+データを開く
-基本情報
登録情報 | データベース: SASBDB / ID: SASDEE2 |
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試料 | The N-terminal domain of estrogen receptor alpha
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機能・相同性 | 機能・相同性情報 regulation of epithelial cell apoptotic process / antral ovarian follicle growth / G protein-coupled estrogen receptor activity / regulation of branching involved in prostate gland morphogenesis / RUNX1 regulates transcription of genes involved in WNT signaling / RUNX1 regulates estrogen receptor mediated transcription / regulation of toll-like receptor signaling pathway / prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis / nuclear estrogen receptor activity / epithelial cell proliferation involved in mammary gland duct elongation ...regulation of epithelial cell apoptotic process / antral ovarian follicle growth / G protein-coupled estrogen receptor activity / regulation of branching involved in prostate gland morphogenesis / RUNX1 regulates transcription of genes involved in WNT signaling / RUNX1 regulates estrogen receptor mediated transcription / regulation of toll-like receptor signaling pathway / prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis / nuclear estrogen receptor activity / epithelial cell proliferation involved in mammary gland duct elongation / epithelial cell development / prostate epithelial cord elongation / negative regulation of smooth muscle cell apoptotic process / mammary gland branching involved in pregnancy / uterus development / vagina development / androgen metabolic process / TFIIB-class transcription factor binding / steroid hormone mediated signaling pathway / mammary gland alveolus development / intracellular estrogen receptor signaling pathway / cellular response to estrogen stimulus / estrogen response element binding / : / intracellular steroid hormone receptor signaling pathway / negative regulation of canonical NF-kappaB signal transduction / Nuclear signaling by ERBB4 / RNA polymerase II preinitiation complex assembly / protein localization to chromatin / TBP-class protein binding / TFAP2 (AP-2) family regulates transcription of growth factors and their receptors / steroid binding / nitric-oxide synthase regulator activity / ESR-mediated signaling / 14-3-3 protein binding / transcription corepressor binding / negative regulation of miRNA transcription / cellular response to estradiol stimulus / transcription coregulator binding / 細胞分化 / nuclear estrogen receptor binding / positive regulation of nitric-oxide synthase activity / SUMOylation of intracellular receptors / ユークロマチン / negative regulation of DNA-binding transcription factor activity / transcription coactivator binding / beta-catenin binding / Nuclear Receptor transcription pathway / positive regulation of DNA-binding transcription factor activity / response to estrogen / male gonad development / Constitutive Signaling by Aberrant PI3K in Cancer / Regulation of RUNX2 expression and activity / nuclear receptor activity / positive regulation of nitric oxide biosynthetic process / positive regulation of fibroblast proliferation / Ovarian tumor domain proteases / sequence-specific double-stranded DNA binding / response to estradiol / PIP3 activates AKT signaling / phospholipase C-activating G protein-coupled receptor signaling pathway / ATPase binding / positive regulation of cytosolic calcium ion concentration / regulation of inflammatory response / fibroblast proliferation / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / DNA-binding transcription activator activity, RNA polymerase II-specific / Estrogen-dependent gene expression / transcription regulator complex / Extra-nuclear estrogen signaling / calmodulin binding / DNA-binding transcription factor activity, RNA polymerase II-specific / クロマチンリモデリング / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of gene expression / chromatin binding / クロマチン / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / protein kinase binding / positive regulation of DNA-templated transcription / ゴルジ体 / negative regulation of transcription by RNA polymerase II / enzyme binding / シグナル伝達 / positive regulation of transcription by RNA polymerase II / protein-containing complex / zinc ion binding / 核質 / 生体膜 / identical protein binding / 細胞核 / 細胞膜 / 細胞質基質 / 細胞質 類似検索 - 分子機能 |
生物種 | Homo sapiens (ヒト) |
引用 | 日付: 2018 Dec タイトル: A Metastable Contact and Structural Disorder in the Estrogen Receptor Transactivation Domain 著者: Peng Y / Cao S / Kiselar J / Xiao X / Du Z / Hsieh A / Ko S / Chen Y / Agrawal P / Zheng W / Shi W / Jiang W / Yang L / Chance M / Surewicz W / Buck M |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-モデル
モデル #2229 | タイプ: atomic / カイ2乗値: 0.136161 / P-value: 0.002500 Omokage検索でこの集合体の類似形状データを探す (詳細) |
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モデル #2230 | タイプ: atomic / カイ2乗値: 0.341056 / P-value: 0.002500 Omokage検索でこの集合体の類似形状データを探す (詳細) |
モデル #2231 | タイプ: atomic / カイ2乗値: 0.509796 / P-value: 0.002500 Omokage検索でこの集合体の類似形状データを探す (詳細) |
-試料
試料 | 名称: The N-terminal domain of estrogen receptor alpha / 試料濃度: 2.5 mg/ml |
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バッファ | 名称: 20 mM sodium phosphate, 50 mM NaCl, 0.05 mM TCEP / pH: 7.4 |
要素 #1227 | 名称: ER-NTD / タイプ: protein / 記述: The N-terminal domain of estrogen receptor alpha / 分子量: 20.175 / 分子数: 1 / 由来: Homo sapiens / 参照: UniProt: P03372 配列: SNAMTMTLHT KASGMALLHQ IQGNELEPLN RPQLKIPLER PLGEVYLDSS KPAVYNYPEG AAYEFNAAAA ANAQVYGQTG LPYGPGSEAA AFGSNGLGGF PPLNSVSPSP LMLLHPPPQL SPFLQPHGQQ VPYYLENEPS GYTVREAGPP AFYRPNSDNR RQGGRERLAS TNDKGSMAME SAKETRY |
-実験情報
ビーム | 設備名称: National Synchrotron Light Source (NSLS-II) 16-ID (LiX) 地域: Brookhaven, NY / 国: USA / 線源: X-ray synchrotronシンクロトロン / 波長: 0.09 Å / スペクトロメータ・検出器間距離: 3 mm | |||||||||||||||||||||
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検出器 | 名称: Pilatus3 S 1M / Pixsize x: 172 mm | |||||||||||||||||||||
スキャン | タイトル: The N-terminal domain of estrogen receptor alpha 測定日: 2017年6月12日 / セル温度: 10 °C / 照射時間: 3 sec. / フレーム数: 3 / 単位: 1/A /
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距離分布関数 P(R) | ソフトウェア P(R): GNOM 4.6 / ポイント数: 79 /
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結果 | Experimental MW: 20.18 kDa / カーブのタイプ: single_conc
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