登録情報 データベース : EMDB / ID : EMD-30407 構造の表示 ダウンロードとリンクタイトル The LAT2-4F2hc complex in complex with leucine マップデータcryo EM map of the LAT2-4F2hc complex in complex with Leucine 詳細 試料複合体 : The LAT2-4F2hc complex in complex with leucineタンパク質・ペプチド : 4F2 cell-surface antigen heavy chainタンパク質・ペプチド : Large neutral amino acids transporter small subunit 2リガンド : LEUCINEリガンド : 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATEリガンド : water 詳細機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
proline transmembrane transport / glycine transmembrane transporter activity / organic cation transmembrane transporter activity / glycine transport / thyroid hormone transmembrane transporter activity / neutral L-amino acid secondary active transmembrane transporter activity / amino acid import across plasma membrane / Defective SLC7A7 causes lysinuric protein intolerance (LPI) / methionine transport / tyrosine transport ... proline transmembrane transport / glycine transmembrane transporter activity / organic cation transmembrane transporter activity / glycine transport / thyroid hormone transmembrane transporter activity / neutral L-amino acid secondary active transmembrane transporter activity / amino acid import across plasma membrane / Defective SLC7A7 causes lysinuric protein intolerance (LPI) / methionine transport / tyrosine transport / L-histidine transport / apical pole of neuron / aromatic amino acid transmembrane transporter activity / amino acid transport complex / L-amino acid transmembrane transporter activity / : / L-leucine import across plasma membrane / L-alanine transmembrane transporter activity / isoleucine transport / L-alanine import across plasma membrane / phenylalanine transport / valine transport / L-leucine transmembrane transporter activity / amino acid transmembrane transport / calcium:sodium antiporter activity / L-leucine transport / thyroid hormone transport / proline transport / toxin transmembrane transporter activity / neutral amino acid transport / amino acid transmembrane transporter activity / Amino acid transport across the plasma membrane / neutral L-amino acid transmembrane transporter activity / Tryptophan catabolism / exogenous protein binding / antiporter activity / anchoring junction / Basigin interactions / microvillus membrane / amino acid transport / response to exogenous dsRNA / tryptophan transport / transport across blood-brain barrier / basal plasma membrane / peptide antigen binding / calcium ion transport / double-stranded RNA binding / melanosome / virus receptor activity / basolateral plasma membrane / carbohydrate metabolic process / cadherin binding / symbiont entry into host cell / apical plasma membrane / protein heterodimerization activity / lysosomal membrane / synapse / cell surface / protein homodimerization activity / RNA binding / extracellular exosome / nucleoplasm / membrane / plasma membrane 類似検索 - 分子機能 L-type amino acid transporter / Solute carrier family 3 member 2, N-terminal domain / 4F2 cell-surface antigen heavy chain / Solute carrier family 3 member 2 N-terminus / Amino acid/polyamine transporter I / Amino acid permease / Alpha amylase, catalytic domain / Glycosyl hydrolase, family 13, catalytic domain / Alpha-amylase domain / Glycosyl hydrolase, all-beta / Glycoside hydrolase superfamily 類似検索 - ドメイン・相同性 Amino acid transporter heavy chain SLC3A2 / Large neutral amino acids transporter small subunit 2 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度 : 2.9 Å 詳細 データ登録者Yan RH / Zhou JY / Li YN / Lei JL / Zhou Q 資金援助 中国, 4件 詳細 詳細を隠すOrganization Grant number 国 National Science Foundation (NSF, China) 31971123 中国 National Science Foundation (NSF, China) 31930059 中国 National Science Foundation (NSF, China) 81920108015 中国 National Science Foundation (NSF, China) 31800139 中国
引用ジャーナル : Cell Discov / 年 : 2020タイトル : Structural insight into the substrate recognition and transport mechanism of the human LAT2-4F2hc complex.著者 : Renhong Yan / Jiayao Zhou / Yaning Li / Jianlin Lei / Qiang Zhou / 履歴 登録 2020年7月27日 - ヘッダ(付随情報) 公開 2020年12月23日 - マップ公開 2020年12月23日 - 更新 2020年12月23日 - 現状 2020年12月23日 処理サイト : PDBj / 状態 : 公開
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