登録情報 | データベース: PDB / ID: 7uf6 |
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タイトル | Crystal structure of liganded Hb with the 5-HMF analog, MMA509 |
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要素 | (Hemoglobin subunit ...) x 2 |
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キーワード | OXYGEN TRANSPORT / hemoglobin / 5-HMF / sickle cell disease / antisickling / oxygen equilibrium / aromatic aldehydes |
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機能・相同性 | 機能・相同性情報
nitric oxide transport / cellular oxidant detoxification / hemoglobin binding / hemoglobin alpha binding / haptoglobin-hemoglobin complex / organic acid binding / renal absorption / hemoglobin complex / oxygen transport / Scavenging of heme from plasma ...nitric oxide transport / cellular oxidant detoxification / hemoglobin binding / hemoglobin alpha binding / haptoglobin-hemoglobin complex / organic acid binding / renal absorption / hemoglobin complex / oxygen transport / Scavenging of heme from plasma / endocytic vesicle lumen / blood vessel diameter maintenance / hydrogen peroxide catabolic process / oxygen carrier activity / regulation of blood pressure / Late endosomal microautophagy / Heme signaling / carbon dioxide transport / Erythrocytes take up oxygen and release carbon dioxide / response to hydrogen peroxide / Erythrocytes take up carbon dioxide and release oxygen / Cytoprotection by HMOX1 / platelet aggregation / oxygen binding / Chaperone Mediated Autophagy / positive regulation of nitric oxide biosynthetic process / Factors involved in megakaryocyte development and platelet production / tertiary granule lumen / ficolin-1-rich granule lumen / blood microparticle / iron ion binding / heme binding / Neutrophil degranulation / extracellular space / extracellular exosome / extracellular region / membrane / metal ion binding / cytosol類似検索 - 分子機能 : / Hemoglobin, pi / Hemoglobin, alpha-type / Hemoglobin, beta-type / Globin/Protoglobin / Globin domain profile. / Globin / Globin / Globin-like superfamily類似検索 - ドメイン・相同性 CARBON MONOXIDE / PROTOPORPHYRIN IX CONTAINING FE / (2S)-2-(5-methylfuran-2-yl)oxane / Hemoglobin subunit beta / Hemoglobin subunit alpha類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 2 Å |
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データ登録者 | Donkor, A.K. / Musayev, F.N. / Safo, M.K. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) | R61HL156158 | 米国 | National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD) | S10OD021756 | 米国 |
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引用 | ジャーナル: To be published タイトル: Improving the antisickling activity of furaldehyde 著者: El-Araby, M.E. / Omar, A.M. / Ghatge, M.S. / Musayev, F.N. / Donkor, A.K. / Paredes, S.D. / Abdulmalik, O. / Safo, M.K. |
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履歴 | 登録 | 2022年3月22日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年3月30日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月18日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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