1 / U-box domain profile. / Zinc finger, CCCH-type superfamily / Modified RING finger domain / U-box domain / zinc finger / 116kDa U5 small nuclear ribonucleoprotein component, N-terminal / 116kDa U5 small nuclear ribonucleoprotein component, C-terminal / Snu114, GTP-binding domain / 116 kDa U5 small nuclear ribonucleoprotein component N-terminus / Pre-mRNA-splicing factor Syf1-like / : / Helicase associated domain (HA2), ratchet-like / DEAD-box helicase, OB fold / Oligonucleotide/oligosaccharide-binding (OB)-fold / Helicase associated domain (HA2), winged-helix / Helicase-associated domain / Helicase associated domain (HA2) Add an annotation / Small nuclear ribonucleoprotein Sm D3 / Small nuclear ribonucleoprotein Sm D2 / Small nuclear ribonucleoprotein E / Small nuclear ribonucleoprotein G / Small nuclear ribonucleoprotein F / Sm-like protein Lsm7/SmG / Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3 / Sm-like protein Lsm6/SmF / Myb-type HTH DNA-binding domain profile. / Zinc finger, CCCH-type
類似検索 - ドメイン・相同性
Pre-mRNA-splicing factor prp5 / Uncharacterized protein C17A2.08c / Pre-mRNA-processing factor 19 / Small nuclear ribonucleoprotein Sm D2 / Pre-mRNA-splicing factor cwf21 / Pre-mRNA-splicing factor spp42 / Small nuclear ribonucleoprotein Sm D1 / Pre-mRNA-processing factor 17 / Pre-mRNA-splicing factor syf2 / Small nuclear ribonucleoprotein F ...Pre-mRNA-splicing factor prp5 / Uncharacterized protein C17A2.08c / Pre-mRNA-processing factor 19 / Small nuclear ribonucleoprotein Sm D2 / Pre-mRNA-splicing factor cwf21 / Pre-mRNA-splicing factor spp42 / Small nuclear ribonucleoprotein Sm D1 / Pre-mRNA-processing factor 17 / Pre-mRNA-splicing factor syf2 / Small nuclear ribonucleoprotein F / Stress response protein bis1 / Pre-mRNA-splicing factor cwf5 / Protein saf4 / Pre-mRNA-splicing factor cwf14 / Small nuclear ribonucleoprotein G / Pre-mRNA-splicing factor cwf10 / Pre-mRNA-splicing factor cwf11 / Pre-mRNA-splicing factor cwf17 / Pre-mRNA-splicing factor cdc5 / Pre-mRNA-splicing factor cwf15 / Peptidyl-prolyl cis-trans isomerase ppi1 / Pre-mRNA-splicing factor cwf2 / Pre-mRNA-splicing factor cwf4 / Pre-mRNA-processing protein 45 / Small nuclear ribonucleoprotein-associated protein B / Putative pre-mRNA-splicing factor ATP-dependent RNA helicase C20H4.09 / Uncharacterized protein C20H4.06c / Pre-mRNA-splicing factor cwf22 / Pre-mRNA-splicing factor cwf3 / Pre-mRNA-splicing factor cwf7 / Small nuclear ribonucleoprotein E / G-patch domain-containing protein C1486.03 / Small nuclear ribonucleoprotein Sm D3
類似検索 - 構成要素
生物種Schizosaccharomyces pombe (分裂酵母)
手法単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.1 Å
データ登録者Soni K / Wild K / Sinning I
資金援助 ドイツ, 2件
OrganizationGrant number国
German Research Foundation (DFG)SI 586/6-1 ドイツ
German Research Foundation (DFG)Project-ID 439669440, TP B03 ドイツ
引用ジャーナル: Nat Struct Mol Biol / 年: 2025
タイトル: Structures of aberrant spliceosome intermediates on their way to disassembly.
著者: Komal Soni / Attila Horvath / Olexandr Dybkov / Merlin Schwan / Sasanan Trakansuebkul / Dirk Flemming / Klemens Wild / Henning Urlaub / Tamás Fischer / Irmgard Sinning /
要旨: Intron removal during pre-mRNA splicing is of extraordinary complexity and its disruption causes a vast number of genetic diseases in humans. While key steps of the canonical spliceosome cycle have ...Intron removal during pre-mRNA splicing is of extraordinary complexity and its disruption causes a vast number of genetic diseases in humans. While key steps of the canonical spliceosome cycle have been revealed by combined structure-function analyses, structural information on an aberrant spliceosome committed to premature disassembly is not available. Here, we report two cryo-electron microscopy structures of post-B spliceosome intermediates from Schizosaccharomyces pombe primed for disassembly. We identify the DEAH-box helicase-G-patch protein pair (Gih35-Gpl1, homologous to human DHX35-GPATCH1) and show how it maintains catalytic dormancy. In both structures, Gpl1 recognizes a remodeled active site introduced by an overstabilization of the U5 loop I interaction with the 5' exon leading to a single-nucleotide insertion at the 5' splice site. Remodeling is communicated to the spliceosome surface and the Ntr1 complex that mediates disassembly is recruited. Our data pave the way for a targeted analysis of splicing quality control.
履歴
登録2024年3月26日-
ヘッダ(付随情報) 公開2024年12月25日-
マップ公開2024年12月25日-
更新2025年5月28日-
現状2025年5月28日処理サイト: PDBe / 状態: 公開

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構造の表示

添付画像

emd_19942.png

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マップ

ファイルダウンロード / ファイル: emd_19942.map.gz / 形式: CCP4 / 大きさ: 669.9 MB / タイプ: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
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軸Z (Sec.)Y (Row.)X (Col.)
0.82 Å/pix.
x 560 pix.
= 460.32 Å		0.82 Å/pix.
x 560 pix.
= 460.32 Å		0.82 Å/pix.
x 560 pix.
= 460.32 Å

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画像は Spider により作成

ボクセルのサイズX=Y=Z: 0.822 Å
密度

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ヒストグラム (対数)
表面レベル登録者による: 3.2
最小 - 最大-23.068339999999999 - 37.66431
平均 (標準偏差)0.00013976364 (±0.9043063)
対称性空間群: 1
詳細

EMDB XML:

マップ形状
Axis orderXYZ
Origin000
サイズ560560560
Spacing560560560
セルA=B=C: 460.32 Å
α=β=γ: 90.0 °

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マスク #1

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試料の構成要素

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全体 : Bd-II complex

全体名称: Bd-II complex
要素
  • 複合体: Bd-II complex
    • タンパク質・ペプチド: Stress response protein bis1
    • タンパク質・ペプチド: Protein saf4
    • RNA: U2snRNA
    • RNA: U5snRNA
    • タンパク質・ペプチド: Pre-mRNA-splicing factor spp42
    • タンパク質・ペプチド: Pre-mRNA-splicing factor cwf10
    • タンパク質・ペプチド: Pre-mRNA-splicing factor cwf17
    • タンパク質・ペプチド: Small nuclear ribonucleoprotein Sm D3
    • タンパク質・ペプチド: Small nuclear ribonucleoprotein-associated protein B
    • タンパク質・ペプチド: Small nuclear ribonucleoprotein Sm D1
    • タンパク質・ペプチド: Small nuclear ribonucleoprotein Sm D2
    • タンパク質・ペプチド: Small nuclear ribonucleoprotein E
    • タンパク質・ペプチド: Small nuclear ribonucleoprotein F
    • タンパク質・ペプチド: Small nuclear ribonucleoprotein G
    • タンパク質・ペプチド: Pre-mRNA-splicing factor prp5
    • タンパク質・ペプチド: Pre-mRNA-processing protein 45
    • タンパク質・ペプチド: Pre-mRNA-splicing factor cwf5
    • タンパク質・ペプチド: Pre-mRNA-splicing factor cwf11
    • タンパク質・ペプチド: Pre-mRNA-splicing factor cwf14
    • タンパク質・ペプチド: Pre-mRNA-splicing factor cwf2
    • タンパク質・ペプチド: Pre-mRNA-splicing factor cwf15
    • タンパク質・ペプチド: Pre-mRNA-splicing factor cwf4
    • タンパク質・ペプチド: Pre-mRNA-processing factor 19
    • タンパク質・ペプチド: Pre-mRNA-splicing factor cdc5
    • タンパク質・ペプチド: Pre-mRNA-splicing factor cwf3
    • タンパク質・ペプチド: Pre-mRNA-splicing factor syf2
    • タンパク質・ペプチド: Pre-mRNA-splicing factor cwf7
    • タンパク質・ペプチド: Pre-mRNA-processing factor 17
    • タンパク質・ペプチド: Pre-mRNA-splicing factor cwf21
    • タンパク質・ペプチド: Pre-mRNA-splicing factor cwf22
    • タンパク質・ペプチド: Peptidyl-prolyl cis-trans isomerase ppi1
    • タンパク質・ペプチド: G-patch domain-containing protein C1486.03
    • タンパク質・ペプチド: Uncharacterized protein C17A2.08c
    • タンパク質・ペプチド: Uncharacterized protein C20H4.06c
    • タンパク質・ペプチド: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase C20H4.09
    • タンパク質・ペプチド: UNK1
    • タンパク質・ペプチド: UNK2
    • RNA: U6snRNA
    • RNA: pre-mRNA
    • タンパク質・ペプチド: UNK3
  • リガンド: INOSITOL HEXAKISPHOSPHATE
  • リガンド: GUANOSINE-5'-TRIPHOSPHATE
  • リガンド: MAGNESIUM ION
  • リガンド: ZINC ION
  • リガンド: POTASSIUM ION

