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- EMDB-14322: Human nuclear pore complex (constricted) -

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Basic information

Entry
Database: EMDB / ID: EMD-14322
TitleHuman nuclear pore complex (constricted)
Map dataStructure of the human nuclear pore complex from isolated nuclear envelopes
Sample
  • Organelle or cellular component: Nuclear pore complex
    • Protein or peptide: x 25 types
Keywordsmultiprotein complex / nucleocytoplasmic transport / TRANSPORT PROTEIN
Function / homology
Function and homology information


cytoplasmic side of nuclear pore / nuclear pore transmembrane ring / GATOR2 complex / nephron development / centriole assembly / positive regulation of centriole replication / cytoplasmic periphery of the nuclear pore complex / regulation of protein import into nucleus / regulation of Ras protein signal transduction / HuR (ELAVL1) binds and stabilizes mRNA ...cytoplasmic side of nuclear pore / nuclear pore transmembrane ring / GATOR2 complex / nephron development / centriole assembly / positive regulation of centriole replication / cytoplasmic periphery of the nuclear pore complex / regulation of protein import into nucleus / regulation of Ras protein signal transduction / HuR (ELAVL1) binds and stabilizes mRNA / positive regulation of mitotic cytokinetic process / Seh1-associated complex / SUMO ligase complex / SUMO ligase activity / protein exit from endoplasmic reticulum / COPII-coated vesicle budding / protein localization to nuclear inner membrane / nuclear pore inner ring / nuclear envelope organization / annulate lamellae / nuclear pore localization / regulation of nucleocytoplasmic transport / nuclear pore central transport channel / transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery / COPII-coated vesicle cargo loading / nuclear pore outer ring / nuclear pore complex assembly / telomere tethering at nuclear periphery / nuclear pore organization / atrial cardiac muscle cell action potential / homologous chromosome pairing at meiosis / somite development / COPII vesicle coat / positive regulation of protein localization to centrosome / nuclear pore cytoplasmic filaments / post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery / nuclear export signal receptor activity / paraxial mesoderm development / Nuclear Pore Complex (NPC) Disassembly / nuclear inclusion body / Amino acids regulate mTORC1 / Transport of Ribonucleoproteins into the Host Nucleus / nuclear pore nuclear basket / Regulation of Glucokinase by Glucokinase Regulatory Protein / Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) / miRNA processing / attachment of mitotic spindle microtubules to kinetochore / Transport of the SLBP independent Mature mRNA / Transport of the SLBP Dependant Mature mRNA / NS1 Mediated Effects on Host Pathways / SUMOylation of SUMOylation proteins / negative regulation of Ras protein signal transduction / NLS-bearing protein import into nucleus / protein-containing complex localization / microtubule bundle formation / Transport of Mature mRNA Derived from an Intronless Transcript / structural constituent of nuclear pore / nuclear localization sequence binding / positive regulation of mRNA splicing, via spliceosome / Rev-mediated nuclear export of HIV RNA / Nuclear import of Rev protein / Flemming body / SUMOylation of RNA binding proteins / nuclear export / fertilization / mitotic centrosome separation / NEP/NS2 Interacts with the Cellular Export Machinery / kinase activator activity / Transport of Mature mRNA derived from an Intron-Containing Transcript / Transferases; Acyltransferases; Aminoacyltransferases / centrosome cycle / tRNA processing in the nucleus / RNA export from nucleus / SUMO transferase activity / Postmitotic nuclear pore complex (NPC) reformation / COPII-mediated vesicle transport / negative regulation of programmed cell death / lamellipodium assembly / neural tube development / nucleocytoplasmic transport / centrosome localization / positive regulation of epidermal growth factor receptor signaling pathway / Viral Messenger RNA Synthesis / poly(A)+ mRNA export from nucleus / regulation of gluconeogenesis / PTB domain binding / mitotic metaphase chromosome alignment / SUMOylation of ubiquitinylation proteins / female gonad development / Vpr-mediated nuclear import of PICs / negative regulation of epidermal growth factor receptor signaling pathway / macrophage chemotaxis / protein sumoylation / SUMOylation of DNA replication proteins / Hydrolases; Acting on peptide bonds (peptidases); Serine endopeptidases / positive regulation of SMAD protein signal transduction / ribosomal large subunit export from nucleus / RHOA GTPase cycle / mitotic spindle assembly / positive regulation of TOR signaling
Similarity search - Function
: / NUP210 Ig-like domain / Nucleoporin protein Ndc1-Nup / Nuclear pore membrane glycoprotein 210-like / : / : / : / : / : / Nucleoporin protein Ndc1-Nup ...: / NUP210 Ig-like domain / Nucleoporin protein Ndc1-Nup / Nuclear pore membrane glycoprotein 210-like / : / : / : / : / : / Nucleoporin protein Ndc1-Nup / NUP210 Ig-like domain 15 / NUP210 Ig-like domain 7 / NUP210 Ig-like domain 3 / NUP210 Ig-like domain 1 / NUP210 Ig-like domain 2 / Nucleoporin, NUP53 / Aladin / Nuclear pore complex protein Nup214, phenylalanine-glycine (FG) domain / Nucleoporin Nup214 phenylalanine-glycine (FG) domain / ELYS-like domain / ELYS, beta-propeller domain / : / Nuclear pore complex assembly / beta-propeller of ELYS nucleoporin / : / : / : / Nucleoporin NUP160, helical domain / Nup160 C-terminal TPR / NUP160/120 middle TPR / Nucleoporin Nup88 / Nuclear pore component / Nup188 SH3-like domain / RNA-recognition motif (RRM) Nup35-type domain / Nup53/35/40-type RNA recognition motif / Nucleoporin FG repeated region / RNA-recognition motif (RRM) Nup35-type domain profile. / Nucleoporin NUP88/NUP82 / Nup54, C-terminal interacting domain / Nup54 C-terminal interacting domain / Nucleoporin Nup159/Nup146, N-terminal / NUP159/214 beta propeller / Nucleoporin Nup120/160, beta-propeller domain / Nucleoporin Nup188, N-terminal / Nucleoporin Nup188, N-terminal / Nucleoporin p58/p45 / Nucleoporin Nup37 / Nucleoporin Nup188 / : / Nucleoporin Nup188, N-terminal subdomain III / Nucleoporin, Nup155-like, C-terminal, subdomain 3 / Nucleoporin Nup54/Nup57/Nup44 / Nucleoporin Nup54, alpha-helical domain / Nucleoporin complex subunit 54 / Nucleoporin, NSP1-like, C-terminal / Nucleoporin NSP1/NUP62 / Nsp1-like C-terminal region / Nucleoporin Nup85-like / Nucleoporin Nup120/160 / Nup85 Nucleoporin / Nup98, Gle2-binding sequence / Nuclear pore protein 84/107 / Nuclear pore protein 84 / 107 / Nuclear pore complex protein Nup133-like / Nucleoporin, Nup155-like, C-terminal, subdomain 1 / Nucleoporin, Nup155-like, C-terminal, subdomain 2 / Nucleoporin, Nup155-like / Nuclear pore complex protein / Nucleoporin Nup186/Nup192/Nup205 / Nuclear pore complex scaffold, nucleoporins 186/192/205 / Nucleoporin, Nup133/Nup155-like, C-terminal / Nup358/RanBP2 E3 ligase domain / Non-repetitive/WGA-negative nucleoporin C-terminal / Nup358/RanBP2 E3 ligase domain / Nucleoporin interacting component Nup93/Nic96 / Nup93/Nic96 / Nucleoporin, Nup133/Nup155-like, N-terminal / Nup133 N terminal like / Sec13/Seh1 family / Nuclear pore complex protein NUP96, C-terminal domain / Nuclear protein 96 / Nuclear pore complex protein Nup98-Nup96-like, autopeptidase S59 domain / Nuclear pore complex protein Nup98-Nup96-like, autopeptidase S59 domain superfamily / Nucleoporin peptidase S59-like / Nup98-96 autopeptidase S59 / NUP C-terminal domain profile. / Bacterial Ig-like domain (group 2) / Ran binding protein RanBP1-like / Bacterial Ig-like domain 2 / Invasin/intimin cell-adhesion fragments / Ran binding domain / RanBP1 domain / Ran binding domain type 1 profile. / Ran-binding domain / Bacterial Ig-like domain, group 2 / Zinc finger domain / Zn-finger in Ran binding protein and others / Zinc finger RanBP2 type profile. / Zinc finger, RanBP2-type superfamily / Zinc finger RanBP2-type signature.
Similarity search - Domain/homology
Nuclear pore complex protein Nup155 / Nuclear pore complex protein Nup214 / Nuclear pore glycoprotein p62 / E3 SUMO-protein ligase RanBP2 / Nuclear pore complex protein Nup98-Nup96 / Protein SEC13 homolog / Nuclear pore complex protein Nup107 / Nuclear pore complex protein Nup160 / Nucleoporin NUP188 / Nucleoporin p54 ...Nuclear pore complex protein Nup155 / Nuclear pore complex protein Nup214 / Nuclear pore glycoprotein p62 / E3 SUMO-protein ligase RanBP2 / Nuclear pore complex protein Nup98-Nup96 / Protein SEC13 homolog / Nuclear pore complex protein Nup107 / Nuclear pore complex protein Nup160 / Nucleoporin NUP188 / Nucleoporin p54 / Nuclear pore complex protein Nup93 / Nucleoporin Nup43 / Nucleoporin Nup37 / Nucleoporin NUP35 / Nuclear pore membrane glycoprotein 210 / Nuclear pore complex protein Nup133 / Protein ELYS / Nuclear pore complex protein Nup205 / Nucleoporin SEH1 / Nuclear pore complex protein Nup88 / Nucleoporin NDC1 / Nucleoporin p58/p45 / Nuclear pore complex protein Nup85 / Aladin
Similarity search - Component
Biological speciesHomo sapiens (human)
Methodsubtomogram averaging / cryo EM / Resolution: 12.0 Å
AuthorsMosalaganti S / Obarska-Kosinska A
Funding supportEuropean Union, Germany, 2 items
OrganizationGrant numberCountry
European Research Council (ERC)724349European Union
German Federal Ministry for Education and Research031L0100 Germany
CitationJournal: Science / Year: 2022
Title: AI-based structure prediction empowers integrative structural analysis of human nuclear pores.
Authors: Shyamal Mosalaganti / Agnieszka Obarska-Kosinska / Marc Siggel / Reiya Taniguchi / Beata Turoňová / Christian E Zimmerli / Katarzyna Buczak / Florian H Schmidt / Erica Margiotta / Marie- ...Authors: Shyamal Mosalaganti / Agnieszka Obarska-Kosinska / Marc Siggel / Reiya Taniguchi / Beata Turoňová / Christian E Zimmerli / Katarzyna Buczak / Florian H Schmidt / Erica Margiotta / Marie-Therese Mackmull / Wim J H Hagen / Gerhard Hummer / Jan Kosinski / Martin Beck /
Abstract: INTRODUCTION The eukaryotic nucleus pro-tects the genome and is enclosed by the two membranes of the nuclear envelope. Nuclear pore complexes (NPCs) perforate the nuclear envelope to facilitate ...INTRODUCTION The eukaryotic nucleus pro-tects the genome and is enclosed by the two membranes of the nuclear envelope. Nuclear pore complexes (NPCs) perforate the nuclear envelope to facilitate nucleocytoplasmic transport. With a molecular weight of ∼120 MDa, the human NPC is one of the larg-est protein complexes. Its ~1000 proteins are taken in multiple copies from a set of about 30 distinct nucleoporins (NUPs). They can be roughly categorized into two classes. Scaf-fold NUPs contain folded domains and form a cylindrical scaffold architecture around a central channel. Intrinsically disordered NUPs line the scaffold and extend into the central channel, where they interact with cargo complexes. The NPC architecture is highly dynamic. It responds to changes in nuclear envelope tension with conforma-tional breathing that manifests in dilation and constriction movements. Elucidating the scaffold architecture, ultimately at atomic resolution, will be important for gaining a more precise understanding of NPC function and dynamics but imposes a substantial chal-lenge for structural biologists. RATIONALE Considerable progress has been made toward this goal by a joint effort in the field. A synergistic combination of complementary approaches has turned out to be critical. In situ structural biology techniques were used to reveal the overall layout of the NPC scaffold that defines the spatial reference for molecular modeling. High-resolution structures of many NUPs were determined in vitro. Proteomic analysis and extensive biochemical work unraveled the interaction network of NUPs. Integra-tive modeling has been used to combine the different types of data, resulting in a rough outline of the NPC scaffold. Previous struc-tural models of the human NPC, however, were patchy and limited in accuracy owing to several challenges: (i) Many of the high-resolution structures of individual NUPs have been solved from distantly related species and, consequently, do not comprehensively cover their human counterparts. (ii) The scaf-fold is interconnected by a set of intrinsically disordered linker NUPs that are not straight-forwardly accessible to common structural biology techniques. (iii) The NPC scaffold intimately embraces the fused inner and outer nuclear membranes in a distinctive topol-ogy and cannot be studied in isolation. (iv) The conformational dynamics of scaffold NUPs limits the resolution achievable in structure determination. RESULTS In this study, we used artificial intelligence (AI)-based prediction to generate an exten-sive repertoire of structural models of human NUPs and their subcomplexes. The resulting models cover various domains and interfaces that so far remained structurally uncharac-terized. Benchmarking against previous and unpublished x-ray and cryo-electron micros-copy structures revealed unprecedented accu-racy. We obtained well-resolved cryo-electron tomographic maps of both the constricted and dilated conformational states of the hu-man NPC. Using integrative modeling, we fit-ted the structural models of individual NUPs into the cryo-electron microscopy maps. We explicitly included several linker NUPs and traced their trajectory through the NPC scaf-fold. We elucidated in great detail how mem-brane-associated and transmembrane NUPs are distributed across the fusion topology of both nuclear membranes. The resulting architectural model increases the structural coverage of the human NPC scaffold by about twofold. We extensively validated our model against both earlier and new experimental data. The completeness of our model has enabled microsecond-long coarse-grained molecular dynamics simulations of the NPC scaffold within an explicit membrane en-vironment and solvent. These simulations reveal that the NPC scaffold prevents the constriction of the otherwise stable double-membrane fusion pore to small diameters in the absence of membrane tension. CONCLUSION Our 70-MDa atomically re-solved model covers >90% of the human NPC scaffold. It captures conforma-tional changes that occur during dilation and constriction. It also reveals the precise anchoring sites for intrinsically disordered NUPs, the identification of which is a prerequisite for a complete and dy-namic model of the NPC. Our study exempli-fies how AI-based structure prediction may accelerate the elucidation of subcellular ar-chitecture at atomic resolution. [Figure: see text].
History
DepositionFeb 10, 2022-
Header (metadata) releaseJun 22, 2022-
Map releaseJun 22, 2022-
UpdateJul 17, 2024-
Current statusJul 17, 2024Processing site: PDBe / Status: Released

