- EMDB-41105: CryoEM structure of human DDB1-DCAF12 in complex with MAGEA3 -
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Basic information
Entry
Database: EMDB / ID: EMD-41105
Title
CryoEM structure of human DDB1-DCAF12 in complex with MAGEA3
Map data
the CryoEM map
Sample
Complex: Ternary complex of DCAF12-DDB1-MAGEA3
Protein or peptide: DNA damage-binding protein 1
Protein or peptide: DDB1- and CUL4-associated factor 12
Protein or peptide: Melanoma-associated antigen 3
Keywords
DCAF12 / DNA damage-binding protein 1 / DDB1 / E3 ligase / LIGASE
Function / homology
Function and homology information
caspase binding / positive regulation by virus of viral protein levels in host cell / ubiquitin-dependent protein catabolic process via the C-end degron rule pathway / epigenetic programming in the zygotic pronuclei / spindle assembly involved in female meiosis / Cul4-RING E3 ubiquitin ligase complex / UV-damage excision repair / negative regulation of protein processing / biological process involved in interaction with symbiont / WD40-repeat domain binding ...caspase binding / positive regulation by virus of viral protein levels in host cell / ubiquitin-dependent protein catabolic process via the C-end degron rule pathway / epigenetic programming in the zygotic pronuclei / spindle assembly involved in female meiosis / Cul4-RING E3 ubiquitin ligase complex / UV-damage excision repair / negative regulation of protein processing / biological process involved in interaction with symbiont / WD40-repeat domain binding / regulation of mitotic cell cycle phase transition / Cul4A-RING E3 ubiquitin ligase complex / Cul4B-RING E3 ubiquitin ligase complex / ubiquitin ligase complex scaffold activity / negative regulation of reproductive process / negative regulation of developmental process / cullin family protein binding / viral release from host cell / ubiquitin-like ligase-substrate adaptor activity / ectopic germ cell programmed cell death / proteasomal protein catabolic process / positive regulation of viral genome replication / negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway / positive regulation of gluconeogenesis / T cell activation / negative regulation of autophagy / regulation of autophagy / nucleotide-excision repair / Recognition of DNA damage by PCNA-containing replication complex / DNA Damage Recognition in GG-NER / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / regulation of circadian rhythm / Dual Incision in GG-NER / Transcription-Coupled Nucleotide Excision Repair (TC-NER) / Formation of TC-NER Pre-Incision Complex / Wnt signaling pathway / Formation of Incision Complex in GG-NER / histone deacetylase binding / Dual incision in TC-NER / Gap-filling DNA repair synthesis and ligation in TC-NER / positive regulation of protein catabolic process / cellular response to UV / rhythmic process / protein-macromolecule adaptor activity / Neddylation / site of double-strand break / ubiquitin-dependent protein catabolic process / proteasome-mediated ubiquitin-dependent protein catabolic process / chromosome, telomeric region / damaged DNA binding / protein ubiquitination / DNA repair / centrosome / apoptotic process / DNA damage response / protein-containing complex binding / nucleolus / negative regulation of apoptotic process / negative regulation of transcription by RNA polymerase II / endoplasmic reticulum / protein-containing complex / DNA binding / extracellular space / extracellular exosome / nucleoplasm / nucleus / cytoplasm / cytosol Similarity search - Function
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