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超分子 #1: Bd-II complex

超分子名称: Bd-II complex / タイプ: complex / ID: 1 / 親要素: 0 / 含まれる分子: #1-#40
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)

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分子 #1: Stress response protein bis1

分子名称: Stress response protein bis1 / タイプ: protein_or_peptide / ID: 1 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 43.084047 KDa
配列文字列: MSLAKKIDDD EKQLVKPVNK EQTYKKPIPL EEDDYIEGLS YIIQQQYFPD LPKLKAEVVL ESEEVGSFDA QNESRDEKLK YLIAKNSED PLRKRLPSLA IHEITKAQLD GENKPISVAS YQNKFTSEDN ASFGELMEDE SRLRAEQHKR RFGVHSQQPS N SIQTIGYS ...文字列:
MSLAKKIDDD EKQLVKPVNK EQTYKKPIPL EEDDYIEGLS YIIQQQYFPD LPKLKAEVVL ESEEVGSFDA QNESRDEKLK YLIAKNSED PLRKRLPSLA IHEITKAQLD GENKPISVAS YQNKFTSEDN ASFGELMEDE SRLRAEQHKR RFGVHSQQPS N SIQTIGYS NSDAIKSIAW KEKDKSIKTW NYQPKNALMY TPETNHSSSL SQIKKQSTEI QADATGLSQS FLEAANQPST DP IVPPSVN ETDASVNGYP LVDVNFGQAV GSSSKSYFNI PERPRRERLH AMRVRDIRSH STNTTITSVD SASTALNSYS TPN SVSRKL TNLTPAARRL VARSYLRSPL HGSSPSASRH TALRTSIPKF SWTPTPRVKS TAPTPKRV

UniProtKB: Stress response protein bis1

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分子 #2: Protein saf4

分子名称: Protein saf4 / タイプ: protein_or_peptide / ID: 2 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 34.751523 KDa
配列文字列: MQGFNMGKYI PPEGPNAKRK FDKLRNVIRF EMPFPVWCNN CENIIQQGTR FNAVKKEIGS YYTTKIWSFS LKCHLCSNPI DVHTDPKNT EYIVASGGRR KIEPQDINER PAKAENDEKV PSDAIEALET QLTQQKSEKH NSSVINFIYE KNERLWSDPF V SSQRLRKQ ...文字列:
MQGFNMGKYI PPEGPNAKRK FDKLRNVIRF EMPFPVWCNN CENIIQQGTR FNAVKKEIGS YYTTKIWSFS LKCHLCSNPI DVHTDPKNT EYIVASGGRR KIEPQDINER PAKAENDEKV PSDAIEALET QLTQQKSEKH NSSVINFIYE KNERLWSDPF V SSQRLRKQ FRERKKIEKK QEAKDLSLKN RAALDIDILP PSSSDKDKAL LLLDNELGKN KFIRKLDYRR TLMPSSRTFS TF AKFAETS FAKKDPFARK FVPSEKLRSE QRKFPTENLK GEKILEDNSV SLVNYEVSDD EG

UniProtKB: Protein saf4

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分子 #5: Pre-mRNA-splicing factor spp42

分子名称: Pre-mRNA-splicing factor spp42 / タイプ: protein_or_peptide / ID: 5 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 274.917781 KDa
配列文字列: MASLPPGNPP PPPPPPGFEP PSQPPPPPPP GYVKKRKNKT PAQSGNLEKQ LNERARKWRA SQKSKFGVKR KQGYVQTEKA DLPPEHLRK IMKDRGDMSS RKFRADKRSY LGALKYLPHA VLKLLENMPM PWEEYREVKV LYHVTGAITF VNESPRVIEP H FIAQWGTM ...文字列:
MASLPPGNPP PPPPPPGFEP PSQPPPPPPP GYVKKRKNKT PAQSGNLEKQ LNERARKWRA SQKSKFGVKR KQGYVQTEKA DLPPEHLRK IMKDRGDMSS RKFRADKRSY LGALKYLPHA VLKLLENMPM PWEEYREVKV LYHVTGAITF VNESPRVIEP H FIAQWGTM WMMMRREKRD RKNFKRLRFP PFDDEEPPFS IDQLLDLEPL EAIRMDLDEE DDAPVMDWFY ENKALEDTPH VN GPTYRRW KLNLPQMANL HRLGYQLLSD LRDDNYFYLF NDNSFFTAKA LNVAIPGGPK FEPLYKDEAP EMEDWNEFND IYK LIIRHP IKTEYRIAFP YLYNSRARSV ALSEYHQPSN VFVPPEDPDL PAFFWDPIIN PITSRQLTLH ELDTSPEDSA IEED PNFEI PFDPFFHSED IEFEHTASAL ILLWAPHPFN KRSGATKRAQ DVPLIKHWYL EHCPPNQPVK VRVSYQKLLK SHVMN KLHM AHPKSHTNRS LLRQLKNTKF FQSTSIDWVE AGLQVCRQGY NMLQLLIHRK GLTYLHLDYN CNLKPTKTLT TKERKK SRF GNAFHLMREI LRLTKLIVDS HVQYRLGNID AYQLADGLHY IFNHVGQLTG MYRYKYRLMR QIRACKDFKH LIYYRFN TG PVGKGPGCGF WAPSWRVWLF FLRGIVPLLE RWLGNLLARQ FEGRHSTGVA KQITKQRVDS HQDLELRAAV MNDILDMI P EGIRQGKSKT ILQHLSEAWR CWKANIPWKV PGLPAPIENM ILRYVKSKAD WWTSVAHFNR ERIRRGATVD KTVAKKNLG RLTRLWLKAE QERQHNYLKD GPYVTADEAV AIYTTFVHWL ESRRFQPIPF PPLSYKHDTK LLVLALERLK EAYSVKGRLN QSQREELAL VEQAYDNPHE MLSQIKRRLL TMRTFKEVGI EFMDMYSHLI PVYSVDPMEK ICDAYLDQYL WFEADRRHLF P SWVKPSDS EPPPLLVYKW CQGINNLTDV WETSNGECNV LMETRLSKVF EKVDLTLLNR LMSLLMDTNL ASYASAKNNV VL SYKDMSH TNSYGLVRGL QFSSFIWQFY GLVLDLLILG LQRATEIAGP ADAPNDFLHF KDQATETSHP IRLYTRYIDK VYI MFRFTD EESRDLIQRF LNENPDPTNS NVVNYSKGKK NCWPRDARMR LMKHDVNLGR AVFWEIRNRL PRSLTTLEWE DTFP SVYSK DNPNLLFSMT GFEVRILPKI RQNEEFSLKD GVWNLTDNRT KQRTAQAFIR VTEDGINQFG NRIRQILMSS GSTTF TKIA NKWNTALIAL MTYYREAAIS TPELLDLLVK CESKIQTRVK ISLNSKMPSR FPPAVFYSPK ELGGLGMLSM GHVLIP QSD LRWSKQTDTG ITHFRSGMTT NGEHLIPNLY RYIQPWESEF IDSQRVWAEY AMKRQEALQQ NRRLTLEDLE DSWDRGI PR INTLFQKDRH TLAYDKGWRV RTEFKQYQLL KNNPFWWTSQ RHDGKLWQLN NYRVDVIQAL GGVEGILEHT MFKATGFP S WEGLFWEKAS GFEESMKFKK LTNAQRSGLN QIPNRRFTLW WSPTINRANV YVGFQVQLDL TGIMMHGKIP TLKISLIQI FRSHLWQKIH ESVVWDLCQV LDQELESLQI ETVQKETIHP RKSYKMNSSC ADILLLAAYK WNVSRPSLLN DNRDVLDNTT TNKYWIDVQ LRFGDYDSHD IERYTRAKFL DYSTDAQSMY PSPTGVLIGI DLCYNMHSAY GNWIPGMKPL IQQSMNKIMK A NPALYVLR ERIRKGLQLY ASEPQEQYLS SSNYAELFSN QIQLFVDDTN VYRVTIHKTF EGNLTTKPIN GAIFIFNPRT GQ LFLKVIH TSVWAGQKRL GQLAKWKTAE EVAALIRSLP VEEQPRQIIV TRKGMLDPLE VHLLDFPNIT IKGSELQLPF QAI IKLDKI NDLILRATEP QMVLFNLYDD WLQSVSSYTA FSRLILILRA LNVNTEKTKL ILRPDKSIIT KENHVWPNLD DQQW LDVEP KLRDLILADY AKKNNINVAS LTNSEVRDII LGMTITAPSL QRQQIAEIEK QGRENAQVTA VTTKTTNVHG DEMVV TTTS AYENEKFSSK TEWRNRAISS ISLPLRTKNI YVNSDNISET FPYTYILPQN LLRKFVTISD LRTQVAGYMY GKSPSD NPQ IKEIRCIALV PQLGSIRNVQ LPSKLPHDLQ PSILEDLEPL GWIHTQSSEL PYLSSVDVTT HAKILSSHPE WDTKAVT LT VSYIPGSISL AAYTVSKEGI EWGSKNMDIN SDEAIGYEPS MAEKCQLLLS DRIQGFFLVP EEGVWNYNFN GASFSPKM T YSLKLDVPLP FFALEHRPTH VISYTELETN DRLEEDMPDA FA

