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- SASDFD2: wild-type human Latent Transforming Growth Factor beta 1 (LTGFB-1) -
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Open data
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Basic information
Entry | ![]() |
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![]() | wild-type human Latent Transforming Growth Factor beta 1 (LTGFB-1)
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Function / homology | ![]() adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains / regulation of interleukin-23 production / branch elongation involved in mammary gland duct branching / positive regulation of primary miRNA processing / regulation of branching involved in mammary gland duct morphogenesis / positive regulation of microglia differentiation / Influenza Virus Induced Apoptosis / frontal suture morphogenesis / negative regulation of skeletal muscle tissue development / regulation of enamel mineralization ...adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains / regulation of interleukin-23 production / branch elongation involved in mammary gland duct branching / positive regulation of primary miRNA processing / regulation of branching involved in mammary gland duct morphogenesis / positive regulation of microglia differentiation / Influenza Virus Induced Apoptosis / frontal suture morphogenesis / negative regulation of skeletal muscle tissue development / regulation of enamel mineralization / regulatory T cell differentiation / regulation of cartilage development / TGFBR2 MSI Frameshift Mutants in Cancer / regulation of blood vessel remodeling / tolerance induction to self antigen / regulation of striated muscle tissue development / negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target / regulation of protein import into nucleus / embryonic liver development / columnar/cuboidal epithelial cell maturation / type III transforming growth factor beta receptor binding / positive regulation of odontogenesis / Langerhans cell differentiation / negative regulation of hyaluronan biosynthetic process / positive regulation of cardiac muscle cell differentiation / myofibroblast differentiation / positive regulation of receptor signaling pathway via STAT / connective tissue replacement involved in inflammatory response wound healing / positive regulation of exit from mitosis / extracellular matrix assembly / negative regulation of macrophage cytokine production / odontoblast differentiation / TGFBR2 Kinase Domain Mutants in Cancer / positive regulation of smooth muscle cell differentiation / positive regulation of isotype switching to IgA isotypes / positive regulation of mesenchymal stem cell proliferation / mammary gland branching involved in thelarche / SMAD2/3 Phosphorylation Motif Mutants in Cancer / TGFBR1 KD Mutants in Cancer / retina vasculature development in camera-type eye / heart valve morphogenesis / macrophage derived foam cell differentiation / membrane protein intracellular domain proteolysis / response to laminar fluid shear stress / positive regulation of vasculature development / bronchiole development / hyaluronan catabolic process / ATP biosynthetic process / positive regulation of branching involved in ureteric bud morphogenesis / positive regulation of extracellular matrix assembly / receptor catabolic process / lens fiber cell differentiation / negative regulation of extracellular matrix disassembly / type II transforming growth factor beta receptor binding / oligodendrocyte development / TGFBR1 LBD Mutants in Cancer / response to salt / germ cell migration / negative regulation of biomineral tissue development / positive regulation of mononuclear cell migration / endoderm development / type I transforming growth factor beta receptor binding / phospholipid homeostasis / positive regulation of chemotaxis / negative regulation of myoblast differentiation / positive regulation of endothelial cell apoptotic process / positive regulation of vascular permeability / cell-cell junction organization / response to vitamin D / positive regulation of regulatory T cell differentiation / response to cholesterol / digestive tract development / negative regulation of interleukin-17 production / surfactant homeostasis / deubiquitinase activator activity / negative regulation of release of sequestered calcium ion into cytosol / negative regulation of ossification / positive regulation of chemokine (C-X-C motif) ligand 2 production / positive regulation of fibroblast migration / phosphate-containing compound metabolic process / aortic valve morphogenesis / negative regulation of blood vessel endothelial cell migration / negative regulation of protein localization to plasma membrane / sprouting angiogenesis / face morphogenesis / cellular response to low-density lipoprotein particle stimulus / negative regulation of phagocytosis / neural tube development / Molecules associated with elastic fibres / RUNX3 regulates CDKN1A transcription / ventricular cardiac muscle tissue morphogenesis / cellular response to insulin-like growth factor stimulus / ureteric bud development / positive regulation of epidermal growth factor receptor signaling pathway / negative regulation of neuroblast proliferation / Syndecan interactions / muscle cell cellular homeostasis / negative regulation of cell-cell adhesion / lung alveolus development / negative regulation of fat cell differentiation Similarity search - Function |
Biological species | ![]() |
![]() | ![]() Title: Structural consequences of transforming growth factor beta-1 activation from near-therapeutic X-ray doses Authors: Stachowski T / Grant T |
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Structure visualization
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Downloads & links
-Data source
SASBDB page | ![]() |
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-Related structure data
Related structure data | C: citing same article ( |
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Similar structure data | Similarity search - Function & homology ![]() |
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External links
Related items in Molecule of the Month |
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-Models
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Sample
![]() | Name: wild-type human Latent Transforming Growth Factor beta 1 (LTGFB-1) Specimen concentration: 1 mg/ml |
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Buffer | Name: phosphate buffered saline 2% glycerol / pH: 7.4 |
Entity #1478 | Name: LTGFB-1 / Type: protein / Description: Human Latent Transforming Growth Factor beta 1 / Formula weight: 42.958 / Num. of mol.: 2 / Source: Homo sapiens / References: UniProt: P01137 Sequence: HHHHHHLEVL FQGPLSTSKT IDMELVKRKR IEAIRGQILS KLRLASPPSQ GEVPPGPLPE AVLALYNSTR DRVAGESAEP EPEPEADYYA KEVTRVLMVE THNEIYDKFK QSTHSIYMFF NTSELREAVP EPVLLSRAEL RLLRLKLKVE QHVELYQKYS NNSWRYLSNR ...Sequence: HHHHHHLEVL FQGPLSTSKT IDMELVKRKR IEAIRGQILS KLRLASPPSQ GEVPPGPLPE AVLALYNSTR DRVAGESAEP EPEPEADYYA KEVTRVLMVE THNEIYDKFK QSTHSIYMFF NTSELREAVP EPVLLSRAEL RLLRLKLKVE QHVELYQKYS NNSWRYLSNR LLAPSDSPEW LSFDVTGVVR QWLSRGGEIE GFRLSAHCSC DSRDNTLQVD INGFTTGRRG DLATIHGMNR PFLLLMATPL ERAQHLQSSR HRRALDTNYC FSSTEKNCCV RQLYIDFRKD LGWKWIHEPK GYHANFCLGP CPYIWSLDTQ YSKVLALYNQ HNPGASAAPC CVPQALEPLP IVYYVGRKPK VEQLSNMIVR SCKCS |
-Experimental information
Beam | Instrument name: Advanced Light Source (ALS) 12.3.1 (SIBYLS) City: Berkeley, CA / 国: USA ![]() | ||||||||||||||||||||||||||||||
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Detector | Name: Pilatus3 X 2M / Pixsize x: 172 mm | ||||||||||||||||||||||||||||||
Scan | Measurement date: Oct 4, 2018 / Storage temperature: 4 °C / Cell temperature: 10 °C / Exposure time: 0.1 sec. / Number of frames: 49 / Unit: 1/A /
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Distance distribution function P(R) |
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Result |
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