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- SASDFD2: wild-type human Latent Transforming Growth Factor beta 1 (LTGFB-1) -

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Basic information

Entry
Database: SASBDB / ID: SASDFD2
Samplewild-type human Latent Transforming Growth Factor beta 1 (LTGFB-1)
  • Human Latent Transforming Growth Factor beta 1 (protein), LTGFB-1, Homo sapiens
Function / homology
Function and homology information


cellular response to acetaldehyde / adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains / positive regulation of microglia differentiation / regulation of interleukin-23 production / branch elongation involved in mammary gland duct branching / positive regulation of primary miRNA processing / Influenza Virus Induced Apoptosis / negative regulation of skeletal muscle tissue development / regulation of branching involved in mammary gland duct morphogenesis / macrophage derived foam cell differentiation ...cellular response to acetaldehyde / adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains / positive regulation of microglia differentiation / regulation of interleukin-23 production / branch elongation involved in mammary gland duct branching / positive regulation of primary miRNA processing / Influenza Virus Induced Apoptosis / negative regulation of skeletal muscle tissue development / regulation of branching involved in mammary gland duct morphogenesis / macrophage derived foam cell differentiation / frontal suture morphogenesis / regulation of enamel mineralization / regulation of cartilage development / TGFBR2 MSI Frameshift Mutants in Cancer / regulation of striated muscle tissue development / regulatory T cell differentiation / tolerance induction to self antigen / regulation of blood vessel remodeling / regulation of protein import into nucleus / embryonic liver development / extracellular matrix assembly / negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target / columnar/cuboidal epithelial cell maturation / negative regulation of hyaluronan biosynthetic process / type III transforming growth factor beta receptor binding / positive regulation of cardiac muscle cell differentiation / myofibroblast differentiation / odontoblast differentiation / positive regulation of odontogenesis / connective tissue replacement involved in inflammatory response wound healing / Langerhans cell differentiation / negative regulation of macrophage cytokine production / positive regulation of smooth muscle cell differentiation / TGFBR2 Kinase Domain Mutants in Cancer / positive regulation of exit from mitosis / positive regulation of isotype switching to IgA isotypes / positive regulation of mesenchymal stem cell proliferation / SMAD2/3 Phosphorylation Motif Mutants in Cancer / TGFBR1 KD Mutants in Cancer / membrane protein intracellular domain proteolysis / positive regulation of receptor signaling pathway via STAT / heart valve morphogenesis / retina vasculature development in camera-type eye / TGFBR3 regulates TGF-beta signaling / mammary gland branching involved in thelarche / bronchiole development / hyaluronan catabolic process / positive regulation of vasculature development / response to laminar fluid shear stress / lens fiber cell differentiation / positive regulation of extracellular matrix assembly / negative regulation of extracellular matrix disassembly / ATP biosynthetic process / positive regulation of branching involved in ureteric bud morphogenesis / receptor catabolic process / type II transforming growth factor beta receptor binding / TGFBR1 LBD Mutants in Cancer / oligodendrocyte development / type I transforming growth factor beta receptor binding / response to salt / germ cell migration / negative regulation of biomineral tissue development / positive regulation of mononuclear cell migration / endoderm development / phospholipid homeostasis / negative regulation of myoblast differentiation / positive regulation of chemotaxis / negative regulation of cell-cell adhesion mediated by cadherin / cell-cell junction organization / response to vitamin D / response to cholesterol / positive regulation of vascular permeability / negative regulation of interleukin-17 production / surfactant homeostasis / deubiquitinase activator activity / phosphate-containing compound metabolic process / negative regulation of release of sequestered calcium ion into cytosol / positive regulation of chemokine (C-X-C motif) ligand 2 production / digestive tract development / positive regulation of fibroblast migration / aortic valve morphogenesis / sprouting angiogenesis / negative regulation of ossification / face morphogenesis / RUNX3 regulates CDKN1A transcription / neural tube development / positive regulation of regulatory T cell differentiation / ureteric bud development / Molecules associated with elastic fibres / positive regulation of epidermal growth factor receptor signaling pathway / negative regulation of phagocytosis / positive regulation of peptidyl-tyrosine phosphorylation / negative regulation of neuroblast proliferation / muscle cell cellular homeostasis / cellular response to insulin-like growth factor stimulus / Syndecan interactions / ventricular cardiac muscle tissue morphogenesis / lung alveolus development / negative regulation of fat cell differentiation / positive regulation of interleukin-17 production
Similarity search - Function
Transforming growth factor beta-1 proprotein / Transforming growth factor-beta / TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / Transforming growth factor-beta (TGF-beta) family / Transforming growth factor-beta, C-terminal / Transforming growth factor beta like domain ...Transforming growth factor beta-1 proprotein / Transforming growth factor-beta / TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / Transforming growth factor-beta (TGF-beta) family / Transforming growth factor-beta, C-terminal / Transforming growth factor beta like domain / TGF-beta family profile. / Cystine-knot cytokine
Similarity search - Domain/homology
Transforming growth factor beta-1 proprotein
Similarity search - Component
Biological speciesHomo sapiens (human)
CitationDate: 2019 Jul 1
Title: Structural consequences of transforming growth factor beta-1 activation from near-therapeutic X-ray doses
Authors: Stachowski T / Grant T
Contact author
  • Tim Stachowski (Hauptman-Woodward Medical Research Institute, New York, USA)