UniProtKB: Pre-mRNA-splicing factor spp42

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分子 #6: Pre-mRNA-splicing factor cwf10

分子名称: Pre-mRNA-splicing factor cwf10 / タイプ: protein_or_peptide / ID: 6 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 111.445281 KDa
配列文字列: MMEEDLYDEF GNYIGPENEE DEEELFPQAP SPTIAQVPSF EEVIPDEELE DVERAEEMAL SHLEPQNAVV LHEDKQYYPS AEEVYGSNV DIMVQEQDTQ PLSQPIIEPI RHKRIAIETT NVPDTVYKKE FLFGLLTGTD DVRSFIVAGH LHHGKSALLD L LVYYTHPD ...文字列:
MMEEDLYDEF GNYIGPENEE DEEELFPQAP SPTIAQVPSF EEVIPDEELE DVERAEEMAL SHLEPQNAVV LHEDKQYYPS AEEVYGSNV DIMVQEQDTQ PLSQPIIEPI RHKRIAIETT NVPDTVYKKE FLFGLLTGTD DVRSFIVAGH LHHGKSALLD L LVYYTHPD TKPPKRRSLR YTDTHYLERE RVMSIKSTPL TLAVSDMKGK TFAFQCIDTP GHVDFVDEVA APMAISDGVV LV VDVIEGV MINTTRIIKH AILHDMPIVL VLNKVDRLIL ELRLPPNDAY HKLRHVIDEV NDNICQISKD LKYRVSPELG NVC FASCDL GYCFTLSSFA KLYIDRHGGI DVDLFSKRLW GDIYFDSKTR KFAKQSLDGS GVRSFVHFIL EPLYKLHTLT ISDE AEKLK KHLSSFQIYL KPKDYLLDPK PLLQLICASF FGFPVGFVNA VTRHIPSPRE NAARKASQSY IGPINSSIGK AILEM SREE SAPLVMHVTK LYNTVDANNF YAFARVYSGQ VKKGQKVKVL GENYSLEDEE DMVVAHIAEI CVPCARYRLH VDGAVA GML VLLGGVDNSI SKTATIVSDN LKDDPYIFRP IAHMSESVFK VAVEPHNPSE LPKLLDGLRK TNKSYPLSIT KVEESGE HT IFGTGEMYMD CLLYDLRTLY SEIEIRVSDP VARFCETAVD TSSIKCFSDT PNKKNRITMV VEPLEKGISN DIENGKVN I NWPQKRISEF FQKNYDWDLL ASRSIWAFGP DDRGTNILRD DTLSTDVDKN VLNSVKEYIK QGFQWGTREG PLCDETIRN VNFRLMDVVL APEQIYRGGG QIIPTARRVC YSSFLTASPR LMEPVYMVEV HAPADSLPII YDLLTRRRGH VLQDIPRPGS PLYLVRALI PVIDSCGFET DLRVHTQGQA MCQMVFDHWQ VVPGDPLDKS IKPKPLEPAR GSDLARDFLI KTRRRKGLVE D VSTTRYFD QEMIDSLKEA GVVLSL

UniProtKB: Pre-mRNA-splicing factor cwf10

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分子 #7: Pre-mRNA-splicing factor cwf17

分子名称: Pre-mRNA-splicing factor cwf17 / タイプ: protein_or_peptide / ID: 7 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 37.477242 KDa
配列文字列: MDKRKESESA TNGHLVKRIR IQDSSLITEG SVLQRTSDLN VPNLQMFGHT AEVLVARFDP SGSYFASGGM DRQILLWNVF GDVKNYGVL NGCKGAITDL QWSRDSRVVY CSSSDTHLMS WDAVSGQKIR KHKGHAGVVN ALDVLKVGSE LLTSVSDDCT M KVWDSRSK ...文字列:
MDKRKESESA TNGHLVKRIR IQDSSLITEG SVLQRTSDLN VPNLQMFGHT AEVLVARFDP SGSYFASGGM DRQILLWNVF GDVKNYGVL NGCKGAITDL QWSRDSRVVY CSSSDTHLMS WDAVSGQKIR KHKGHAGVVN ALDVLKVGSE LLTSVSDDCT M KVWDSRSK DCIKTIEEKY PLTAVAIAQQ GTQVFIGGID GAIKIWDLRN NHCSHVLKGH KDIITSLAIS KDGSSLLSNS MD NTVRIFD VKPFASAQRQ LQIFEGAIHG QEHNLLGVAW SRNSRFVGAG SSDKNVYVWS ATGDLRYVLP GHEGSVNHVD FHP HQDIIL SCSSDRTIFL GELN

UniProtKB: Pre-mRNA-splicing factor cwf17

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分子 #8: Small nuclear ribonucleoprotein Sm D3

分子名称: Small nuclear ribonucleoprotein Sm D3 / タイプ: protein_or_peptide / ID: 8 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 11.050884 KDa
配列文字列:
MSLCIKLLHE TQGHIVTMEL ENGSTYRGKL IEAEDNMNCQ MRDISVTARD GRVSHLDQVY IRGSHIRFLI VPDMLRNAPM FKVGPGRSV PLPTRGRR

UniProtKB: Small nuclear ribonucleoprotein Sm D3

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分子 #9: Small nuclear ribonucleoprotein-associated protein B

分子名称: Small nuclear ribonucleoprotein-associated protein B
タイプ: protein_or_peptide / ID: 9 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 15.493004 KDa
配列文字列:
MGTTKMVSLL NHSLNVTTKD GRTFVGQLLA FDGFMNLVLS DCQEYRHIKK QNVPSNSVYE EKRMLGLVIL RGEFIVSLSV QGPPPMDPS MRGSLLSGPG VARPAGRGIP LGQAPVGLAG PVRGVGYTAP PPPAGFGRGA PPPGFRPV

UniProtKB: Small nuclear ribonucleoprotein-associated protein B

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分子 #10: Small nuclear ribonucleoprotein Sm D1

分子名称: Small nuclear ribonucleoprotein Sm D1 / タイプ: protein_or_peptide / ID: 10 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 13.115422 KDa
配列文字列:
MKLVRFLMKL TNETVSIELK NGTIVHGTIT SVDMQMNTHL KAVKMTVKGR EPVPVETLSI RGNNIRYYIL PDSLPLDTLL IDDSTKPKQ KKKEVVRGRG RGRGRGTRGR GRGASRGF

UniProtKB: Small nuclear ribonucleoprotein Sm D1

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分子 #11: Small nuclear ribonucleoprotein Sm D2

分子名称: Small nuclear ribonucleoprotein Sm D2 / タイプ: protein_or_peptide / ID: 11 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 13.119311 KDa
配列文字列:
MADLVDKPRS ELSEIELARL EEYEFSAGPL SVLQQAVKNH DQVLINCRNN KKLLARVKAF DRHSNMVLEN VKEMWTEKKR TASGKKGKA INKDRFISKM FLRGDGVVLV VRIPSA

UniProtKB: Small nuclear ribonucleoprotein Sm D2

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分子 #12: Small nuclear ribonucleoprotein E

分子名称: Small nuclear ribonucleoprotein E / タイプ: protein_or_peptide / ID: 12 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 9.702353 KDa
配列文字列:
MSGRVQKVMI PPINFIFKLL QQHTPVSIWL FEQTDIRLQG QIRGFDEFMN IVLDDAVQVD AKNNKRELGR ILLKGDNITL IQAI

UniProtKB: Small nuclear ribonucleoprotein E

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分子 #13: Small nuclear ribonucleoprotein F

分子名称: Small nuclear ribonucleoprotein F / タイプ: protein_or_peptide / ID: 13 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 8.667062 KDa
配列文字列:
MSFVPVNPKP FLQGLIGKPV LVRLKWGQEY KGTLQSVDSY MNLQLLNAEE LVDGVKTGDL GEILIRCNNV LWVGESTV

UniProtKB: Small nuclear ribonucleoprotein F

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分子 #14: Small nuclear ribonucleoprotein G

分子名称: Small nuclear ribonucleoprotein G / タイプ: protein_or_peptide / ID: 14 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 8.616038 KDa
配列文字列:
MSKAGAPDLK KYLDRQVFVQ LNGSRKVYGV LRGYDIFLNI VLEDSIEEKV DGEKVKIGSV AIRGNSVIMI ETLDKMT

UniProtKB: Small nuclear ribonucleoprotein G

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分子 #15: Pre-mRNA-splicing factor prp5

分子名称: Pre-mRNA-splicing factor prp5 / タイプ: protein_or_peptide / ID: 15 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 52.492133 KDa
配列文字列: MTEAKNISDD TDVLSLTTNS LRTSKTLFGA EFGSVTSFDD TVAQNLKRTY KEHLEYGSVL GGTVGKRKNR HYEEDTIGSN ALTVRADSE NPSSQVITKF SDPNKKIAGQ VSMQSLEKIK GVPEAAHRIA GESQASLVKR TLAEQIRPEW HAPWTLMRVI S GHLGWVRC ...文字列:
MTEAKNISDD TDVLSLTTNS LRTSKTLFGA EFGSVTSFDD TVAQNLKRTY KEHLEYGSVL GGTVGKRKNR HYEEDTIGSN ALTVRADSE NPSSQVITKF SDPNKKIAGQ VSMQSLEKIK GVPEAAHRIA GESQASLVKR TLAEQIRPEW HAPWTLMRVI S GHLGWVRC VDVEPGNQWF CTGAGDRTIK IWDLASGVLK LTLTGHIATV RGLAVSPRHP YLFSCGEDKM VKCWDLETNK VI RHYHGHL SGVYALKLHP TLDVLVTAGR DAVARVWDMR TRQNVHVLSG HKSTVASLAV QEFDPQVVTG SMDSTIRLWD LAA GKTLTT LTHHKKTVRA LSLHPDEFTF ASGSSDNIKH WKFPEGAFMG NFEGHNAIVN TLSINSDNVM FSGADNGSMC FWDW KSGHK YQELQSVVQP GSLDSEAGIF ASSFDKTGLR LITCEADKSV KIYKQVDNAT PETHPNLPWT PSNLRRRY

