登録情報 | データベース: EMDB / ID: EMD-36003 |
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タイトル | Cryo-EM structure of the Tocilizumab Fab/IL-6R complex |
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マップデータ | |
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試料 | - 複合体: the tocilizumab Fab/IL-6R complex
- タンパク質・ペプチド: Heavy chain of Tocilizumab Fab
- タンパク質・ペプチド: Light chain of Tocilizumab Fab
- タンパク質・ペプチド: Interleukin-6 receptor subunit alpha
- タンパク質・ペプチド: IL6R-D2 peptide
- リガンド: 2-acetamido-2-deoxy-beta-D-glucopyranose
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キーワード | antibody / IL-6R / structural protein / IMMUNE SYSTEM |
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機能・相同性 | 機能・相同性情報
ciliary neurotrophic factor binding / interleukin-6 receptor activity / interleukin-6 binding / hepatic immune response / interleukin-11 receptor activity / interleukin-11 binding / ciliary neurotrophic factor-mediated signaling pathway / ciliary neurotrophic factor receptor complex / interleukin-6 receptor complex / negative regulation of collagen biosynthetic process ...ciliary neurotrophic factor binding / interleukin-6 receptor activity / interleukin-6 binding / hepatic immune response / interleukin-11 receptor activity / interleukin-11 binding / ciliary neurotrophic factor-mediated signaling pathway / ciliary neurotrophic factor receptor complex / interleukin-6 receptor complex / negative regulation of collagen biosynthetic process / : / T-helper 17 cell lineage commitment / endocrine pancreas development / positive regulation of glomerular mesangial cell proliferation / negative regulation of interleukin-8 production / vascular endothelial growth factor production / positive regulation of leukocyte chemotaxis / neutrophil mediated immunity / cytokine receptor activity / interleukin-6-mediated signaling pathway / Interleukin-6 signaling / MAPK3 (ERK1) activation / monocyte chemotaxis / MAPK1 (ERK2) activation / positive regulation of osteoblast differentiation / positive regulation of chemokine production / extrinsic apoptotic signaling pathway / positive regulation of tyrosine phosphorylation of STAT protein / positive regulation of smooth muscle cell proliferation / response to cytokine / acute-phase response / Transcriptional regulation of granulopoiesis / cytokine-mediated signaling pathway / positive regulation of interleukin-6 production / positive regulation of peptidyl-tyrosine phosphorylation / Potential therapeutics for SARS / Interleukin-4 and Interleukin-13 signaling / defense response to Gram-negative bacterium / receptor complex / positive regulation of MAPK cascade / defense response to Gram-positive bacterium / apical plasma membrane / external side of plasma membrane / positive regulation of cell population proliferation / enzyme binding / protein homodimerization activity / extracellular space / extracellular region / plasma membrane類似検索 - 分子機能 Type I cytokine receptor, cytokine-binding domain / Interleukin-6 receptor alpha chain, binding / Long hematopoietin receptor, soluble alpha chain, conserved site / Long hematopoietin receptor, soluble alpha chains family signature. / : / Immunoglobulin / Immunoglobulin domain / Fibronectin type 3 domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type ...Type I cytokine receptor, cytokine-binding domain / Interleukin-6 receptor alpha chain, binding / Long hematopoietin receptor, soluble alpha chain, conserved site / Long hematopoietin receptor, soluble alpha chains family signature. / : / Immunoglobulin / Immunoglobulin domain / Fibronectin type 3 domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / Immunoglobulin subtype / Immunoglobulin / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.3 Å |
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データ登録者 | She J / Chen L |
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資金援助 | 中国, 1件 Organization | Grant number | 国 |
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Ministry of Science and Technology (MoST, China) | 2021YFF0600800 | 中国 |
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引用 | ジャーナル: To Be Published タイトル: Cryo-EM structures of tocilizumab and sarilumab Fabs in complex with IL-6R 著者: She J / Wang MX |
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履歴 | 登録 | 2023年4月25日 | - |
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ヘッダ(付随情報) 公開 | 2024年3月27日 | - |
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マップ公開 | 2024年3月27日 | - |
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更新 | 2024年3月27日 | - |
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現状 | 2024年3月27日 | 処理サイト: PDBj / 状態: 公開 |
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