登録情報 | データベース: PDB / ID: 7x11 |
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タイトル | Crystal structure of ME1 in complex with NADPH |
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要素 | NADP-dependent malic enzyme |
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キーワード | OXIDOREDUCTASE / malic enzyme / complex |
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機能・相同性 | 機能・相同性情報
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) / regulation of NADP metabolic process / malic enzyme activity / malate dehydrogenase (decarboxylating) (NADP+) activity / nucleotide biosynthetic process / NFE2L2 regulating TCA cycle genes / oxaloacetate decarboxylase activity / malate metabolic process / NADP metabolic process / Pyruvate metabolism ...malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) / regulation of NADP metabolic process / malic enzyme activity / malate dehydrogenase (decarboxylating) (NADP+) activity / nucleotide biosynthetic process / NFE2L2 regulating TCA cycle genes / oxaloacetate decarboxylase activity / malate metabolic process / NADP metabolic process / Pyruvate metabolism / response to carbohydrate / NADH metabolic process / pyruvate metabolic process / Regulation of pyruvate metabolism / response to hormone / PPARA activates gene expression / ADP binding / NAD binding / NADP binding / manganese ion binding / protein homotetramerization / carbohydrate metabolic process / electron transfer activity / magnesium ion binding / mitochondrion / identical protein binding / cytoplasm / cytosol類似検索 - 分子機能 Malic enzyme, conserved site / Malic enzymes signature. / Malic oxidoreductase / Malic enzyme, N-terminal domain / Malic enzyme, N-terminal domain / Malic enzyme, NAD-binding / Malic enzyme, N-terminal domain superfamily / Malic enzyme, N-terminal domain / Malic enzyme, NAD binding domain / Malic enzyme, NAD binding domain ...Malic enzyme, conserved site / Malic enzymes signature. / Malic oxidoreductase / Malic enzyme, N-terminal domain / Malic enzyme, N-terminal domain / Malic enzyme, NAD-binding / Malic enzyme, N-terminal domain superfamily / Malic enzyme, N-terminal domain / Malic enzyme, NAD binding domain / Malic enzyme, NAD binding domain / Aminoacid dehydrogenase-like, N-terminal domain superfamily / NAD(P)-binding domain superfamily類似検索 - ドメイン・相同性 Chem-86I / : / Chem-NDP / NADP-dependent malic enzyme類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.07 Å |
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データ登録者 | Amano, Y. |
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資金援助 | 1件 |
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引用 | ジャーナル: Biochemistry / 年: 2022 タイトル: Discovery and Characterization of a Novel Allosteric Small-Molecule Inhibitor of NADP + -Dependent Malic Enzyme 1. 著者: Yoshida, T. / Kawabe, T. / Cantley, L.C. / Lyssiotis, C.A. |
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履歴 | 登録 | 2022年2月22日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2022年7月20日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2022年8月17日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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改定 1.2 | 2023年11月29日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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