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Structure visualization

Supplemental images

emd_14322.png

Downloads & links

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Map

FileDownload / File: emd_14322.map.gz / Format: CCP4 / Size: 729 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
AnnotationStructure of the human nuclear pore complex from isolated nuclear envelopes
Projections & slices

Image control

Size
Brightness
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Others
AxesZ (Sec.)Y (Row.)X (Col.)
3.37 Å/pix.
x 576 pix.
= 1941.12 Å		3.37 Å/pix.
x 576 pix.
= 1941.12 Å		3.37 Å/pix.
x 576 pix.
= 1941.12 Å

Surface

Projections

Slices (1/3)

Slices (1/2)

Slices (2/3)

Images are generated by Spider.

Voxel sizeX=Y=Z: 3.37 Å
Density

Histogram

Histogram (log scale)
Contour LevelBy AUTHOR: 3.5
Minimum - Maximum-69.68647 - 82.184974999999994
Average (Standard dev.)0.07747576 (±0.7912433)
SymmetrySpace group: 1
Details

EMDB XML:

Map geometry
Axis orderXYZ
Origin000
Dimensions576576576
Spacing576576576
CellA=B=C: 1941.1199 Å
α=β=γ: 90.0 °

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Supplemental data

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Sample components

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Entire : Nuclear pore complex

EntireName: Nuclear pore complex
Components
  • Organelle or cellular component: Nuclear pore complex
    • Protein or peptide: E3 SUMO-protein ligase RanBP2
    • Protein or peptide: Nuclear pore membrane glycoprotein 210
    • Protein or peptide: Aladin
    • Protein or peptide: Nuclear pore complex protein Nup93
    • Protein or peptide: Nucleoporin NUP188 homolog
    • Protein or peptide: Nuclear pore complex protein Nup205
    • Protein or peptide: Nuclear pore complex protein Nup155
    • Protein or peptide: Nucleoporin NDC1
    • Protein or peptide: Nucleoporin NUP35
    • Protein or peptide: Nucleoporin p54
    • Protein or peptide: Nucleoporin p58/p45
    • Protein or peptide: Nuclear pore glycoprotein p62
    • Protein or peptide: Nuclear pore complex protein Nup133
    • Protein or peptide: Nuclear pore complex protein Nup107
    • Protein or peptide: Nuclear pore complex protein Nup96
    • Protein or peptide: Protein SEC13 homolog
    • Protein or peptide: Nucleoporin SEH1
    • Protein or peptide: Nuclear pore complex protein Nup85
    • Protein or peptide: Nucleoporin Nup43
    • Protein or peptide: Nuclear pore complex protein Nup160
    • Protein or peptide: Nucleoporin Nup37
    • Protein or peptide: Protein ELYS
    • Protein or peptide: Nuclear pore complex protein Nup98
    • Protein or peptide: Nuclear pore complex protein Nup214
    • Protein or peptide: Nuclear pore complex protein Nup88

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Supramolecule #1: Nuclear pore complex

SupramoleculeName: Nuclear pore complex / type: organelle_or_cellular_component / ID: 1 / Parent: 0 / Macromolecule list: all
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 120 MDa

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Macromolecule #1: E3 SUMO-protein ligase RanBP2

MacromoleculeName: E3 SUMO-protein ligase RanBP2 / type: protein_or_peptide / ID: 1 / Number of copies: 5 / Enantiomer: LEVO
EC number: Transferases; Acyltransferases; Aminoacyltransferases
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 358.654375 KDa
SequenceString: MRRSKADVER YIASVQGSTP SPRQKSMKGF YFAKLYYEAK EYDLAKKYIC TYINVQERDP KAHRFLGLLY ELEENTDKAV ECYRRSVEL NPTQKDLVLK IAELLCKNDV TDGRAKYWLE RAAKLFPGSP AIYKLKEQLL DCEGEDGWNK LFDLIQSELY V RPDDVHVN ...String:
MRRSKADVER YIASVQGSTP SPRQKSMKGF YFAKLYYEAK EYDLAKKYIC TYINVQERDP KAHRFLGLLY ELEENTDKAV ECYRRSVEL NPTQKDLVLK IAELLCKNDV TDGRAKYWLE RAAKLFPGSP AIYKLKEQLL DCEGEDGWNK LFDLIQSELY V RPDDVHVN IRLVEVYRST KRLKDAVAHC HEAERNIALR SSLEWNSCVV QTLKEYLESL QCLESDKSDW RATNTDLLLA YA NLMLLTL STRDVQESRE LLQSFDSALQ SVKSLGGNDE LSATFLEMKG HFYMHAGSLL LKMGQHSSNV QWRALSELAA LCY LIAFQV PRPKIKLIKG EAGQNLLEMM ACDRLSQSGH MLLNLSRGKQ DFLKEIVETF ANKSGQSALY DALFSSQSPK DTSF LGSDD IGNIDVREPE LEDLTRYDVG AIRAHNGSLQ HLTWLGLQWN SLPALPGIRK WLKQLFHHLP HETSRLETNA PESIC ILDL EVFLLGVVYT SHLQLKEKCN SHHSSYQPLC LPLPVCKQLC TERQKSWWDA VCTLIHRKAV PGNVAKLRLL VQHEIN TLR AQEKHGLQPA LLVHWAECLQ KTGSGLNSFY DQREYIGRSV HYWKKVLPLL KIIKKKNSIP EPIDPLFKHF HSVDIQA SE IVEYEEDAHI TFAILDAVNG NIEDAVTAFE SIKSVVSYWN LALIFHRKAE DIENDALSPE EQEECKNYLR KTRDYLIK I IDDSDSNLSV VKKLPVPLES VKEMLNSVMQ ELEDYSEGGP LYKNGSLRNA DSEIKHSTPS PTRYSLSPSK SYKYSPKTP PRWAEDQNSL LKMICQQVEA IKKEMQELKL NSSNSASPHR WPTENYGPDS VPDGYQGSQT FHGAPLTVAT TGPSVYYSQS PAYNSQYLL RPAANVTPTK GPVYGMNRLP PQQHIYAYPQ QMHTPPVQSS SACMFSQEMY GPPALRFESP ATGILSPRGD D YFNYNVQQ TSTNPPLPEP GYFTKPPIAA HASRSAESKT IEFGKTNFVQ PMPGEGLRPS LPTQAHTTQP TPFKFNSNFK SN DGDFTFS SPQVVTQPPP AAYSNSESLL GLLTSDKPLQ GDGYSGAKPI PGGQTIGPRN TFNFGSKNVS GISFTENMGS SQQ KNSGFR RSDDMFTFHG PGKSVFGTPT LETANKNHET DGGSAHGDDD DDGPHFEPVV PLPDKIEVKT GEEDEEEFFC NRAK LFRFD VESKEWKERG IGNVKILRHK TSGKIRLLMR REQVLKICAN HYISPDMKLT PNAGSDRSFV WHALDYADEL PKPEQ LAIR FKTPEEAALF KCKFEEAQSI LKAPGTNVAM ASNQAVRIVK EPTSHDNKDI CKSDAGNLNF EFQVAKKEGS WWHCNS CSL KNASTAKKCV SCQNLNPSNK ELVGPPLAET VFTPKTSPEN VQDRFALVTP KKEGHWDCSI CLVRNEPTVS RCIACQN TK SANKSGSSFV HQASFKFGQG DLPKPINSDF RSVFSTKEGQ WDCSACLVQN EGSSTKCAAC QNPRKQSLPA TSIPTPAS F KFGTSETSKT LKSGFEDMFA KKEGQWDCSS CLVRNEANAT RCVACQNPDK PSPSTSVPAP ASFKFGTSET SKAPKSGFE GMFTKKEGQW DCSVCLVRNE ASATKCIACQ NPGKQNQTTS AVSTPASSET SKAPKSGFEG MFTKKEGQWD CSVCLVRNEA SATKCIACQ NPGKQNQTTS AVSTPASSET SKAPKSGFEG MFTKKEGQWD CSVCLVRNEA SATKCIACQC PSKQNQTTAI S TPASSEIS KAPKSGFEGM FIRKGQWDCS VCCVQNESSS LKCVACDASK PTHKPIAEAP SAFTLGSEMK LHDSSGSQVG TG FKSNFSE KASKFGNTEQ GFKFGHVDQE NSPSFMFQGS SNTEFKSTKE GFSIPVSADG FKFGISEPGN QEKKSEKPLE NGT GFQAQD ISGQKNGRGV IFGQTSSTFT FADLAKSTSG EGFQFGKKDP NFKGFSGAGE KLFSSQYGKM ANKANTSGDF EKDD DAYKT EDSDDIHFEP VVQMPEKVEL VTGEEDEKVL YSQRVKLFRF DAEVSQWKER GLGNLKILKN EVNGKLRMLM RREQV LKVC ANHWITTTMN LKPLSGSDRA WMWLASDFSD GDAKLEQLAA KFKTPELAEE FKQKFEECQR LLLDIPLQTP HKLVDT GRA AKLIQRAEEM KSGLKDFKTF LTNDQTKVTE EENKGSGTGA AGASDTTIKP NPENTGPTLE WDNYDLREDA LDDSVSS SS VHASPLASSP VRKNLFRFGE STTGFNFSFK SALSPSKSPA KLNQSGTSVG TDEESDVTQE EERDGQYFEP VVPLPDLV E VSSGEENEQV VFSHRAKLYR YDKDVGQWKE RGIGDIKILQ NYDNKQVRIV MRRDQVLKLC ANHRITPDMT LQNMKGTER VWLWTACDFA DGERKVEHLA VRFKLQDVAD SFKKIFDEAK TAQEKDSLIT PHVSRSSTPR ESPCGKIAVA VLEETTRERT DVIQGDDVA DATSEVEVSS TSETTPKAVV SPPKFVFGSE SVKSIFSSEK SKPFAFGNSS ATGSLFGFSF NAPLKSNNSE T SSVAQSGS ESKVEPKKCE LSKNSDIEQS SDSKVKNLFA SFPTEESSIN YTFKTPEKAK EKKKPEDSPS DDDVLIVYEL TP TAEQKAL ATKLKLPPTF FCYKNRPDYV SEEEEDDEDF ETAVKKLNGK LYLDGSEKCR PLEENTADNE KECIIVWEKK PTV EEKAKA DTLKLPPTFF CGVCSDTDED NGNGEDFQSE LQKVQEAQKS QTEEITSTTD SVYTGGTEVM VPSFCKSEEP DSIT KSISS PSVSSETMDK PVDLSTRKEI DTDSTSQGES KIVSFGFGSS TGLSFADLAS SNSGDFAFGS KDKNFQWANT GAAVF GTQS VGTQSAGKVG EDEDGSDEEV VHNEDIHFEP IVSLPEVEVK SGEEDEEILF KERAKLYRWD RDVSQWKERG VGDIKI LWH TMKNYYRILM RRDQVFKVCA NHVITKTMEL KPLNVSNNAL VWTASDYADG EAKVEQLAVR FKTKEVADCF KKTFEEC QQ NLMKLQKGHV SLAAELSKET NPVVFFDVCA DGEPLGRITM ELFSNIVPRT AENFRALCTG EKGFGFKNSI FHRVIPDF V CQGGDITKHD GTGGQSIYGD KFEDENFDVK HTGPGLLSMA NQGQNTNNSQ FVITLKKAEH LDFKHVVFGF VKDGMDTVK KIESFGSPKG SVCRRITITE CGQI

