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-Structure paper
Title | Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on alpha-Hydroxy-beta-amino Acid Derivatives of Bestatin. |
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Journal, issue, pages | J. Med. Chem., Vol. 65, Page 10098-10117, Year 2022 |
Publish date | Feb 26, 2022 (structure data deposition date) |
Authors | Vourloumis, D. / Mavridis, I. / Athanasoulis, A. / Temponeras, I. / Koumantou, D. / Giastas, P. / Mpakali, A. / Magrioti, V. / Leib, J. / van Endert, P. ...Vourloumis, D. / Mavridis, I. / Athanasoulis, A. / Temponeras, I. / Koumantou, D. / Giastas, P. / Mpakali, A. / Magrioti, V. / Leib, J. / van Endert, P. / Stratikos, E. / Papakyriakou, A. |
External links | J. Med. Chem. / PubMed:35833347 |
Methods | X-ray diffraction |
Resolution | 1.55 - 2.81 Å |
Structure data | PDB-7z28: PDB-7zyf: |
Chemicals | ChemComp-NAG: ChemComp-ZN: ChemComp-I88: ChemComp-EDO: ChemComp-MLT: ChemComp-PGE: ChemComp-HOH: ChemComp-KFR: ChemComp-PEG: ChemComp-TRS: |
Source |
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Keywords | HYDROLASE / Erap1 / Aminopeptidase / Zinc / metallopeptidase / bestatin / bestatin analogue / inhibitor / insulin regulated aminopeptidase / IRAP / hsplap / bestatin analogues / alpla hydroxy beta amino acid based inhibitor |