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- EMDB-31926: The overall structure of human chromatin remodeling PBAF-nucleoso... -

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基本情報

登録情報
データベース: EMDB / ID: EMD-31926
タイトルThe overall structure of human chromatin remodeling PBAF-nucleosome complex
マップデータThe structure of human chromatin remodeling PBAF-nucleosome complex
試料
  • 複合体: The motor-nucleosome module of human chromatin remodeling PBAF-nucleosome complex
    • タンパク質・ペプチド: x 17種
    • DNA: x 2種
  • リガンド: x 3種
キーワードcomplex / DNA BINDING PROTEIN
機能・相同性
機能・相同性情報


single stranded viral RNA replication via double stranded DNA intermediate / positive regulation of glucose mediated signaling pathway / regulation of DNA strand elongation / positive regulation of telomere maintenance in response to DNA damage / positive regulation of norepinephrine uptake / positive regulation of transcription of nucleolar large rRNA by RNA polymerase I / bBAF complex / Formation of the embryonic stem cell BAF (esBAF) complex / cellular response to cytochalasin B / neural retina development ...single stranded viral RNA replication via double stranded DNA intermediate / positive regulation of glucose mediated signaling pathway / regulation of DNA strand elongation / positive regulation of telomere maintenance in response to DNA damage / positive regulation of norepinephrine uptake / positive regulation of transcription of nucleolar large rRNA by RNA polymerase I / bBAF complex / Formation of the embryonic stem cell BAF (esBAF) complex / cellular response to cytochalasin B / neural retina development / npBAF complex / brahma complex / nBAF complex / Formation of the canonical BAF (cBAF) complex / negative regulation of androgen receptor signaling pathway / blastocyst hatching / regulation of transepithelial transport / EGR2 and SOX10-mediated initiation of Schwann cell myelination / N-acetyltransferase activity / hepatocyte differentiation / Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) / coronary artery morphogenesis / morphogenesis of a polarized epithelium / Formation of the polybromo-BAF (pBAF) complex / structural constituent of postsynaptic actin cytoskeleton / Formation of annular gap junctions / Formation of the dystrophin-glycoprotein complex (DGC) / Gap junction degradation / Formation of the non-canonical BAF (ncBAF) complex / GBAF complex / regulation of G0 to G1 transition / protein localization to adherens junction / Cell-extracellular matrix interactions / dense body / Folding of actin by CCT/TriC / Tat protein binding / nucleosome array spacer activity / histone H3K14ac reader activity / RNA polymerase I preinitiation complex assembly / postsynaptic actin cytoskeleton / Ino80 complex / RSC-type complex / blastocyst formation / Regulation of CDH1 Function / cellular response to fatty acid / XY body / host-mediated activation of viral transcription / regulation of double-strand break repair / regulation of nucleotide-excision repair / Prefoldin mediated transfer of substrate to CCT/TriC / Adherens junctions interactions / germ cell nucleus / RHOF GTPase cycle / adherens junction assembly / nucleosome disassembly / apical protein localization / Sensory processing of sound by outer hair cells of the cochlea / ATP-dependent chromatin remodeler activity / Interaction between L1 and Ankyrins / SWI/SNF complex / regulation of mitotic metaphase/anaphase transition / tight junction / Sensory processing of sound by inner hair cells of the cochlea / positive regulation of T cell differentiation / nuclear androgen receptor binding / apical junction complex / negative regulation of G1/S transition of mitotic cell cycle / positive regulation of double-strand break repair / histone acetyltransferase activity / nuclear chromosome / spinal cord development / regulation of chromosome organization / maintenance of blood-brain barrier / regulation of norepinephrine uptake / transporter regulator activity / positive regulation of stem cell population maintenance / NuA4 histone acetyltransferase complex / homeostatic process / RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known / establishment or maintenance of cell polarity / Regulation of MITF-M-dependent genes involved in pigmentation / Recycling pathway of L1 / cortical cytoskeleton / regulation of DNA replication / nitric-oxide synthase binding / regulation of embryonic development / regulation of G1/S transition of mitotic cell cycle / brush border / EPH-ephrin mediated repulsion of cells / negative regulation of cell differentiation / RHO GTPases Activate WASPs and WAVEs / cardiac muscle cell proliferation / regulation of synaptic vesicle endocytosis / embryonic organ development / positive regulation of myoblast differentiation / kinesin binding / positive regulation of signal transduction by p53 class mediator / ATP-dependent activity, acting on DNA / regulation of DNA repair / positive regulation of Wnt signaling pathway
類似検索 - 分子機能
PHD finger protein 10 / RFX DNA-binding domain / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 / : / SWIB domain / SWI complex, BAF60b domains / SMARCC, SWIRM-associated domain / SMARCC, N-terminal / : / SWIRM-associated domain at the N-terminal ...PHD finger protein 10 / RFX DNA-binding domain / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 / : / SWIB domain / SWI complex, BAF60b domains / SMARCC, SWIRM-associated domain / SMARCC, N-terminal / : / SWIRM-associated domain at the N-terminal / SWIRM-associated domain at the C-terminal / MarR-like, BRCT and chromo domains module profile. / DNA-binding RFX-type winged-helix domain / : / SWI/SNF Subunit INI1, DNA binding domain / RFX-type winged-helix DNA-binding domain profile. / Protein polybromo-1, Bromodomain 5 / SWI/SNF complex subunit BRG1 / Chromatin-remodeling complex component Sfh1/SNF5 / SMARCC, C-terminal / SWIRM-associated region 1 / SNF5/SMARCB1/INI1 / SNF5 / SMARCB1 / INI1 / Remodelling complex subunit Rsc/polybromo / Protein of unknown function DUF3512 / Domain of unknown function (DUF3512) / BRK domain / BRK domain / BRK domain superfamily / domain in transcription and CHROMO domain helicases / : / Glutamine-Leucine-Glutamine, QLQ / QLQ / QLQ domain profile. / QLQ / Snf2-ATP coupling, chromatin remodelling complex / Snf2, ATP coupling domain / Snf2-ATP coupling, chromatin remodelling complex / domain in helicases and associated with SANT domains / HSA domain / ARID DNA-binding domain / ARID DNA-binding domain superfamily / ARID/BRIGHT DNA binding domain / ARID domain profile. / BRIGHT, ARID (A/T-rich interaction domain) domain / ARID/BRIGHT DNA binding domain / Helicase/SANT-associated domain / HSA domain profile. / SWIRM domain / SWIRM domain / SWIRM domain profile. / SWIB/MDM2 domain / SWIB/MDM2 domain / SWIB/MDM2 domain profile. / Bromo adjacent homology domain / SWIB/MDM2 domain superfamily / BAH domain / Bromo adjacent homology (BAH) domain / Bromo adjacent homology (BAH) domain superfamily / BAH domain profile. / HMG (high mobility group) box / SANT domain profile. / Chromo/chromo shadow domain / Chromatin organization modifier domain / SANT domain / HMG boxes A and B DNA-binding domains profile. / high mobility group / High mobility group box domain / High mobility group box domain superfamily / Myb-like DNA-binding domain / : / SNF2-like, N-terminal domain superfamily / SNF2, N-terminal / SNF2-related domain / SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains / SANT/Myb domain / PHD-finger / BRCT domain superfamily / Actins signature 1. / Actin, conserved site / Actins signature 2. / Actin/actin-like conserved site / Actins and actin-related proteins signature. / Zinc finger PHD-type signature. / Zinc finger C2H2 type domain signature. / Actin / Actin family / Actin / Zinc finger PHD-type profile. / Zinc finger C2H2-type / Zinc finger, PHD-finger / Zinc finger, PHD-type / PHD zinc finger / : / Histone H2A conserved site / Histone H2A signature. / Histone H2B signature. / Histone H2B / Histone H2B / Histone H2A, C-terminal domain
類似検索 - ドメイン・相同性
Histone H3 / Actin-like protein 6A / Histone H2B 1.1 / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 / Actin, cytoplasmic 1 / Histone H4 / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 / AT-rich interactive domain-containing protein 2 / Histone H2A / Protein polybromo-1 ...Histone H3 / Actin-like protein 6A / Histone H2B 1.1 / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4 / Actin, cytoplasmic 1 / Histone H4 / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 / AT-rich interactive domain-containing protein 2 / Histone H2A / Protein polybromo-1 / SWI/SNF complex subunit SMARCC2 / PHD finger protein 10 / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 / SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 / Bromodomain-containing protein 7
類似検索 - 構成要素
生物種Homo sapiens (ヒト) / Xenopus laevis (アフリカツメガエル) / unidentified (未定義) / synthetic construct (人工物)
手法単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.4 Å
データ登録者Chen ZC / Chen KJ
資金援助 中国, 1件
OrganizationGrant number国
National Natural Science Foundation of China (NSFC) 中国
引用ジャーナル: Nature / 年: 2022
タイトル: Structure of human chromatin-remodelling PBAF complex bound to a nucleosome.
著者: Junjie Yuan / Kangjing Chen / Wenbo Zhang / Zhucheng Chen /
要旨: DNA wraps around the histone octamer to form nucleosomes, the repeating unit of chromatin, which create barriers for accessing genetic information. Snf2-like chromatin remodellers couple the energy ...DNA wraps around the histone octamer to form nucleosomes, the repeating unit of chromatin, which create barriers for accessing genetic information. Snf2-like chromatin remodellers couple the energy of ATP binding and hydrolysis to reposition and recompose the nucleosome, and have vital roles in various chromatin-based transactions. Here we report the cryo-electron microscopy structure of the 12-subunit human chromatin-remodelling polybromo-associated BRG1-associated factor (PBAF) complex bound to the nucleosome. The motor subunit SMARCA4 engages the nucleosome in the active conformation, which reveals clustering of multiple disease-associated mutations at the interfaces that are essential for chromatin-remodelling activity. SMARCA4 recognizes the H2A-H2B acidic pocket of the nucleosome through three arginine anchors of the Snf2 ATP coupling (SnAc) domain. PBAF shows notable functional modularity, and most of the auxiliary subunits are interwoven into three lobe-like submodules for nucleosome recognition. The PBAF-specific auxiliary subunit ARID2 acts as the structural core for assembly of the DNA-binding lobe, whereas PBRM1, PHF10 and BRD7 are collectively incorporated into the lobe for histone tail binding. Together, our findings provide mechanistic insights into nucleosome recognition by PBAF and a structural basis for understanding SMARCA4-related human diseases.
履歴
登録2021年9月7日-
ヘッダ(付随情報) 公開2022年5月18日-
マップ公開2022年5月18日-
更新2025年9月17日-
現状2025年9月17日処理サイト: PDBj / 状態: 公開