UniProtKB: E3 SUMO-protein ligase RanBP2

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Macromolecule #2: Nuclear pore membrane glycoprotein 210

MacromoleculeName: Nuclear pore membrane glycoprotein 210 / type: protein_or_peptide / ID: 2 / Number of copies: 8 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 205.314406 KDa
SequenceString: MAARGRGLLL LTLSVLLAAG PSAAAAKLNI PKVLLPFTRA TRVNFTLEAS EGCYRWLSTR PEVASIEPLG LDEQQCSQKA VVQARLTQP ARLTSIIFAE DITTGQVLRC DAIVDLIHDI QIVSTTRELY LEDSPLELKI QALDSEGNTF STLAGLVFEW T IVKDSEAD ...String:
MAARGRGLLL LTLSVLLAAG PSAAAAKLNI PKVLLPFTRA TRVNFTLEAS EGCYRWLSTR PEVASIEPLG LDEQQCSQKA VVQARLTQP ARLTSIIFAE DITTGQVLRC DAIVDLIHDI QIVSTTRELY LEDSPLELKI QALDSEGNTF STLAGLVFEW T IVKDSEAD RFSDSHNALR ILTFLESTYI PPSYISEMEK AAKQGDTILV SGMKTGSSKL KARIQEAVYK NVRPAEVRLL IL ENILLNP AYDVYLMVGT SIHYKVQKIR QGKITELSMP SDQYELQLQN SIPGPEGDPA RPVAVLAQDT SMVTALQLGQ SSL VLGHRS IRMQGASRLP NSTIYVVEPG YLGFTVHPGD RWVLETGRLY EITIEVFDKF SNKVYVSDNI RIETVLPAEF FEVL SSSQN GSYHRIRALK RGQTAIDAAL TSVVDQDGGV HILQVPVWNQ QEVEIHIPIT LYPSILTFPW QPKTGAYQYT IRAHG GSGN FSWSSSSHLV ATVTVKGVMT TGSDIGFSVI QAHDVQNPLH FGEMKVYVIE PHSMEFAPCQ VEARVGQALE LPLRIS GLM PGGASEVVTL SDCSHFDLAV EVENQGVFQP LPGRLPPGSE HCSGIRVKAE AQGSTTLLVS YRHGHVHLSA KITIAAY LP LKAVDPSSVA LVTLGSSKEM LFEGGPRPWI LEPSKFFQNV TAEDTDSIGL ALFAPHSSRN YQQHWILVTC QALGEQVI A LSVGNKPSLT NPFPAVEPAV VKFVCAPPSR LTLAPVYTSP QLDMSCPLLQ QNKQVVPVSS HRNPRLDLAA YDQEGRRFD NFSSLSIQWE STRPVLASIE PELPMQLVSQ DDESGQKKLH GLQAILVHEA SGTTAITATA TGYQESHLSS ARTKQPHDPL VPLSASIEL ILVEDVRVSP EEVTIYNHPG IQAELRIREG SGYFFLNTST ADVVKVAYQE ARGVAMVHPL LPGSSTIMIH D LCLVFPAP AKAVVYVSDI QELYIRVVDK VEIGKTVKAY VRVLDLHKKP FLAKYFPFMD LKLRAASPII TLVALDEALD NY TITFLIR GVAIGQTSLT ASVTNKAGQR INSAPQQIEV FPPFRLMPRK VTLLIGATMQ VTSEGGPQPQ SNILFSISNE SVA LVSAAG LVQGLAIGNG TVSGLVQAVD AETGKVVIIS QDLVQVEVLL LRAVRIRAPI MRMRTGTQMP IYVTGITNHQ NPFS FGNAV PGLTFHWSVT KRDVLDLRGR HHEASIRLPS QYNFAMNVLG RVKGRTGLRV VVKAVDPTSG QLYGLARELS DEIQV QVFE KLQLLNPEIE AEQILMSPNS YIKLQTNRDG AASLSYRVLD GPEKVPVVHV DEKGFLASGS MIGTSTIEVI AQEPFG ANQ TIIVAVKVSP VSYLRVSMSP VLHTQNKEAL VAVPLGMTVT FTVHFHDNSG DVFHAHSSVL NFATNRDDFV QIGKGPT NN TCVVRTVSVG LTLLRVWDAE HPGLSDFMPL PVLQAISPEL SGAMVVGDVL CLATVLTSLE GLSGTWSSSA NSILHIDP K TGVAVARAVG SVTVYYEVAG HLRTYKEVVV SVPQRIMARH LHPIQTSFQE ATASKVIVAV GDRSSNLRGE CTPTQREVI QALHPETLIS CQSQFKPAVF DFPSQDVFTV EPQFDTALGQ YFCSITMHRL TDKQRKHLSM KKTALVVSAS LSSSHFSTEQ VGAEVPFSP GLFADQAEIL LSNHYTSSEI RVFGAPEVLE NLEVKSGSPA VLAFAKEKSF GWPSFITYTV GVLDPAAGSQ G PLSTTLTF SSPVTNQAIA IPVTVAFVVD RRGPGPYGAS LFQHFLDSYQ VMFFTLFALL AGTAVMIIAY HTVCTPRDLA VP AALTPRA SPGHSPHYFA ASSPTSPNAL PPARKASPPS GLWSPAYASH

UniProtKB: Nuclear pore membrane glycoprotein 210

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Macromolecule #3: Aladin

MacromoleculeName: Aladin / type: protein_or_peptide / ID: 3 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 59.635918 KDa
SequenceString: MCSLGLFPPP PPRGQVTLYE HNNELVTGSS YESPPPDFRG QWINLPVLQL TKDPLKTPGR LDHGTRTAFI HHREQVWKRC INIWRDVGL FGVLNEIANS EEEVFEWVKT ASGWALALCR WASSLHGSLF PHLSLRSEDL IAEFAQVTNW SSCCLRVFAW H PHTNKFAV ...String:
MCSLGLFPPP PPRGQVTLYE HNNELVTGSS YESPPPDFRG QWINLPVLQL TKDPLKTPGR LDHGTRTAFI HHREQVWKRC INIWRDVGL FGVLNEIANS EEEVFEWVKT ASGWALALCR WASSLHGSLF PHLSLRSEDL IAEFAQVTNW SSCCLRVFAW H PHTNKFAV ALLDDSVRVY NASSTIVPSL KHRLQRNVAS LAWKPLSASV LAVACQSCIL IWTLDPTSLS TRPSSGCAQV LS HPGHTPV TSLAWAPSGG RLLSASPVDA AIRVWDVSTE TCVPLPWFRG GGVTNLLWSP DGSKILATTP SAVFRVWEAQ MWT CERWPT LSGRCQTGCW SPDGSRLLFT VLGEPLIYSL SFPERCGEGK GCVGGAKSAT IVADLSETTI QTPDGEERLG GEAH SMVWD PSGERLAVLM KGKPRVQDGK PVILLFRTRN SPVFELLPCG IIQGEPGAQP QLITFHPSFN KGALLSVGWS TGRIA HIPL YFVNAQFPRF SPVLGRAQEP PAGGGGSIHD LPLFTETSPT SAPWDPLPGP PPVLPHSPHS HL

UniProtKB: Aladin

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Macromolecule #4: Nuclear pore complex protein Nup93

MacromoleculeName: Nuclear pore complex protein Nup93 / type: protein_or_peptide / ID: 4 / Number of copies: 7 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 93.599102 KDa
SequenceString: MDTEGFGELL QQAEQLAAET EGISELPHVE RNLQEIQQAG ERLRSRTLTR TSQETADVKA SVLLGSRGLD ISHISQRLES LSAATTFEP LEPVKDTDIQ GFLKNEKDNA LLSAIEESRK RTFGMAEEYH RESMLVEWEQ VKQRILHTLL ASGEDALDFT Q ESEPSYIS ...String:
MDTEGFGELL QQAEQLAAET EGISELPHVE RNLQEIQQAG ERLRSRTLTR TSQETADVKA SVLLGSRGLD ISHISQRLES LSAATTFEP LEPVKDTDIQ GFLKNEKDNA LLSAIEESRK RTFGMAEEYH RESMLVEWEQ VKQRILHTLL ASGEDALDFT Q ESEPSYIS DVGPPGRSSL DNIEMAYARQ IYIYNEKIVN GHLQPNLVDL CASVAELDDK SISDMWTMVK QMTDVLLTPA TD ALKNRSS VEVRMEFVRQ ALAYLEQSYK NYTLVTVFGN LHQAQLGGVP GTYQLVRSFL NIKLPAPLPG LQDGEVEGHP VWA LIYYCM RCGDLLAASQ VVNRAQHQLG EFKTWFQEYM NSKDRRLSPA TENKLRLHYR RALRNNTDPY KRAVYCIIGR CDVT DNQSE VADKTEDYLW LKLNQVCFDD DGTSSPQDRL TLSQFQKQLL EDYGESHFTV NQQPFLYFQV LFLTAQFEAA VAFLF RMER LRCHAVHVAL VLFELKLLLK SSGQSAQLLS HEPGDPPCLR RLNFVRLLML YTRKFESTDP REALQYFYFL RDEKDS QGE NMFLRCVSEL VIESREFDMI LGKLENDGSR KPGVIDKFTS DTKPIINKVA SVAENKGLFE EAAKLYDLAK NADKVLE LM NKLLSPVVPQ ISAPQSNKER LKNMALSIAE RYRAQGISAN KFVDSTFYLL LDLITFFDEY HSGHIDRAFD IIERLKLV P LNQESVEERV AAFRNFSDEI RHNLSEVLLA TMNILFTQFK RLKGTSPSSS SRPQRVIEDR DSQLRSQART LITFAGMIP YRTSGDTNAR LVQMEVLMN

UniProtKB: Nuclear pore complex protein Nup93

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Macromolecule #5: Nucleoporin NUP188 homolog

