Complex: C1 microtubule and its associated projection of central pair
Protein or peptide: x 52 types
Ligand: x 2 types
Function / homology
Function and homology information
axonemal central pair projection / : / axonemal central apparatus / axonemal central apparatus assembly / establishment of meiotic spindle localization / positive regulation of flagellated sperm motility / sperm axoneme assembly / sperm principal piece / cilium movement involved in cell motility / epithelial cilium movement involved in extracellular fluid movement ...axonemal central pair projection / : / axonemal central apparatus / axonemal central apparatus assembly / establishment of meiotic spindle localization / positive regulation of flagellated sperm motility / sperm axoneme assembly / sperm principal piece / cilium movement involved in cell motility / epithelial cilium movement involved in extracellular fluid movement / cilium movement / guanylate kinase activity / axoneme assembly / response to odorant / calcium-dependent cysteine-type endopeptidase activity / phosphopyruvate hydratase / phosphopyruvate hydratase complex / phosphopyruvate hydratase activity / adenylate kinase / adenylate kinase activity / manchette / filopodium assembly / MLL3/4 complex / Set1C/COMPASS complex / non-motile cilium / SRP-dependent cotranslational protein targeting to membrane, translocation / motile cilium / neuron projection extension / spindle organization / myosin phosphatase activity / protein serine/threonine phosphatase activity / protein-serine/threonine phosphatase / axoneme / : / chaperone cofactor-dependent protein refolding / cilium assembly / subtelomeric heterochromatin formation / enzyme regulator activity / protein folding chaperone / sperm midpiece / heat shock protein binding / tubulin binding / acrosomal vesicle / glycolytic process / electron transport chain / ATP-dependent protein folding chaperone / Hydrolases; Acting on acid anhydrides; Acting on GTP to facilitate cellular and subcellular movement / structural constituent of cytoskeleton / cilium / spindle pole / microtubule cytoskeleton organization / microtubule cytoskeleton / mitotic cell cycle / protein refolding / microtubule binding / microtubule / chromosome, telomeric region / hydrolase activity / calmodulin binding / negative regulation of cell population proliferation / phosphorylation / GTPase activity / calcium ion binding / GTP binding / magnesium ion binding / ATP hydrolysis activity / proteolysis / ATP binding / membrane / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol Similarity search - Function
Sperm-associated antigen 17 / Cilia- and flagella-associated protein 54 / Domain of unknown function DUF4456 / Domain of unknown function DUF4455 / Primary ciliary dyskinesia protein 1 / Flagellar C1a complex subunit C1a-32 / Deleted in lung and esophageal cancer protein 1 / Cilia- and flagella-associated protein 99 / Cilia- and flagella-associated protein 46 / Leucine-rich repeat-containing protein 72 ...Sperm-associated antigen 17 / Cilia- and flagella-associated protein 54 / Domain of unknown function DUF4456 / Domain of unknown function DUF4455 / Primary ciliary dyskinesia protein 1 / Flagellar C1a complex subunit C1a-32 / Deleted in lung and esophageal cancer protein 1 / Cilia- and flagella-associated protein 99 / Cilia- and flagella-associated protein 46 / Leucine-rich repeat-containing protein 72 / : / : / Domain of unknown function (DUF4455) / Domain of unknown function (DUF4456) / Flagellar C1a complex subunit C1a-32 / Cilia- and flagella-associated protein 54 / Cilia- and flagella-associated protein 69, ARM repeat / Hydrocephalus-inducing-like / Flagellar-associated PapD-like / CH-like domain in sperm protein / CH-like domain in sperm protein / Sdc1/DPY30 / Adenylate kinase, active site lid domain superfamily / Dpy-30 motif / Dpy-30 motif / Peptidase C2, calpain, catalytic domain / Calpain family cysteine protease / Cysteine proteinase, calpain-type, catalytic domain profile. / Calpain-like thiol protease family. / Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases. / MORN motif / MORN repeat / Serine-threonine protein phosphatase, N-terminal / Serine-threonine protein phosphatase N-terminal domain / Transglutaminase/protease-like homologues / Transglutaminase-like / RNA polymerase III subunit RPC82-related, helix-turn-helix / RNA polymerase III subunit RPC82 helix-turn-helix domain / Enolase / Enolase, conserved site / Enolase, C-terminal TIM barrel domain / Enolase, N-terminal / Enolase, C-terminal TIM barrel domain / Enolase, N-terminal domain / Enolase signature. / Enolase, C-terminal TIM barrel domain / Enolase, N-terminal domain / Adenylate kinase / Adenylate kinase, conserved site / Adenylate kinase signature. / Adenylate kinase/UMP-CMP kinase / Leucine rich repeat, ribonuclease inhibitor type / Leucine-rich repeat / Serine/threonine specific protein phosphatases signature. / Protein phosphatase 2A homologues, catalytic