UniProtKB: Pre-mRNA-splicing factor prp5

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分子 #16: Pre-mRNA-processing protein 45

分子名称: Pre-mRNA-processing protein 45 / タイプ: protein_or_peptide / ID: 16 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 62.798176 KDa
配列文字列: MALLSEELSS ILPNPDFDDE EEDYVERETS HADERQIGVK FHIPPYGQRK GWFPSSPEDF GDGGAFPEIH VAQYPLDMGR KRSAKSAGN TLALQVTSSG AVDYNAIARQ GHEHGELVQA SFRDLIPLRA RLGVGEISLE KPSDEQKQEV ANKTKLALQK I LSKQIAQS ...文字列:
MALLSEELSS ILPNPDFDDE EEDYVERETS HADERQIGVK FHIPPYGQRK GWFPSSPEDF GDGGAFPEIH VAQYPLDMGR KRSAKSAGN TLALQVTSSG AVDYNAIARQ GHEHGELVQA SFRDLIPLRA RLGVGEISLE KPSDEQKQEV ANKTKLALQK I LSKQIAQS QPKSAVVQQR DDPVYIRYTP SNQMGQALSK QRIIKMVTAE QDPMEPPKFR HKKVPRGPPS PPPPVLHSPP RK VSAQEQQ DWQIPPSISN WKNPKGYTIP LDKRLAADGR GLNDVEINDG FAKFSEALYT VERQAREEVR YRAIMRQKMA EKE KQEKEQ RLFMLAQKAR EDRMGRNAAS SGPSHAKPRS TSVSSEERSR SRAGSFSHHS ESENEDEDSE AFRRRQELRR ERRR QAEKD LRLSRMGAEK RAKLAEKDRP RDVAERVALG LSKPSMSSDT MIDSRLFNQA SGLGSGFQDE DSYNVYDKPW RAAPS STLY RPGATLSRQV DASAELERIT SESRYDVLGN AHKKFKGSDE VVESRAGPVT FEKDIADPFG VDTFLNNVSS KKT

UniProtKB: Pre-mRNA-processing protein 45

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分子 #17: Pre-mRNA-splicing factor cwf5

分子名称: Pre-mRNA-splicing factor cwf5 / タイプ: protein_or_peptide / ID: 17 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 39.640363 KDa
配列文字列: MSHGPKGDIN KQEWEDVEFP SICERCLGDN SYVRMTKEPL GQECKICSKP CTIFRWIKER GQKPGKTQIC VGCARYKNCC QSCMLDLQF GLPIALRDAA LKLVESGPTN DINREFFAQN QQRLLSNGET AYDSQEASAA ARNLVKKVEK RELHSRPPKR K LDDVESKQ ...文字列:
MSHGPKGDIN KQEWEDVEFP SICERCLGDN SYVRMTKEPL GQECKICSKP CTIFRWIKER GQKPGKTQIC VGCARYKNCC QSCMLDLQF GLPIALRDAA LKLVESGPTN DINREFFAQN QQRLLSNGET AYDSQEASAA ARNLVKKVEK RELHSRPPKR K LDDVESKQ ILKEARASDA SLNAERPLFP VKKIINGNVS LSINMEPPKD KKIASLFLIG VEDELADYKI RKHFEQYGPL KS VVCSHRA KCAFVNFKTR SSAEIAAAAS PDGNVVIEGF RLKVQWGKPR SLGGPEGEVR NAKLADLVMR GSSHGNKTSQ KST IKNIEN EDHENTKSPA VAIPIDPNQP RYRSQIPR

UniProtKB: Pre-mRNA-splicing factor cwf5

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分子 #18: Pre-mRNA-splicing factor cwf11

分子名称: Pre-mRNA-splicing factor cwf11 / タイプ: protein_or_peptide / ID: 18 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 148.532906 KDa
配列文字列: MVLYKNKKKQ IINYANSNWG QNEGVEFQET MLQCILEAVI VSKDAKQVLS LLHELKLFEN FLWQRVNTEM SLNHINLTCM LLLYKSKYE YITWDLIDEN RFQLFFEKVI EVSLSLNLSE VVYMIQFITL CFQFSNIEKL RKLVYQLTNI SILNSLDNLD K VKYLLHDS ...文字列:
MVLYKNKKKQ IINYANSNWG QNEGVEFQET MLQCILEAVI VSKDAKQVLS LLHELKLFEN FLWQRVNTEM SLNHINLTCM LLLYKSKYE YITWDLIDEN RFQLFFEKVI EVSLSLNLSE VVYMIQFITL CFQFSNIEKL RKLVYQLTNI SILNSLDNLD K VKYLLHDS SSLTKAFDSY KEKRPSIVEK FPLHNLLSRW IHSLLIKSIS YAQTEKQEAK VTPLLAIINM SLVLLSAFPT RR FAHPVIE DSCFYTALRM SLYYDSNELF KKMTDDLNYV LKFPFDNTRG NEYEKEQKIR NDELVYYHLQ LTLFSDFQKE LGD LVFCTQ TSLQQRQKLE EITSFLSFNS LKSLCSKCYL RTSFPEKYAI KVDFEFLKNV FINTYDRTRL VNDYDEIINF TLKD VLGER SVMDQENSLT NYFLLQNTAI QYLSISFFMR QQSKAYKKLL LRSLYAELLN FSEQYRRLSI KNATKNLTKD NFFSL NNFK VTSVAPPQIG QVLPQFVKCQ MGLSRPGPFH SALRDLKNSI KSPFLCLIYI SKDMEYKLLH GNALDPLEGV TDFTIA TIC NDDVGMFQSD MQSDSDNKSI NVYLSPFYYH SLAGLGEYRP KQLKFNFALV LSPEANKYWL DLNILVSLLN RAKEFPK WF EDLFLGFGTP DICAFPNAGL NSIYARNLFN TVEQLQSVLP NCHVPSNLST ESLLIKFYTN QNKISADVTA SDRHFLLP S NRLYTYNDKQ LESILRGSQP GLTMVNGPTR CGKHVLVCKL LEVLQDTSPN DRTVVLSDSN FSMNTLFTLL EKARCFHQG HLLYLSDEGK DETLERYGTL SSWISKLPGL LREIGRLAAS IQAPGSHDAS PDTALYFRDA YIKRLWEKYL NTVDDKDSVD AYNRFPFHS YFGDKSKRPI ETYNKDNFFD YATKLYGELE YMFQQLEEIR PFGLLRYYED QELYALCQQS RIIGCTWTSL S TRLGTLKE KGFCFNNLIV MNSQNISESS ITSILLSNCE PTGFDRLVLL GNQYLTSGNQ DINNTSNGSL FKRLRYLKSR II DLNTQYN VRESISSLCS SIYPLDIKTV DSSPNKRLDY GNSGFAHEVQ FINVGAFKGS QETEPVSGYK QNLGEAEYAV ALF QYMRML GYPTNEIVIC TLYESQVSLL NEIISVRCSH NSFFGQPAFV GTVEKLPSDK RVNFVIFTTV ESKEASDHWN PKTF YKAFS ACSYGLYVLC NRDLFRSTRG LEKLWNEIEK TPDKLLLTTG EIYPSSHKIG SSVETFEIEN LLHLSNYVVE MTKKR LNTN

UniProtKB: Pre-mRNA-splicing factor cwf11

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分子 #19: Pre-mRNA-splicing factor cwf14

分子名称: Pre-mRNA-splicing factor cwf14 / タイプ: protein_or_peptide / ID: 19 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 17.12285 KDa
配列文字列:
MPRLRTSRTK RPPDGFDEIE PTLIEFQDRM RQIENTMGKG TKTEMLAPIF QLHHQRSRYI YDLYYKREAI STELYNWLLK QNYADGNLI AKWKKPGYEK LCCLRCIQTA ESKFGSTCIC RVPKSKLDKD QRVRCTHCGC NGCASCD

UniProtKB: Pre-mRNA-splicing factor cwf14

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分子 #20: Pre-mRNA-splicing factor cwf2