MacromoleculeName: Nucleoporin NUP188 homolog / type: protein_or_peptide / ID: 5 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 196.256688 KDa
SequenceString: MAAAAGGPCV RSSRELWTIL LGRSALRELS QIEAELNKHW RRLLEGLSYY KPPSPSSAEK VKANKDVASP LKELGLRISK FLGLDEEQS VQLLQCYLQE DYRGTRDSVK TVLQDERQSQ ALILKIADYY YEERTCILRC VLHLLTYFQD ERHPYRVEYA D CVDKLEKE ...String:
MAAAAGGPCV RSSRELWTIL LGRSALRELS QIEAELNKHW RRLLEGLSYY KPPSPSSAEK VKANKDVASP LKELGLRISK FLGLDEEQS VQLLQCYLQE DYRGTRDSVK TVLQDERQSQ ALILKIADYY YEERTCILRC VLHLLTYFQD ERHPYRVEYA D CVDKLEKE LVSKYRQQFE ELYKTEAPTW ETHGNLMTER QVSRWFVQCL REQSMLLEII FLYYAYFEMA PSDLLVLTKM FK EQGFGSR QTNRHLVDET MDPFVDRIGY FSALILVEGM DIESLHKCAL DDRRELHQFA QDGLICQDMD CLMLTFGDIP HHA PVLLAW ALLRHTLNPE ETSSVVRKIG GTAIQLNVFQ YLTRLLQSLA SGGNDCTTST ACMCVYGLLS FVLTSLELHT LGNQ QDIID TACEVLADPS LPELFWGTEP TSGLGIILDS VCGMFPHLLS PLLQLLRALV SGKSTAKKVY SFLDKMSFYN ELYKH KPHD VISHEDGTLW RRQTPKLLYP LGGQTNLRIP QGTVGQVMLD DRAYLVRWEY SYSSWTLFTC EIEMLLHVVS TADVIQ HCQ RVKPIIDLVH KVISTDLSIA DCLLPITSRI YMLLQRLTTV ISPPVDVIAS CVNCLTVLAA RNPAKVWTDL RHTGFLP FV AHPVSSLSQM ISAEGMNAGG YGNLLMNSEQ PQGEYGVTIA FLRLITTLVK GQLGSTQSQG LVPCVMFVLK EMLPSYHK W RYNSHGVREQ IGCLILELIH AILNLCHETD LHSSHTPSLQ FLCICSLAYT EAGQTVINIM GIGVDTIDMV MAAQPRSDG AEGQGQGQLL IKTVKLAFSV TNNVIRLKPP SNVVSPLEQA LSQHGAHGNN LIAVLAKYIY HKHDPALPRL AIQLLKRLAT VAPMSVYAC LGNDAAAIRD AFLTRLQSKI EDMRIKVMIL EFLTVAVETQ PGLIELFLNL EVKDGSDGSK EFSLGMWSCL H AVLELIDS QQQDRYWCPP LLHRAAIAFL HALWQDRRDS AMLVLRTKPK FWENLTSPLF GTLSPPSETS EPSILETCAL IM KIICLEI YYVVKGSLDQ SLKDTLKKFS IEKRFAYWSG YVKSLAVHVA ETEGSSCTSL LEYQMLVSAW RMLLIIATTH ADI MHLTDS VVRRQLFLDV LDGTKALLLV PASVNCLRLG SMKCTLLLIL LRQWKRELGS VDEILGPLTE ILEGVLQADQ QLME KTKAK VFSAFITVLQ MKEMKVSDIP QYSQLVLNVC ETLQEEVIAL FDQTRHSLAL GSATEDKDSM ETDDCSRSRH RDQRD GVCV LGLHLAKELC EVDEDGDSWL QVTRRLPILP TLLTTLEVSL RMKQNLHFTE ATLHLLLTLA RTQQGATAVA GAGITQ SIC LPLLSVYQLS TNGTAQTPSA SRKSLDAPSW PGVYRLSMSL MEQLLKTLRY NFLPEALDFV GVHQERTLQC LNAVRTV QS LACLEEADHT VGFILQLSNF MKEWHFHLPQ LMRDIQVNLG YLCQACTSLL HSRKMLQHYL QNKNGDGLPS AVAQRVQR P PSAASAAPSS SKQPAADTEA SEQQALHTVQ YGLLKILSKT LAALRHFTPD VCQILLDQSL DLAEYNFLFA LSFTTPTFD SEVAPSFGTL LATVNVALNM LGELDKKKEP LTQAVGLSTQ AEGTRTLKSL LMFTMENCFY LLISQAMRYL RDPAVHPRDK QRMKQELSS ELSTLLSSLS RYFRRGAPSS PATGVLPSPQ GKSTSLSKAS PESQEPLIQL VQAFVRHMQR

UniProtKB: Nucleoporin NUP188

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Macromolecule #6: Nuclear pore complex protein Nup205

MacromoleculeName: Nuclear pore complex protein Nup205 / type: protein_or_peptide / ID: 6 / Number of copies: 5 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 228.172875 KDa
SequenceString: MATPLAVNSA ASLWGPYKDI WHKVGNALWR RQPEAVHLLD KILKKHKPDF ISLFKNPPKN VQQHEKVQKA STEGVAIQGQ QGTRLLPEQ LIKEAFILSD LFDIGELAAV ELLLAGEHQQ PHFPGLTRGL VAVLLYWDGK RCIANSLKAL IQSRRGKTWT L ELSPELAS ...String:
MATPLAVNSA ASLWGPYKDI WHKVGNALWR RQPEAVHLLD KILKKHKPDF ISLFKNPPKN VQQHEKVQKA STEGVAIQGQ QGTRLLPEQ LIKEAFILSD LFDIGELAAV ELLLAGEHQQ PHFPGLTRGL VAVLLYWDGK RCIANSLKAL IQSRRGKTWT L ELSPELAS MTTRFTDELM EQGLTYKVLT LVSQIDVNNE FEKLQRERGL GSEKHRKEVS DLIKECRQSL AESLFAWACQ SP LGKEDTL LLIGHLERVT VEANGSLDAV NLALLMALLY CFDISFIEQS TEERDDMIHQ LPLLTEKQYI ATIHSRLQDS QLW KLPGLQ ATVRLAWALA LRGISQLPDV TALAEFTEAD EAMAELAIAD NVFLFLMESV VVSEYFYQEE FYIRRVHNLI TDFL ALMPM KVKQLRNRAD EDARMIHMSM QMGNEPPISL RRDLEHLMLL IGELYKKNPF HLELALEYWC PTEPLQTPTI MGSYL GVAH QRPPQRQVVL SKFVRQMGDL LPPTIYIPYL KMLQGLANGP QCAHYCFSLL KVNGSSHVEN IQGAGGSPVS WEHFFH SLM LYHEHLRKDL PSADSVQYRH LPSRGITQKE QDGLIAFLQL TSTIITWSEN ARLALCEHPQ WTPVVVILGL LQCSIPP VL KAELLKTLAA FGKSPEIAAS LWQSLEYTQI LQTVRIPSQR QAIGIEVELN EIESRCEEYP LTRAFCQLIS TLVESSFP S NLGAGLRPPG FDPYLQFLRD SVFLRFRTRA YRRAAEKWEV AEVVLEVFYK LLRDYEPQLE DFVDQFVELQ GEEIIAYKP PGFSLMYHLL NESPMLELAL SLLEEGVKQL DTYAPFPGKK HLEKAVQHCL ALLNLTLQKE NLFMDLLRES QLALIVCPLE QLLQGINPR TKKADNVVNI ARYLYHGNTN PELAFESAKI LCCISCNSNI QIKLVGDFTH DQSISQKLMA GFVECLDCED A EEFVRLEE GSELEKKLVA IRHETRIHIL NLLITSLECN PPNLALYLLG FELKKPVSTT NLQDPGVLGC PRTCLHAILN IL EKGTEGR TGPVAVRESP QLAELCYQVI YQLCACSDTS GPTMRYLRTS QDFLFSQLQY LPFSNKEYEI SMLNQMSWLM KTA SIELRV TSLNRQRSHT QRLLHLLLDD MPVKPYSDGE GGIEDENRSV SGFLHFDTAT KVRRKILNIL DSIDFSQEIP EPLQ LDFFD RAQIEQVIAN CEHKNLRGQT VCNVKLLHRV LVAEVNALQG MAAIGQRPLL MEEISTVLQY VVGRNKLLQC LHAKR HALE SWRQLVEIIL TACPQDLIQA EDRQLIIRDI LQDVHDKILD DEAAQELMPV VAGAVFTLTA HLSQAVLTEQ KETSVL GPA EAHYAFMLDS CFTSPPPEEN PLVGFASIGD SSLYIILKKL LDFILKTGGG FQRVRTHLYG SLLYYLQIAQ RPDEPDT LE AAKKTMWERL TAPEDVFSKL QRENIAIIES YGAALMEVVC RDACDGHEIG RMLALALLDR IVSVDKQQQW LLYLSNSG Y LKVLVDSLVE DDRTLQSLLT PQPPLLKALY TYESKMAFLT RVAKIQQGAL ELLRSGVIVR LAQCQVYDMR PETDPQSMF GMRDPPMFIP TPVDRYRQIL LPALQLCQVI LTSSMAQHLQ AAGQVLQFLI SHSDTIQAIL RCQDVSAGSL QELALLTGII SKAALPGIL SELDVDVNEG SLMELQGHIG RFQRQCLGLL SRFGGSDRLR QFKFQDDNVE GDKVSKKDEI ELAMQQICAN V MEYCQSLM LQSSPTFQHA VCLFTPSLSE TVNRDGPRQD TQAPVVPYWR LPGLGIIIYL LKQSANDFFS YYDSHRQSVS KL QNVEQLP PDEIKELCQS VMPAGVDKIS TAQKYVLARR RLVKVINNRA KLLSLCSFII ETCLFILWRH LEYYLLHCMP TDS QDSLFA SRTLFKSRRL QDSFASETNL DFRSGLAIVS QHDLDQLQAD AINAFGESLQ KKLLDIEGLY SKVRSRYSFI QALV RRIRG LLRISRN

UniProtKB: Nuclear pore complex protein Nup205

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Macromolecule #7: Nuclear pore complex protein Nup155

MacromoleculeName: Nuclear pore complex protein Nup155 / type: protein_or_peptide / ID: 7 / Number of copies: 6 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 155.357281 KDa
SequenceString: MPSSLLGAAM PASTSAAALQ EALENAGRLI DRQLQEDRMY PDLSELLMVS APNNPTVSGM SDMDYPLQGP GLLSVPNLPE ISSIRRVPL PPELVEQFGH MQCNCMMGVF PPISRAWLTI DSDIFMWNYE DGGDLAYFDG LSETILAVGL VKPKAGIFQP H VRHLLVLA ...String:
MPSSLLGAAM PASTSAAALQ EALENAGRLI DRQLQEDRMY PDLSELLMVS APNNPTVSGM SDMDYPLQGP GLLSVPNLPE ISSIRRVPL PPELVEQFGH MQCNCMMGVF PPISRAWLTI DSDIFMWNYE DGGDLAYFDG LSETILAVGL VKPKAGIFQP H VRHLLVLA TPVDIVILGL SYANLQTGSG VLNDSLSGGM QLLPDPLYSL PTDNTYLLTI TSTDNGRIFL AGKDGCLYEV AY QAEAGWF SQRCRKINHS KSSLSFLVPS LLQFTFSEDD PILQIAIDNS RNILYTRSEK GVIQVYDLGQ DGQGMSRVAS VSQ NAIVSA AGNIARTIDR SVFKPIVQIA VIENSESLDC QLLAVTHAGV RLYFSTCPFR QPLARPNTLT LVHVRLPPGF SASS TVEKP SKVHRALYSK GILLMAASEN EDNDILWCVN HDTFPFQKPM METQMTAGVD GHSWALSAID ELKVDKIITP LNKDH IPIT DSPVVVQQHM LPPKKFVLLS AQGSLMFHKL RPVDQLRHLL VSNVGGDGEE IERFFKLHQE DQACATCLIL ACSTAA CDR EVSAWATRAF FRYGGEAQMR FPTTLPPPSN VGPILGSPVY SSSPVPSGSP YPNPSFLGTP SHGIQPPAMS TPVCALG NP ATQATNMSCV TGPEIVYSGK HNGICIYFSR IMGNIWDASL VVERIFKSGN REITAIESSV PCQLLESVLQ ELKGLQEF L DRNSQFAGGP LGNPNTTAKV QQRLIGFMRP ENGNPQQMQQ ELQRKFHEAQ LSEKISLQAI QQLVRKSYQA LALWKLLCE HQFTIIVAEL QKELQEQLKI TTFKDLVIRD KELTGALIAS LINCYIRDNA AVDGISLHLQ DICPLLYSTD DAICSKANEL LQRSRQVQN KTEKERMLRE SLKEYQKISN QVDLSNVCAQ YRQVRFYEGV VELSLTAAEK KDPQGLGLHF YKHGEPEEDI V GLQAFQER LNSYKCITDT LQELVNQSKA APQSPSVPKK PGPPVLSSDP NMLSNEEAGH HFEQMLKLSQ RSKDELFSIA LY NWLIQVD LADKLLQVAS PFLEPHLVRM AKVDQNRVRY MDLLWRYYEK NRSFSNAARV LSRLADMHST EISLQQRLEY IAR AILSAK SSTAISSIAA DGEFLHELEE KMEVARIQLQ IQETLQRQYS HHSSVQDAVS QLDSELMDIT KLYGEFADPF KLAE CKLAI IHCAGYSDPI LVQTLWQDII EKELSDSVTL SSSDRMHALS LKIVLLGKIY AGTPRFFPLD FIVQFLEQQV CTLNW DVGF VIQTMNEIGV PLPRLLEVYD QLFKSRDPFW NRMKKPLHLL DCIHVLLIRY VENPSQVLNC ERRRFTNLCL DAVCGY LVE LQSMSSSVAV QAITGNFKSL QAKLERLH

