Serum amyloid A protein / Serum amyloid A protein / Serum amyloid A proteins signature. / Serum amyloid A proteins / response to stilbenoid / high-density lipoprotein particle / acute-phase response / Serum amyloid A-2 protein
Function and homology information
Biological species
Mus musculus (house mouse)
Method
ELECTRON MICROSCOPY / helical reconstruction / cryo EM / Resolution: 3.5 Å
Journal: Nat Commun / Year: 2021 Title: AA amyloid fibrils from diseased tissue are structurally different from in vitro formed SAA fibrils. Authors: Akanksha Bansal / Matthias Schmidt / Matthies Rennegarbe / Christian Haupt / Falk Liberta / Sabrina Stecher / Ioana Puscalau-Girtu / Alexander Biedermann / Marcus Fändrich / Abstract: Systemic AA amyloidosis is a world-wide occurring protein misfolding disease of humans and animals. It arises from the formation of amyloid fibrils from serum amyloid A (SAA) protein. Using cryo ...Systemic AA amyloidosis is a world-wide occurring protein misfolding disease of humans and animals. It arises from the formation of amyloid fibrils from serum amyloid A (SAA) protein. Using cryo electron microscopy we here show that amyloid fibrils which were purified from AA amyloidotic mice are structurally different from fibrils formed from recombinant SAA protein in vitro. Ex vivo amyloid fibrils consist of fibril proteins that contain more residues within their ordered parts and possess a higher β-sheet content than in vitro fibril proteins. They are also more resistant to proteolysis than their in vitro formed counterparts. These data suggest that pathogenic amyloid fibrils may originate from proteolytic selection, allowing specific fibril morphologies to proliferate and to cause damage to the surrounding tissue.
I: Serum amyloid A-2 protein J: Serum amyloid A-2 protein H: Serum amyloid A-2 protein F: Serum amyloid A-2 protein G: Serum amyloid A-2 protein E: Serum amyloid A-2 protein C: Serum amyloid A-2 protein D: Serum amyloid A-2 protein B: Serum amyloid A-2 protein A: Serum amyloid A-2 protein L: Serum amyloid A-2 protein M: Serum amyloid A-2 protein K: Serum amyloid A-2 protein O: Serum amyloid A-2 protein P: Serum amyloid A-2 protein N: Serum amyloid A-2 protein R: Serum amyloid A-2 protein Q: Serum amyloid A-2 protein
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