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- ChemComp-H8H: N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYLPIPERAZIN-1-YL)ET... -
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Open data
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Basic information
Entry | ![]() | ||||
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Name | Name: Synonyms: SARACATINIB Wikipedia | ![]() It was originally under development for the treatment of cancer, but while it appeared promising in animal studies and was well tolerated in humans, it failed to show sufficient efficacy in cancer patients and was ultimately not developed further for this application... Comment | inhibitor*YM | |
-Chemical information
Composition | |||||||||
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Others | Type: NON-POLYMER / PDB classification: HETAIN / Three letter code: H8H / Ideal coordinates details: Corina / Model coordinates PDB-ID: 2H8H | ||||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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-Details
-SMILES
ACDLabs 10.04 | CACTVS 3.385 | OpenEye OEToolkits 1.7.6 | |
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-SMILES CANONICAL
CACTVS 3.385 | OpenEye OEToolkits 1.7.6 | |
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-InChI
InChI 1.03 |
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-InChIKey
InChI 1.03 |
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-SYSTEMATIC NAME
ACDLabs 10.04 | OpenEye OEToolkits 1.7.6 | |
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-PDB entries
Showing all 5 items
![](data/pdb/img/2h8h.jpg)
PDB-2h8h:
Src kinase in complex with a quinazoline inhibitor
![](data/pdb/img/4qmx.jpg)
PDB-4qmx:
MST3 in complex with SARACATINIB
![](data/pdb/img/5vcx.jpg)
PDB-5vcx:
CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN (UNTREATED) IN COMPLEX WITH SARACATINIB
![](data/pdb/img/5vd3.jpg)
PDB-5vd3:
CRYSTAL STRUCTURE OF HUMAN MYT1 KINASE DOMAIN (de-phosphorylated) IN COMPLEX WITH SARACATINIB
![](data/pdb/img/6zgc.jpg)
PDB-6zgc:
Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound Saracatinib (AZD0530)