UniProtKB: Nuclear pore complex protein Nup155

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Macromolecule #8: Nucleoporin NDC1

MacromoleculeName: Nucleoporin NDC1 / type: protein_or_peptide / ID: 8 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 76.377445 KDa
SequenceString: MATAVSRPCA GRSRDILWRV LGWRIVASIV WSVLFLPICT TVFIIFSRID LFHPIQWLSD SFSDLYSSYV IFYFLLLSVV IIIISIFNV EFYAVVPSIP CSRLALIGKI IHPQQLMHSF IHAAMGMVMA WCAAVITQGQ YSFLVVPCTG TNSFGSPAAQ T CLNEYHLF ...String:
MATAVSRPCA GRSRDILWRV LGWRIVASIV WSVLFLPICT TVFIIFSRID LFHPIQWLSD SFSDLYSSYV IFYFLLLSVV IIIISIFNV EFYAVVPSIP CSRLALIGKI IHPQQLMHSF IHAAMGMVMA WCAAVITQGQ YSFLVVPCTG TNSFGSPAAQ T CLNEYHLF FLLTGAFMGY SYSLLYFVNN MNYLPFPIIQ QYKFLRFRRS LLLLVKHSCV ESLFLVRNFC ILYYFLGYIP KA WISTAMN LHIDEQVHRP LDTVSGLLNL SLLYHVWLCG VFLLTTWYVS WILFKIYATE AHVFPVQPPF AEGSDECLPK VLN SNPPPI IKYLALQDLM LLSQYSPSRR QEVFSLSQPG GHPHNWTAIS RECLNLLNGM TQKLILYQEA AATNGRVSSS YPVE PKKLN SPEETAFQTP KSSQMPRPSV PPLVKTSLFS SKLSTPDVVS PFGTPFGSSV MNRMAGIFDV NTCYGSPQSP QLIRR GPRL WTSASDQQMT EFSNPSPSTS ISAEGKTMRQ PSVIYSWIQN KREQIKNFLS KRVLIMYFFS KHPEASIQAV FSDAQM HIW ALEGLSHLVA ASFTEDRFGV VQTTLPAILN TLLTLQEAVD KYFKLPHASS KPPRISGSLV DTSYKTLRFA FRASLKT AI YRITTTFGEH LNAVQASAEH QKRLQQFLEF KE

UniProtKB: Nucleoporin NDC1

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Macromolecule #9: Nucleoporin NUP35

MacromoleculeName: Nucleoporin NUP35 / type: protein_or_peptide / ID: 9 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 34.805664 KDa
SequenceString: MAAFAVEPQG PALGSEPMML GSPTSPKPGV NAQFLPGFLM GDLPAPVTPQ PRSISGPSVG VMEMRSPLLA GGSPPQPVVP AHKDKSGAP PVRSIYDDIS SPGLGSTPLT SRRQPNISVM QSPLVGVTST PGTGQSMFSP ASIGQPRKTT LSPAQLDPFY T QGDSLTSE ...String:
MAAFAVEPQG PALGSEPMML GSPTSPKPGV NAQFLPGFLM GDLPAPVTPQ PRSISGPSVG VMEMRSPLLA GGSPPQPVVP AHKDKSGAP PVRSIYDDIS SPGLGSTPLT SRRQPNISVM QSPLVGVTST PGTGQSMFSP ASIGQPRKTT LSPAQLDPFY T QGDSLTSE DHLDDSWVTV FGFPQASASY ILLQFAQYGN ILKHVMSNTG NWMHIRYQSK LQARKALSKD GRIFGESIMI GV KPCIDKS VMESSDRCAL SSPSLAFTPP IKTLGTPTQP GSTPRISTMR PLATAYKAST SDYQVISDRQ TPKKDESLVS KAM EYMFGW

UniProtKB: Nucleoporin NUP35

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Macromolecule #10: Nucleoporin p54

MacromoleculeName: Nucleoporin p54 / type: protein_or_peptide / ID: 10 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 55.491156 KDa
SequenceString: MAFNFGAPSG TSGTAAATAA PAGGFGGFGT TSTTAGSAFS FSAPTNTGTT GLFGGTQNKG FGFGTGFGTT TGTSTGLGTG LGTGLGFGG FNTQQQQQTT LGGLFSQPTQ APTQSNQLIN TASALSAPTL LGDERDAILA KWNQLQAFWG TGKGYFNNNI P PVEFTQEN ...String:
MAFNFGAPSG TSGTAAATAA PAGGFGGFGT TSTTAGSAFS FSAPTNTGTT GLFGGTQNKG FGFGTGFGTT TGTSTGLGTG LGTGLGFGG FNTQQQQQTT LGGLFSQPTQ APTQSNQLIN TASALSAPTL LGDERDAILA KWNQLQAFWG TGKGYFNNNI P PVEFTQEN PFCRFKAVGY SCMPSNKDED GLVVLVFNKK ETEIRSQQQQ LVESLHKVLG GNQTLTVNVE GTKTLPDDQT EV VIYVVER SPNGTSRRVP ATTLYAHFEQ ANIKTQLQQL GVTLSMTRTE LSPAQIKQLL QNPPAGVDPI IWEQAKVDNP DSE KLIPVP MVGFKELLRR LKVQDQMTKQ HQTRLDIISE DISELQKNQT TSVAKIAQYK RKLMDLSHRT LQVLIKQEIQ RKSG YAIQA DEEQLRVQLD TIQGELNAPT QFKGRLNELM SQIRMQNHFG AVRSEERYYI DADLLREIKQ HLKQQQEGLS HLISI IKDD LEDIKLVEHG LNETIHIRGG VFS

UniProtKB: Nucleoporin p54

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Macromolecule #11: Nucleoporin p58/p45

MacromoleculeName: Nucleoporin p58/p45 / type: protein_or_peptide / ID: 11 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 60.94148 KDa
SequenceString: MSTGFSFGSG TLGSTTVAAG GTSTGGVFSF GTGASSNPSV GLNFGNLGST STPATTSAPS SGFGTGLFGS KPATGFTLGG TNTGIATTI TTGLTLGTPA TTSAATTGFS LGFNKPAASA TPFALPITST SASGLTLSSA LTSTPAASTG FTLNNLGGTT A TTTTASTG ...String:
MSTGFSFGSG TLGSTTVAAG GTSTGGVFSF GTGASSNPSV GLNFGNLGST STPATTSAPS SGFGTGLFGS KPATGFTLGG TNTGIATTI TTGLTLGTPA TTSAATTGFS LGFNKPAASA TPFALPITST SASGLTLSSA LTSTPAASTG FTLNNLGGTT A TTTTASTG LSLGGALAGL GGSLFQSTNT GTSGLGQNAL GLTLGTTAAT STAGNEGLGG IDFSSSSDKK SDKTGTRPED SK ALKDENL PPVICQDVEN LQKFVKEQKQ VQEEISRMSS KAMLKVQEDI KALKQLLSLA ANGIQRNTLN IDKLKIETAQ ELK NAEIAL RTQKTPPGLQ HEYAAPADYF RILVQQFEVQ LQQYRQQIEE LENHLATQAN NSHITPQDLS MAMQKIYQTF VALA AQLQS IHENVKVLKE QYLGYRKMFL GDAVDVFETR RAEAKKWQNT PRVTTGPTPF STMPNAAAVA MAATLTQQQQ PATGP QPSL GVSFGTPFGS GIGTGLQSSG LGSSNLGGFG TSSGFGCSTT GASTFGFGTT NKPSGSLSAG FGSSSTSGFN FSNPGI TAS AGLTFGVSNP ASAGFGTGGQ LLQLKKPPAG NKRGKR

UniProtKB: Nucleoporin p58/p45

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Macromolecule #12: Nuclear pore glycoprotein p62

MacromoleculeName: Nuclear pore glycoprotein p62 / type: protein_or_peptide / ID: 12 / Number of copies: 5 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 53.289574 KDa
SequenceString: MSGFNFGGTG APTGGFTFGT AKTATTTPAT GFSFSTSGTG GFNFGAPFQP ATSTPSTGLF SLATQTPATQ TTGFTFGTAT LASGGTGFS LGIGASKLNL SNTAATPAMA NPSGFGLGSS NLTNAISSTV TSSQGTAPTG FVFGPSTTSV APATTSGGFS F TGGSTAQP ...String:
MSGFNFGGTG APTGGFTFGT AKTATTTPAT GFSFSTSGTG GFNFGAPFQP ATSTPSTGLF SLATQTPATQ TTGFTFGTAT LASGGTGFS LGIGASKLNL SNTAATPAMA NPSGFGLGSS NLTNAISSTV TSSQGTAPTG FVFGPSTTSV APATTSGGFS F TGGSTAQP SGFNIGSAGN SAQPTAPATL PFTPATPAAT TAGATQPAAP TPTATITSTG PSLFASIATA PTSSATTGLS LC TPVTTAG APTAGTQGFS LKAPGAASGT STTTSTAATA TATTTSSSST TGFALNLKPL APAGIPSNTA AAVTAPPGPG AAA GAAASS AMTYAQLESL INKWSLELED QERHFLQQAT QVNAWDRTLI ENGEKITSLH REVEKVKLDQ KRLDQELDFI LSQQ KELED LLSPLEELVK EQSGTIYLQH ADEEREKTYK LAENIDAQLK RMAQDLKDII EHLNTSGAPA DTSDPLQQIC KILNA HMDS LQWIDQNSAL LQRKVEEVTK VCEGRRKEQE RSFRITFD

UniProtKB: Nuclear pore glycoprotein p62

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Macromolecule #13: Nuclear pore complex protein Nup133

MacromoleculeName: Nuclear pore complex protein Nup133 / type: protein_or_peptide / ID: 13 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 129.108461 KDa
SequenceString: MFPAAPSPRT PGTGSRRGPL AGLGPGSTPR TASRKGLPLG SAVSSPVLFS PVGRRSSLSS RGTPTRMFPH HSITESVNYD VKTFGSSLP VKVMEALTLA EVDDQLTINI DEGGWACLVC KEKLIIWKIA LSPITKLSVC KELQLPPSDF HWSADLVALS Y SSPSGEAH ...String:
MFPAAPSPRT PGTGSRRGPL AGLGPGSTPR TASRKGLPLG SAVSSPVLFS PVGRRSSLSS RGTPTRMFPH HSITESVNYD VKTFGSSLP VKVMEALTLA EVDDQLTINI DEGGWACLVC KEKLIIWKIA LSPITKLSVC KELQLPPSDF HWSADLVALS Y SSPSGEAH STQAVAVMVA TREGSIRYWP SLAGEDTYTE AFVDSGGDKT YSFLTAVQGG SFILSSSGSQ LIRLIPESSG KI HQHILPQ GQGMLSGIGR KVSSLFGILS PSSDLTLSSV LWDRERSSFY SLTSSNISKW ELDDSSEKHA YSWDINRALK ENI TDAIWG SESNYEAIKE GVNIRYLDLK QNCDGLVILA AAWHSADNPC LIYYSLITIE DNGCQMSDAV TVEVTQYNPP FQSE DLILC QLTVPNFSNQ TAYLYNESAV YVCSTGTGKF SLPQEKIVFN AQGDSVLGAG ACGGVPIIFS RNSGLVSITS RENVS ILAE DLEGSLASSV AGPNSESMIF ETTTKNETIA QEDKIKLLKA AFLQYCRKDL GHAQMVVDEL FSSHSDLDSD SELDRA VTQ ISVDLMDDYP ASDPRWAESV PEEAPGFSNT SLIILHQLED KMKAHSFLMD FIHQVGLFGR LGSFPVRGTP MATRLLL CE HAEKLSAAIV LKNHHSRLSD LVNTAILIAL NKREYEIPSN LTPADVFFRE VSQVDTICEC LLEHEEQVLR DAPMDSIE W AEVVINVNNI LKDMLQAASH YRQNRNSLYR REESLEKEPE YVPWTATSGP GGIRTVIIRQ HEIVLKVAYP QADSNLRNI VTEQLVALID CFLDGYVSQL KSVDKSSNRE RYDNLEMEYL QKRSDLLSPL LSLGQYLWAA SLAEKYCDFD ILVQMCEQTD NQSRLQRYM TQFADQNFSD FLFRWYLEKG KRGKLLSQPI SQHGQLANFL QAHEHLSWLH EINSQELEKA HATLLGLANM E TRYFAKKK TLLGLSKLAA LASDFSEDML QEKIEEMAEQ ERFLLHQETL PEQLLAEKQL NLSAMPVLTA PQLIGLYICE EN RRANEYD FKKALDLLEY IDEEEDININ DLKLEILCKA LQRDNWSSSD GKDDPIEVSK DSIFVKILQK LLKDGIQLSE YLP EVKDLL QADQLGSLKS NPYFEFVLKA NYEYYVQGQI

