登録情報 データベース : PDB / ID : 8k5x 構造の表示 ダウンロードとリンクタイトル Crystal structure of human proMMP-9 catalytic domain in complex with inhibitor 要素Matrix metalloproteinase-9 詳細 キーワード HYDROLASE / MMP-9 / 92 kDa gelatinase / 92 kDa type IV collagenase / Gelatinase B機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
gelatinase B / negative regulation of epithelial cell differentiation involved in kidney development / negative regulation of cation channel activity / negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway / cellular response to UV-A / positive regulation of keratinocyte migration / regulation of neuroinflammatory response / positive regulation of epidermal growth factor receptor signaling pathway / Assembly of collagen fibrils and other multimeric structures / positive regulation of DNA binding ... gelatinase B / negative regulation of epithelial cell differentiation involved in kidney development / negative regulation of cation channel activity / negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway / cellular response to UV-A / positive regulation of keratinocyte migration / regulation of neuroinflammatory response / positive regulation of epidermal growth factor receptor signaling pathway / Assembly of collagen fibrils and other multimeric structures / positive regulation of DNA binding / Activation of Matrix Metalloproteinases / endodermal cell differentiation / positive regulation of release of cytochrome c from mitochondria / response to amyloid-beta / macrophage differentiation / Collagen degradation / collagen catabolic process / extracellular matrix disassembly / EPH-ephrin mediated repulsion of cells / ephrin receptor signaling pathway / negative regulation of intrinsic apoptotic signaling pathway / positive regulation of vascular associated smooth muscle cell proliferation / collagen binding / cellular response to cadmium ion / embryo implantation / Degradation of the extracellular matrix / extracellular matrix organization / positive regulation of receptor binding / skeletal system development / Signaling by SCF-KIT / metalloendopeptidase activity / cellular response to reactive oxygen species / metallopeptidase activity / cell migration / tertiary granule lumen / peptidase activity / cellular response to lipopolysaccharide / Interleukin-4 and Interleukin-13 signaling / collagen-containing extracellular matrix / endopeptidase activity / ficolin-1-rich granule lumen / Extra-nuclear estrogen signaling / positive regulation of protein phosphorylation / positive regulation of apoptotic process / serine-type endopeptidase activity / Neutrophil degranulation / negative regulation of apoptotic process / apoptotic process / proteolysis / extracellular space / extracellular exosome / zinc ion binding / extracellular region / identical protein binding 類似検索 - 分子機能 Fibronectin type II domain / Fibronectin type II domain superfamily / Fibronectin type II domain / Fibronectin type-II collagen-binding domain signature. / Fibronectin type-II collagen-binding domain profile. / Fibronectin type 2 domain / Hemopexin, conserved site / Hemopexin domain signature. / Hemopexin-like domain / Peptidase M10A, cysteine switch, zinc binding site ... Fibronectin type II domain / Fibronectin type II domain superfamily / Fibronectin type II domain / Fibronectin type-II collagen-binding domain signature. / Fibronectin type-II collagen-binding domain profile. / Fibronectin type 2 domain / Hemopexin, conserved site / Hemopexin domain signature. / Hemopexin-like domain / Peptidase M10A, cysteine switch, zinc binding site / Matrixins cysteine switch. / Hemopexin-like repeats / Hemopexin-like domain superfamily / Hemopexin / Hemopexin repeat profile. / Hemopexin-like repeats. / Peptidase M10A / Peptidase M10A, catalytic domain / Peptidase M10, metallopeptidase / Matrixin / PGBD-like superfamily / Peptidase, metallopeptidase / Zinc-dependent metalloprotease / Metallopeptidase, catalytic domain superfamily / Kringle-like fold / Neutral zinc metallopeptidases, zinc-binding region signature. 類似検索 - ドメイン・相同性 DIHYDROGENPHOSPHATE ION / Chem-VOZ / Matrix metalloproteinase-9 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / 分子置換 / 解像度 : 1.9 Å 詳細データ登録者 Kamitani, M. / Mima, M. / Nishikawa-Shimono, R. 資金援助 1件 詳細 詳細を隠す 引用ジャーナル : Bioorg.Med.Chem.Lett. / 年 : 2023タイトル : Discovery of novel indole derivatives as potent and selective inhibitors of proMMP-9 activation.著者: Nishikawa-Shimono, R. / Kuwabara, M. / Fujisaki, S. / Matsuda, D. / Endo, M. / Kamitani, M. / Futamura, A. / Nomura, Y. / Yamaguchi-Sasaki, T. / Yabuuchi, T. / Yamaguchi, C. / Tanaka- ... 著者 : Nishikawa-Shimono, R. / Kuwabara, M. / Fujisaki, S. / Matsuda, D. / Endo, M. / Kamitani, M. / Futamura, A. / Nomura, Y. / Yamaguchi-Sasaki, T. / Yabuuchi, T. / Yamaguchi, C. / Tanaka-Yamamoto, N. / Satake, S. / Abe-Sato, K. / Funayama, K. / Sakata, M. / Takahashi, S. / Hirano, K. / Fukunaga, T. / Uozumi, Y. / Kato, S. / Tamura, Y. / Nakamori, T. / Mima, M. / Mishima-Tsumagari, C. / Nozawa, D. / Imai, Y. / Asami, T. 履歴 登録 2023年7月24日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2023年12月6日 Provider : repository / タイプ : Initial release