ジャーナル: J Virol / 年: 2023 タイトル: Toward the understanding of DSG2 and CD46 interaction with HAdV-11 fiber, a super-complex analysis. 著者: Gregory Effantin / Marc-André Hograindleur / Daphna Fenel / Pascal Fender / Emilie Vassal-Stermann / 要旨: The main limitation of oncolytic vectors is neutralization by blood components, which prevents intratumoral administration to patients. Enadenotucirev, a chimeric HAdV-11p/HAdV-3 adenovirus ...The main limitation of oncolytic vectors is neutralization by blood components, which prevents intratumoral administration to patients. Enadenotucirev, a chimeric HAdV-11p/HAdV-3 adenovirus identified by bio-selection, is a low seroprevalence vector active against a broad range of human carcinoma cell lines. At this stage, there's still some uncertainty about tropism and primary receptor utilization by HAdV-11. However, this information is very important, as it has a direct influence on the effectiveness of HAdV-11-based vectors. The aim of this work is to determine which of the two receptors, DSG2 and CD46, is involved in the attachment of the virus to the host, and what role they play in the early stages of infection.
全体 : Complex between the human adenovirus 11 fiber knob and 2 copies o...
全体
名称: Complex between the human adenovirus 11 fiber knob and 2 copies of the human desmoglein 2 (domains ec2/ec3)
要素
複合体: Complex between the human adenovirus 11 fiber knob and 2 copies of the human desmoglein 2 (domains ec2/ec3)
タンパク質・ペプチド: Desmoglein-2
タンパク質・ペプチド: Fiber protein
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超分子 #1: Complex between the human adenovirus 11 fiber knob and 2 copies o...
超分子
名称: Complex between the human adenovirus 11 fiber knob and 2 copies of the human desmoglein 2 (domains ec2/ec3) タイプ: complex / ID: 1 / 親要素: 0 / 含まれる分子: all