Protein of unknown function DUF5762 / Protein of unknown function DUF5761 / Domain of unknown function DUF5899 / : / Minor capsid protein P8 central region / Minor capsid protein P9 transmembrane helices / Minor capsid protein P2, DUF5899 / Minor capsid protein P11, C-terminal conserved region / Major capsid protein, N-terminal / Major capsid protein N-terminus ...Protein of unknown function DUF5762 / Protein of unknown function DUF5761 / Domain of unknown function DUF5899 / : / Minor capsid protein P8 central region / Minor capsid protein P9 transmembrane helices / Minor capsid protein P2, DUF5899 / Minor capsid protein P11, C-terminal conserved region / Major capsid protein, N-terminal / Major capsid protein N-terminus / Major capsid protein, C-terminal / Major capsid protein, C-terminal domain superfamily / Large eukaryotic DNA virus major capsid protein / Group II dsDNA virus coat/capsid protein 類似検索 - ドメイン・相同性
Minor capsid protein P4 / Minor capsid protein P8 / Major capsid protein / Minor capsid protein P12 / Minor capsid protein P6 / Minor capsid protein P7 / Penton capsid protein P1 / Minor capsid protein P2 / Minor capsid protein P11 / Minor capsid protein P9 ...Minor capsid protein P4 / Minor capsid protein P8 / Major capsid protein / Minor capsid protein P12 / Minor capsid protein P6 / Minor capsid protein P7 / Penton capsid protein P1 / Minor capsid protein P2 / Minor capsid protein P11 / Minor capsid protein P9 / Minor capsid protein P13 / Minor capsid protein P10 / Minor capsid protein P14 / Minor capsid protein 3 / Minor capsid protein P5 類似検索 - 構成要素
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)
AI011219
米国
引用
ジャーナル: Nat Commun / 年: 2019 タイトル: Near-atomic structure of a giant virus. 著者: Qianglin Fang / Dongjie Zhu / Irina Agarkova / Jagat Adhikari / Thomas Klose / Yue Liu / Zhenguo Chen / Yingyuan Sun / Michael L Gross / James L Van Etten / Xinzheng Zhang / Michael G Rossmann / 要旨: Although the nucleocytoplasmic large DNA viruses (NCLDVs) are one of the largest group of viruses that infect many eukaryotic hosts, the near-atomic resolution structures of these viruses have ...Although the nucleocytoplasmic large DNA viruses (NCLDVs) are one of the largest group of viruses that infect many eukaryotic hosts, the near-atomic resolution structures of these viruses have remained unknown. Here we describe a 3.5 Å resolution icosahedrally averaged capsid structure of Paramecium bursaria chlorella virus 1 (PBCV-1). This structure consists of 5040 copies of the major capsid protein, 60 copies of the penton protein and 1800 minor capsid proteins of which there are 13 different types. The minor capsid proteins form a hexagonal network below the outer capsid shell, stabilizing the capsid by binding neighboring capsomers together. The size of the viral capsid is determined by a tape-measure, minor capsid protein of which there are 60 copies in the virion. Homologs of the tape-measure protein and some of the other minor capsid proteins exist in other NCLDVs. Thus, a similar capsid assembly pathway might be used by other NCLDVs.