UniProtKB: Nuclear pore complex protein Nup133

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Macromolecule #14: Nuclear pore complex protein Nup107

MacromoleculeName: Nuclear pore complex protein Nup107 / type: protein_or_peptide / ID: 14 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 106.504969 KDa
SequenceString: MDRSGFGEIS SPVIREAEVT RTARKQSAQK RVLLQASQDE NFGNTTPRNQ VIPRTPSSFR QPFTPTSRSL LRQPDISCIL GTGGKSPRL TQSSGFFGNL SMVTNLDDSN WAAAFSSQRS GLFTNTEPHS ITEDVTISAV MLREDDPGEA ASMSMFSDFL Q SFLKHSSS ...String:
MDRSGFGEIS SPVIREAEVT RTARKQSAQK RVLLQASQDE NFGNTTPRNQ VIPRTPSSFR QPFTPTSRSL LRQPDISCIL GTGGKSPRL TQSSGFFGNL SMVTNLDDSN WAAAFSSQRS GLFTNTEPHS ITEDVTISAV MLREDDPGEA ASMSMFSDFL Q SFLKHSSS TVFDLVEEYE NICGSQVNIL SKIVSRATPG LQKFSKTASM LWLLQQEMVT WRLLASLYRD RIQSALEEES VF AVTAVNA SEKTVVEALF QRDSLVRQSQ LVVDWLESIA KDEIGEFSDN IEFYAKSVYW ENTLHTLKQR QLTSYVGSVR PLV TELDPD APIRQKMPLD DLDREDEVRL LKYLFTLIRA GMTEEAQRLC KRCGQAWRAA TLEGWKLYHD PNVNGGTELE PVEG NPYRR IWKISCWRMA EDELFNRYER AIYAALSGNL KQLLPVCDTW EDTVWAYFRV MVDSLVEQEI QTSVATLDET EELPR EYLG ANWTLEKVFE ELQATDKKRV LEENQEHYHI VQKFLILGDI DGLMDEFSKW LSKSRNNLPG HLLRFMTHLI LFFRTL GLQ TKEEVSIEVL KTYIQLLIRE KHTNLIAFYT CHLPQDLAVA QYALFLESVT EFEQRHHCLE LAKEADLDVA TITKTVV EN IRKKDNGEFS HHDLAPALDT GTTEEDRLKI DVIDWLVFDP AQRAEALKQG NAIMRKFLAS KKHEAAKEVF VKIPQDSI A EIYNQCEEQG MESPLPAEDD NAIREHLCIR AYLEAHETFN EWFKHMNSVP QKPALIPQPT FTEKVAHEHK EKKYEMDFG IWKGHLDALT ADVKEKMYNV LLFVDGGWMV DVREDAKEDH ERTHQMVLLR KLCLPMLCFL LHTILHSTGQ YQECLQLADM VSSERHKLY LVFSKEELRK LLQKLRESSL MLLDQGLDPL GYEIQL

UniProtKB: Nuclear pore complex protein Nup107

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Macromolecule #15: Nuclear pore complex protein Nup96

MacromoleculeName: Nuclear pore complex protein Nup96 / type: protein_or_peptide / ID: 15 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 106.039656 KDa
SequenceString: SKYGLQDSDE EEEEHPSKTS TKKLKTAPLP PASQTTPLQM ALNGKPAPPP QSQSPEVEQL GRVVELDSDM VDITQEPVLD TMLEESMPE DQEPVSASTH IASSLGINPH VLQIMKASLL TDEEDVDMAL DQRFSRLPSK ADTSQEICSP RLPISASHSS K TRSLVGGL ...String:
SKYGLQDSDE EEEEHPSKTS TKKLKTAPLP PASQTTPLQM ALNGKPAPPP QSQSPEVEQL GRVVELDSDM VDITQEPVLD TMLEESMPE DQEPVSASTH IASSLGINPH VLQIMKASLL TDEEDVDMAL DQRFSRLPSK ADTSQEICSP RLPISASHSS K TRSLVGGL LQSKFTSGAF LSPSVSVQEC RTPRAASLMN IPSTSSWSVP PPLTSVFTMP SPAPEVPLKT VGTRRQLGLV PR EKSVTYG KGKLLMDMAL FMGRSFRVGW GPNWTLANSG EQLNGSHELE NHQIADSMEF GFLPNPVAVK PLTESPFKVH LEK LSLRQR KPDEDMKLYQ TPLELKLKHS TVHVDELCPL IVPNLGVAVI HDYADWVKEA SGDLPEAQIV KHWSLTWTLC EALW GHLKE LDSQLNEPRE YIQILERRRA FSRWLSCTAT PQIEEEVSLT QKNSPVEAVF SYLTGKRISE ACSLAQQSGD HRLAL LLSQ FVGSQSVREL LTMQLVDWHQ LQADSFIQDE RLRIFALLAG KPVWQLSEKK QINVCSQLDW KRSLAIHLWY LLPPTA SIS RALSMYEEAF QNTSDSDRYA CSPLPSYLEG SGCVIAEEQN SQTPLRDVCF HLLKLYSDRH YDLNQLLEPR SITADPL DY RLSWHLWEVL RALNYTHLSA QCEGVLQASY AGQLESEGLW EWAIFVLLHI DNSGIREKAV RELLTRHCQL LETPESWA K ETFLTQKLRV PAKWIHEAKA VRAHMESDKH LEALCLFKAE HWNRCHKLII RHLASDAIIN ENYDYLKGFL EDLAPPERS SLIQDWETSG LVYLDYIRVI EMLRHIQQVD CSGNDLEQLH IKVTSLCSRI EQIQCYSAKD RLAQSDMAKR VANLLRVVLS LHHPPDRTS DSTPDPQRVP LRLLAPHIGR LPMPEDYAMD ELRSLTQSYL RELAVGSL

UniProtKB: Nuclear pore complex protein Nup98-Nup96

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Macromolecule #16: Protein SEC13 homolog

MacromoleculeName: Protein SEC13 homolog / type: protein_or_peptide / ID: 16 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 35.578438 KDa
SequenceString: MVSVINTVDT SHEDMIHDAQ MDYYGTRLAT CSSDRSVKIF DVRNGGQILI ADLRGHEGPV WQVAWAHPMY GNILASCSYD RKVIIWREE NGTWEKSHEH AGHDSSVNSV CWAPHDYGLI LACGSSDGAI SLLTYTGEGQ WEVKKINNAH TIGCNAVSWA P AVVPGSLI ...String:
MVSVINTVDT SHEDMIHDAQ MDYYGTRLAT CSSDRSVKIF DVRNGGQILI ADLRGHEGPV WQVAWAHPMY GNILASCSYD RKVIIWREE NGTWEKSHEH AGHDSSVNSV CWAPHDYGLI LACGSSDGAI SLLTYTGEGQ WEVKKINNAH TIGCNAVSWA P AVVPGSLI DHPSGQKPNY IKRFASGGCD NLIKLWKEEE DGQWKEEQKL EAHSDWVRDV AWAPSIGLPT STIASCSQDG RV FIWTCDD ASSNTWSPKL LHKFNDVVWH VSWSITANIL AVSGGDNKVT LWKESVDGQW VCISDVNKGQ GSVSASVTEG QQN EQ

UniProtKB: Protein SEC13 homolog

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Macromolecule #17: Nucleoporin SEH1

MacromoleculeName: Nucleoporin SEH1 / type: protein_or_peptide / ID: 17 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 39.700566 KDa
SequenceString: MFVARSIAAD HKDLIHDVSF DFHGRRMATC SSDQSVKVWD KSESGDWHCT ASWKTHSGSV WRVTWAHPEF GQVLASCSFD RTAAVWEEI VGESNDKLRG QSHWVKRTTL VDSRTSVTDV KFAPKHMGLM LATCSADGIV RIYEAPDVMN LSQWSLQHEI S CKLSCSCI ...String:
MFVARSIAAD HKDLIHDVSF DFHGRRMATC SSDQSVKVWD KSESGDWHCT ASWKTHSGSV WRVTWAHPEF GQVLASCSFD RTAAVWEEI VGESNDKLRG QSHWVKRTTL VDSRTSVTDV KFAPKHMGLM LATCSADGIV RIYEAPDVMN LSQWSLQHEI S CKLSCSCI SWNPSSSRAH SPMIAVGSDD SSPNAMAKVQ IFEYNENTRK YAKAETLMTV TDPVHDIAFA PNLGRSFHIL AI ATKDVRI FTLKPVRKEL TSSGGPTKFE IHIVAQFDNH NSQVWRVSWN ITGTVLASSG DDGCVRLWKA NYMDNWKCTG ILK GNGSPV NGSSQQGTSN PSLGSTIPSL QNSLNGSSAG RKHS

UniProtKB: Nucleoporin SEH1

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Macromolecule #18: Nuclear pore complex protein Nup85

MacromoleculeName: Nuclear pore complex protein Nup85 / type: protein_or_peptide / ID: 18 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 75.105266 KDa
SequenceString: MEELDGEPTV TLIPGVNSKK NQMYFDWGPG EMLVCETSFN KKEKSEMVPS CPFIYIIRKD VDVYSQILRK LFNESHGIFL GLQRIDEEL TGKSRKSQLV RVSKNYRSVI RACMEEMHQV AIAAKDPANG RQFSSQVSIL SAMELIWNLC EILFIEVAPA G PLLLHLLD ...String:
MEELDGEPTV TLIPGVNSKK NQMYFDWGPG EMLVCETSFN KKEKSEMVPS CPFIYIIRKD VDVYSQILRK LFNESHGIFL GLQRIDEEL TGKSRKSQLV RVSKNYRSVI RACMEEMHQV AIAAKDPANG RQFSSQVSIL SAMELIWNLC EILFIEVAPA G PLLLHLLD WVRLHVCEVD SLSADVLGSE NPSKHDSFWN LVTILVLQGR LDEARQMLSK EADASPASAG ICRIMGDLMR TM PILSPGN TQTLTELELK WQHWHEECER YLQDSTFATS PHLESLLKIM LGDEAALLEQ KELLSNWYHF LVTRLLYSNP TVK PIDLHY YAQSSLDLFL GGESSPEPLD NILLAAFEFD IHQVIKECSI ALSNWWFVAH LTDLLDHCKL LQSHNLYFGS NMRE FLLLE YASGLFAHPS LWQLGVDYFD YCPELGRVSL ELHIERIPLN TEQKALKVLR ICEQRQMTEQ VRSICKILAM KAVRN NRLG SALSWSIRAK DAAFATLVSD RFLRDYCERG CFSDLDLIDN LGPAMMLSDR LTFLGKYREF HRMYGEKRFA DAASLL LSL MTSRIAPRSF WMTLLTDALP LLEQKQVIFS AEQTYELMRC LEDLTSRRPV HGESDTEQLQ DDDIETTKVE MLRLSLA RN LARAIIREGS LEGS

UniProtKB: Nuclear pore complex protein Nup85

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Macromolecule #19: Nucleoporin Nup43

