登録情報 | データベース: PDB / ID: 8egi |
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タイトル | X-ray structure of carbonmonoxy hemoglobin in complex with VZHE039-NO |
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要素 | (Hemoglobin subunit ...) x 2 |
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キーワード | OXYGEN TRANSPORT / Hemoglobin / sickle cell disease / antisickling / nitric oxide / oxygen equilibrium curve |
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機能・相同性 | 機能・相同性情報
nitric oxide transport / hemoglobin binding / hemoglobin alpha binding / haptoglobin binding / haptoglobin-hemoglobin complex / renal absorption / organic acid binding / hemoglobin complex / oxygen transport / Scavenging of heme from plasma ...nitric oxide transport / hemoglobin binding / hemoglobin alpha binding / haptoglobin binding / haptoglobin-hemoglobin complex / renal absorption / organic acid binding / hemoglobin complex / oxygen transport / Scavenging of heme from plasma / endocytic vesicle lumen / blood vessel diameter maintenance / hydrogen peroxide catabolic process / oxygen carrier activity / Late endosomal microautophagy / Heme signaling / carbon dioxide transport / response to hydrogen peroxide / Erythrocytes take up oxygen and release carbon dioxide / Erythrocytes take up carbon dioxide and release oxygen / Cytoprotection by HMOX1 / oxygen binding / regulation of blood pressure / platelet aggregation / Chaperone Mediated Autophagy / peroxidase activity / positive regulation of nitric oxide biosynthetic process / tertiary granule lumen / Factors involved in megakaryocyte development and platelet production / ficolin-1-rich granule lumen / blood microparticle / iron ion binding / heme binding / Neutrophil degranulation / extracellular space / extracellular exosome / extracellular region / membrane / metal ion binding / cytosol類似検索 - 分子機能 Hemoglobin, pi / Hemoglobin, alpha-type / Hemoglobin, beta-type / Globin/Protoglobin / Globin domain profile. / Globin / Globin / Globin-like superfamily類似検索 - ドメイン・相同性 CARBON MONOXIDE / PROTOPORPHYRIN IX CONTAINING FE / Chem-VZN / Hemoglobin subunit beta / Hemoglobin subunit alpha類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 2.3 Å |
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データ登録者 | Donkor, A.K. / Musayev, F.N. / Safo, M.K. |
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資金援助 | 米国, 3件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute on Minority Health and Health Disparities (NIH/NIMHD) | R01MD009124 | 米国 | National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) | R61HL156158 | 米国 | National Institutes of Health/National Center for Research Resources (NIH/NCRR) | S10OD021756 | 米国 |
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引用 | ジャーナル: Molecules / 年: 2022 タイトル: Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease. 著者: Huang, B. / Ghatge, M.S. / Donkor, A.K. / Musayev, F.N. / Deshpande, T.M. / Al-Awadh, M. / Alhashimi, R.T. / Zhu, H. / Omar, A.M. / Telen, M.J. / Zhang, Y. / McMahon, T.J. / Abdulmalik, O. / Safo, M.K. |
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履歴 | 登録 | 2022年9月12日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年11月16日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月18日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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