Entry | Database: PDB / ID: 8khu |
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Title | Hepatitis B virus core protein Y132A mutant in complex with THPP derivatives 48 |
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Components | Capsid protein |
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Keywords | VIRAL PROTEIN / HBV capsid assembly mudulator / ANTIVIRAL PROTEIN |
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Function / homology | Function and homology information
microtubule-dependent intracellular transport of viral material towards nucleus / T=4 icosahedral viral capsid / viral penetration into host nucleus / host cell / host cell cytoplasm / symbiont entry into host cell / structural molecule activity / DNA binding / RNA binding / identical protein bindingSimilarity search - Function |
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Biological species | Hepatitis B virus adw/991 |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2 Å |
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Authors | Zhou, Z. / Xu, Z.H. |
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Funding support | 1items Organization | Grant number | Country |
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Not funded | | |
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Citation | Journal: J.Med.Chem. / Year: 2023 Title: Discovery of 4,5,6,7-Tetrahydropyrazolo[1.5-a]pyrizine Derivatives as Core Protein Allosteric Modulators (CpAMs) for the Inhibition of Hepatitis B Virus. Authors: Kou, B. / Zhang, Z. / Han, X. / Zhou, Z. / Xu, Z. / Zhou, X. / Shen, F. / Zhou, Y. / Tian, X. / Yang, G. / Young, J.A.T. / Qiu, H. / Ottaviani, G. / Mayweg, A. / Zhu, W. / Shen, H.C. / Liu, H. / Hu, T. |
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History | Deposition | Aug 22, 2023 | Deposition site: PDBJ / Processing site: PDBJ |
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Revision 1.0 | Oct 25, 2023 | Provider: repository / Type: Initial release |
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Revision 1.1 | Nov 8, 2023 | Group: Database references / Category: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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