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基本情報
登録情報 | ![]() |
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![]() | Mixed lineage leukemia protein-1 complex, MLL1-WDR5-ASH2L-RBBP5(2-480)
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機能・相同性 | ![]() protein-cysteine methyltransferase activity / response to potassium ion / [histone H3]-lysine4 N-methyltransferase / histone H3K4 monomethyltransferase activity / unmethylated CpG binding / histone H3K4 trimethyltransferase activity / negative regulation of DNA methylation-dependent heterochromatin formation / regulation of short-term neuronal synaptic plasticity / MLL3/4 complex / Set1C/COMPASS complex ...protein-cysteine methyltransferase activity / response to potassium ion / [histone H3]-lysine4 N-methyltransferase / histone H3K4 monomethyltransferase activity / unmethylated CpG binding / histone H3K4 trimethyltransferase activity / negative regulation of DNA methylation-dependent heterochromatin formation / regulation of short-term neuronal synaptic plasticity / MLL3/4 complex / Set1C/COMPASS complex / MLL1/2 complex / T-helper 2 cell differentiation / ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() 類似検索 - 分子機能 |
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![]() | ![]() タイトル: The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex. 著者: Jianming Han / Tingting Li / Yanjing Li / Muchun Li / Xiaoman Wang / Chao Peng / Chen Su / Na Li / Yiwen Li / Ying Xu / Yong Chen / ![]() 要旨: The Mixed Lineage Leukemia protein 1 (MLL1) plays an essential role in the maintenance of the histone H3 lysine 4 (H3K4) methylation status for gene expression during differentiation and development. ...The Mixed Lineage Leukemia protein 1 (MLL1) plays an essential role in the maintenance of the histone H3 lysine 4 (H3K4) methylation status for gene expression during differentiation and development. The methyltransferase activity of MLL1 is regulated by three conserved core subunits, WDR5, RBBP5 and ASH2L. Here, we determined the structure of human RBBP5 and demonstrated its role in the assembly and regulation of the MLL1 complex. We identified an internal interaction between the WD40 propeller and the C-terminal distal region in RBBP5, which assisted the maintenance of the compact conformation of the MLL1 complex. We also discovered a vertebrate-specific motif in the C-terminal distal region of RBBP5 that contributed to nucleosome recognition and methylation of nucleosomes by the MLL1 complex. Our results provide new insights into functional conservation and evolutionary plasticity of the scaffold protein RBBP5 in the regulation of KMT2-family methyltransferase complexes. |
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試料
![]() | 名称: Mixed lineage leukemia protein-1 complex, MLL1-WDR5-ASH2L-RBBP5(2-480) 試料濃度: 2 mg/ml / Entity id: 1862 / 1863 / 1864 / 1865 |
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バッファ | 名称: 300 mM NaCl, 25mM Tris-HCl, 4% glycerol, 1 mM TCEP / pH: 8 / コメント: degassing treatment |
