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- SASDA98: Thyroglobulin in Tris/HCl (Thyroglobulin) -

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Basic information

Entry
Database: SASBDB / ID: SASDA98
SampleThyroglobulin in Tris/HCl
  • Thyroglobulin (protein), Bos taurus
Function / homologyCarboxylesterase type B, conserved site / Thyroglobulin type-1 repeat signature. / Thyroglobulin type-1 domain profile. / Thyroglobulin type-1 / Carboxylesterase, type B / Growth factor receptor cysteine-rich domain superfamily / Tyrosine-protein kinase ephrin type A/B receptor-like / Thyroglobulin / Carboxylesterases type-B signature 2. / Alpha/Beta hydrolase fold ...Carboxylesterase type B, conserved site / Thyroglobulin type-1 repeat signature. / Thyroglobulin type-1 domain profile. / Thyroglobulin type-1 / Carboxylesterase, type B / Growth factor receptor cysteine-rich domain superfamily / Tyrosine-protein kinase ephrin type A/B receptor-like / Thyroglobulin / Carboxylesterases type-B signature 2. / Alpha/Beta hydrolase fold / Thyroglobulin type-1 superfamily / Thyroglobulin type-1 repeat / Carboxylesterase family / Putative ephrin-receptor like / hormone biosynthetic process / hormone activity / histone binding / extracellular region / Thyroglobulin
Function and homology information
SourceBos taurus (cattle)
CitationYear: 2007
Title: Accuracy of molecular mass determination of proteins in solution by small-angle X-ray scattering
Authors: "Mylonas E", "Svergun D"
Contact authorEfstratios Mylonas (EMBL-Hamburg, FORTH, European Molecular Biology Laboratory (EMBL) - Hamburg outstation, Foundation for Research and Technology-Hellas, Notkestraße 85, Geb. 25A, 22607 Hamburg, Deutschland, Germany, Heraklion, Greece)

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Models

Model #316
Type: dummy / Software: DAMMIN / Radius of dummy atoms: 6.10 A / Chi-square value: 16.507969
Search similar-shape structures of this assembly by Omokage search (details)