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構造の表示

添付画像

emd_31926.png

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マップ

ファイルダウンロード / ファイル: emd_31926.map.gz / 形式: CCP4 / 大きさ: 178 MB / タイプ: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
注釈The structure of human chromatin remodeling PBAF-nucleosome complex
投影像・断面図

画像のコントロール

大きさ
明度
コントラスト
その他
軸Z (Sec.)Y (Row.)X (Col.)
1.08 Å/pix.
x 360 pix.
= 389.7 Å		1.08 Å/pix.
x 360 pix.
= 389.7 Å		1.08 Å/pix.
x 360 pix.
= 389.7 Å

表面

投影像

断面 (1/3)

断面 (1/2)

断面 (2/3)

画像は Spider により作成

ボクセルのサイズX=Y=Z: 1.0825 Å
密度

ヒストグラム

ヒストグラム (対数)
表面レベル登録者による: 0.0062
最小 - 最大-0.020798853 - 0.05585075
平均 (標準偏差)0.00017559006 (±0.0013961836)
対称性空間群: 1
詳細

EMDB XML:

マップ形状
Axis orderXYZ
Origin000
サイズ360360360
Spacing360360360
セルA=B=C: 389.69998 Å
α=β=γ: 90.0 °

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添付データ

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試料の構成要素

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全体 : The motor-nucleosome module of human chromatin remodeling PBAF-nu...

全体名称: The motor-nucleosome module of human chromatin remodeling PBAF-nucleosome complex
要素
  • 複合体: The motor-nucleosome module of human chromatin remodeling PBAF-nucleosome complex
    • タンパク質・ペプチド: Histone H4
    • タンパク質・ペプチド: Histone H2A
    • タンパク質・ペプチド: Histone H2B 1.1
    • タンパク質・ペプチド: Histone H3
    • DNA: DNA (207-MER)
    • DNA: DNA (207-MER)
    • タンパク質・ペプチド: Isoform 2 of Transcription activator BRG1
    • タンパク質・ペプチド: Actin-like protein 6A
    • タンパク質・ペプチド: Actin, cytoplasmic 1
    • タンパク質・ペプチド: AT-rich interactive domain-containing protein 2,AT-rich interactive domain-containing protein 2
    • タンパク質・ペプチド: PHD finger protein 10
    • タンパク質・ペプチド: Isoform 2 of Bromodomain-containing protein 7
    • タンパク質・ペプチド: unknown
    • タンパク質・ペプチド: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
    • タンパク質・ペプチド: SWI/SNF complex subunit SMARCC2
    • タンパク質・ペプチド: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
    • タンパク質・ペプチド: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
    • タンパク質・ペプチド: Protein polybromo-1
    • タンパク質・ペプチド: unknown
  • リガンド: BERYLLIUM TRIFLUORIDE ION
  • リガンド: MAGNESIUM ION
  • リガンド: ADENOSINE-5'-DIPHOSPHATE

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超分子 #1: The motor-nucleosome module of human chromatin remodeling PBAF-nu...

