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Yorodumi- PDB-7zyf: Insulin regulated aminopeptidase (IRAP) in complex with a nanomol... -
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-Basic information
Entry | Database: PDB / ID: 7zyf | ||||||
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Title | Insulin regulated aminopeptidase (IRAP) in complex with a nanomolar alpha hydroxy beta amino acid based inhibitor. | ||||||
Components | Leucyl-cystinyl aminopeptidase, pregnancy serum form | ||||||
Keywords | HYDROLASE / insulin regulated aminopeptidase / IRAP / hsplap / bestatin analogues / alpla hydroxy beta amino acid based inhibitor | ||||||
Function / homology | Function and homology information cystinyl aminopeptidase / antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent / negative regulation of cold-induced thermogenesis / peptide catabolic process / metalloaminopeptidase activity / aminopeptidase activity / early endosome lumen / Translocation of SLC2A4 (GLUT4) to the plasma membrane / female pregnancy / Endosomal/Vacuolar pathway ...cystinyl aminopeptidase / antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent / negative regulation of cold-induced thermogenesis / peptide catabolic process / metalloaminopeptidase activity / aminopeptidase activity / early endosome lumen / Translocation of SLC2A4 (GLUT4) to the plasma membrane / female pregnancy / Endosomal/Vacuolar pathway / peptide binding / cytoplasmic vesicle membrane / protein catabolic process / regulation of blood pressure / protein polyubiquitination / metallopeptidase activity / Antigen processing: Ubiquitination & Proteasome degradation / cell-cell signaling / lysosomal membrane / perinuclear region of cytoplasm / proteolysis / extracellular space / zinc ion binding / membrane / plasma membrane / cytosol / cytoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.81 Å | ||||||
Authors | Mpakali, A. / Stratikos, E. / Giastas, P. / Papakyriakou, A. | ||||||
Funding support | European Union, 1items
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Citation | Journal: J.Med.Chem. / Year: 2022 Title: Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on alpha-Hydroxy-beta-amino Acid Derivatives of Bestatin. Authors: Vourloumis, D. / Mavridis, I. / Athanasoulis, A. / Temponeras, I. / Koumantou, D. / Giastas, P. / Mpakali, A. / Magrioti, V. / Leib, J. / van Endert, P. / Stratikos, E. / Papakyriakou, A. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7zyf.cif.gz | 861.3 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7zyf.ent.gz | 585.8 KB | Display | PDB format |
PDBx/mmJSON format | 7zyf.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 7zyf_validation.pdf.gz | 4.2 MB | Display | wwPDB validaton report |
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Full document | 7zyf_full_validation.pdf.gz | 4.2 MB | Display | |
Data in XML | 7zyf_validation.xml.gz | 66 KB | Display | |
Data in CIF | 7zyf_validation.cif.gz | 90.1 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/zy/7zyf ftp://data.pdbj.org/pub/pdb/validation_reports/zy/7zyf | HTTPS FTP |
-Related structure data
Related structure data | 7z28C 5mj6S S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data | Similarity search - Function & homologyF&H Search |
-Links
-Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
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