登録情報 | データベース: EMDB / ID: EMD-25765 |
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タイトル | Cryo-EM structure of Human Enterovirus D68 US/MO/14-18947 strain native virion |
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マップデータ | Enterovirus D68 US/MO/14-18947 strain native virion |
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試料 | - ウイルス:
enterovirus D68 (エンテロウイルス)- タンパク質・ペプチド: viral protein 1
- タンパク質・ペプチド: viral protein 3
- タンパク質・ペプチド: viral protein 2
- タンパク質・ペプチド: viral protein 4
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キーワード | Virus / EV-D68 / acute flaccid myelitis / AFM / Structural Genomics / Center for Structural Genomics of Infectious Diseases / CSGID |
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機能・相同性 | 機能・相同性情報
picornain 2A / symbiont-mediated suppression of host mRNA export from nucleus / symbiont genome entry into host cell via pore formation in plasma membrane / picornain 3C / T=pseudo3 icosahedral viral capsid / host cell cytoplasmic vesicle membrane / cytoplasmic vesicle membrane / endocytosis involved in viral entry into host cell / nucleoside-triphosphate phosphatase / protein complex oligomerization ...picornain 2A / symbiont-mediated suppression of host mRNA export from nucleus / symbiont genome entry into host cell via pore formation in plasma membrane / picornain 3C / T=pseudo3 icosahedral viral capsid / host cell cytoplasmic vesicle membrane / cytoplasmic vesicle membrane / endocytosis involved in viral entry into host cell / nucleoside-triphosphate phosphatase / protein complex oligomerization / monoatomic ion channel activity / RNA helicase activity / symbiont-mediated suppression of host innate immune response / induction by virus of host autophagy / RNA-directed RNA polymerase / viral RNA genome replication / cysteine-type endopeptidase activity / RNA-dependent RNA polymerase activity / virus-mediated perturbation of host defense response / DNA-templated transcription / virion attachment to host cell / structural molecule activity / ATP hydrolysis activity / proteolysis / RNA binding / ATP binding / metal ion binding類似検索 - 分子機能 Poliovirus 3A protein-like / Poliovirus 3A protein like / Picornavirus 2B protein / Poliovirus core protein 3a, soluble domain / Picornavirus 2B protein / Peptidase C3, picornavirus core protein 2A / Picornavirus core protein 2A / Picornavirus coat protein VP4 / Picornavirus coat protein (VP4) / Picornavirales 3C/3C-like protease domain ...Poliovirus 3A protein-like / Poliovirus 3A protein like / Picornavirus 2B protein / Poliovirus core protein 3a, soluble domain / Picornavirus 2B protein / Peptidase C3, picornavirus core protein 2A / Picornavirus core protein 2A / Picornavirus coat protein VP4 / Picornavirus coat protein (VP4) / Picornavirales 3C/3C-like protease domain / Picornavirales 3C/3C-like protease domain profile. / Peptidase C3A/C3B, picornaviral / 3C cysteine protease (picornain 3C) / Picornavirus capsid / picornavirus capsid protein / Helicase, superfamily 3, single-stranded RNA virus / Superfamily 3 helicase of positive ssRNA viruses domain profile. / Helicase, superfamily 3, single-stranded DNA/RNA virus / RNA helicase / Picornavirus/Calicivirus coat protein / Viral coat protein subunit / RNA-directed RNA polymerase, C-terminal domain / Viral RNA-dependent RNA polymerase / Reverse transcriptase/Diguanylate cyclase domain / RNA-directed RNA polymerase, catalytic domain / RdRp of positive ssRNA viruses catalytic domain profile. / ATPases associated with a variety of cellular activities / AAA+ ATPase domain / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / DNA/RNA polymerase superfamily / P-loop containing nucleoside triphosphate hydrolase類似検索 - ドメイン・相同性 |
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生物種 | enterovirus D68 (エンテロウイルス) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 2.0 Å |
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データ登録者 | Fu J / Klose T |
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資金援助 | 米国, 1件 Organization | Grant number | 国 |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | R01-AI011219 | 米国 |
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引用 | ジャーナル: To Be Published タイトル: Isoxazole-3-Carboxamide Derivatives of Pleconaril Destabilize the Viral Capsid of Enterovirus-D68 著者: Lane T / Fu J / Sherry B / Tarbet B / Hurst BL / Riabova O / Kazakova E / Egorova A / Clarke P / Leser S / Frost J / Rudy M / Tyler K / Klose T / Kuhn RJ / Makarov V / Ekins S |
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履歴 | 登録 | 2021年12月19日 | - |
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ヘッダ(付随情報) 公開 | 2023年1月25日 | - |
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マップ公開 | 2023年1月25日 | - |
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更新 | 2024年6月5日 | - |
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現状 | 2024年6月5日 | 処理サイト: RCSB / 状態: 公開 |
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