超分子名称: The motor-nucleosome module of human chromatin remodeling PBAF-nucleosome complex
タイプ: complex / ID: 1 / 親要素: 0 / 含まれる分子: #1-#19
由来(天然)生物種: Homo sapiens (ヒト)

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分子 #1: Histone H4

分子名称: Histone H4 / タイプ: protein_or_peptide / ID: 1 / コピー数: 2 / 光学異性体: LEVO
由来(天然)生物種: Xenopus laevis (アフリカツメガエル)
分子量理論値: 11.394426 KDa
組換発現生物種: Escherichia coli (大腸菌)
配列文字列:
MSGRGKGGKG LGKGGAKRHR KVLRDNIQGI TKPAIRRLAR RGGVKRISGL IYEETRGVLK VFLENVIRDA VTYTEHAKRK TVTAMDVVY ALKRQGRTLY GFGG

UniProtKB: Histone H4

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分子 #2: Histone H2A

分子名称: Histone H2A / タイプ: protein_or_peptide / ID: 2 / コピー数: 2 / 光学異性体: LEVO
由来(天然)生物種: Xenopus laevis (アフリカツメガエル)
分子量理論値: 14.109436 KDa
組換発現生物種: Escherichia coli (大腸菌)
配列文字列:
MSGRGKQGGK TRAKAKTRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV YLAAVLEYLT AEILELAGNA ARDNKKTRII PRHLQLAVR NDEELNKLLG RVTIAQGGVL PNIQSVLLPK KTESSKSAKS K

UniProtKB: Histone H2A

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分子 #3: Histone H2B 1.1

分子名称: Histone H2B 1.1 / タイプ: protein_or_peptide / ID: 3 / コピー数: 2 / 光学異性体: LEVO
由来(天然)生物種: Xenopus laevis (アフリカツメガエル)
分子量理論値: 13.965265 KDa
組換発現生物種: Escherichia coli (大腸菌)
配列文字列:
MPEPAKSAPA PKKGSKKAVT KTQKKDGKKR RKSRKESYAI YVYKVLKQVH PDTGISSKAM SIMNSFVNDV FERIAGEASR LAHYNKRST ITSREIQTAV RLLLPGELAK HAVSEGTKAV TKYTSAK

UniProtKB: Histone H2B 1.1

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分子 #4: Histone H3

分子名称: Histone H3 / タイプ: protein_or_peptide / ID: 4 / コピー数: 2 / 光学異性体: LEVO
由来(天然)生物種: Xenopus laevis (アフリカツメガエル)
分子量理論値: 15.435126 KDa
組換発現生物種: Escherichia coli (大腸菌)
配列文字列:
MARTKQTARK STGGKAPRKQ LATKAARKSA PATGGVKKPH RYRPGTVALR EIRRYQKSTE LLIRKLPFQR LVREIAQDFK TDLRFQSSA VMALQEASEA YLVALFEDTN LCAIHAKRVT IMPKDIQLAR RIRGERA

UniProtKB: Histone H3

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分子 #7: Isoform 2 of Transcription activator BRG1

分子名称: Isoform 2 of Transcription activator BRG1 / タイプ: protein_or_peptide / ID: 7 / コピー数: 1 / 光学異性体: LEVO
EC番号: 加水分解酵素; 酸無水物に作用; 酸無水物に作用・細胞または細胞小器官の運動に関与
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 169.597938 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列: MQALGQQNRG PTPFNQNQLH QLRAQIMAYK MLARGQPLPD HLQMAVQGKR PMPGMQQQMP TLPPPSVSAT GPGPGPGPGP GPGPGPAPP NYSRPHGMGG PNMPPPGPSG VPPGMPGQPP GGPPKPWPEG PMANAAAPTS TPQKLIPPQP TGRPSPAPPA V PPAASPVM ...文字列:
MQALGQQNRG PTPFNQNQLH QLRAQIMAYK MLARGQPLPD HLQMAVQGKR PMPGMQQQMP TLPPPSVSAT GPGPGPGPGP GPGPGPAPP NYSRPHGMGG PNMPPPGPSG VPPGMPGQPP GGPPKPWPEG PMANAAAPTS TPQKLIPPQP TGRPSPAPPA V PPAASPVM PPQTQSPGQP AQPAPMVPLH QKQSRITPIQ KPRGLDPVEI LQEREYRLQA RIAHRIQELE NLPGSLAGDL RT KATIELK ALRLLNFQRQ LRQEVVVCMR RDTALETALN AKAYKRSKRQ SLREARITEK LEKQQKIEQE RKRRQKHQEY LNS ILQHAK DFKEYHRSVT GKIQKLTKAV ATYHANTERE QKKENERIEK ERMRRLMAED EEGYRKLIDQ KKDKRLAYLL QQTD EYVAN LTELVRQHKA AQVAKEKKKK KKKKKAENAE GQTPAIGPDG EPLDETSQMS DLPVKVIHVE SGKILTGTDA PKAGQ LEAW LEMNPGYEVA PRSDSEESGS EEEEEEEEEE QPQAAQPPTL PVEEKKKIPD PDSDDVSEVD ARHIIENAKQ DVDDEY GVS QALARGLQSY YAVAHAVTER VDKQSALMVN GVLKQYQIKG LEWLVSLYNN NLNGILADEM GLGKTIQTIA LITYLME HK RINGPFLIIV PLSTLSNWAY EFDKWAPSVV KVSYKGSPAA RRAFVPQLRS GKFNVLLTTY EYIIKDKHIL AKIRWKYM I VDEGHRMKNH HCKLTQVLNT HYVAPRRLLL TGTPLQNKLP ELWALLNFLL PTIFKSCSTF EQWFNAPFAM TGEKVDLNE EETILIIRRL HKVLRPFLLR RLKKEVEAQL PEKVEYVIKC DMSALQRVLY RHMQAKGVLL TDGSEKDKKG KGGTKTLMNT IMQLRKICN HPYMFQHIEE SFSEHLGFTG GIVQGLDLYR ASGKFELLDR ILPKLRATNH KVLLFCQMTS LMTIMEDYFA Y RGFKYLRL DGTTKAEDRG MLLKTFNEPG SEYFIFLLST RAGGLGLNLQ SADTVIIFDS DWNPHQDLQA QDRAHRIGQQ NE VRVLRLC TVNSVEEKIL AAAKYKLNVD QKVIQAGMFD QKSSSHERRA FLQAILEHEE QDEEEDEVPD DETVNQMIAR HEE EFDLFM RMDLDRRREE ARNPKRKPRL MEEDELPSWI IKDDAEVERL TCEEEEEKMF GRGSRHRKEV DYSDSLTEKQ WLKA IEEGT LEEIEEEVRQ KKSSRKRKRD SDAGSSTPTT STRSRDKDDE SKKQKKRGRP PAEKLSPNPP NLTKKMKKIV DAVIK YKDS SSGRQLSEVF IQLPSRKELP EYYELIRKPV DFKKIKERIR NHKYRSLNDL EKDVMLLCQN AQTFNLEGSL IYEDSI VLQ SVFTSVRQKI EKEDDSEGEE SEEEEEGEEE GSESESRSVK VKIKLGRKEK AQDRLKGGRR RPSRGSRAKP VVSDDDS EE EQEEDRSGSG SEEDASGGSW SHPQFEKWSH PQFEKWSHPQ FEK

