+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 7sp1 | |||||||||
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タイトル | RNA-induced tau amyloid fibril | |||||||||
要素 |
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キーワード | PROTEIN FIBRIL/RNA / amyloid fibril / complex / PROTEIN FIBRIL-RNA complex | |||||||||
機能・相同性 | Activation of AMPK downstream of NMDARs / PKR-mediated signaling / RNA / Isoform Tau-F of Microtubule-associated protein tau 機能・相同性情報 | |||||||||
生物種 | Homo sapiens (ヒト) Mus (ネズミ) | |||||||||
手法 | 電子顕微鏡法 / らせん対称体再構成法 / クライオ電子顕微鏡法 / 解像度: 3.4 Å | |||||||||
データ登録者 | Abskharon, R. / Sawaya, M.R. / Boyer, D.R. / Eisenberg, D.S. | |||||||||
資金援助 | 米国, 2件
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引用 | ジャーナル: Proc Natl Acad Sci U S A / 年: 2022 タイトル: Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation. 著者: Romany Abskharon / Michael R Sawaya / David R Boyer / Qin Cao / Binh A Nguyen / Duilio Cascio / David S Eisenberg / 要旨: In neurodegenerative diseases including Alzheimer’s and amyotrophic lateral sclerosis, proteins that bind RNA are found in aggregated forms in autopsied brains. Evidence suggests that RNA aids ...In neurodegenerative diseases including Alzheimer’s and amyotrophic lateral sclerosis, proteins that bind RNA are found in aggregated forms in autopsied brains. Evidence suggests that RNA aids nucleation of these pathological aggregates; however, the mechanism has not been investigated at the level of atomic structure. Here, we present the 3.4-Å resolution structure of fibrils of full-length recombinant tau protein in the presence of RNA, determined by electron cryomicroscopy (cryo-EM). The structure reveals the familiar in-register cross-β amyloid scaffold but with a small fibril core spanning residues Glu391 to Ala426, a region disordered in the fuzzy coat in all previously studied tau polymorphs. RNA is bound on the fibril surface to the positively charged residues Arg406 and His407 and runs parallel to the fibril axis. The fibrils dissolve when RNase is added, showing that RNA is necessary for fibril integrity. While this structure cannot exist simultaneously with the tau fibril structures extracted from patients’ brains, it could conceivably account for the nucleating effects of RNA cofactors followed by remodeling as fibrils mature. | |||||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 7sp1.cif.gz | 183.6 KB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb7sp1.ent.gz | 102.8 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 7sp1.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
文書・要旨 | 7sp1_validation.pdf.gz | 1003.3 KB | 表示 | wwPDB検証レポート |
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文書・詳細版 | 7sp1_full_validation.pdf.gz | 1007.8 KB | 表示 | |
XML形式データ | 7sp1_validation.xml.gz | 22 KB | 表示 | |
CIF形式データ | 7sp1_validation.cif.gz | 34.3 KB | 表示 | |
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/sp/7sp1 ftp://data.pdbj.org/pub/pdb/validation_reports/sp/7sp1 | HTTPS FTP |
-関連構造データ
関連構造データ | 25364MC M: このデータのモデリングに利用したマップデータ C: 同じ文献を引用 (文献) |
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類似構造データ | 類似検索 - 機能・相同性F&H 検索 |
電子顕微鏡画像生データ | EMPIAR-11004 (タイトル: Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation Data size: 2.4 TB Data #1: Unaligned movies of recombinant tau amyloid fibrils formed in the presence of RNA [micrographs - multiframe]) |
-リンク
-集合体
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非結晶学的対称性 (NCS) | NCSドメイン:
NCSドメイン領域:
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