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Sample

SampleName: Thyroglobulin in Tris/HCl / Specimen concentration: 3.9 / Entity id: 182
BufferName: Tris/HCl / Concentration: 100.00 mM / pH: 7.5 / Composition: 100 mM NaCl / Sample id: 160
Entity #182Name: , , / Type: protein / Description: Thyroglobulin / Formula weight: 303.218 / Number of molecules: 2 / Source: Bos taurus / References: UniProt: P01267
Sequence:
MALALWVFGL LDLICLASAN IFEYQVDAQP LRPCELQRER AFLKREDYVP QCAEDGSFQT VQCGKDGASC WCVDADGREV PGSRQPGRPA ACLSFCQLQK QQILLSSYIN STATSYLPQC QDSGDYSPVQ CDLRRRQCWC VDAEGMEVYG TRQQGRPARC PRSCEIRNRR LLHGVGDRSP PQCSPDGAFR PVQCKLVNTT DMMIFDLVHS YSRFPDAFVT FSSFRSRFPE VSGYCYCADS QGRELAETGL ELLLDEIYDT IFAGLDLAST FAETTLYRIL QRRFLAVQLV ISGRFRCPTK CEVERFAATS FRHPYVPSCH PDGEYQAAQC QQGGPCWCVD SRGQEIPGTR QRGEPPSCAE DQSCPSERRR AFSRLRFGPS GYFSRRSLLL APEEGPVSQR FARFTASCPP SIKELFLDSG IFQPMLQGRD TRFVAPESLK EAIRGLFPSR ELARLALQFT TNAKRLQQNL FGGRFLVKVG QFNLSGALGT RGTFNFSHFF QQLGLPGFQD GRALADLAKP LSVGLNSNPA SEAPKASKID VALRKPVVGS FGFEVNLQEN QNALQFLSSF LELPEFLLFL QHAISVPEDI ARDLGDVMEM VFSSQGCGQA PGSLFVPACT AEGSYEEVQC FAGDCWCVDA QGRELAGSRV RGGRPRCPTE CEKQRARMQS LLGSQPAGSS LFVPACTSKG NFLPVQCFNS ECYCVDTEGQ PIPGTRSALG EPKKCPSPCQ LQAERAFLGT VRTLVSNPST LPALSSIYIP QCSASGQWSP VQCDGPPEQA FEWYERWEAQ NSAGQALTPA ELLMKIMSYR EAASRNFRLF IQNLYEAGQQ GIFPGLARYS SFQDVPVSVL EGNQTQPGGN VFLEPYLFWQ ILNGQLDRYP GPYSDFSAPL AHFDLRSCWC VDEAGQKLEG TRNEPNKVPA CPGSCEEVKL RVLQFIREAE EIVTYSNSSR FPLGESFLAA KGIRLTDEEL AFPPLSPSRE TFLEKFLSGS DYAIRLAAQS TFDFYQRRLV TLAESPRAPS PVWSSAYLPQ CDAFGGWEPV QCHAATGHCW CVDGKGEYVP TSLTARSRQI PQCPTSCERL RASGLLSSWK QAGVQAEPSP KDLFIPTCLE TGEFARLQAS EAGTWCVDPA SGEGVPPGTN SSAQCPSLCE VLQSGVPSRR TSPGYSPACR AEDGGFSPVQ CDPAQGSCWC VLGSGEEVPG TRVAGSQPAC ESPQCPLPFS VADVAGGAIL CERASGLGAA AGQRCQLRCS QGYRSAFPPE PLLCSVQRRR WESRPPQPRA CQRPQFWQTL QTQAQFQLLL PLGKVCSADY SGLLLAFQVF LLDELTARGF CQIQVKTAGT PVSIPVCDDS SVKVECLSRE RLGVNITWKL QLVDAPPASL PDLQDVEEAL AGKYLAGRFA DLIQSGTFQL HLDSKTFSAD TSIRFLQGDR FGTSPRTQFG CLEGFGRVVA ASDASQDALG CVKCPEGSYF QDEQCIPCPA GFYQEQAGSL ACVPCPEGRT TVYAGAFSQT HCVTDCQKNE VGLQCDQDSQ YRASQRDRTS GKAFCVDGEG RRLPWTEAEA PLVDAQCLVM RKFEKLPESK VIFSADVAVM VRSEVPGSES SLMQCLADCA LDEACGFLTV STAGSEVSCD FYAWASDSIA CTTSGRSEDA LGTSQATSFG SLQCQVKVRS REGDPLAVYL KKGQEFTITG QKRFEQTGFQ SALSGMYSPV TFSASGASLA EVHLFCLLAC DHDSCCDGFI LVQVQGGPLL CGLLSSPDVL LCHVRDWRDP AEAQANASCP GVTYDQDSRQ VTLRLGGQEI RGLTPLEGTQ DTLTSFQQVY LWKDSDMGSR SESMGCRRDT EPRPASPSET DLTTGLFSPV DLIQVIVDGN VSLPSQQHWL FKHLFSLQQA NLWCLSRCAG EPSFCQLAEV TDSEPLYFTC TLYPEAQVCD DILESSPKGC RLILPRRPSA LYRKKVVLQD RVKNFYNRLP FQKLTGISIR NKVPMSDKSI SSGFFECERL CDMDPCCTGF GFLNVSQLKG GEVTCLTLNS LGLQTCSEEY GGVWRILDCG SPDTEVRTYP FGWYQKPVSP SDAPSFCPSV ALPALTENVA LDSWQSLALS SVIVDPSIRN FDVAHISTAA VGNFSAARDR CLWECSRHQD CLVTTLQTQP GAVRCMFYAD TQSCTHSLQA QNCRLLLHEE ATYIYRKPNI PLPGFGTSSP SVPIATHGQL LGRSQAIQVG TSWKPVDQFL GVPYAAPPLG EKRFRAPEHL NWTGSWEATK PRARCWQPGI RTPTPPGVSE DCLYLNVFVP QNMAPNASVL VFFHNAAEGK GSGDRPAVDG SFLAAVGNLI VVTASYRTGI FGFLSSGSSE LSGNWGLLDQ VVALTWVQTH IQAFGGDPRR VTLAADRGGA DIASIHLVTT RAANSRLFRR AVLMGGSALS PAAVIRPERA RQQAAALAKE VGCPSSSVQE MVSCLRQEPA RILNDAQTKL LAVSGPFHYW GPVVDGQYLR ETPARVLQRA PRVKVDLLIG SSQDDGLINR AKAVKQFEES QGRTSSKTAF YQALQNSLGG EAADAGVQAA ATWYYSLEHD SDDYASFSRA LEQATRDYFI ICPVIDMASH WARTVRGNVF MYHAPESYSH SSLELLTDVL YAFGLPFYPA YEGQFTLEEK SLSLKIMQYF SNFIRSGNPN YPHEFSRRAP EFAAPWPDFV PRDGAESYKE LSVLLPNRQG LKKADCSFWS KYIQSLKASA DETKDGPSAD SEEEDQPAGS GLTEDLLGLP ELASKTYSK

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Experimental information

BeamInstrument name: DORIS III X33 / Instrument city: Hamburg / Instrument country: Germany / Type of source: X-ray synchrotronSynchrotron
DetectorName: MAR 345 Image Plate
Scan
Title: Thyroglobulin / Detc id: 6 / Measurement date: May 19, 2006 / Cell temperature: 2 / Unit: 1/nm / Qmin: 0.097 / Qmax: 4.9563 / Sample id: 160 / Result id: 200 / Beam id: 9
Distance distribution function P(R)
Intensity id: 200 / Software p of R: GNOM 4.5a / Number of points: 512 / Qmin: 0.121 / Qmax: 4.791 / P of R point min: 10 / P of R point max: 521 / Rmin: 0 / Rmax: 24
Result
SASBDB code: SASDA98 / Experimental MW: 622 / MW standard: 622 / I0 from PR: 2331 / I0 from Guinier: 2510.92 / Rg from PR: 7.41 / Rg from Guinier: 7.86 / D max: 24 / Guinier point min: 9 / Guinier point max: 30 / Type of curve: single_conc
Comments: Thyroglobulin contains glycans and extra iodines, for these reasons the molecular weight based on the sequence (606 kDa) does not agree with the experimentally calculated one (622 kDa).

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