登録情報 | データベース: EMDB / ID: EMD-33494 |
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タイトル | Cryo-EM structure of the TRH-bound human TRHR-Gq complex |
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マップデータ | |
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試料 | - 複合体: Cryo-EM structure of the TRH-bound TRHR-Gq complex
- 複合体: Thyrotropin-releasing hormone receptor
- タンパク質・ペプチド: Thyrotropin-releasing hormone receptor
- 複合体: antibody
- タンパク質・ペプチド: single Fab chain (svFv16)
- 複合体: G protein
- タンパク質・ペプチド: Guanine nucleotide-binding protein G(q) subunit alpha
- タンパク質・ペプチド: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
- タンパク質・ペプチド: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
- 複合体: TRH peptide
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キーワード | TRHR / TRH / Class A GPCR / BIOSYNTHETIC PROTEIN / MEMBRANE PROTEIN / STRUCTURAL PROTEIN |
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機能・相同性 | 機能・相同性情報
thyrotropin-releasing hormone receptor activity / G-protein activation / Activation of the phototransduction cascade / Glucagon-type ligand receptors / Thromboxane signalling through TP receptor / Sensory perception of sweet, bitter, and umami (glutamate) taste / G beta:gamma signalling through PI3Kgamma / G beta:gamma signalling through CDC42 / Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding / Activation of G protein gated Potassium channels ...thyrotropin-releasing hormone receptor activity / G-protein activation / Activation of the phototransduction cascade / Glucagon-type ligand receptors / Thromboxane signalling through TP receptor / Sensory perception of sweet, bitter, and umami (glutamate) taste / G beta:gamma signalling through PI3Kgamma / G beta:gamma signalling through CDC42 / Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding / Activation of G protein gated Potassium channels / Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits / Ca2+ pathway / G alpha (z) signalling events / Vasopressin regulates renal water homeostasis via Aquaporins / Glucagon-like Peptide-1 (GLP1) regulates insulin secretion / Adrenaline,noradrenaline inhibits insulin secretion / ADP signalling through P2Y purinoceptor 12 / G alpha (q) signalling events / Thrombin signalling through proteinase activated receptors (PARs) / G alpha (i) signalling events / Activation of G protein gated Potassium channels / G-protein activation / G beta:gamma signalling through PI3Kgamma / Prostacyclin signalling through prostacyclin receptor / G beta:gamma signalling through PLC beta / ADP signalling through P2Y purinoceptor 1 / Thromboxane signalling through TP receptor / Presynaptic function of Kainate receptors / G beta:gamma signalling through CDC42 / Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits / Glucagon-type ligand receptors / Adrenaline,noradrenaline inhibits insulin secretion / G alpha (12/13) signalling events / G beta:gamma signalling through BTK / ADP signalling through P2Y purinoceptor 12 / alkylglycerophosphoethanolamine phosphodiesterase activity / Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding / Thrombin signalling through proteinase activated receptors (PARs) / Ca2+ pathway / G alpha (z) signalling events / Extra-nuclear estrogen signaling / G alpha (s) signalling events / G alpha (q) signalling events / photoreceptor outer segment membrane / G alpha (i) signalling events / Glucagon-like Peptide-1 (GLP1) regulates insulin secretion / spectrin binding / Vasopressin regulates renal water homeostasis via Aquaporins / photoreceptor outer segment / cardiac muscle cell apoptotic process / photoreceptor inner segment / Peptide ligand-binding receptors / cellular response to catecholamine stimulus / sensory perception of taste / adenylate cyclase-activating dopamine receptor signaling pathway / cellular response to prostaglandin E stimulus / G-protein beta-subunit binding / heterotrimeric G-protein complex / signaling receptor complex adaptor activity / GTPase binding / retina development in camera-type eye / cellular response to hypoxia / phospholipase C-activating G protein-coupled receptor signaling pathway / positive regulation of cytosolic calcium ion concentration / cell body / G alpha (q) signalling events / cell population proliferation / G protein-coupled receptor signaling pathway / GTPase activity / dendrite / protein-containing complex binding / membrane / plasma membrane / cytoplasm類似検索 - 分子機能 Thyrotropin-releasing hormone receptor / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein, gamma subunit / G-protein gamma subunit domain profile. / GGL domain / G-protein gamma-like domain superfamily / G-protein gamma-like domain / GGL domain / G protein gamma subunit-like motifs / Guanine nucleotide-binding protein, beta subunit ...Thyrotropin-releasing hormone receptor / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein, gamma subunit / G-protein gamma subunit domain profile. / GGL domain / G-protein gamma-like domain superfamily / G-protein gamma-like domain / GGL domain / G protein gamma subunit-like motifs / Guanine nucleotide-binding protein, beta subunit / G-protein, beta subunit / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / G-protein beta WD-40 repeat / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily類似検索 - ドメイン・相同性 Thyrotropin-releasing hormone receptor / Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 / Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) / synthetic construct (人工物) / ![](img/tx_mammal.gif) Rattus norvegicus (ドブネズミ) / ![](img/tx_mammal.gif) Bos taurus (ウシ) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 2.7 Å |
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データ登録者 | Ji S / Dong Y / Chen L / Zang S / Shen D / Guo J / Qin J / Zhang H / Wang W / Shen Q ...Ji S / Dong Y / Chen L / Zang S / Shen D / Guo J / Qin J / Zhang H / Wang W / Shen Q / Mao C / Zhang Y |
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資金援助 | 1件 Organization | Grant number | 国 |
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Not funded | | |
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引用 | ジャーナル: Cell Discov / 年: 2022 タイトル: Molecular basis for the activation of thyrotropin-releasing hormone receptor. 著者: Su-Yu Ji / Ying-Jun Dong / Li-Nan Chen / Shao-Kun Zang / Jiawei Wang / Dan-Dan Shen / Jia Guo / Jiao Qin / Huibing Zhang / Wei-Wei Wang / Qingya Shen / Yan Zhang / Zhangfa Song / Chunyou Mao / ![](img/flg_china.gif) |
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履歴 | 登録 | 2022年5月26日 | - |
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ヘッダ(付随情報) 公開 | 2022年12月28日 | - |
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マップ公開 | 2022年12月28日 | - |
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更新 | 2024年1月10日 | - |
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現状 | 2024年1月10日 | 処理サイト: PDBj / 状態: 公開 |
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