UniProtKB: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

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分子 #8: Actin-like protein 6A

分子名称: Actin-like protein 6A / タイプ: protein_or_peptide / ID: 8 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 47.509812 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列: MSGGVYGGDE VGALVFDIGS YTVRAGYAGE DCPKVDFPTA IGMVVERDDG STLMEIDGDK GKQGGPTYYI DTNALRVPRE NMEAISPLK NGMVEDWDSF QAILDHTYKM HVKSEASLHP VLMSEAPWNT RAKREKLTEL MFEHYNIPAF FLCKTAVLTA F ANGRSTGL ...文字列:
MSGGVYGGDE VGALVFDIGS YTVRAGYAGE DCPKVDFPTA IGMVVERDDG STLMEIDGDK GKQGGPTYYI DTNALRVPRE NMEAISPLK NGMVEDWDSF QAILDHTYKM HVKSEASLHP VLMSEAPWNT RAKREKLTEL MFEHYNIPAF FLCKTAVLTA F ANGRSTGL ILDSGATHTT AIPVHDGYVL QQGIVKSPLA GDFITMQCRE LFQEMNIELV PPYMIASKEA VREGSPANWK RK EKLPQVT RSWHNYMCNC VIQDFQASVL QVSDSTYDEQ VAAQMPTVHY EFPNGYNCDF GAERLKIPEG LFDPSNVKGL SGN TMLGVS HVVTTSVGMC DIDIRPGLYG SVIVAGGNTL IQSFTDRLNR ELSQKTPPSM RLKLIANNTT VERRFSSWIG GSIL ASLGT FQQMWISKQE YEEGGKQCVE RKCP

UniProtKB: Actin-like protein 6A

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分子 #9: Actin, cytoplasmic 1

分子名称: Actin, cytoplasmic 1 / タイプ: protein_or_peptide / ID: 9 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 41.78266 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列: MDDDIAALVV DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK DSYVGDEAQS KRGILTLKYP IEHGIVTNWD DMEKIWHHT FYNELRVAPE EHPVLLTEAP LNPKANREKM TQIMFETFNT PAMYVAIQAV LSLYASGRTT GIVMDSGDGV T HTVPIYEG ...文字列:
MDDDIAALVV DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK DSYVGDEAQS KRGILTLKYP IEHGIVTNWD DMEKIWHHT FYNELRVAPE EHPVLLTEAP LNPKANREKM TQIMFETFNT PAMYVAIQAV LSLYASGRTT GIVMDSGDGV T HTVPIYEG YALPHAILRL DLAGRDLTDY LMKILTERGY SFTTTAEREI VRDIKEKLCY VALDFEQEMA TAASSSSLEK SY ELPDGQV ITIGNERFRC PEALFQPSFL GMESCGIHET TFNSIMKCDV DIRKDLYANT VLSGGTTMYP GIADRMQKEI TAL APSTMK IKIIAPPERK YSVWIGGSIL ASLSTFQQMW ISKQEYDESG PSIVHRKCF

UniProtKB: Actin, cytoplasmic 1

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分子 #10: AT-rich interactive domain-containing protein 2,AT-rich interacti...

分子名称: AT-rich interactive domain-containing protein 2,AT-rich interactive domain-containing protein 2
タイプ: protein_or_peptide / ID: 10 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 97.547102 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列: MANSTGKAPP DERRKGLAFL DELRQFHHSR GSPFKKIPAV GGKELDLHGL YTRVTTLGGF AKVSEKNQWG EIVEEFNFPR SCSNAAFAL KQYYLRYLEK YEKVHHFGED DDEVPPGNPK PQLPIGAIPS SYNYQQHSVS DYLRQSYGLS MDFNSPNDYN K LVLSLLSG ...文字列:
MANSTGKAPP DERRKGLAFL DELRQFHHSR GSPFKKIPAV GGKELDLHGL YTRVTTLGGF AKVSEKNQWG EIVEEFNFPR SCSNAAFAL KQYYLRYLEK YEKVHHFGED DDEVPPGNPK PQLPIGAIPS SYNYQQHSVS DYLRQSYGLS MDFNSPNDYN K LVLSLLSG LPNEVDFAIN VCTLLSNESK HVMQLEKDPK IITLLLANAG VFDDTLGSFS TVFGEEWKEK TDRDFVKFWK DI VDDNEVR DLISDRNKSH EGTSGEWIWE SLFHPPRKLG INDIEGQRVL QIAVILRNLS FEEGNVKLLA ANRTCLRFLL LSA HSHFIS LRQLGLDTLG NIAAELLLDP VDFKTTHLMF HTVTKCLMSR DRFLKMRGME ILGNLCKAED NGVLICEYVD QDSY REIIC HLTLPDVLLV ISTLEVLYML TEMGDVACTK IAKVEKSIDM LVCLVSMDIQ MFGPDALAAV KLIEHPSSSH QMLSE IRPQ AIEQVQTQTH VASAPASRAV VAQHVAPPPG IVEIDSEKFA CQWLNAHFEV NPDCSVSRAE MYSEYLSTCS KLARGG ILT STGFYKCLRT VFPNHTVKRV EDSSSNGQAH IHVVGVKRRA IPLPIQMYYQ QQPVSTSVVR VDSNTPMPPS PAVQVQG QP NSSQPSPFSG SSQPGDPMRK PGQNFMCLWQ SCKKWFQTPS QVFYHAATEH GGKDVYPGQC LWEGCEPFQR QRFSFITH L QDKHCSKDAL LAGLKQDEPG QAGSQKSSTK QPTVGGTSST PRAQKAIVNH PSAALMALRR GSRNLVFRDF TDEKEGPIT KHIRLTAALI LKNIGKYSEC GRRLLKRHEN NLSVLAISNM EASSTLAKCL YELNFTVQSK EQEKDSEMLQ

UniProtKB: AT-rich interactive domain-containing protein 2, AT-rich interactive domain-containing protein 2