分子名称: Pre-mRNA-splicing factor cwf2 / タイプ: protein_or_peptide / ID: 20 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 44.343074 KDa
配列文字列: MSENGLEQEV TVEEKNNDVT EKILVEGEKS KEYEETPRKV KIVKRKKQPA RKQIETRPEY EMEPEQPGQV YNLWYNKWSG GMRQDPLKS QVKSETRCVI SRDSGYTKAD KNPGSFFCLY FARGMCSEGS KCEYLHRLPK DTDFFNANVD CFGREKHADY R DDMGGVGS ...文字列:
MSENGLEQEV TVEEKNNDVT EKILVEGEKS KEYEETPRKV KIVKRKKQPA RKQIETRPEY EMEPEQPGQV YNLWYNKWSG GMRQDPLKS QVKSETRCVI SRDSGYTKAD KNPGSFFCLY FARGMCSEGS KCEYLHRLPK DTDFFNANVD CFGREKHADY R DDMGGVGS FLRQNYTLYV GGITPTDDIE EIVSRHFAEW GDIERIRVLN SRGIAFITYL NEANAQFAKE AMAHQSLDHD EC LNVRWAT TDPNPASQAR NQRRLEERAA NAVKKLLPKQ FLLDLEETKN GKSGNRKRKL ELEFGLKGYV PSDDLLYADG ANS VHNQLA ANEFPNKSQS EEGSNDDHKS VTTTESQNKF VNSQILSDLQ VAKQAVHTNQ SALVSYYDSD ED

UniProtKB: Pre-mRNA-splicing factor cwf2

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分子 #21: Pre-mRNA-splicing factor cwf15

分子名称: Pre-mRNA-splicing factor cwf15 / タイプ: protein_or_peptide / ID: 21 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 30.478979 KDa
配列文字列: MTTAHRPQFD PARGHSEMAP TRITSSRALP AHLKLKYRQE SQGTEEEVRK QDLREALLRA EAAHFATQEH GASSEEVSQN SKLIEGFTS PSTDDKPNND VEVDYQELLR QTLEADEDAS DSDDSVDSSN KNSEVSIKRR KTESNSQESV DSSNSESSDE E SDSEDETQ ...文字列:
MTTAHRPQFD PARGHSEMAP TRITSSRALP AHLKLKYRQE SQGTEEEVRK QDLREALLRA EAAHFATQEH GASSEEVSQN SKLIEGFTS PSTDDKPNND VEVDYQELLR QTLEADEDAS DSDDSVDSSN KNSEVSIKRR KTESNSQESV DSSNSESSDE E SDSEDETQ QLLRELENIK QERKREQMLQ EEKNRALEQE KREREIAFGN ELLNKASSGS FQVKRRWDED VVFRNTHKGV DD TPRPGFV NDMLRSEFHK KFLARFVD

UniProtKB: Pre-mRNA-splicing factor cwf15

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分子 #22: Pre-mRNA-splicing factor cwf4

分子名称: Pre-mRNA-splicing factor cwf4 / タイプ: protein_or_peptide / ID: 22 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 80.964758 KDa
配列文字列: MTSEAPRVKN KNPAPIQISA EQLLREAVER QDVAFVPPKI NITDLEELQE FQGRKRKEFE DAIRRNRLAM GHWMRYGQWE LDQKEFARA RSVFERALDV DSTYIPLWLK YIECEMKNRN INHARNLFDR AVTQLPRVDK LWYKYVYMEE MLGNITGCRQ V FERWLKWE ...文字列:
MTSEAPRVKN KNPAPIQISA EQLLREAVER QDVAFVPPKI NITDLEELQE FQGRKRKEFE DAIRRNRLAM GHWMRYGQWE LDQKEFARA RSVFERALDV DSTYIPLWLK YIECEMKNRN INHARNLFDR AVTQLPRVDK LWYKYVYMEE MLGNITGCRQ V FERWLKWE PDENCWMSYI RMERRYHENE RARGIYERFV VVHPEVTNWL RWARFEEECG NAANVRQVYL AAIDALGQEF LN ERFFIAF AKFEIRQKEY ERARTIFKYA IDFMPRSKSM ELYKEYTHFE KQFGDHLGVE STVLDKRRLQ YEKLLKDSPY DYD TWLDLL KLEESAGDIN TIRETYEKAI AKVPEVVEKN AWRRYVYIWL NYCLFEEIDV KDVDRARKVY QEALKLIPHK KFTF AKLWL MYAMFELRQR KIDVARKTLG RALGMCPKPK LFRGYIEFED AIKQFDRCRI LYEKWILYDP EACAPWLGYA ALETK LGDS DRARALYNLA VNQPILETPE LVWKAYIDFE FEEMEYGKAR SIYQQLLRTA PHVKVWISFA NFEIAHLEDD DEEPPN EEV ASPTAVVRAR NVFENALAHL RQQGLKEERV VLLEAWKQFE AMHGTEDTRK HVSSLMPQVV KKRRRLEDGS FEEYLDY LF PDTATDQGDK MRKMLELSRK WKEEMAKKKL EA

UniProtKB: Pre-mRNA-splicing factor cwf4

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分子 #23: Pre-mRNA-processing factor 19

分子名称: Pre-mRNA-processing factor 19 / タイプ: protein_or_peptide / ID: 23 / コピー数: 4 / 光学異性体: LEVO / EC番号: RING-type E3 ubiquitin transferase
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 54.243988 KDa
配列文字列: MFCSISGETP KEPVISRVSG NVYEKRLIEQ VIRETSKDPV TQQECTLEDL VPVKVPDFVR PRPPSATSLP ALLSLFQEEW DSVALEQFE LRRNLTETKQ ELSTALYSLD AALRVISRLT KERDEAREAL AKFSDNIGTV SSKTIEVQEV EMGESDDQLK T SLRSTVEK ...文字列:
MFCSISGETP KEPVISRVSG NVYEKRLIEQ VIRETSKDPV TQQECTLEDL VPVKVPDFVR PRPPSATSLP ALLSLFQEEW DSVALEQFE LRRNLTETKQ ELSTALYSLD AALRVISRLT KERDEAREAL AKFSDNIGTV SSKTIEVQEV EMGESDDQLK T SLRSTVEK TFQELSSKRK RTKLQPKWAT DDAVSQLLQA TPSTILENLE TESTTSFFPS PENSSFVLCL HKDELLCLDI QS NSTLKIF EGSALACCWL TSSKIAVATA DAISIFEFPV SSSGLQSVGE PTSSIPIDEK VNFLQAHPSG EYLLAASNEK CYI FSLKSQ VYNITVAQHI TSLAVHPDGN LFVAGLENGE LRFFETSSGN ELTKFGPHSS PVKTLQFGEN GYWLVVTTND DSDI FIWDL RKSELVQKIP LQTKVAAVSL DITSQLLVSS DGETLYVHIY VKSSKSWRCM SQTHVSSISN LVWLNELHQL LFSTS NGAI LRLG

UniProtKB: Pre-mRNA-processing factor 19

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分子 #24: Pre-mRNA-splicing factor cdc5

分子名称: Pre-mRNA-splicing factor cdc5 / タイプ: protein_or_peptide / ID: 24 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 86.981344 KDa
配列文字列: MVVLKGGAWK NTEDEILKAA VSKYGKNQWA RISSLLVRKT PKQCKARWYE WIDPSIKKTE WSREEDEKLL HLAKLLPTQW RTIAPIVGR TATQCLERYQ KLLDDLEAKE NEQLGLISGE GAEAAAPVND PNSRLRFGEA EPNLETLPAL PDAIDMDEDE K EMLSEARA ...文字列:
MVVLKGGAWK NTEDEILKAA VSKYGKNQWA RISSLLVRKT PKQCKARWYE WIDPSIKKTE WSREEDEKLL HLAKLLPTQW RTIAPIVGR TATQCLERYQ KLLDDLEAKE NEQLGLISGE GAEAAAPVND PNSRLRFGEA EPNLETLPAL PDAIDMDEDE K EMLSEARA RLANTQGKKA KRKDREKQLE LTRRLSHLQK RRELKAAGIN IKLFRRKKNE MDYNASIPFE KKPAIGFYDT SE EDRQNFR EKREADQKII ENGIRNNEME SEGRKFGHFE KPKPIDRVKK PNKDAQEEKM RRLAEAEQMS KRRKLNLPSP TVS QDELDK VVKLGFAGDR ARAMTDTTPD ANYSTNLLGK YTQIERATPL RTPISGELEG REDSVTIEVR NQLMRNREQS SLLG QESIP LQPGGTGYTG VTPSHAANGS ALAAPQATPF RTPRDTFSIN AAAERAGRLA SERENKIRLK ALRELLAKLP KPKND YELM EPRFADETDV EATVGVLEED ATDRERRIQE RIAEKERLAK ARRSQVIQRD LIRPSVTQPE KWKRSLENED PTANVL LKE MIALISSDAI NYPFGNSKVK GTANKVPDLS NEEIERCRLL LKKEIGQLES DDYIQFEKEF LETYSALHNT SSLLPGL VI YEEDDEDVEA AEKFYTNDIQ RDLAKKALEC NKLENRVYDL VRSSYEQRNF LIKKISHAWK ALQTERKNLT CYEFLYNQ E RLALPNRLEA AEIELSKMQQ IEAYAQQDYA RVTGQN

UniProtKB: Pre-mRNA-splicing factor cdc5

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分子 #25: Pre-mRNA-splicing factor cwf3