domain. / Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase / IQ calmodulin-binding motif / Guanylate kinase-like domain profile. / Guanylate kinase-like domain / Leucine-rich repeats, bacterial type / Heat shock hsp70 proteins family signature 2. / Heat shock hsp70 proteins family signature 1. / Heat shock hsp70 proteins family signature 3. / Heat shock protein 70, conserved site / Guanylate kinase/L-type calcium channel beta subunit / Guanylate kinase / Guanylate kinase homologues. / Heat shock protein 70kD, peptide-binding domain superfamily / Heat shock protein 70 family / Hsp70 protein / Calponin homology domain / Heat shock protein 70kD, C-terminal domain superfamily / Armadillo/beta-catenin-like repeat / Calponin homology (CH) domain / Leucine-rich repeat, SDS22-like subfamily / Short calmodulin-binding motif containing conserved Ile and Gln residues. / Enolase-like, N-terminal / Calponin homology domain / Enolase-like, C-terminal domain superfamily / CH domain superfamily / Calponin homology (CH) domain profile. / NADH dehydrogenase ubiquinone Fe-S protein 4, mitochondrial / Calcineurin-like phosphoesterase domain, ApaH type / Calcineurin-like phosphoesterase / IQ motif profile. / Armadillo/beta-catenin-like repeats / Armadillo / Metallo-dependent phosphatase-like / IQ motif, EF-hand binding site / Leucine rich repeat / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily / Tubulin-beta mRNA autoregulation signal. / Alpha tubulin / Beta tubulin, autoregulation binding site / Beta tubulin / Tubulin / Tubulin, C-terminal / Tubulin C-terminal domain / Tubulin, conserved site Similarity search - Domain/homology
Uncharacterized protein / Calponin-homology (CH) domain-containing protein / EF-hand domain-containing protein / Uncharacterized protein / adenylate kinase / Flagellar associated protein / HTH_9 domain-containing protein / Spermatogenesis-associated protein 17 / Flagellar associated protein / Sperm-associated antigen 6 ...Uncharacterized protein / Calponin-homology (CH) domain-containing protein / EF-hand domain-containing protein / Uncharacterized protein / adenylate kinase / Flagellar associated protein / HTH_9 domain-containing protein / Spermatogenesis-associated protein 17 / Flagellar associated protein / Sperm-associated antigen 6 / Flagellar associated protein / Flagellar associated protein / Flagellar associated protein / Cilia- and flagella-associated protein 69 ARM repeats domain-containing protein / Uncharacterized protein / Minichromosome loss protein Mcl1 middle region domain-containing protein / Cilia- and flagella-associated protein 46 / Calmodulin / Cilia- and flagella-associated protein 99 / Uncharacterized protein / Subunit of chromatin modifying protein / Cilia- and flagella-associated protein 54 / Uncharacterized protein / Flagellar associated coiled-coil protein / Uncharacterized protein / Uncharacterized protein / phosphopyruvate hydratase / Cilia- and flagella-associated protein 74 / Tubulin beta-1/beta-2 chain / Tubulin alpha-1 chain / Central apparatus associated protein C1a-86 / Central apparatus associated protein C1a-34 / Central apparatus associated protein C1a-32 / Central apparatus associated protein C1a-18 / Central pair complex 1 / PF6 protein / Serine/threonine-protein phosphatase Similarity search - Component
Journal: Nat Struct Mol Biol / Year: 2022 Title: Cryo-EM structure of an active central apparatus. Authors: Long Han / Qinhui Rao / Renbin Yang / Yue Wang / Pengxin Chai / Yong Xiong / Kai Zhang / Abstract: Accurately regulated ciliary beating in time and space is critical for diverse cellular activities, which impact the survival and development of nearly all eukaryotic species. An essential beating ...Accurately regulated ciliary beating in time and space is critical for diverse cellular activities, which impact the survival and development of nearly all eukaryotic species. An essential beating regulator is the conserved central apparatus (CA) of motile cilia, composed of a pair of microtubules (C1 and C2) associated with hundreds of protein subunits per repeating unit. It is largely unclear how the CA plays its regulatory roles in ciliary motility. Here, we present high-resolution structures of Chlamydomonas reinhardtii CA by cryo-electron microscopy (cryo-EM) and its dynamic conformational behavior at multiple scales. The structures show how functionally related projection proteins of CA are clustered onto a spring-shaped scaffold of armadillo-repeat proteins, facilitated by elongated rachis-like proteins. The two halves of the CA are brought together by elastic chain-like bridge proteins to achieve coordinated activities. We captured an array of kinesin-like protein (KLP1) in two different stepping states, which are actively correlated with beating wave propagation of cilia. These findings establish a structural framework for understanding the role of the CA in cilia.
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