要素 #1862 | 名称: MLL1![]() 配列: NEPPLNPHGS ARAEVHLRKS AFDMFNFLAS KHRQPPEYNP NDEEEEEVQL KSARRATSMD LPMPMRFRHL KKTSKEAVGV YRSPIHGRGL FCKRNIDAGE MVIEYAGNVI RSIQTDKREK YYDSKGIGCY MFRIDDSEVV DATMHGNAAR FINHSCEPNC YSRVINIDGQ ...配列: NEPPLNPHGS ARAEVHLRKS AFDMFNFLAS KHRQPPEYNP NDEEEEEVQL KSARRATSMD LPMPMRFRHL KKTSKEAVGV YRSPIHGRGL FCKRNIDAGE MVIEYAGNVI RSIQTDKREK YYDSKGIGCY MFRIDDSEVV DATMHGNAAR FINHSCEPNC YSRVINIDGQ KHIVIFAMRK IYRGEELTYD YKFPIEDASN KLPCNCGAKK CRKFLN |
要素 #1863 | 名称: WDR5![]() 配列: ATQSKPTPVK PNYALKFTLA GHTKAVSSVK FSPNGEWLAS SSADKLIKIW GAYDGKFEKT ISGHKLGISD VAWSSDSNLL VSASDDKTLK IWDVSSGKCL KTLKGHSNYV FCCNFNPQSN LIVSGSFDES VRIWDVKTGK CLKTLPAHSD PVSAVHFNRD GSLIVSSSYD ...配列: ATQSKPTPVK PNYALKFTLA GHTKAVSSVK FSPNGEWLAS SSADKLIKIW GAYDGKFEKT ISGHKLGISD VAWSSDSNLL VSASDDKTLK IWDVSSGKCL KTLKGHSNYV FCCNFNPQSN LIVSGSFDES VRIWDVKTGK CLKTLPAHSD PVSAVHFNRD GSLIVSSSYD GLCRIWDTAS GQCLKTLIDD DNPPVSFVKF SPNGKYILAA TLDNTLKLWD YSKGKCLKTY TGHKNEKYCI FANFSVTGGK WIVSGSEDNL VYIWNLQTKE IVQKLQGHTD VVISTACHPT ENIIASAALE NDKTIKLWKS DC |
要素 #1864 | 名称: ASH2L / タイプ: protein 記述: Set1/Ash2 histone methyltransferase complex subunit ASH2 分子量: 60.207 / 分子数: 1 / 由来: Homo sapiens / 参照: UniProt: Q9UBL3-3 配列: MDTQAGSVDE ENGRQLGEVE LQCGICTKWF TADTFGIDTS SCLPFMTNYS FHCNVCHHSG NTYFLRKQAN LKEMCLSALA NLTWQSRTQD EHPKTMFSKD KDIIPFIDKY WECMTTRQRP GKMTWPNNIV KTMSKERDVF LVKEHPDPGS KDPEEDYPKF GLLDQDLSNI ...配列: MDTQAGSVDE ENGRQLGEVE LQCGICTKWF TADTFGIDTS SCLPFMTNYS FHCNVCHHSG NTYFLRKQAN LKEMCLSALA NLTWQSRTQD EHPKTMFSKD KDIIPFIDKY WECMTTRQRP GKMTWPNNIV KTMSKERDVF LVKEHPDPGS KDPEEDYPKF GLLDQDLSNI GPAYDNQKQS SAVSTSGNLN GGIAAGSSGK GRGAKRKQQD GGTTGTTKKA RSDPLFSAQR LPPHGYPLEH PFNKDGYRYI LAEPDPHAPD PEKLELDCWA GKPIPGDLYR ACLYERVLLA LHDRAPQLKI SDDRLTVVGE KGYSMVRASH GVRKGAWYFE ITVDEMPPDT AARLGWSQPL GNLQAPLGYD KFSYSWRSKK GTKFHQSIGK HYSSGYGQGD VLGFYINLPE DTETAKSLPD TYKDKALIKF KSYLYFEEKD FVDKAEKSLK QTPHSEIIFY KNGVNQGVAY KDIFEGVYFP AISLYKSCTV SINFGPCFKY PPKDLTYRPM SDMGWGAVVE HTLADVLYHV ETEVDGRRSP PWEP |
要素 #1865 | 名称: RBBP5![]() 配列: NLELLESFGQ NYPEEADGTL DCISMALTCT FNRWGTLLAV GCNDGRIVIW DFLTRGIAKI ISAHIHPVCS LCWSRDGHKL VSASTDNIVS QWDVLSGDCD QRFRFPSPIL KVQYHPRDQN KVLVCPMKSA PVMLTLSDSK HVVLPVDDDS DLNVVASFDR RGEYIYTGNA ...配列: NLELLESFGQ NYPEEADGTL DCISMALTCT FNRWGTLLAV GCNDGRIVIW DFLTRGIAKI ISAHIHPVCS LCWSRDGHKL VSASTDNIVS QWDVLSGDCD QRFRFPSPIL KVQYHPRDQN KVLVCPMKSA PVMLTLSDSK HVVLPVDDDS DLNVVASFDR RGEYIYTGNA KGKILVLKTD SQDLVASFRV TTGTSNTTAI KSIEFARKGS CFLINTADRI IRVYDGREIL TCGRDGEPEP MQKLQDLVNR TPWKKCCFSG DGEYIVAGSA RQHALYIWEK SIGNLVKILH GTRGELLLDV AWHPVRPIIA SISSGVVSIW AQNQVENWSA FAPDFKELDE NVEYEERESE FDIEDEDKSE PEQTGADAAE DEEVDVTSVD PIAAFCSSDE ELEDSKALLY LPIAPEVEDP EENPYGPPPD AVQTSLMDEG ASSEKKRQSS ADGSQPPKKK PKTTNIELQG VPNDEVHPLL GVKGDGKSK |
-実験情報
ビーム | 設備名称: Shanghai Synchrotron Radiation Facility (SSRF) BL19U2 地域: Shanghai / 国: China ![]() ![]() | ||||||||||||||||||||||||||||||
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検出器 | 名称: Pilatus 1M / タイプ: Dectris / Pixsize x: 172 mm | ||||||||||||||||||||||||||||||
スキャン | 測定日: 2019年6月22日 / 保管温度: 10 °C / セル温度: 10 °C / 照射時間: 1 sec. / フレーム数: 20 / 単位: 1/A /
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距離分布関数 P(R) |
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