登録情報 | データベース: EMDB / ID: EMD-40715 |
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タイトル | Structure of human ULK1 complex core (2:2:2 stoichiometry) in the PI3KC3-C1 mixture |
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マップデータ | |
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試料 | - 複合体: Human autophagy initiation ULK1 complex core
- タンパク質・ペプチド: RB1-inducible coiled-coil protein 1
- タンパク質・ペプチド: Serine/threonine-protein kinase ULK1
- タンパク質・ペプチド: Autophagy-related protein 13
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キーワード | Autophagy / Protein kinase / Complex / IMMUNE SYSTEM |
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機能・相同性 | 機能・相同性情報
omegasome membrane / regulation of protein lipidation / neuron projection regeneration / ribophagy / glycophagy / negative regulation of collateral sprouting / Atg1/ULK1 kinase complex / response to mitochondrial depolarisation / positive regulation of autophagosome assembly / protein localization to phagophore assembly site ...omegasome membrane / regulation of protein lipidation / neuron projection regeneration / ribophagy / glycophagy / negative regulation of collateral sprouting / Atg1/ULK1 kinase complex / response to mitochondrial depolarisation / positive regulation of autophagosome assembly / protein localization to phagophore assembly site / phagophore assembly site membrane / piecemeal microautophagy of the nucleus / RAB GEFs exchange GTP for GDP on RABs / protein kinase regulator activity / regulation of tumor necrosis factor-mediated signaling pathway / phagophore assembly site / axon extension / TBC/RABGAPs / reticulophagy / positive regulation of protein targeting to mitochondrion / Macroautophagy / Receptor Mediated Mitophagy / response to starvation / cellular response to nutrient levels / autophagosome membrane / mitophagy / positive regulation of cell size / autophagosome assembly / autophagosome / regulation of macroautophagy / negative regulation of protein-containing complex assembly / positive regulation of autophagy / extrinsic apoptotic signaling pathway / protein-membrane adaptor activity / protein serine/threonine kinase activator activity / liver development / negative regulation of extrinsic apoptotic signaling pathway / macroautophagy / Regulation of TNFR1 signaling / positive regulation of JNK cascade / peptidyl-threonine phosphorylation / protein localization / recycling endosome / autophagy / small GTPase binding / neuron projection development / GTPase binding / heart development / peptidyl-serine phosphorylation / nuclear membrane / mitochondrial outer membrane / protein autophosphorylation / molecular adaptor activity / lysosome / non-specific serine/threonine protein kinase / positive regulation of protein phosphorylation / cell cycle / negative regulation of cell population proliferation / axon / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / protein-containing complex binding / endoplasmic reticulum membrane / protein kinase binding / signal transduction / mitochondrion / ATP binding / identical protein binding / cytoplasm / cytosol類似検索 - 分子機能 Autophagy-related protein 11, C-terminal / Autophagy-related protein 11 / Autophagy-related protein 11 / Serine/threonine-protein kinase, Ulk1/Ulk2 / : / ATG1-like, MIT domain 2 / Autophagy-related protein 13, N-terminal / Autophagy-related protein 13 / Autophagy-related protein 13 / Serine/threonine-protein kinase Atg1-like, tMIT domain ...Autophagy-related protein 11, C-terminal / Autophagy-related protein 11 / Autophagy-related protein 11 / Serine/threonine-protein kinase, Ulk1/Ulk2 / : / ATG1-like, MIT domain 2 / Autophagy-related protein 13, N-terminal / Autophagy-related protein 13 / Autophagy-related protein 13 / Serine/threonine-protein kinase Atg1-like, tMIT domain / Atg1-like, MIT domain 1 / Serine/threonine-protein kinase Atg1-like / HORMA domain superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily類似検索 - ドメイン・相同性 Autophagy-related protein 13 / Serine/threonine-protein kinase ULK1 / RB1-inducible coiled-coil protein 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 5.85 Å |
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データ登録者 | Chen M / Hurley JH |
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資金援助 | 米国, 2件 Organization | Grant number | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM111730 | 米国 | Michael J. Fox Foundation | ASAP-000350 | 米国 |
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引用 | ジャーナル: bioRxiv / 年: 2023 タイトル: Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex 著者: Chen M / Ren X / Cook A / Hurley JH |
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履歴 | 登録 | 2023年5月4日 | - |
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ヘッダ(付随情報) 公開 | 2023年6月21日 | - |
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マップ公開 | 2023年6月21日 | - |
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更新 | 2024年6月19日 | - |
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現状 | 2024年6月19日 | 処理サイト: RCSB / 状態: 公開 |
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