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Structure visualization

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Models

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Sample

SampleName: wild-type human Latent Transforming Growth Factor beta 1 (LTGFB-1)
Specimen concentration: 1 mg/ml
BufferName: phosphate buffered saline 2% glycerol / pH: 7.4
Entity #1478Name: LTGFB-1 / Type: protein / Description: Human Latent Transforming Growth Factor beta 1 / Formula weight: 42.958 / Num. of mol.: 2 / Source: Homo sapiens / References: UniProt: P01137
Sequence: HHHHHHLEVL FQGPLSTSKT IDMELVKRKR IEAIRGQILS KLRLASPPSQ GEVPPGPLPE AVLALYNSTR DRVAGESAEP EPEPEADYYA KEVTRVLMVE THNEIYDKFK QSTHSIYMFF NTSELREAVP EPVLLSRAEL RLLRLKLKVE QHVELYQKYS NNSWRYLSNR ...Sequence:
HHHHHHLEVL FQGPLSTSKT IDMELVKRKR IEAIRGQILS KLRLASPPSQ GEVPPGPLPE AVLALYNSTR DRVAGESAEP EPEPEADYYA KEVTRVLMVE THNEIYDKFK QSTHSIYMFF NTSELREAVP EPVLLSRAEL RLLRLKLKVE QHVELYQKYS NNSWRYLSNR LLAPSDSPEW LSFDVTGVVR QWLSRGGEIE GFRLSAHCSC DSRDNTLQVD INGFTTGRRG DLATIHGMNR PFLLLMATPL ERAQHLQSSR HRRALDTNYC FSSTEKNCCV RQLYIDFRKD LGWKWIHEPK GYHANFCLGP CPYIWSLDTQ YSKVLALYNQ HNPGASAAPC CVPQALEPLP IVYYVGRKPK VEQLSNMIVR SCKCS

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Experimental information

BeamInstrument name: Advanced Light Source (ALS) 12.3.1 (SIBYLS)
City: Berkeley, CA / 国: USA / Type of source: X-ray synchrotron / Wavelength: 0.1127 Å / Dist. spec. to detc.: 2 mm
DetectorName: Pilatus3 X 2M / Pixsize x: 172 mm
Scan
Title: wild-type human Latent Transforming Growth Factor beta 1 (LTGFB-1)
Measurement date: Oct 4, 2018 / Storage temperature: 4 °C / Cell temperature: 10 °C / Exposure time: 0.1 sec. / Number of frames: 49 / Unit: 1/A /
MinMax
Q0.012 0.4038
Distance distribution function P(R)
Sofotware P(R): GNOM 5.0 / Number of points: 703 /
MinMax
Q0.012543 0.403785
P(R) point1 703
R0 175
Result
Type of curve: single_conc /
ExperimentalPorod
MW104 kDa120 kDa
Volume-200 nm3

P(R)GuinierGuinier error
Forward scattering, I06.803 6.69 0.0016
Radius of gyration, Rg4.06 nm3.8 nm0.014

MinMax
D-17.5
Guinier point1 40

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