登録情報 | データベース: PDB / ID: 7sly |
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タイトル | Vanin-1 complexed with Compound 27 |
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要素 | Pantetheinase |
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キーワード | HYDROLASE / Pantetheine / SBDD / pyrimdine carboxamide |
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機能・相同性 | 機能・相同性情報
pantetheine hydrolase / pantetheine hydrolase activity / pantothenate metabolic process / chronic inflammatory response / coenzyme A catabolic process / Vitamin B5 (pantothenate) metabolism / Post-translational modification: synthesis of GPI-anchored proteins / positive regulation of T cell differentiation in thymus / acute inflammatory response / positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ...pantetheine hydrolase / pantetheine hydrolase activity / pantothenate metabolic process / chronic inflammatory response / coenzyme A catabolic process / Vitamin B5 (pantothenate) metabolism / Post-translational modification: synthesis of GPI-anchored proteins / positive regulation of T cell differentiation in thymus / acute inflammatory response / positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / azurophil granule membrane / side of membrane / cell-cell adhesion / response to oxidative stress / inflammatory response / innate immune response / Neutrophil degranulation / extracellular region / membrane / plasma membrane類似検索 - 分子機能 Biotinidase-like, eukaryotic / Biotinidase/VNN family / Vanin, C-terminal / Vanin C-terminal domain / Carbon-nitrogen hydrolase superfamily / Carbon-nitrogen hydrolase / Carbon-nitrogen hydrolase domain profile. / Carbon-nitrogen hydrolase類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.17 Å |
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データ登録者 | Vajdos, F.F. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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Other private | | 米国 |
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引用 | ジャーナル: J.Med.Chem. / 年: 2022 タイトル: Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1. 著者: Casimiro-Garcia, A. / Allais, C. / Brennan, A. / Choi, C. / Dower, G. / Farley, K.A. / Fleming, M. / Flick, A. / Frisbie, R.K. / Hall, J. / Hepworth, D. / Jones, H. / Knafels, J.D. / Kortum, ...著者: Casimiro-Garcia, A. / Allais, C. / Brennan, A. / Choi, C. / Dower, G. / Farley, K.A. / Fleming, M. / Flick, A. / Frisbie, R.K. / Hall, J. / Hepworth, D. / Jones, H. / Knafels, J.D. / Kortum, S. / Lovering, F.E. / Mathias, J.P. / Mohan, S. / Morgan, P.M. / Parng, C. / Parris, K. / Pullen, N. / Schlerman, F. / Stansfield, J. / Strohbach, J.W. / Vajdos, F.F. / Vincent, F. / Wang, H. / Wang, X. / Webster, R. / Wright, S.W. |
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履歴 | 登録 | 2021年10月25日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年1月12日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2022年1月26日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.year / _citation_author.identifier_ORCID |
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改定 1.2 | 2024年4月3日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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