MacromoleculeName: Nucleoporin Nup43 / type: protein_or_peptide / ID: 19 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 42.195652 KDa
SequenceString: MEEIYAKFVS QKISKTRWRP LPPGSLQTAE TFATGSWDNE ENYISLWSIG DFGNLDSDGG FEGDHQLLCD IRHHGDVMDL QFFDQERIV AASSTGCVTV FLHHPNNQTL SVNQQWTTAH YHTGPGSPSY SSAPCTGVVC NNPEIVTVGE DGRINLFRAD H KEAVRTID ...String:
MEEIYAKFVS QKISKTRWRP LPPGSLQTAE TFATGSWDNE ENYISLWSIG DFGNLDSDGG FEGDHQLLCD IRHHGDVMDL QFFDQERIV AASSTGCVTV FLHHPNNQTL SVNQQWTTAH YHTGPGSPSY SSAPCTGVVC NNPEIVTVGE DGRINLFRAD H KEAVRTID NADSSTLHAV TFLRTPEILT VNSIGQLKIW DFRQQGNEPS QILSLTGDRV PLHCVDRHPN QQHVVATGGQ DG MLSIWDV RQGTMPVSLL KAHEAEMWEV HFHPSNPEHL FTCSEDGSLW HWDASTDVPE KSSLFHQGGR SSTFLSHSIS NQA NVHQSV ISSWLSTDPA KDRIEITSLL PSRSLSVNTL DVLGPCLVCG TDAEAIYVTR HLFS

UniProtKB: Nucleoporin Nup43

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Macromolecule #20: Nuclear pore complex protein Nup160

MacromoleculeName: Nuclear pore complex protein Nup160 / type: protein_or_peptide / ID: 20 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 162.280203 KDa
SequenceString: MLHLSAAPPA PPPEVTATAR PCLCSVGRRG DGGKMAAAGA LERSFVELSG AERERPRHFR EFTVCSIGTA NAVAGAVKYS ESAGGFYYV ESGKLFSVTR NRFIHWKTSG DTLELMEESL DINLLNNAIR LKFQNCSVLP GGVYVSETQN RVIILMLTNQ T VHRLLLPH ...String:
MLHLSAAPPA PPPEVTATAR PCLCSVGRRG DGGKMAAAGA LERSFVELSG AERERPRHFR EFTVCSIGTA NAVAGAVKYS ESAGGFYYV ESGKLFSVTR NRFIHWKTSG DTLELMEESL DINLLNNAIR LKFQNCSVLP GGVYVSETQN RVIILMLTNQ T VHRLLLPH PSRMYRSELV VDSQMQSIFT DIGKVDFTDP CNYQLIPAVP GISPNSTAST AWLSSDGEAL FALPCASGGI FV LKLPPYD IPGMVSVVEL KQSSVMQRLL TGWMPTAIRG DQSPSDRPLS LAVHCVEHDA FIFALCQDHK LRMWSYKEQM CLM VADMLE YVPVKKDLRL TAGTGHKLRL AYSPTMGLYL GIYMHAPKRG QFCIFQLVST ESNRYSLDHI SSLFTSQETL IDFA LTSTD IWALWHDAEN QTVVKYINFE HNVAGQWNPV FMQPLPEEEI VIRDDQDPRE MYLQSLFTPG QFTNEALCKA LQIFC RGTE RNLDLSWSEL KKEVTLAVEN ELQGSVTEYE FSQEEFRNLQ QEFWCKFYAC CLQYQEALSH PLALHLNPHT NMVCLL KKG YLSFLIPSSL VDHLYLLPYE NLLTEDETTI SDDVDIARDV ICLIKCLRLI EESVTVDMSV IMEMSCYNLQ SPEKAAE QI LEDMITIDVE NVMEDICSKL QEIRNPIHAI GLLIREMDYE TEVEMEKGFN PAQPLNIRMN LTQLYGSNTA GYIVCRGV H KIASTRFLIC RDLLILQQLL MRLGDAVIWG TGQLFQAQQD LLHRTAPLLL SYYLIKWGSE CLATDVPLDT LESNLQHLS VLELTDSGAL MANRFVSSPQ TIVELFFQEV ARKHIISHLF SQPKAPLSQT GLNWPEMITA ITSYLLQLLW PSNPGCLFLE CLMGNCQYV QLQDYIQLLH PWCQVNVGSC RFMLGRCYLV TGEGQKALEC FCQAASEVGK EEFLDRLIRS EDGEIVSTPR L QYYDKVLR LLDVIGLPEL VIQLATSAIT EAGDDWKSQA TLRTCIFKHH LDLGHNSQAY EALTQIPDSS RQLDCLRQLV VV LCERSQL QDLVEFPYVN LHNEVVGIIE SRARAVDLMT HNYYELLYAF HIYRHNYRKA GTVMFEYGMR LGREVRTLRG LEK QGNCYL AALNCLRLIR PEYAWIVQPV SGAVYDRPGA SPKRNHDGEC TAAPTNRQIE ILELEDLEKE CSLARIRLTL AQHD PSAVA VAGSSSAEEM VTLLVQAGLF DTAISLCQTF KLPLTPVFEG LAFKCIKLQF GGEAAQAEAW AWLAANQLSS VITTK ESSA TDEAWRLLST YLERYKVQNN LYHHCVINKL LSHGVPLPNW LINSYKKVDA AELLRLYLNY DLLEEAVDLV SEYVDA VLG KGHQYFGIEF PLSATAPMVW LPYSSIDQLL QALGENSANS HNIALSQKIL DKLEDYQQKV DKATRDLLYR RTL

UniProtKB: Nuclear pore complex protein Nup160

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Macromolecule #21: Nucleoporin Nup37

MacromoleculeName: Nucleoporin Nup37 / type: protein_or_peptide / ID: 21 / Number of copies: 4 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 36.748512 KDa
SequenceString: MKQDASRNAA YTVDCEDYVH VVEFNPFENG DSGNLIAYGG NNYVVIGTCT FQEEEADVEG IQYKTLRTFH HGVRVDGIAW SPETRLDSL PPVIKFCTSA ADMKIRLFTS DLQDKNEYKV LEGHTDFING LVFDPKEGQE IASVSDDHTC RIWNLEGVQT A HFVLHSPG ...String:
MKQDASRNAA YTVDCEDYVH VVEFNPFENG DSGNLIAYGG NNYVVIGTCT FQEEEADVEG IQYKTLRTFH HGVRVDGIAW SPETRLDSL PPVIKFCTSA ADMKIRLFTS DLQDKNEYKV LEGHTDFING LVFDPKEGQE IASVSDDHTC RIWNLEGVQT A HFVLHSPG MSVCWHPEET FKLMVAEKNG TIRFYDLLAQ QAILSLESEQ VPLMSAHWCL KNTFKVGAVA GNDWLIWDIT RS SYPQNKR PVHMDRACLF RWSTISENLF ATTGYPGKMA SQFQIHHLGH PQPILMGSVA VGSGLSWHRT LPLCVIGGDH KLL FWVTEV

UniProtKB: Nucleoporin Nup37

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Macromolecule #22: Protein ELYS

MacromoleculeName: Protein ELYS / type: protein_or_peptide / ID: 22 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 252.807984 KDa
SequenceString: MRDLRAQVTS GLLPFPEVTL QALGEDEITL ESVLRGKFAA GKNGLACLAC GPQLEVVNSI TGERLSAYRF SGVNEQPPVV LAVKEFSWQ KRTGLLIGLE ETEGSVLCLY DLGISKVVKA VVLPGRVTAI EPIINHGGAS ASTQHLHPSL RWLFGVAAVV T DVGQILLV ...String:
MRDLRAQVTS GLLPFPEVTL QALGEDEITL ESVLRGKFAA GKNGLACLAC GPQLEVVNSI TGERLSAYRF SGVNEQPPVV LAVKEFSWQ KRTGLLIGLE ETEGSVLCLY DLGISKVVKA VVLPGRVTAI EPIINHGGAS ASTQHLHPSL RWLFGVAAVV T DVGQILLV DLCLDDLSCN QNEVEASDLE VLTGIPAEVP HIRESVMRQG RHLCFQLVSP TGTAVSTLSY ISRTNQLAVG FS DGYLALW NMKSMKREYY IQLESGQVPV YAVTFQEPEN DPRNCCYLWA VQSTQDSEGD VLSLHLLQLA FGNRKCLASG QIL YEGLEY CEERYTLDLT GGMFPLRGQT SNTKLLGCQS IEKFRSHGDR EEGVNEALSP DTSVSVFTWQ VNIYGQGKPS VYLG LFDIN RWYHAQMPDS LRSGEYLHNC SYFALWSLES VVSRTSPHGI LDILVHERSL NRGVPPSYPP PEQFFNPSTY NFDAT CLLN SGVVHLTCTG FQKETLTFLK KSGPSLNELI PDGYNRCLVA GLLSPRFVDV QPSSLSQEEQ LEAILSAAIQ TSSLGL LTG YIRRWITEEQ PNSATNLRFV LEWTWNKVVL TKEEFDRLCV PLFDGSCHFM DPQTIQSIQQ CYLLLSNLNI VLSCFAS EA REITERGLID LSNKFVVSHL ICQYAQVVLW FSHSGLLPEG IDDSVQLSRL CYNYPVIQNY YTSRRQKFER LSRGKWNP D CLMIDGLVSQ LGERIEKLWK RDEGGTGKYP PASLHAVLDM YLLDGVTEAA KHSITIYLLL DIMYSFPNKT DTPIESFPT VFAISWGQVK LIQGFWLIDH NDYESGLDLL FHPATAKPLS WQHSKIIQAF MSQGEHRQAL RYIQTMKPTV SSGNDVILHL TVLLFNRCM VEAWNFLRQH CNRLNIEELL KHMYEVCQEM GLMEDLLKLP FTDTEQECLV KFLQSSASVQ NHEFLLVHHL Q RANYVPAL KLNQTLKINV MNDRDPRLRE RSLARNSILD QYGKILPRVH RKLAIERAKP YHLSTSSVFR LVSRPKPLSA VP KQVVTGT VLTRSVFINN VLSKIGEVWA SKEPINSTTP FNSSKIEEPS PIVYSLPAPE LPEAFFGTPI SKASQKISRL LDL VVQPVP RPSQCSEFIQ QSSMKSPLYL VSRSLPSSSQ LKGSPQAISR ASELHLLETP LVVKKAKSLA MSVTTSGFSE FTPQ SILRS TLRSTPLASP SPSPGRSPQR LKETRISFVE EDVHPKWIPG AADDSKLEVF TTPKKCAVPV ETEWLKSKDR TTSFF LNSP EKEHQEMDEG SQSLEKLDVS KGNSSVSITS DETTLEYQDA PSPEDLEETV FTASKPKSSS TALTTNVTEQ TEKDGD KDV FASEVTPSDL QKQMGNLEDA ETKDLLVAAE AFSELNHLSP VQGTEASLCA PSVYEGKIFT QKSKVPVLDE GLTSVET YT PAIRANDNKS MADVLGDGGN SSLTISEGPI VSERRLNQEV ALNLKEDHEV EVGVLKESVD LPEEKLPISD SPPDTQEI H VIEQEKLEAQ DSGEEARNLS FNELYPSGTL KLQYNFDTID QQFCDLADNK DTAECDIAEV DGELFVAQSN FTLILEGEE GEVEPGDFAS SDVLPKAANT ATEEKLVCSG ENDNHGQIAN LPSAVTSDQK SQKVDTLPYV PEPIKVAIAE NLLDVIKDTR SKEITSDTM EQSIHETIPL VSQNIMCPTK LVKSAFKTAQ ETSTMTMNVS QVDDVVSSKT RTRGQRIQNV NVKSAQQEAS A DVATPKMP GQSVRKKTRK AKEISEASEN IYSDVRGLSQ NQQIPQNSVT PRRGRRKKEV NQDILENTSS VEQELQITTG RE SKRLKSS QLLEPAVEET TKKEVKVSSV TKRTPRRIKR SVENQESVEI INDLKVSTVT SPSRMIRKLR STNLDASENT GNK QDDKSS DKQLRIKHVR RVRGREVSPS DVREDSNLES SQLTVQAEFD MSAIPRKRGR PRKINPSEDV GSKAVKEERS PKKK EAPSI RRRSTRNTPA KSENVDVGKP ALGKSILVPN EELSMVMSSK KKLTKKTESQ SQKRSLHSVS EERTDEMTHK ETNEQ EERL LATASFTKSS RSSRTRSSKA ILLPDLSEPN NEPLFSPASE VPRKAKAKKI EVPAQLKELV SDLSSQFVIS PPALRS RQK NTSNKNKLED ELKDDAQSVE TLGKPKAKRI RTSKTKQASK NTEKESAWSP PPIEIRLISP LASPADGVKS KPRKTTE VT GTGLGRNRKK LSSYPKQILR RKML

