登録情報 | データベース: PDB / ID: 8ckf |
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タイトル | Crystal Structure of the first bromodomain of human BRD4 L94C variant in complex with racemic 3,5-dimethylisoxazol ligand |
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要素 | Bromodomain-containing protein 4 |
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キーワード | GENE REGULATION / BROMODOMAIN / LIGAND / EPIGENETICS / READER DOMAIN / TRANSCRIPTION REGULATION |
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機能・相同性 | 機能・相同性情報
RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II ...RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II / transcription coregulator activity / lysine-acetylated histone binding / p53 binding / chromosome / regulation of inflammatory response / positive regulation of canonical NF-kappaB signal transduction / Potential therapeutics for SARS / transcription coactivator activity / transcription cis-regulatory region binding / chromatin remodeling / DNA damage response / chromatin binding / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus類似検索 - 分子機能 Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / : / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site ...Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / : / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily類似検索 - ドメイン・相同性 Chem-E5Q / Chem-V0R / Bromodomain-containing protein 4類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.88 Å |
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データ登録者 | Thomas, A.M. / McDonough, M.A. / Schiedel, M. / Conway, S.J. |
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資金援助 | 英国, 1件 組織 | 認可番号 | 国 |
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UK Research and Innovation (UKRI) | EP/R512333/1 | 英国 |
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引用 | ジャーナル: Acs Chem.Biol. / 年: 2023 タイトル: Mutate and Conjugate: A Method to Enable Rapid In-Cell Target Validation. 著者: Thomas, A.M. / Serafini, M. / Grant, E.K. / Coombs, E.A.J. / Bluck, J.P. / Schiedel, M. / McDonough, M.A. / Reynolds, J.K. / Lee, B. / Platt, M. / Sharlandjieva, V. / Biggin, P.C. / Duarte, F. ...著者: Thomas, A.M. / Serafini, M. / Grant, E.K. / Coombs, E.A.J. / Bluck, J.P. / Schiedel, M. / McDonough, M.A. / Reynolds, J.K. / Lee, B. / Platt, M. / Sharlandjieva, V. / Biggin, P.C. / Duarte, F. / Milne, T.A. / Bush, J.T. / Conway, S.J. |
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履歴 | 登録 | 2023年2月15日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2023年8月2日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年11月1日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.identifier_ORCID / _citation_author.name |
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改定 1.2 | 2023年11月29日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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