分子名称: Pre-mRNA-splicing factor cwf3 / タイプ: protein_or_peptide / ID: 25 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 92.759914 KDa
配列文字列: MGDVIPLKVN FDLINVDDEP FELELLRDPY SLKSWLRYIK THEGSTLEKR VLLFERACSE LPGSYKIWKS YLELRVAHVE HLNPYFHAE AFASVNDCFE RSLILLHKMP VIWKLYLQFL MKQPNVTKIR CTFNSALRAL PVTQHDDIWD MFTKYAEDIG G LFCIHVYR ...文字列:
MGDVIPLKVN FDLINVDDEP FELELLRDPY SLKSWLRYIK THEGSTLEKR VLLFERACSE LPGSYKIWKS YLELRVAHVE HLNPYFHAE AFASVNDCFE RSLILLHKMP VIWKLYLQFL MKQPNVTKIR CTFNSALRAL PVTQHDDIWD MFTKYAEDIG G LFCIHVYR RYIQVEPRAI ENYIEILCKL GLWNEAARQY EDILNRPVFL SAKRKSNYQI WLEFSELVVQ HPDHTQNIDV EK VFRAGIK RFSDQAGKLW TYLAQYYIRI GDYEKARSTF YEGMNNIMTV RNFTIIFDAF VEFEEQWLSA RVEASSGNAN DEL SIDFHM AWLEKILDKR PLYINDVLLR QNINNVDEWL RRVKFLEDDS EKVVQVYTDA IKNVNPKLAH GSLGKLFSEF ARFY ENFDD LEQSRIIFEK ATHVPYKTVN ELAQVWIDWA EMELRHQNFD AARKLIGDAV HAPRKSHISF FDESLSPQVR LHKSS KIWM YYLDLEESVG TIETTRKLYD RVFELKIATP QVVVNYANLL EENAYFEDSF KIYERGVALF SYPVAFELWN LYLTKF VKR YQGTHMERTR DLFEQALEGC PPEFSKSIYL LYADFEEKFG KAKRSISILE KAADKVKTAD RLAIYNVLLV KVALNYG VL ATRTVYEKAI ESLSDSEVKD MCLRFAEMET KLGEIDRARL IYIHGSQYCD PRVETDYWKA WQEFEIRYGN PEETVKEM L RIKRSVQTKF STDSLHIAKR AAKIESAAAP MDPMEQLEME KSEGPKALAG FVLSKSNPQE TSKITGEEN

UniProtKB: Pre-mRNA-splicing factor cwf3

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分子 #26: Pre-mRNA-splicing factor syf2

分子名称: Pre-mRNA-splicing factor syf2 / タイプ: protein_or_peptide / ID: 26 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 28.037457 KDa
配列文字列: MDSPSHSREA RVEKLKKIRE QMRKSSHENR KEVVQEHSRM RIDPALERRL ERKRMEAEEE LAKIETEEEG GDFERRRAWD WTIEESEKW DQRLRKKKQT IQNVAFSDYH SQASKDYNRG IRDLKPDYEK YDKDKKEEKS KSRSVALYDE AERLDWVSNK P DKEHVERL ...文字列:
MDSPSHSREA RVEKLKKIRE QMRKSSHENR KEVVQEHSRM RIDPALERRL ERKRMEAEEE LAKIETEEEG GDFERRRAWD WTIEESEKW DQRLRKKKQT IQNVAFSDYH SQASKDYNRG IRDLKPDYEK YDKDKKEEKS KSRSVALYDE AERLDWVSNK P DKEHVERL VESIKKQDQR RLKNTKRRGT DEEDHITFIN ERNRKFNLKL QRFYSKYTKD IKEDLERGTA L

UniProtKB: Pre-mRNA-splicing factor syf2

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分子 #27: Pre-mRNA-splicing factor cwf7

分子名称: Pre-mRNA-splicing factor cwf7 / タイプ: protein_or_peptide / ID: 27 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 21.348246 KDa
配列文字列:
MSYNISLDSL PYFESTYNEE DRSAAAQIVE EELKRSGGLL IKQEEQKKKF QSHRLSDRLE NAIVAAGKGE KLAAIDVQRY IQLKPPGTR ESLLQSAVVW EYQKSRNDNL YLLEKHGEKA FDSSLEALEV QLELLEKELV NTKKLSQGCN RKRKHYQMEV G ARLAEAEV KFGQLLQSSI QCRVATLLS

UniProtKB: Pre-mRNA-splicing factor cwf7

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分子 #28: Pre-mRNA-processing factor 17

分子名称: Pre-mRNA-processing factor 17 / タイプ: protein_or_peptide / ID: 28 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 63.211309 KDa
配列文字列: MLVANYSSDS EEQENSQSPN IQPLLHTENL APAVVDNVKD DLIVSKGGNS RELARNVPVN EMVQPALGPA NPFVTKEQDS IKNSITGYA EREYVPNFVF NQEYYANTHA IYGKRNFDDN EATTSTDLKR KSQKIKERRE DPGDPSILEG DGAYKGPWAG Y GSEQSSSP ...文字列:
MLVANYSSDS EEQENSQSPN IQPLLHTENL APAVVDNVKD DLIVSKGGNS RELARNVPVN EMVQPALGPA NPFVTKEQDS IKNSITGYA EREYVPNFVF NQEYYANTHA IYGKRNFDDN EATTSTDLKR KSQKIKERRE DPGDPSILEG DGAYKGPWAG Y GSEQSSSP LEYSEYEEVE SLDVKSEKDT ESNNLGQNEL LKEQLATPEV ETHRSKEETI LHKDRLFDYQ NRSYMHVPND VG INLSEEP GEQTCYIPKK HIFTWKGHTK GISCLRFFPI SGHLLLSGSM DNQIKIWEVY HDRSLLRTFQ GHARPIRDLS FSQ DGRSFL STSFDKTIKL WDTELGKCLN CFNSDRLTNC VKFQVDPDKP NEFLAGTADK RILQFDIRSP DIVQAYDHHL GGIN SITFL ENGKRFVTTS DDSSMRFWEY GTPVPIKFVA DIAMHSMPRV ALRPNGKSIA CQSLDNCIYV YSAYEKYRQN KKKVF KGYS CSGYSLEVGF SPDGRFVFSG DSSGNACFWD WKTCKLMAKL PAHSGPVQSM AFHPQETSKV ATSSIVDGSI KYWD

UniProtKB: Pre-mRNA-processing factor 17

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分子 #29: Pre-mRNA-splicing factor cwf21

分子名称: Pre-mRNA-splicing factor cwf21 / タイプ: protein_or_peptide / ID: 29 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 34.617762 KDa
配列文字列: MSYNGIGLPT PRGSGTNGYV MRNLSHVKKY DKNTNLQSNR NAKALEKRVQ DPSISEHECR RQIESKLLLY REQLLEEVSS QHSTDAAAS DSNTNFGTEN PKPPKAIIKD EQSQSKTKSL DEADVEILVQ KYREQLLKEL QLQKSTEKGK NFESILQPQK R KETRGFHS ...文字列:
MSYNGIGLPT PRGSGTNGYV MRNLSHVKKY DKNTNLQSNR NAKALEKRVQ DPSISEHECR RQIESKLLLY REQLLEEVSS QHSTDAAAS DSNTNFGTEN PKPPKAIIKD EQSQSKTKSL DEADVEILVQ KYREQLLKEL QLQKSTEKGK NFESILQPQK R KETRGFHS KNDDDGRLEE RDDLRSSVDD DYYDYPRYSE RKSLNSKRHV DNYNENRRRH YDSYSSYDEL ERRRSSNESY SR RSELPRR DYNRHDERER YSYHRRRERS NSPSYTKNES IPVVDRDSSP EGGEIV

UniProtKB: Pre-mRNA-splicing factor cwf21

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分子 #30: Pre-mRNA-splicing factor cwf22

分子名称: Pre-mRNA-splicing factor cwf22 / タイプ: protein_or_peptide / ID: 30 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 102.928359 KDa
配列文字列: MEKEDKSFGI GMLDYNRENP ESSGHSRVAV IRKQKTEQEN NNLSWEDRHY IPDLHKSNKI KTPTSLADEK KSHNELDPKA QIKKLMETR SGGTYIPPAK LKALQAQLTD VNTPEYQRMQ WEALKKSING LINKVNKSNI RDIIPELFQE NIIRGRALYC R SIMKAQAA ...文字列:
MEKEDKSFGI GMLDYNRENP ESSGHSRVAV IRKQKTEQEN NNLSWEDRHY IPDLHKSNKI KTPTSLADEK KSHNELDPKA QIKKLMETR SGGTYIPPAK LKALQAQLTD VNTPEYQRMQ WEALKKSING LINKVNKSNI RDIIPELFQE NIIRGRALYC R SIMKAQAA SLPFTPIYAA MTAVINTKFP QIGELLLTRL IVQFRKSFQR NDKSMCISSS SFIAHLINQK IAHEIVGLQI LA VLLERPT NDSIEIAVML LREIGAYLAE VSTRAYNGVF ERFRTILHEG QLERRTQFII EVLFQTRKDK FKNNPTIPQE LDL VEEEDQ ITHYISLDDN LDVQESLGIF HYDPDYEENE KKYDAIKHEI LGEEDDDENE EDEEDSEETS ESEEDESVND EKPQ VIDQT NASLVNLRKS IYLTIMSSVD FEECCHKLLK IDLPEGQEIE LCNMVIECNS QERTYAKFYG LIGERFCKLS RTWRS TYEQ CFKNYYETIH RYETNRLRNI ALFFANLLST DSIGWEVYDC VRLTEDDTTA SSRIFLKIMF QEIVEALGLK SLVERL HDP NLVPYLHGLF PVDEARNVRF SINYFTSIGL GALTEEMREY LLTMPKSEPK EQDSEGYSSG SETGSTYSSS YSSTYSR GR SYSRSTRSYS KSRSYSRSRS VTPINNINHK KYIRKDRELS PRGRERSSNR NSYSDLSRSS SLSRGRSRSY TPEGRLIE S EDKGYRSRSS SPASRKYRSR QRYRRSYAGS TSRGRSFSRS PSYRRRLSMS CSVSYSRSPS PAARPISRSP ARNKRSYDS LSYNRQYSPK VSRKRSNESR SPSPYTLRKQ KTYHLNKRNE DFVVKMDKKG SESPVILAPW LREVDDGELY KDRNSESDSV RKQPRAD