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分子 #11: PHD finger protein 10

分子名称: PHD finger protein 10 / タイプ: protein_or_peptide / ID: 11 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 58.254164 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列: MHHHHHHHHH HHHGEFMAAA AGPGAALSPR PCDSDPATPG AQSPKDDNED NSNDGTQPSK RRRMGSGDSS RSCETSSQDL GFSYYPAEN LIEYKWPPDE TGEYYMLQEQ VSEYLGVTSF KRKYPDLERR DLSHKEKLYL RELNVITETQ CTLGLTALRS D EVIDLMIK ...文字列:
MHHHHHHHHH HHHGEFMAAA AGPGAALSPR PCDSDPATPG AQSPKDDNED NSNDGTQPSK RRRMGSGDSS RSCETSSQDL GFSYYPAEN LIEYKWPPDE TGEYYMLQEQ VSEYLGVTSF KRKYPDLERR DLSHKEKLYL RELNVITETQ CTLGLTALRS D EVIDLMIK EYPAKHAEYS VILQEKERQR ITDHYKEYSQ MQQQNTQKVE ASKVPEYIKK AAKKAAEFNS NLNRERMEER RA YFDLQTH VIQVPQGKYK VLPTERTKVS SYPVALIPGQ FQEYYKRYSP DELRYLPLNT ALYEPPLDPE LPALDSDGDS DDG EDGRGD EKRKNKGTSD SSSGNVSEGE SPPDSQEDSF QGRQKSKDKA ATPRKDGPKR SVLSKSVPGY KPKVIPNAIC GICL KGKES NKKGKAESLI HCSQCENSGH PSCLDMTMEL VSMIKTYPWQ CMECKTCIIC GQPHHEEEMM FCDMCDRGYH TFCVG LGAI PSGRWICDCC QRAPPTPRKV GRRGKNSKEG

UniProtKB: PHD finger protein 10

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分子 #12: Isoform 2 of Bromodomain-containing protein 7

分子名称: Isoform 2 of Bromodomain-containing protein 7 / タイプ: protein_or_peptide / ID: 12 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 74.385812 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列: MGKKHKKHKS DKHLYEEYVE KPLKLVLKVG GNEVTELSTG SSGHDSSLFE DKNDHDKHKD RKRKKRKKGE KQIPGEEKGR KRRRVKEDK KKRDRDRVEN EAEKDLQCHA PVRLDLPPEK PLTSSLAKQE EVEQTPLQEA LNQLMRQLQR KDPSAFFSFP V TDFIAPGY ...文字列:
MGKKHKKHKS DKHLYEEYVE KPLKLVLKVG GNEVTELSTG SSGHDSSLFE DKNDHDKHKD RKRKKRKKGE KQIPGEEKGR KRRRVKEDK KKRDRDRVEN EAEKDLQCHA PVRLDLPPEK PLTSSLAKQE EVEQTPLQEA LNQLMRQLQR KDPSAFFSFP V TDFIAPGY SMIIKHPMDF STMKEKIKNN DYQSIEELKD NFKLMCTNAM IYNKPETIYY KAAKKLLHSG MKILSQERIQ SL KQSIDFM ADLQKTRKQK DGTDTSQSGE DGGCWQRERE DSGDAEAHAF KSPSKENKKK DKDMLEDKFK SNNLEREQEQ LDR IVKESG GKLTRRLVNS QCEFERRKPD GTTTLGLLHP VDPIVGEPGY CPVRLGMTTG RLQSGVNTLQ GFKEDKRNKV TPVL YLNYG PYSSYAPHYD STFANISKDD SDLIYSTYGE DSDLPSDFSI HEFLATCQDY PYVMADSLLD VLTKGGHSRT LQEME MSLP EDEGHTRTLD TAKEMEQITE VEPPGRLDSS TQDRLIALKA VTNFGVPVEV FDSEEAEIFQ KKLDETTRLL RELQEA QNE RLSTRPPPNM ICLLGPSYRE MHLAEQVTNN LKELAQQVTP GDIVSTYGVR KAMGISIPSP VMENNFVDLT EDTEEPK KT DVAECGPGGS

UniProtKB: Bromodomain-containing protein 7

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分子 #13: unknown

分子名称: unknown / タイプ: protein_or_peptide / ID: 13 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: unidentified (未定義)
分子量理論値: 613.749 Da
組換発現生物種: Homo sapiens (ヒト)
配列文字列:
(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)

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分子 #14: SWI/SNF-related matrix-associated actin-dependent regulator of ch...

分子名称: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
タイプ: protein_or_peptide / ID: 14 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 44.199188 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列: MMMMALSKTF GQKPVKFQLE DDGEFYMIGS EVGNYLRMFR GSLYKRYPSL WRRLATVEER KKIVASSHGK KTKPNTKDHG YTTLATSVT LLKASEVEEI LDGNDEKYKA VSISTEPPTY LREQKAKRNS QWVPTLPNSS HHLDAVPCST TINRNRMGRD K KRTFPLCF ...文字列:
MMMMALSKTF GQKPVKFQLE DDGEFYMIGS EVGNYLRMFR GSLYKRYPSL WRRLATVEER KKIVASSHGK KTKPNTKDHG YTTLATSVT LLKASEVEEI LDGNDEKYKA VSISTEPPTY LREQKAKRNS QWVPTLPNSS HHLDAVPCST TINRNRMGRD K KRTFPLCF DDHDPAVIHE NASQPEVLVP IRLDMEIDGQ KLRDAFTWNM NEKLMTPEMF SEILCDDLDL NPLTFVPAIA SA IRQQIES YPTDSILEDQ SDQRVIIKLN IHVGNISLVD QFEWDMSEKE NSPEKFALKL CSELGLGGEF VTTIAYSIRG QLS WHQKTY AFSENPLPTV EIAIRNTGDA DQWCPLLETL TDAEMEKKIR DQDRNTRRMR RLANTAPAW

UniProtKB: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

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分子 #15: SWI/SNF complex subunit SMARCC2

