登録情報 | データベース: PDB / ID: 7l7h |
---|
タイトル | Alpha-synuclein fibrils |
---|
要素 | Alpha-synuclein |
---|
キーワード | PROTEIN FIBRIL / neurodegenerative diseases / TEM / DARR / dipolar assisted rotational resonance |
---|
機能・相同性 | 機能・相同性情報
regulation of phospholipase activity / negative regulation of monooxygenase activity / negative regulation of mitochondrial electron transport, NADH to ubiquinone / positive regulation of glutathione peroxidase activity / neutral lipid metabolic process / regulation of acyl-CoA biosynthetic process / negative regulation of dopamine uptake involved in synaptic transmission / negative regulation of norepinephrine uptake / positive regulation of SNARE complex assembly / positive regulation of hydrogen peroxide catabolic process ...regulation of phospholipase activity / negative regulation of monooxygenase activity / negative regulation of mitochondrial electron transport, NADH to ubiquinone / positive regulation of glutathione peroxidase activity / neutral lipid metabolic process / regulation of acyl-CoA biosynthetic process / negative regulation of dopamine uptake involved in synaptic transmission / negative regulation of norepinephrine uptake / positive regulation of SNARE complex assembly / positive regulation of hydrogen peroxide catabolic process / supramolecular fiber / negative regulation of transporter activity / mitochondrial membrane organization / negative regulation of chaperone-mediated autophagy / regulation of reactive oxygen species biosynthetic process / regulation of synaptic vesicle recycling / negative regulation of platelet-derived growth factor receptor signaling pathway / positive regulation of protein localization to cell periphery / negative regulation of exocytosis / regulation of glutamate secretion / response to iron(II) ion / regulation of norepinephrine uptake / SNARE complex assembly / positive regulation of neurotransmitter secretion / dopamine biosynthetic process / regulation of locomotion / positive regulation of inositol phosphate biosynthetic process / synaptic vesicle priming / regulation of macrophage activation / negative regulation of microtubule polymerization / synaptic vesicle transport / dopamine uptake involved in synaptic transmission / dynein complex binding / positive regulation of receptor recycling / regulation of dopamine secretion / protein kinase inhibitor activity / negative regulation of thrombin-activated receptor signaling pathway / response to type II interferon / cuprous ion binding / synaptic vesicle exocytosis / positive regulation of exocytosis / positive regulation of endocytosis / kinesin binding / cysteine-type endopeptidase inhibitor activity involved in apoptotic process / response to magnesium ion / mitochondrial ATP synthesis coupled electron transport / synaptic vesicle endocytosis / regulation of presynapse assembly / negative regulation of serotonin uptake / alpha-tubulin binding / phospholipid metabolic process / supramolecular fiber organization / axon terminus / inclusion body / cellular response to copper ion / cellular response to epinephrine stimulus / Hsp70 protein binding / response to interleukin-1 / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / adult locomotory behavior / positive regulation of release of sequestered calcium ion into cytosol / SNARE binding / excitatory postsynaptic potential / fatty acid metabolic process / long-term synaptic potentiation / phosphoprotein binding / protein tetramerization / regulation of transmembrane transporter activity / negative regulation of protein kinase activity / microglial cell activation / synapse organization / regulation of long-term neuronal synaptic plasticity / protein destabilization / ferrous iron binding / positive regulation of protein serine/threonine kinase activity / tau protein binding / PKR-mediated signaling / phospholipid binding / receptor internalization / activation of cysteine-type endopeptidase activity involved in apoptotic process / synaptic vesicle membrane / positive regulation of inflammatory response / actin cytoskeleton / positive regulation of peptidyl-serine phosphorylation / actin binding / cellular response to oxidative stress / histone binding / cell cortex / growth cone / chemical synaptic transmission / neuron apoptotic process / negative regulation of neuron apoptotic process / postsynapse / amyloid fibril formation / response to lipopolysaccharide / molecular adaptor activity / oxidoreductase activity / lysosome / transcription cis-regulatory region binding / response to xenobiotic stimulus類似検索 - 分子機能 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | 電子顕微鏡法 / らせん対称体再構成法 / クライオ電子顕微鏡法 / 解像度: 4 Å |
---|
データ登録者 | Hojjatian, A. / Dasari, A. |
---|
資金援助 | 米国, 3件 組織 | 認可番号 | 国 |
---|
National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) | R01 NS097490 | 米国 | National Institutes of Health/National Institute on Aging (NIH/NIA) | R01 AG054025 | 米国 | National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) | R01 NS094557 | 米国 |
|
---|
引用 | ジャーナル: To Be Published タイトル: Distinct cryo-EM Structure of Alpha-synuclein Filaments derived by Tau 著者: Hojjatian, A. / Dasari, A. / Sengupta, U. / Taylor, D. / Daneshparvar, N. / Abbasi Yeganeh, F. / Dillard, L. / Michael, B. / Griffin, R. / Borgnia, M. / Kayed, R. / Taylor, K. / Lim, K. |
---|
履歴 | 登録 | 2020年12月28日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2022年1月12日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2024年5月29日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond |
---|
|
---|