UniProtKB: Protein ELYS

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Macromolecule #23: Nuclear pore complex protein Nup98

MacromoleculeName: Nuclear pore complex protein Nup98 / type: protein_or_peptide / ID: 23 / Number of copies: 7 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 91.760117 KDa
SequenceString: MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG GLFGTSSFSQ PATSTSTGFG FGTSTGTAN TLFGTASTGT SLFSSQNNAF AQNKPTGFGN FGTSTSSGGL FGTTNTTSNP FGSTSGSLFG PSSFTAAPTG T TIKFNPPT ...String:
MFNKSFGTPF GGGTGGFGTT STFGQNTGFG TTSGGAFGTS AFGSSNNTGG LFGNSQTKPG GLFGTSSFSQ PATSTSTGFG FGTSTGTAN TLFGTASTGT SLFSSQNNAF AQNKPTGFGN FGTSTSSGGL FGTTNTTSNP FGSTSGSLFG PSSFTAAPTG T TIKFNPPT GTDTMVKAGV STNISTKHQC ITAMKEYESK SLEELRLEDY QANRKGPQNQ VGAGTTTGLF GSSPATSSAT GL FSSSTTN SGFAYGQNKT AFGTSTTGFG TNPGGLFGQQ NQQTTSLFSK PFGQATTTQN TGFSFGNTST IGQPSTNTMG LFG VTQASQ PGGLFGTATN TSTGTAFGTG TGLFGQTNTG FGAVGSTLFG NNKLTTFGSS TTSAPSFGTT SGGLFGNKPT LTLG TNTNT SNFGFGTNTS GNSIFGSKPA PGTLGTGLGA GFGTALGAGQ ASLFGNNQPK IGGPLGTGAF GAPGFNTTTA TLGFG APQA PVALTDPNAS AAQQAVLQQH INSLTYSPFG DSPLFRNPMS DPKKKEERLK PTNPAAQKAL TTPTHYKLTP RPATRV RPK ALQTTGTAKS HLFDGLDDDE PSLANGAFMP KKSIKKLVLK NLNNSNLFSP VNRDSENLAS PSEYPENGER FSFLSKP VD ENHQQDGDED SLVSHFYTNP IAKPIPQTPE SAGNKHSNSN SVDDTIVALN MRAALRNGLE GSSEETSFHD ESLQDDRE E IENNSYHMHP AGIILTKVGY YTIPSMDDLA KITNEKGECI VSDFTIGRKG YGSIYFEGDV NLTNLNLDDI VHIRRKEVV VYLDDNQKPP VGEGLNRKAE VTLDGVWPTD KTSRCLIKSP DRLADINYEG RLEAVSRKQG AQFKEYRPET GSWVFKVSHF

UniProtKB: Nuclear pore complex protein Nup98-Nup96

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Macromolecule #24: Nuclear pore complex protein Nup214

MacromoleculeName: Nuclear pore complex protein Nup214 / type: protein_or_peptide / ID: 24 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 213.784828 KDa
SequenceString: MGDEMDAMIP EREMKDFQFR ALKKVRIFDS PEELPKERSS LLAVSNKYGL VFAGGASGLQ IFPTKNLLIQ NKPGDDPNKI VDKVQGLLV PMKFPIHHLA LSCDNLTLSA CMMSSEYGSI IAFFDVRTFS NEAKQQKRPF AYHKLLKDAG GMVIDMKWNP T VPSMVAVC ...String:
MGDEMDAMIP EREMKDFQFR ALKKVRIFDS PEELPKERSS LLAVSNKYGL VFAGGASGLQ IFPTKNLLIQ NKPGDDPNKI VDKVQGLLV PMKFPIHHLA LSCDNLTLSA CMMSSEYGSI IAFFDVRTFS NEAKQQKRPF AYHKLLKDAG GMVIDMKWNP T VPSMVAVC LADGSIAVLQ VTETVKVCAT LPSTVAVTSV CWSPKGKQLA VGKQNGTVVQ YLPTLQEKKV IPCPPFYESD HP VRVLDVL WIGTYVFAIV YAAADGTLET SPDVVMALLP KKEEKHPEIF VNFMEPCYGS CTERQHHYYL SYIEEWDLVL AAS AASTEV SILARQSDQI NWESWLLEDS SRAELPVTDK SDDSLPMGVV VDYTNQVEIT ISDEKTLPPA PVLMLLSTDG VLCP FYMIN QNPGVKSLIK TPERLSLEGE RQPKSPGSTP TTPTSSQAPQ KLDASAAAAP ASLPPSSPAA PIATFSLLPA GGAPT VFSF GSSSLKSSAT VTGEPPSYSS GSDSSKAAPG PGPSTFSFVP PSKASLAPTP AASPVAPSAA SFSFGSSGFK PTLEST PVP SVSAPNIAMK PSFPPSTSAV KVNLSEKFTA AATSTPVSSS QSAPPMSPFS SASKPAASGP LSHPTPLSAP PSSVPLK SS VLPSPSGRSA QGSSSPVPSM VQKSPRITPP AAKPGSPQAK SLQPAVAEKQ GHQWKDSDPV MAGIGEEIAH FQKELEEL K ARTSKACFQV GTSEEMKMLR TESDDLHTFL LEIKETTESL HGDISSLKTT LLEGFAGVEE AREQNERNRD SGYLHLLYK RPLDPKSEAQ LQEIRRLHQY VKFAVQDVND VLDLEWDQHL EQKKKQRHLL VPERETLFNT LANNREIINQ QRKRLNHLVD SLQQLRLYK QTSLWSLSSA VPSQSSIHSF DSDLESLCNA LLKTTIESHT KSLPKVPAKL SPMKQAQLRN FLAKRKTPPV R STAPASLS RSAFLSQRYY EDLDEVSSTS SVSQSLESED ARTSCKDDEA VVQAPRHAPV VRTPSIQPSL LPHAAPFAKS HL VHGSSPG VMGTSVATSA SKIIPQGADS TMLATKTVKH GAPSPSHPIS APQAAAAAAL RRQMASQAPA VNTLTESTLK NVP QVVNVQ ELKNNPATPS TAMGSSVPYS TAKTPHPVLT PVAANQAKQG SLINSLKPSG PTPASGQLSS GDKASGTAKI ETAV TSTPS ASGQFSKPFS FSPSGTGFNF GIITPTPSSN FTAAQGATPS TKESSQPDAF SSGGGSKPSY EAIPESSPPS GITSA SNTT PGEPAASSSR PVAPSGTALS TTSSKLETPP SKLGELLFPS SLAGETLGSF SGLRVGQADD STKPTNKASS TSLTST QPT KTSGVPSGFN FTAPPVLGKH TEPPVTSSAT TTSVAPPAAT STSSTAVFGS LPVTSAGSSG VISFGGTSLS AGKTSFS FG SQQTNSTVPP SAPPPTTAAT PLPTSFPTLS FGSLLSSATT PSLPMSAGRS TEEATSSALP EKPGDSEVSA SAASLLEE Q QSAQLPQAPP QTSDSVKKEP VLAQPAVSNS GTAASSTSLV ALSAEATPAT TGVPDARTEA VPPASSFSVP GQTAVTAAA ISSAGPVAVE TSSTPIASST TSIVAPGPSA EAAAFGTVTS GSSVFAQPPA ASSSSAFNQL TNNTATAPSA TPVFGQVAAS TAPSLFGQQ TGSTASTAAA TPQVSSSGFS SPAFGTTAPG VFGQTTFGQA SVFGQSASSA ASVFSFSQPG FSSVPAFGQP A SSTPTSTS GSVFGAASST SSSSSFSFGQ SSPNTGGGLF GQSNAPAFGQ SPGFGQGGSV FGGTSAATTT AATSGFSFCQ AS GFGSSNT GSVFGQAAST GGIVFGQQSS SSSGSVFGSG NTGRGGGFFS GLGGKPSQDA ANKNPFSSAS GGFGSTATSN TSN LFGNSG AKTFGGFASS SFGEQKPTGT FSSGGGSVAS QGFGFSSPNK TGGFGAAPVF GSPPTFGGSP GFGGVPAFGS APAF TSPLG STGGKVFGEG TAAASAGGFG FGSSSNTTSF GTLASQNAPT FGSLSQQTSG FGTQSSGFSG FGSGTGGFSF GSNNS SVQG FGGWRS

UniProtKB: Nuclear pore complex protein Nup214

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Macromolecule #25: Nuclear pore complex protein Nup88

MacromoleculeName: Nuclear pore complex protein Nup88 / type: protein_or_peptide / ID: 25 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Homo sapiens (human)
Molecular weightTheoretical: 83.644711 KDa
SequenceString: MAAAEGPVGD GELWQTWLPN HVVFLRLREG LKNQSPTEAE KPASSSLPSS PPPQLLTRNV VFGLGGELFL WDGEDSSFLV VRLRGPSGG GEEPALSQYQ RLLCINPPLF EIYQVLLSPT QHHVALIGIK GLMVLELPKR WGKNSEFEGG KSTVNCSTTP V AERFFTSS ...String:
MAAAEGPVGD GELWQTWLPN HVVFLRLREG LKNQSPTEAE KPASSSLPSS PPPQLLTRNV VFGLGGELFL WDGEDSSFLV VRLRGPSGG GEEPALSQYQ RLLCINPPLF EIYQVLLSPT QHHVALIGIK GLMVLELPKR WGKNSEFEGG KSTVNCSTTP V AERFFTSS TSLTLKHAAW YPSEILDPHV VLLTSDNVIR IYSLREPQTP TNVIILSEAE EESLVLNKGR AYTASLGETA VA FDFGPLA AVPKTLFGQN GKDEVVAYPL YILYENGETF LTYISLLHSP GNIGKLLGPL PMHPAAEDNY GYDACAVLCL PCV PNILVI ATESGMLYHC VVLEGEEEDD HTSEKSWDSR IDLIPSLYVF ECVELELALK LASGEDDPFD SDFSCPVKLH RDPK CPSRY HCTHEAGVHS VGLTWIHKLH KFLGSDEEDK DSLQELSTEQ KCFVEHILCT KPLPCRQPAP IRGFWIVPDI LGPTM ICIT STYECLIWPL LSTVHPASPP LLCTREDVEV AESPLRVLAE TPDSFEKHIR SILQRSVANP AFLKASEKDI APPPEE CLQ LLSRATQVFR EQYILKQDLA KEEIQRRVKL LCDQKKKQLE DLSYCREERK SLREMAERLA DKYEEAKEKQ EDIMNRM KK LLHSFHSELP VLSDSERDMK KELQLIPDQL RHLGNAIKQV TMKKDYQQQK MEKVLSLPKP TIILSAYQRK CIQSILKE E GEHIREMVKQ INDIRNHVNF

UniProtKB: Nuclear pore complex protein Nup88

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Experimental details

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Structure determination

Methodcryo EM
Processingsubtomogram averaging
Aggregation statecell

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Sample preparation

BufferpH: 7.5
VitrificationCryogen name: ETHANE / Instrument: LEICA EM GP

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Electron microscopy

MicroscopeTFS KRIOS
Image recordingFilm or detector model: GATAN K2 QUANTUM (4k x 4k) / Average electron dose: 2.93 e/Å2
Electron beamAcceleration voltage: 300 kV / Electron source: FIELD EMISSION GUN
Electron opticsC2 aperture diameter: 70.0 µm / Illumination mode: OTHER / Imaging mode: BRIGHT FIELD / Cs: 2.7 mm / Nominal defocus max: 4.0 µm / Nominal defocus min: 2.0 µm
Experimental equipment
Model: Titan Krios / Image courtesy: FEI Company

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Image processing

Final reconstructionApplied symmetry - Point group: C1 (asymmetric) / Resolution.type: BY AUTHOR / Resolution: 12.0 Å / Resolution method: FSC 0.143 CUT-OFF / Number subtomograms used: 7711
ExtractionNumber tomograms: 554 / Number images used: 7711
Final angle assignmentType: OTHER

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