Entry Database : EMDB / ID : EMD-33494 Downloads & linksTitle Cryo-EM structure of the TRH-bound human TRHR-Gq complex Map data Details SampleComplex : Cryo-EM structure of the TRH-bound TRHR-Gq complexComplex : Thyrotropin-releasing hormone receptorProtein or peptide : Thyrotropin-releasing hormone receptorComplex : antibodyProtein or peptide : single Fab chain (svFv16)Complex : G proteinProtein or peptide : Guanine nucleotide-binding protein G(q) subunit alphaProtein or peptide : Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Protein or peptide : Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2Complex : TRH peptideProtein or peptide : TRH peptide Details Keywords TRHR / TRH / Class A GPCR / BIOSYNTHETIC PROTEIN / MEMBRANE PROTEIN / STRUCTURAL PROTEINFunction / homology Function and homology informationFunction Domain/homology Component
thyrotropin-releasing hormone receptor activity / G-protein activation / Activation of the phototransduction cascade / Glucagon-type ligand receptors / Thromboxane signalling through TP receptor / Sensory perception of sweet, bitter, and umami (glutamate) taste / G beta:gamma signalling through PI3Kgamma / G beta:gamma signalling through CDC42 / Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding / Activation of G protein gated Potassium channels ... thyrotropin-releasing hormone receptor activity / G-protein activation / Activation of the phototransduction cascade / Glucagon-type ligand receptors / Thromboxane signalling through TP receptor / Sensory perception of sweet, bitter, and umami (glutamate) taste / G beta:gamma signalling through PI3Kgamma / G beta:gamma signalling through CDC42 / Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding / Activation of G protein gated Potassium channels / Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits / Ca2+ pathway / G alpha (z) signalling events / Vasopressin regulates renal water homeostasis via Aquaporins / Glucagon-like Peptide-1 (GLP1) regulates insulin secretion / Adrenaline,noradrenaline inhibits insulin secretion / ADP signalling through P2Y purinoceptor 12 / G alpha (q) signalling events / G alpha (i) signalling events / Thrombin signalling through proteinase activated receptors (PARs) / Activation of G protein gated Potassium channels / G-protein activation / G beta:gamma signalling through PI3Kgamma / Prostacyclin signalling through prostacyclin receptor / G beta:gamma signalling through PLC beta / ADP signalling through P2Y purinoceptor 1 / Thromboxane signalling through TP receptor / Presynaptic function of Kainate receptors / G beta:gamma signalling through CDC42 / Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits / Glucagon-type ligand receptors / Adrenaline,noradrenaline inhibits insulin secretion / G alpha (12/13) signalling events / G beta:gamma signalling through BTK / alkylglycerophosphoethanolamine phosphodiesterase activity / ADP signalling through P2Y purinoceptor 12 / Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding / Thrombin signalling through proteinase activated receptors (PARs) / Ca2+ pathway / G alpha (z) signalling events / Extra-nuclear estrogen signaling / G alpha (s) signalling events / G alpha (q) signalling events / photoreceptor outer segment membrane / G alpha (i) signalling events / Glucagon-like Peptide-1 (GLP1) regulates insulin secretion / spectrin binding / Vasopressin regulates renal water homeostasis via Aquaporins / photoreceptor outer segment / cardiac muscle cell apoptotic process / photoreceptor inner segment / Peptide ligand-binding receptors / cellular response to catecholamine stimulus / sensory perception of taste / adenylate cyclase-activating dopamine receptor signaling pathway / cellular response to prostaglandin E stimulus / G-protein beta-subunit binding / heterotrimeric G-protein complex / signaling receptor complex adaptor activity / GTPase binding / retina development in camera-type eye / phospholipase C-activating G protein-coupled receptor signaling pathway / positive regulation of cytosolic calcium ion concentration / cell body / cellular response to hypoxia / G alpha (q) signalling events / cell population proliferation / G protein-coupled receptor signaling pathway / GTPase activity / dendrite / protein-containing complex binding / membrane / plasma membrane / cytoplasm Similarity search - Function Thyrotropin-releasing hormone receptor / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein, gamma subunit / G-protein gamma subunit domain profile. / GGL domain / G-protein gamma-like domain superfamily / G-protein gamma-like domain / GGL domain / G protein gamma subunit-like motifs / Guanine nucleotide-binding protein, beta subunit ... Thyrotropin-releasing hormone receptor / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein, gamma subunit / G-protein gamma subunit domain profile. / GGL domain / G-protein gamma-like domain superfamily / G-protein gamma-like domain / GGL domain / G protein gamma subunit-like motifs / Guanine nucleotide-binding protein, beta subunit / G-protein, beta subunit / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / G-protein beta WD-40 repeat / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily Similarity search - Domain/homology Thyrotropin-releasing hormone receptor / Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 / Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Similarity search - ComponentBiological species Homo sapiens (human) / synthetic construct (others) / Rattus norvegicus (Norway rat) / Bos taurus (cattle)Method single particle reconstruction / cryo EM / Resolution : 2.7 Å Details AuthorsJi S / Dong Y / Chen L / Zang S / Shen D / Guo J / Qin J / Zhang H / Wang W / Shen Q ...Ji S / Dong Y / Chen L / Zang S / Shen D / Guo J / Qin J / Zhang H / Wang W / Shen Q / Mao C / Zhang Y Funding support 1 items Details Hide detailsOrganization Grant number Country Not funded
CitationJournal : Cell Discov / Year : 2022Title : Molecular basis for the activation of thyrotropin-releasing hormone receptor.Authors : Su-Yu Ji / Ying-Jun Dong / Li-Nan Chen / Shao-Kun Zang / Jiawei Wang / Dan-Dan Shen / Jia Guo / Jiao Qin / Huibing Zhang / Wei-Wei Wang / Qingya Shen / Yan Zhang / Zhangfa Song / Chunyou Mao / History Deposition May 26, 2022 - Header (metadata) release Dec 28, 2022 - Map release Dec 28, 2022 - Update Jan 10, 2024 - Current status Jan 10, 2024 Processing site : PDBj / Status : Released
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