登録情報 | データベース: PDB / ID: 7ntb |
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タイトル | Crystal structure of human carbonic anhydrase with a benzophenone-derivative |
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要素 | Carbonic anhydrase 2 |
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キーワード | LYASE / Protein-inhibitor adduct |
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機能・相同性 | 機能・相同性情報
positive regulation of cellular pH reduction / positive regulation of dipeptide transmembrane transport / regulation of monoatomic anion transport / secretion / cyanamide hydratase / cyanamide hydratase activity / arylesterase activity / regulation of chloride transport / Reversible hydration of carbon dioxide / angiotensin-activated signaling pathway ...positive regulation of cellular pH reduction / positive regulation of dipeptide transmembrane transport / regulation of monoatomic anion transport / secretion / cyanamide hydratase / cyanamide hydratase activity / arylesterase activity / regulation of chloride transport / Reversible hydration of carbon dioxide / angiotensin-activated signaling pathway / positive regulation of synaptic transmission, GABAergic / morphogenesis of an epithelium / regulation of intracellular pH / carbonic anhydrase / carbonate dehydratase activity / carbon dioxide transport / Erythrocytes take up oxygen and release carbon dioxide / Erythrocytes take up carbon dioxide and release oxygen / neuron cellular homeostasis / one-carbon metabolic process / apical part of cell / myelin sheath / zinc ion binding / extracellular exosome / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Carbonic anhydrase, alpha-class, conserved site / Alpha-carbonic anhydrases signature. / Carbonic anhydrase, alpha-class / Alpha carbonic anhydrase domain / Alpha carbonic anhydrase domain superfamily / Eukaryotic-type carbonic anhydrase / Alpha-carbonic anhydrases profile. / Eukaryotic-type carbonic anhydrase類似検索 - ドメイン・相同性 MERCURIBENZOIC ACID / Chem-URH / Carbonic anhydrase 2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / フーリエ合成 / 解像度: 1.7 Å |
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データ登録者 | Di Fiore, A. / De Simone, G. |
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引用 | ジャーナル: Acs Med.Chem.Lett. / 年: 2022 タイトル: Interaction Studies between Carbonic Anhydrase and a Sulfonamide Inhibitor by Experimental and Theoretical Approaches 著者: Pagnozzi, D. / Pala, N. / Biosa, G. / Dallocchio, R. / Dessi, A. / Singh, P.K. / Rogolino, D. / Di Fiore, A. / De Simone, G. / Supuran, C.T. / Sechi, M. |
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履歴 | 登録 | 2021年3月9日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2022年3月16日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年1月31日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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