分子名称: SWI/SNF complex subunit SMARCC2 / タイプ: protein_or_peptide / ID: 15 / コピー数: 2 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 133.048109 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列: MAVRKKDGGP NVKYYEAADT VTQFDNVRLW LGKNYKKYIQ AEPPTNKSLS SLVVQLLQFQ EEVFGKHVSN APLTKLPIKC FLDFKAGGS LCHILAAAYK FKSDQGWRRY DFQNPSRMDR NVEMFMTIEK SLVQNNCLSR PNIFLCPEIE PKLLGKLKDI I KRHQGTVT ...文字列:
MAVRKKDGGP NVKYYEAADT VTQFDNVRLW LGKNYKKYIQ AEPPTNKSLS SLVVQLLQFQ EEVFGKHVSN APLTKLPIKC FLDFKAGGS LCHILAAAYK FKSDQGWRRY DFQNPSRMDR NVEMFMTIEK SLVQNNCLSR PNIFLCPEIE PKLLGKLKDI I KRHQGTVT EDKNNASHVV YPVPGNLEEE EWVRPVMKRD KQVLLHWGYY PDSYDTWIPA SEIEASVEDA PTPEKPRKVH AK WILDTDT FNEWMNEEDY EVNDDKNPVS RRKKISAKTL TDEVNSPDSD RRDKKGGNYK KRKRSPSPSP TPEAKKKNAK KGP STPYTK SKRGHREEEQ EDLTKDMDEP SPVPNVEEVT LPKTVNTKKD SESAPVKGGT MTDLDEQEDE SMETTGKDED ENST GNKGE QTKNPDLHED NVTEQTHHII IPSYAAWFDY NSVHAIERRA LPEFFNGKNK SKTPEIYLAY RNFMIDTYRL NPQEY LTST ACRRNLAGDV CAIMRVHAFL EQWGLINYQV DAESRPTPMG PPPTSHFHVL ADTPSGLVPL QPKTPQQTSA SQQMLN FPD KGKEKPTDMQ NFGLRTDMYT KKNVPSKSKA AASATREWTE QETLLLLEAL EMYKDDWNKV SEHVGSRTQD ECILHFL RL PIEDPYLEDS EASLGPLAYQ PIPFSQSGNP VMSTVAFLAS VVDPRVASAA AKSALEEFSK MKEEVPTALV EAHVRKVE E AAKVTGKADP AFGLESSGIA GTTSDEPERI EESGNDEARV EGQATDEKKE PKEPREGGGA IEEEAKEKTS EAPKKDEEK GKEGDSEKES EKSDGDPIVD PEKEKEPKEG QEEVLKEVVE SEGERKTKVE RDIGEGNLST AAAAALAAAA VKAKHLAAVE ERKIKSLVA LLVETQMKKL EIKLRHFEEL ETIMDREREA LEYQRQQLLA DRQAFHMEQL KYAEMRARQQ HFQQMHQQQQ Q PPPALPPG SQPIPPTGAA GPPAVHGLAV APASVVPAPA GSGAPPGSLG PSEQIGQAGS TAGPQQQQPA GAPQPGAVPP GV PPPGPHG PSPFPNQQTP PSMMPGAVPG SGHPGVAGNA PLGLPFGMPP PPPPPAPSII PFGSLADSIS INLPAPPNLH GHH HHLPFA PGTLPPPNLP VSMANPLHPN LPATTTMPSS LPLGPGLGSA AAQSPAIVAA VQGNLLPSAS PLPDPGTPLP PDPT APSPG TVTPVPPPQ

UniProtKB: SWI/SNF complex subunit SMARCC2

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分子 #16: SWI/SNF-related matrix-associated actin-dependent regulator of ch...

分子名称: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
タイプ: protein_or_peptide / ID: 16 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 60.127332 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列: MAARAGFQSV APSGGAGASG GAGAAAALGP GGTPGPPVRM GPAPGQGLYR SPMPGAAYPR PGMLPGSRMT PQGPSMGPPG YGGNPSVRP GLAQSGMDQS RKRPAPQQIQ QVQQQAVQNR NHNAKKKKMA DKILPQRIRE LVPESQAYMD LLAFERKLDQ T IMRKRLDI ...文字列:
MAARAGFQSV APSGGAGASG GAGAAAALGP GGTPGPPVRM GPAPGQGLYR SPMPGAAYPR PGMLPGSRMT PQGPSMGPPG YGGNPSVRP GLAQSGMDQS RKRPAPQQIQ QVQQQAVQNR NHNAKKKKMA DKILPQRIRE LVPESQAYMD LLAFERKLDQ T IMRKRLDI QEALKRPIKQ KRKLRIFISN TFNPAKSDAE DGEGTVASWE LRVEGRLLED SALSKYDATK QKRKFSSFFK SL VIELDKD LYGPDNHLVE WHRTATTQET DGFQVKRPGD VNVRCTVLLM LDYQPPQFKL DPRLARLLGI HTQTRPVIIQ ALW QYIKTH KLQDPHEREF VICDKYLQQI FESQRMKFSE IPQRLHALLM PPEPIIINHV ISVDPNDQKK TACYDIDVEV DDTL KTQMN SFLLSTASQQ EIATLDNKIH ETIETINQLK TQREFMLSFA RDPQGFINDW LQSQCRDLKT MTDVVGNPEE ERRAE FYFQ PWAQEAVCRY FYSKVQQRRQ ELEQALGIRN TASHHHHHHH HHHHH

UniProtKB: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

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分子 #17: SWI/SNF-related matrix-associated actin-dependent regulator of ch...

分子名称: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
タイプ: protein_or_peptide / ID: 17 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 46.710371 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列: MSKRPSYAPP PTPAPATQMP STPGFVGYNP YSHLAYNNYR LGGNPGTNSR VTASSGITIP KPPKPPDKPL MPYMRYSRKV WDQVKASNP DLKLWEIGKI IGGMWRDLTD EEKQEYLNEY EAEKIEYNES MKAYHNSPAY LAYINAKSRA EAALEEESRQ R QSRMEKGE ...文字列:
MSKRPSYAPP PTPAPATQMP STPGFVGYNP YSHLAYNNYR LGGNPGTNSR VTASSGITIP KPPKPPDKPL MPYMRYSRKV WDQVKASNP DLKLWEIGKI IGGMWRDLTD EEKQEYLNEY EAEKIEYNES MKAYHNSPAY LAYINAKSRA EAALEEESRQ R QSRMEKGE PYMSIQPAED PDDYDDGFSM KHTATARFQR NHRLISEILS ESVVPDVRSV VTTARMQVLK RQVQSLMVHQ RK LEAELLQ IEERHQEKKR KFLESTDSFN NELKRLCGLK VEVDMEKIAA EIAQAEEQAR KRQEEREKEA AEQAERSQSS IVP EEEQAA NKGEEKKDDE NIPMETEETH LEETTESQQN GEEGTSTPED KESGQEGVDS MAEEGTSDSN TGSESNSATV EEPP TDPIP EDEKKE

