- EMDB-11947: Axonemal 96nm-repeat from active sperm flagella of glycylation de... -
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データベース: EMDB / ID: EMD-11947
タイトル
Axonemal 96nm-repeat from active sperm flagella of glycylation deficient mouse (Ttll3-/-Ttll8-/- mutation). Reconstruction obtained with cryo-ET and sub-tomogram averaging.
マップデータ
Axonemal 96nm-repeat from active sperm flagella of glycylation deficient mouse (Ttll3%u2011/%u2011Ttll8%u2011/%u2011 mutation). Reconstruction obtained with cryo-ET and sub-tomogram averaging.
ジャーナル: Science / 年: 2021 タイトル: Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility. 著者: Sudarshan Gadadhar / Gonzalo Alvarez Viar / Jan Niklas Hansen / An Gong / Aleksandr Kostarev / Côme Ialy-Radio / Sophie Leboucher / Marjorie Whitfield / Ahmed Ziyyat / Aminata Touré / Luis ...著者: Sudarshan Gadadhar / Gonzalo Alvarez Viar / Jan Niklas Hansen / An Gong / Aleksandr Kostarev / Côme Ialy-Radio / Sophie Leboucher / Marjorie Whitfield / Ahmed Ziyyat / Aminata Touré / Luis Alvarez / Gaia Pigino / Carsten Janke / 要旨: Posttranslational modifications of the microtubule cytoskeleton have emerged as key regulators of cellular functions, and their perturbations have been linked to a growing number of human pathologies. ...Posttranslational modifications of the microtubule cytoskeleton have emerged as key regulators of cellular functions, and their perturbations have been linked to a growing number of human pathologies. Tubulin glycylation modifies microtubules specifically in cilia and flagella, but its functional and mechanistic roles remain unclear. In this study, we generated a mouse model entirely lacking tubulin glycylation. Male mice were subfertile owing to aberrant beat patterns of their sperm flagella, which impeded the straight swimming of sperm cells. Using cryo-electron tomography, we showed that lack of glycylation caused abnormal conformations of the dynein arms within sperm axonemes, providing the structural basis for the observed dysfunction. Our findings reveal the importance of microtubule glycylation for controlled flagellar beating, directional sperm swimming, and male fertility.
ダウンロード / ファイル: emd_11947.map.gz / 形式: CCP4 / 大きさ: 3.9 MB / タイプ: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
注釈
Axonemal 96nm-repeat from active sperm flagella of glycylation deficient mouse (Ttll3%u2011/%u2011Ttll8%u2011/%u2011 mutation). Reconstruction obtained with cryo-ET and sub-tomogram averaging.