UniProtKB: Pre-mRNA-splicing factor cwf22

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分子 #31: Peptidyl-prolyl cis-trans isomerase ppi1

分子名称: Peptidyl-prolyl cis-trans isomerase ppi1 / タイプ: protein_or_peptide / ID: 31 / コピー数: 1 / 光学異性体: LEVO / EC番号: peptidylprolyl isomerase
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 16.884201 KDa
配列文字列:
MANVELQTSL GKILIELYTE HAPKTCQNFY TLAKEGYYDG VIFHRVIPDF VIQGGDPTGT GRGGTSIYGD KFDDEIHSDL HHTGAGILS MANAGPNTNS SQFFITLAPT PWLDGKHTIF GRVVSGLSVC KRMGLIRTDS SDRPIEPLKI IKAVAL

UniProtKB: Peptidyl-prolyl cis-trans isomerase ppi1

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分子 #32: G-patch domain-containing protein C1486.03

分子名称: G-patch domain-containing protein C1486.03 / タイプ: protein_or_peptide / ID: 32 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 91.79118 KDa
配列文字列: MQNEYVDMNS SSEDSDGDSI LEEGRLRPSF RGQQKERDML GIFGEEDEDG FHNSGIGSAR LRRKNISFVE KSEQVKANKQ VTADDLLEA HSIPQLKNKN DEVSQAKNIP KMKFNTTGFG AKMLEKMGYK QGQGLGANAE GIAEPVQSKL RPERVGLGAV R ERTEKQRK ...文字列:
MQNEYVDMNS SSEDSDGDSI LEEGRLRPSF RGQQKERDML GIFGEEDEDG FHNSGIGSAR LRRKNISFVE KSEQVKANKQ VTADDLLEA HSIPQLKNKN DEVSQAKNIP KMKFNTTGFG AKMLEKMGYK QGQGLGANAE GIAEPVQSKL RPERVGLGAV R ERTEKQRK EAIARGEISD SEDEKHTVKQ KPLREKKKKP LKSSEEISKD MGSYNLPRFL ASLIDASLND TKEIEFVTSN KE ELGLEGR DMSTSGINQL SRLARVECEH HASAWQQLQA RRAYVKMELK RVTTEFDEKS VEISRLEKLL GKVMEVKSRS MEF TVPEAE IDVIEKRLQP LNNLIETLPV EFSEASMHFE LDSVAVSILA FVLSEPIKNW DVWKHPYFML ESFLSWKNSL YSKD FRPKR EESSTFMDID VEFDDELEGQ SLTHYESFMM FVWKKKIGEE LKKWIIQDSL KALQLLEAWD PVVPEKVKDS LIQDD ILPR LKDAVSKWNP KLKLKKNDSL HHCIFPWLPY LEKHADSLLQ SVLVQFSLIL SPWKIKNGSI DDFSVWRSAF ANDALD RLL EKVILPKLEK LMDEELVIDP SNQDLEIFFI ILSWKGSFKA MVFGQLFADH FFPKWLETLY QWLTEAPNFD EASEWYT WW KSVFPKDLLS NAYIQQGFSK GLDMMNECLE NKSITAPLPF AKDSTKGVNL QFSKEKHEFT AESDDTTSYD EPLVSFRE L VEEFCAENSL LFVPLRRSHL STGSALFRIS TQASKARGIT VYLRNDIIWK KSPGASEDTP YDPIGFNEIL LMFNNN

UniProtKB: G-patch domain-containing protein C1486.03

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分子 #33: Uncharacterized protein C17A2.08c

分子名称: Uncharacterized protein C17A2.08c / タイプ: protein_or_peptide / ID: 33 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 41.93757 KDa
配列文字列: MRRYLKKAKP KIVQTSDNEE EKHEENLNVS QSNKNANRRK TKAKEKNSGK FRVKYENEEG DDDGEDSQIP LIPKVKKQSS FHSVDDLIS RRMDALSHES GYSNAYVDEL KRKSRQTPSE FTKKEEDSST KESELQTRSS PPLPVNTSLE WNMLNQGIPE E AMIKELKD ...文字列:
MRRYLKKAKP KIVQTSDNEE EKHEENLNVS QSNKNANRRK TKAKEKNSGK FRVKYENEEG DDDGEDSQIP LIPKVKKQSS FHSVDDLIS RRMDALSHES GYSNAYVDEL KRKSRQTPSE FTKKEEDSST KESELQTRSS PPLPVNTSLE WNMLNQGIPE E AMIKELKD REGRKRNIAM MTDNYISLET GDQLMLAQNH KEEKLLQTED EIQDEGYSGF ENYVEESEKL QEIYHHSSES LR TRSIQMA VDQKNMEMEL DDEDIAEPIQ SWEHTQIKKG AFGESPAFTN GLSVKLPNIL TMDEQIQRLK EAIASEKLQQ EER SQIIKS LMEEELEINE QEEKIKHSFI DLDKTLLNNL TKSKS

UniProtKB: Uncharacterized protein C17A2.08c

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分子 #34: Uncharacterized protein C20H4.06c

分子名称: Uncharacterized protein C20H4.06c / タイプ: protein_or_peptide / ID: 34 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 60.85007 KDa
配列文字列: MYANSRKRSN VDVHRHPYVV YGSPFDLEPS RINQGVPVWK QEARDERNRK RFHGAFTGGF SAGYFNTVGS KEGWQPKSWK SSRNENKSV HGMTIDDIMD EEDRADQELS KVYTSKINTI DTSIPIDDPL LREFSNRDDS IGEKMLKNLG WNGHDFVISP F QGYYDDTK ...文字列:
MYANSRKRSN VDVHRHPYVV YGSPFDLEPS RINQGVPVWK QEARDERNRK RFHGAFTGGF SAGYFNTVGS KEGWQPKSWK SSRNENKSV HGMTIDDIMD EEDRADQELS KVYTSKINTI DTSIPIDDPL LREFSNRDDS IGEKMLKNLG WNGHDFVISP F QGYYDDTK LTNQAYHGIG YQADDVFQLE RKPVGMAKNL RGGFGSGVLN DDGIEDQDIY DLGAPKMRYD KSINITKKVA SP FTPVKHT FLSKKDRSKG KSIIKSQNCS DGLPPLPGFV VVFNLQSPFQ NNWFPPPTIP EGWEPKLFTN SQGFSQKKAQ TSN ERLPLF AEKSETNSNG EASLPSDVNH GVKEDEGSWQ LIDIETAKNA MSRKDNPYND ERAGIYEIFL KAHLMNMPRL LRDI DSRHL LEFTQTASLY RPMSKNLSMR FVSSFEASTK KESINSHSET DDSILRRPRT VVTFIPERLL CKRFNVALPY GQEKQ KRKN ISSIENVPII AEIENKSIDS IDTRKLNRPQ DIEEKPKAPQ TLFSAIFGDD

UniProtKB: Uncharacterized protein C20H4.06c

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分子 #35: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase C20H4.09

分子名称: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase C20H4.09
タイプ: protein_or_peptide / ID: 35 / コピー数: 1 / 光学異性体: LEVO / EC番号: RNA helicase
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 73.113695 KDa
配列文字列: MPNEFISQSL STLTNTPLNI QKKLLPITKY RNQLLYAVEQ NQITIVLGHT GCGKTTQIPQ FLYEAGWASQ NGIIGCTQPR RLVAKSVSE RVSLELNSPP GSLCGYSIQF DHNVSEKTKI KYMTDGILLN EIFFDPLLER YSIVILDEVH ERTLSTDLLL G VLKRILEK ...文字列:
MPNEFISQSL STLTNTPLNI QKKLLPITKY RNQLLYAVEQ NQITIVLGHT GCGKTTQIPQ FLYEAGWASQ NGIIGCTQPR RLVAKSVSE RVSLELNSPP GSLCGYSIQF DHNVSEKTKI KYMTDGILLN EIFFDPLLER YSIVILDEVH ERTLSTDLLL G VLKRILEK RNDFRLVLSS ASVDANKLSQ FFGQDKVCTM SIEGKLFPVE TLFLQKPTEN YVDSAIETVI NINSTYPPGD IL VFLSGRK EIEYCIKKIE DSLIHASEDC QTLVPLPLHA GLTVDEQMRV FNIYDGDFRK VIFSTNIAET SITIDGIVYV VDS GFNKQR IYNPYTRTSK LINVPISKSS AIQRSGRAGR TMRGKVFRLY TEKAYSLMKE EFEADILNCD MSPLVLFLKG LGLK NILQF PFFVRPPTVH LMAALEDLYL LGVLDESGNL TDPLGIQISN SFLDANISKA LLTSNQFGCT HEILSIASIL TAGEV FYNP TSSSKNDAFV AHSSFFANEG DIITALNVFE SFVGNKKDLQ WCRKNYLNYQ TLRQALDIRT HLVRFLNKFS IPTAQR LPS SDCSKILKCL LDGFVRNVAH LQNDGSYKTI GGKQVWLDSS SVLHEKKTPW IMYSSAVESE TQIFVKNISK IESFWLD KY YKREK