UniProtKB: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

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分子 #18: Protein polybromo-1

分子名称: Protein polybromo-1 / タイプ: protein_or_peptide / ID: 18 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: Homo sapiens (ヒト)
分子量理論値: 116.76243 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列: MDDDMASPKL KLSRKSGISP KKSKYMTPMQ QKLNEVYEAV KNYTDKRGRR LSAIFLRLPS RSELPDYYLT IKKPMDMEKI RSHMMANKY QDIDSMVEDF VMMFNNACTY NEPESLIYKD ALVLHKVLLE TRRDLEGDED SHVPNVTLLI QELIHNLFVS V MSHQDDEG ...文字列:
MDDDMASPKL KLSRKSGISP KKSKYMTPMQ QKLNEVYEAV KNYTDKRGRR LSAIFLRLPS RSELPDYYLT IKKPMDMEKI RSHMMANKY QDIDSMVEDF VMMFNNACTY NEPESLIYKD ALVLHKVLLE TRRDLEGDED SHVPNVTLLI QELIHNLFVS V MSHQDDEG RCYSDSLAEI PAVDPNFPNK PPLTFDIIRK NVENNRYRRL DLFQEHMFEV LERARRMNRT DSEIYEDAVE LQ QFFIKIR DELCKNGEIL LSPALSYTTK HLHNDVEKER KEKLPKEIEE DKLKREEEKR EAEKSEDSSG AAGLSGLHRT YSQ DCSFKN SMYHVGDYVY VEPAEANLQP HIVCIERLWE DSAGEKWLYG CWFYRPNETF HLATRKFLEK EVFKSDYYNK VPVS KILGK CVVMFVKEYF KLCPENFRDE DVFVCESRYS AKTKSFKKIK LWTMPISSVR FVPRDVPLPV VRVASVFANA DKGDD EKNT DNSEDSRAED NFNLEKEKED VPVEMSNGEP GCHYFEQLHY NDMWLKVGDC VFIKSHGLVR PRVGRIEKVW VRDGAA YFY GPIFIHPEET EHEPTKMFYK KEVFLSNLEE TCPMTCILGK CAVLSFKDFL SCRPTEIPEN DILLCESRYN ESDKQMK KF KGLKRFSLSA KVVDDEIYYF RKPIVPQKEP SPLLEKKIQL LEAKFAELEG GDDDIEEMGE EDSEVIEPPS LPQLQTPL A SELDLMPYTP PQSTPKSAKG SAKKEGSKRK INMSGYILFS SEMRAVIKAQ HPDYSFGELS RLVGTEWRNL ETAKKAEYE ERAAKVAEQQ ERERAGMMGG YPPGLPPLQG PVDGLVSMGS MQPLHPGGPP PHHLPPGVPG LPGIPPPGVM NQGVAPMVGT PAPGGSPYG QQVGVLGPPG QQAPPPYPGP HPAGPPVIQQ PTTPMFVAPP PKTQRLLHSE AYLKYIEGLS AESNSISKWD Q TLAARRRD VHLSKEQESR LPSHWLKSKG AHTTMADALW RLRDLMLRDT LNIRQAYNLE NV

UniProtKB: Protein polybromo-1

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分子 #19: unknown

分子名称: unknown / タイプ: protein_or_peptide / ID: 19 / コピー数: 1 / 光学異性体: LEVO
由来(天然)生物種: unidentified (未定義)
分子量理論値: 1.379692 KDa
組換発現生物種: Homo sapiens (ヒト)
配列文字列:
(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)

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分子 #5: DNA (207-MER)

分子名称: DNA (207-MER) / タイプ: dna / ID: 5 / コピー数: 1 / 分類: DNA
由来(天然)生物種: synthetic construct (人工物)
分子量理論値: 63.679574 KDa
配列文字列: (DG)(DG)(DA)(DC)(DC)(DC)(DT)(DA)(DT)(DA) (DC)(DG)(DC)(DG)(DG)(DC)(DC)(DG)(DC)(DC) (DC)(DT)(DG)(DG)(DA)(DG)(DA)(DA)(DT) (DC)(DC)(DC)(DG)(DG)(DT)(DG)(DC)(DC)(DG) (DA) (DG)(DG)(DC)(DC)(DG) ...文字列:
(DG)(DG)(DA)(DC)(DC)(DC)(DT)(DA)(DT)(DA) (DC)(DG)(DC)(DG)(DG)(DC)(DC)(DG)(DC)(DC) (DC)(DT)(DG)(DG)(DA)(DG)(DA)(DA)(DT) (DC)(DC)(DC)(DG)(DG)(DT)(DG)(DC)(DC)(DG) (DA) (DG)(DG)(DC)(DC)(DG)(DC)(DT)(DC) (DA)(DA)(DT)(DT)(DG)(DG)(DT)(DC)(DG)(DT) (DA)(DG) (DA)(DC)(DA)(DG)(DC)(DT)(DC) (DT)(DA)(DG)(DC)(DA)(DC)(DC)(DG)(DC)(DT) (DT)(DA)(DA) (DA)(DC)(DG)(DC)(DA)(DC) (DG)(DT)(DA)(DC)(DG)(DC)(DG)(DC)(DT)(DG) (DT)(DC)(DC)(DC) (DC)(DC)(DG)(DC)(DG) (DT)(DT)(DT)(DT)(DA)(DA)(DC)(DC)(DG)(DC) (DC)(DA)(DA)(DG)(DG) (DG)(DG)(DA)(DT) (DT)(DA)(DC)(DT)(DC)(DC)(DC)(DT)(DA)(DG) (DT)(DC)(DT)(DC)(DC)(DA) (DG)(DG)(DC) (DA)(DC)(DG)(DT)(DG)(DT)(DC)(DA)(DG)(DA) (DT)(DA)(DT)(DA)(DT)(DA)(DC) (DA)(DT) (DC)(DC)(DT)(DG)(DA)(DA)(DG)(DC)(DT)(DT) (DG)(DT)(DC)(DG)(DA)(DG)(DA)(DA) (DG) (DT)(DA)(DC)(DT)(DA)(DG)(DA)(DG)(DG)(DA) (DT)(DC)(DA)(DT)(DA)(DA)(DT)(DC)(DA) (DG)(DC)(DC)(DA)(DT)(DA)(DC)

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分子 #6: DNA (207-MER)

