登録情報 | データベース: PDB / ID: 8opt |
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タイトル | Human terminal uridylyltransferase 7 (TUT7/ZCCHC6) bound with pre-let7g miRNA and Lin28A - complex 2 |
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要素 | - Protein lin-28 homolog A
- RNA (53-MER)
- Terminal uridylyltransferase 7
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キーワード | RNA BINDING PROTEIN / Polymerase / uridylation / RNA maturation and turnover control |
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機能・相同性 | 機能・相同性情報
negative regulation of glial cell differentiation / positive regulation of cell proliferation involved in kidney development / negative regulation of pre-miRNA processing / polyuridylation-dependent mRNA catabolic process / retrotransposon silencing by mRNA destabilization / uridylyltransferase activity / protein-RNA adaptor activity / RNA 3'-end processing / miRNA catabolic process / RNA 3' uridylation ...negative regulation of glial cell differentiation / positive regulation of cell proliferation involved in kidney development / negative regulation of pre-miRNA processing / polyuridylation-dependent mRNA catabolic process / retrotransposon silencing by mRNA destabilization / uridylyltransferase activity / protein-RNA adaptor activity / RNA 3'-end processing / miRNA catabolic process / RNA 3' uridylation / RNA uridylyltransferase / pre-miRNA binding / RNA uridylyltransferase activity / Transcriptional regulation of pluripotent stem cells / Z-decay: degradation of maternal mRNAs by zygotically expressed factors / miRNA metabolic process / Deadenylation of mRNA / positive regulation of cytoplasmic translation / pre-miRNA processing / sequence-specific mRNA binding / oocyte maturation / miRNA binding / stem cell population maintenance / germ cell development / Zygotic genome activation (ZGA) / positive regulation of TOR signaling / rough endoplasmic reticulum / translation initiation factor binding / positive regulation of neuron differentiation / stem cell differentiation / cellular response to glucose stimulus / P-body / cytoplasmic stress granule / G-quadruplex RNA binding / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / negative regulation of translation / mRNA binding / nucleolus / RNA binding / zinc ion binding / nucleoplasm / nucleus / cytoplasm / cytosol類似検索 - 分子機能 Unstructured region 4 on terminal uridylyltransferase 7 / TUTase nucleotidyltransferase domain / TUTase nucleotidyltransferase domain / PAP/25A-associated / Cid1 family poly A polymerase / Cold-shock (CSD) domain profile. / Cold-shock protein, DNA-binding / 'Cold-shock' DNA-binding domain / Cold shock domain / Cold shock protein domain ...Unstructured region 4 on terminal uridylyltransferase 7 / TUTase nucleotidyltransferase domain / TUTase nucleotidyltransferase domain / PAP/25A-associated / Cid1 family poly A polymerase / Cold-shock (CSD) domain profile. / Cold-shock protein, DNA-binding / 'Cold-shock' DNA-binding domain / Cold shock domain / Cold shock protein domain / Matrin/U1-C-like, C2H2-type zinc finger / U1-like zinc finger / Zinc finger C2H2 type domain signature. / Nucleotidyltransferase superfamily / zinc finger / Zinc knuckle / Zinc finger, CCHC-type superfamily / Zinc finger, CCHC-type / Zinc finger CCHC-type profile. / Nucleic acid-binding, OB-fold類似検索 - ドメイン・相同性 RNA / RNA (> 10) / Terminal uridylyltransferase 7 / Protein lin-28 homolog A類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 電子顕微鏡法 / 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.65 Å |
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データ登録者 | Yi, G. / Ye, M. / Gilbert, R.J. |
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資金援助 | 英国, 1件 組織 | 認可番号 | 国 |
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Wellcome Trust | | 英国 |
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引用 | ジャーナル: Nat.Struct.Biol. / 年: 2024 タイトル: Structural basis for activity switching in polymerases determining the fate of let-7 pre-miRNAs 著者: Yi, G. / Ye, M. / Carrique, L. / El-Sagheer, A. / Brown, T. / Norbury, C.J. / Zhang, P. / Gilbert, R.J.C. |
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履歴 | 登録 | 2023年4月8日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2024年7月24日 | Provider: repository / タイプ: Initial release |
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