UniProtKB: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase C20H4.09

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分子 #36: UNK1

分子名称: UNK1 / タイプ: protein_or_peptide / ID: 36 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 29.464186 KDa
配列文字列: (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) ...文字列:
(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)

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分子 #37: UNK2

分子名称: UNK2 / タイプ: protein_or_peptide / ID: 37 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 4.933035 KDa
配列文字列: (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)AWF(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK) ...文字列:
(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)AWF(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)

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分子 #40: UNK3

分子名称: UNK3 / タイプ: protein_or_peptide / ID: 40 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 1.890321 KDa
配列文字列:
(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)

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分子 #3: U2snRNA

分子名称: U2snRNA / タイプ: rna / ID: 3 / コピー数: 1
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 59.207473 KDa
配列文字列:
AUUCUCUCUU UGCCUUUUGG CUUAGAUCAA GUGUAGUAUC UGUUCUUUUC AGUUUAAUCG CUGAAAUCAC CUCACUGAGG UGUUUCCGA UUAAUCUUGU UUUUGGUUUG AGUUGGAAAG CCUCUGGCUU GCUAUGCUUU CCGACACUGG UGUUCUUGCU A UUGCACUA CUGGCAAGCG ACGCCGAA

GENBANK: GENBANK: X55772.1

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分子 #4: U5snRNA

分子名称: U5snRNA / タイプ: rna / ID: 4 / コピー数: 1
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 38.191363 KDa
配列文字列:
AUAAUCCGUC AAAGCACUUU GCAAAAGCUA ACGUAUCUGU UUCUUGCCUU UUACCAGAAA CAGCCGUUUG UAAGGUGUGC UAAUUUGAC UGUAUAGUUU UUGUAAUCUU UUUCUUGAAA C

GENBANK: GENBANK: X16573.1

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分子 #38: U6snRNA

分子名称: U6snRNA / タイプ: rna / ID: 38 / コピー数: 1
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 31.863982 KDa
配列文字列:
GAUCUUCGGA UCACUUUGGU CAAAUUGAAA CGAUACAGAG AAGAUUAGCA UGGCCCCUGC ACAAGGAUGA CACUGCGACA UUGAGAGAA AACCCAUUUU

GENBANK: GENBANK: XM_013166828.1

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分子 #39: pre-mRNA

分子名称: pre-mRNA / タイプ: rna / ID: 39 / コピー数: 1
由来(天然)生物種: Schizosaccharomyces pombe (分裂酵母)
分子量理論値: 9.135291 KDa
配列文字列:
UUUUUAUUAA AAAAUGGUAU GUUUUUUUU

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分子 #41: INOSITOL HEXAKISPHOSPHATE

分子名称: INOSITOL HEXAKISPHOSPHATE / タイプ: ligand / ID: 41 / コピー数: 1 / 式: IHP
分子量理論値: 660.035 Da
Chemical component information

ChemComp-IHP:
INOSITOL HEXAKISPHOSPHATE / myo-イノシト-ル六りん酸

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分子 #42: GUANOSINE-5'-TRIPHOSPHATE

分子名称: GUANOSINE-5'-TRIPHOSPHATE / タイプ: ligand / ID: 42 / コピー数: 1 / 式: GTP
分子量理論値: 523.18 Da
Chemical component information

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP / GTP, エネルギー貯蔵分子*YM

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分子 #43: MAGNESIUM ION

分子名称: MAGNESIUM ION / タイプ: ligand / ID: 43 / コピー数: 4 / 式: MG
分子量理論値: 24.305 Da

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分子 #44: ZINC ION

分子名称: ZINC ION / タイプ: ligand / ID: 44 / コピー数: 6 / 式: ZN
分子量理論値: 65.409 Da

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分子 #45: POTASSIUM ION

分子名称: POTASSIUM ION / タイプ: ligand / ID: 45 / コピー数: 1 / 式: K
分子量理論値: 39.098 Da

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実験情報

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構造解析

手法クライオ電子顕微鏡法
解析単粒子再構成法
試料の集合状態particle

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試料調製

緩衝液pH: 7.5
構成要素:
濃度式名称
20.0 mMC8H18N2O4SHEPES
100.0 mMNaClSodium chloride
1.5 mMMgCl2Magnesium chloride
0.01 %(C2H4O)nC14H22OIGEPAL CA-630

詳細: 20 mM HEPES pH 7.5, 100 mM NaCl, 1.5 mM MgCl2, 0.01% IGEPAL CA-630
グリッドモデル: Quantifoil R2/1 / 材質: COPPER / メッシュ: 300 / 支持フィルム - 材質: CARBON / 支持フィルム - トポロジー: CONTINUOUS
凍結凍結剤: ETHANE / チャンバー内湿度: 100 % / チャンバー内温度: 277.15 K / 装置: FEI VITROBOT MARK IV

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電子顕微鏡法

顕微鏡FEI TITAN KRIOS
撮影フィルム・検出器のモデル: GATAN K3 BIOCONTINUUM (6k x 4k)
撮影したグリッド数: 1 / 実像数: 13096 / 平均露光時間: 1.491 sec. / 平均電子線量: 49.4 e/Å2
電子線加速電圧: 300 kV / 電子線源: FIELD EMISSION GUN
電子光学系照射モード: FLOOD BEAM / 撮影モード: BRIGHT FIELD / Cs: 2.7 mm / 最大 デフォーカス（公称値）: 1.8 µm / 最小 デフォーカス（公称値）: 0.6 µm
実験機器
モデル: Titan Krios / 画像提供: FEI Company

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画像解析

粒子像選択選択した数: 929930
CTF補正タイプ: PHASE FLIPPING AND AMPLITUDE CORRECTION
初期モデルモデルのタイプ: NONE
最終 再構成解像度のタイプ: BY AUTHOR / 解像度: 3.1 Å / 解像度の算出法: FSC 0.143 CUT-OFF / 使用した粒子像数: 72631
初期 角度割当タイプ: MAXIMUM LIKELIHOOD
最終 角度割当タイプ: MAXIMUM LIKELIHOOD
FSC曲線 (解像度の算出)

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原子モデル構築 1

精密化空間: REAL / プロトコル: RIGID BODY FIT
得られたモデル

PDB-9esi:
Structure of a B-state intermediate committed to discard (Bd-II state)

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万見について

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お知らせ

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2022年2月9日: EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

  • EMDBのヘッダファイルのバージョン3が、公式のフォーマットとなりました。
  • これまでは公式だったバージョン1.9は、アーカイブから削除されます。

関連情報:EMDBヘッダ

外部リンク:wwPDBはEMDBデータモデルのバージョン3へ移行します

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2020年8月12日: 新型コロナ情報

新型コロナ情報

URL: https://pdbj.org/emnavi/covid19.php

新ページ: EM Navigatorに新型コロナウイルスの特設ページを開設しました。

関連情報:Covid-19情報 / 2020年3月5日: 新型コロナウイルスの構造データ

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2020年3月5日: 新型コロナウイルスの構造データ

新型コロナウイルスの構造データ

関連情報:万見生物種 / 2020年8月12日: 新型コロナ情報

外部リンク:COVID-19特集ページ - PDBj / 今月の分子2020年2月：コロナウイルスプロテーアーゼ

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2019年1月31日: EMDBのIDの桁数の変更

EMDBのIDの桁数の変更

  • EMDBエントリに付与されているアクセスコード(EMDB-ID)は4桁の数字(例、EMD-1234)でしたが、間もなく枯渇します。これまでの4桁のID番号は4桁のまま変更されませんが、4桁の数字を使い切った後に発行されるIDは5桁以上の数字(例、EMD-12345)になります。5桁のIDは2019年の春頃から発行される見通しです。
  • EM Navigator/万見では、接頭語「EMD-」は省略されています。

関連情報:Q: 「EMD」とは何ですか？ / 万見/EM NavigatorにおけるID/アクセスコードの表記

外部リンク:EMDB Accession Codes are Changing Soon! / PDBjへお問い合わせ

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2017年7月12日: PDB大規模アップデート

PDB大規模アップデート

  • 新バージョンのPDBx/mmCIF辞書形式に基づくデータがリリースされました。
  • 今回の更新はバージョン番号が4から5になる大規模なもので、全エントリデータの書き換えが行われる「Remediation」というアップデートに該当します。
  • このバージョンアップで、電子顕微鏡の実験手法に関する多くの項目の書式が改定されました(例：em_softwareなど)。
  • EM NavigatorとYorodumiでも、この改定に基づいた表示内容になります。

外部リンク:wwPDB Remediation / OneDepデータ基準に準拠した、より強化された内容のモデル構造ファイルが、PDBアーカイブで公開されました。

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万見 (Yorodumi)

幾万の構造データを、幾万の視点から

  • 万見(Yorodumi)は、EMDB/PDB/SASBDBなどの構造データを閲覧するためのページです。
  • EM Navigatorの詳細ページの後継、Omokage検索のフロントエンドも兼ねています。

関連情報:EMDB / PDB / SASBDB / 3つのデータバンクの比較 / 万見検索 / 2016年8月31日: 新しいEM Navigatorと万見 / 万見文献 / Jmol/JSmol / 機能・相同性情報 / 新しいEM Navigatorと万見の変更点

他の情報も見る