分子名称: DNA (207-MER) / タイプ: dna / ID: 6 / コピー数: 1 / 分類: DNA
由来(天然)生物種: synthetic construct (人工物)
分子量理論値: 64.145816 KDa
配列文字列: (DG)(DT)(DA)(DT)(DG)(DG)(DC)(DT)(DG)(DA) (DT)(DT)(DA)(DT)(DG)(DA)(DT)(DC)(DC)(DT) (DC)(DT)(DA)(DG)(DT)(DA)(DC)(DT)(DT) (DC)(DT)(DC)(DG)(DA)(DC)(DA)(DA)(DG)(DC) (DT) (DT)(DC)(DA)(DG)(DG) ...文字列:
(DG)(DT)(DA)(DT)(DG)(DG)(DC)(DT)(DG)(DA) (DT)(DT)(DA)(DT)(DG)(DA)(DT)(DC)(DC)(DT) (DC)(DT)(DA)(DG)(DT)(DA)(DC)(DT)(DT) (DC)(DT)(DC)(DG)(DA)(DC)(DA)(DA)(DG)(DC) (DT) (DT)(DC)(DA)(DG)(DG)(DA)(DT)(DG) (DT)(DA)(DT)(DA)(DT)(DA)(DT)(DC)(DT)(DG) (DA)(DC) (DA)(DC)(DG)(DT)(DG)(DC)(DC) (DT)(DG)(DG)(DA)(DG)(DA)(DC)(DT)(DA)(DG) (DG)(DG)(DA) (DG)(DT)(DA)(DA)(DT)(DC) (DC)(DC)(DC)(DT)(DT)(DG)(DG)(DC)(DG)(DG) (DT)(DT)(DA)(DA) (DA)(DA)(DC)(DG)(DC) (DG)(DG)(DG)(DG)(DG)(DA)(DC)(DA)(DG)(DC) (DG)(DC)(DG)(DT)(DA) (DC)(DG)(DT)(DG) (DC)(DG)(DT)(DT)(DT)(DA)(DA)(DG)(DC)(DG) (DG)(DT)(DG)(DC)(DT)(DA) (DG)(DA)(DG) (DC)(DT)(DG)(DT)(DC)(DT)(DA)(DC)(DG)(DA) (DC)(DC)(DA)(DA)(DT)(DT)(DG) (DA)(DG) (DC)(DG)(DG)(DC)(DC)(DT)(DC)(DG)(DG)(DC) (DA)(DC)(DC)(DG)(DG)(DG)(DA)(DT) (DT) (DC)(DT)(DC)(DC)(DA)(DG)(DG)(DG)(DC)(DG) (DG)(DC)(DC)(DG)(DC)(DG)(DT)(DA)(DT) (DA)(DG)(DG)(DG)(DT)(DC)(DC)

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分子 #20: BERYLLIUM TRIFLUORIDE ION

分子名称: BERYLLIUM TRIFLUORIDE ION / タイプ: ligand / ID: 20 / コピー数: 1 / 式: BEF
分子量理論値: 66.007 Da
Chemical component information

ChemComp-BEF:
BERYLLIUM TRIFLUORIDE ION

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分子 #21: MAGNESIUM ION

分子名称: MAGNESIUM ION / タイプ: ligand / ID: 21 / コピー数: 1 / 式: MG
分子量理論値: 24.305 Da

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分子 #22: ADENOSINE-5'-DIPHOSPHATE

分子名称: ADENOSINE-5'-DIPHOSPHATE / タイプ: ligand / ID: 22 / コピー数: 1 / 式: ADP
分子量理論値: 427.201 Da
Chemical component information

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, エネルギー貯蔵分子*YM

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実験情報

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構造解析

手法クライオ電子顕微鏡法
解析単粒子再構成法
試料の集合状態particle

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試料調製

緩衝液pH: 7.5
凍結凍結剤: ETHANE

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電子顕微鏡法

顕微鏡FEI TITAN KRIOS
撮影フィルム・検出器のモデル: GATAN K3 (6k x 4k) / 平均電子線量: 50.0 e/Å2
電子線加速電圧: 300 kV / 電子線源: FIELD EMISSION GUN
電子光学系照射モード: OTHER / 撮影モード: BRIGHT FIELD
実験機器
モデル: Titan Krios / 画像提供: FEI Company

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画像解析

CTF補正タイプ: NONE
初期モデルモデルのタイプ: OTHER
最終 再構成解像度のタイプ: BY AUTHOR / 解像度: 3.4 Å / 解像度の算出法: FSC 0.143 CUT-OFF / 使用した粒子像数: 137659
初期 角度割当タイプ: OTHER
最終 角度割当タイプ: OTHER

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万見について

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お知らせ

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2022年2月9日: EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

  • EMDBのヘッダファイルのバージョン3が、公式のフォーマットとなりました。
  • これまでは公式だったバージョン1.9は、アーカイブから削除されます。

関連情報:EMDBヘッダ

外部リンク:wwPDBはEMDBデータモデルのバージョン3へ移行します

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2020年8月12日: 新型コロナ情報

新型コロナ情報

URL: https://pdbj.org/emnavi/covid19.php

新ページ: EM Navigatorに新型コロナウイルスの特設ページを開設しました。

関連情報:Covid-19情報 / 2020年3月5日: 新型コロナウイルスの構造データ

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2020年3月5日: 新型コロナウイルスの構造データ

新型コロナウイルスの構造データ

関連情報:万見生物種 / 2020年8月12日: 新型コロナ情報

外部リンク:COVID-19特集ページ - PDBj / 今月の分子2020年2月：コロナウイルスプロテーアーゼ

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2019年1月31日: EMDBのIDの桁数の変更

EMDBのIDの桁数の変更

  • EMDBエントリに付与されているアクセスコード(EMDB-ID)は4桁の数字(例、EMD-1234)でしたが、間もなく枯渇します。これまでの4桁のID番号は4桁のまま変更されませんが、4桁の数字を使い切った後に発行されるIDは5桁以上の数字(例、EMD-12345)になります。5桁のIDは2019年の春頃から発行される見通しです。
  • EM Navigator/万見では、接頭語「EMD-」は省略されています。

関連情報:Q: 「EMD」とは何ですか？ / 万見/EM NavigatorにおけるID/アクセスコードの表記

外部リンク:EMDB Accession Codes are Changing Soon! / PDBjへお問い合わせ

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2017年7月12日: PDB大規模アップデート

PDB大規模アップデート

  • 新バージョンのPDBx/mmCIF辞書形式に基づくデータがリリースされました。
  • 今回の更新はバージョン番号が4から5になる大規模なもので、全エントリデータの書き換えが行われる「Remediation」というアップデートに該当します。
  • このバージョンアップで、電子顕微鏡の実験手法に関する多くの項目の書式が改定されました(例：em_softwareなど)。
  • EM NavigatorとYorodumiでも、この改定に基づいた表示内容になります。

外部リンク:wwPDB Remediation / OneDepデータ基準に準拠した、より強化された内容のモデル構造ファイルが、PDBアーカイブで公開されました。

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万見 (Yorodumi)

幾万の構造データを、幾万の視点から

  • 万見(Yorodumi)は、EMDB/PDB/SASBDBなどの構造データを閲覧するためのページです。
  • EM Navigatorの詳細ページの後継、Omokage検索のフロントエンドも兼ねています。

関連情報:EMDB / PDB / SASBDB / 3つのデータバンクの比較 / 万見検索 / 2016年8月31日: 新しいEM Navigatorと万見 / 万見文献 / Jmol/JSmol / 機能・相同性情報 / 新しいEM Navigatorと万見の変更点

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